The Anthelmintic Activity of <i>Nepeta racemosa</i> Lam. Against Gastrointestinal Nematodes of Sheep: Rosmarinic Acid Quantification and In Silico Tubulin-Binding Studies by Büşra Karpuz Ağören, Mahmut Sinan Erez, Esma Kozan, Aydın Dağyaran, Mevlüt Akdağ, Eduardo Sobarzo-Sánchez, Esra Küpeli Akkol

“…As tubulin plays an important role in the mechanism of anthelmintics, the major compound of the most active extract (NR-EtOAc) rosmarinic acid was docked onto the colchicine-binding site of the tubulin (5OV7) protein. …”
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Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice by Weifeng Gu, Tingting Zheng, Wen Li, Xinkai Luo, Xiaowei Xu, Ying Wang, Chaoming Mao, Yongbin Ma, Liyang Dong

“…The therapeutic effects of migrasomes on airway inflammation in ovalbumin (OVA)-induced asthmatic mice were evaluated by hematoxylin-eosin (HE) and periodic-acid schiff (PAS) staining, and their mechanism were further testified by immunofluorescent staining, real-time PCR and flow cytometry. …”
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HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer by Xin Li, Peng Yang, Jin Gu, Nan Chen, Dengbo Ji, Jinhong Xia, Jinying Jia, Zhuang Sun, Mengyuan Shi, Hanyang Wang, Zhaoya Gao

“…Subsequently, we investigated the synergistic effects of identified effective inhibitors and probed their cooperative mechanisms. Concurrently, we explored the immune characteristics of BRAFV600E MSS CRC using RNA sequencing and multiplex immunohistochemistry. …”
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Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…The hypothalamic-pituitary-ovarian (HPO) axis is an energy-sensitive functional axis for follicle development, synthesis, and secretion of reproductive hormones, and plays a key role in modulating sustained ovulation in layers. To investigate the mechanism of integrated network regulation of the HPO axis under energy fluctuation, ninety Hy-line brown layers (265-day-old, 1.92 ± 0.02 kg) were randomly divided into three groups for a 17-day experiment: a control group (Con group) fed ad libitum from days 1 to 17, an energy-deprived group (ED group) that was fed ad libitum from days 1 to 12 and then underwent a fasting period from days 13 to 17 to induce a pause in laying, and a re-fed group (Rf group) that fasted for seven days (specifically, days 1 to 5, day 7, and day 9), had ad libitum access to feed on days 6 and 8, and was continuously fed from days 10 to 17. …”
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MicroRNA-17-5p and MicroRNA-130b-3p Promote Radioresistance of Glioma Stem Cells by Targeting PTEN/AKT/HIF-1α Pathway-Controlled Phosphopentose Metabolism by Tao Xie, Yu-Hao Ding, Jun Dong, Xi-An Fu

“…Radiation-induced miR-17-5p and miR-130b-3p might cause the radioresistance of GSCs, and the mechanisms were associated with the enhancement of antioxidant production, which was from the increments of AKT/HIF-1α signaling pathway-controlled glucose transmembrane transport and phosphopentose metabolism by targeting PTEN.…”
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New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach by Yin Guan, Xiaoqian Zhao, Yun Lu, Yue Zhang, Yan Lu, Yue Wang

“…These findings support NBTL’s use as a promising candidate for RA treatment, emphasizing the need for further research on its mechanisms and clinical application.…”
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Exploring how graft length shapes root system architecture and morphology in grapevine rootstocks by Mathieu Larrey, Jean-Pascal Tandonnet, Clément Saint Cast, Sarah Jane Cookson, Philippe Vivin

“…The insights gathered here contribute to a deeper understanding of the mechanisms governing root development in grafted grapevines, thereby informing strategies to enhance grafting techniques and optimize grapevine cultivation. …”
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Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle by Ziyu Chen, Xiaoqian Wu, Dongbin Zheng, Yuling Wang, Jie Chai, Tinghuan Zhang, Pingxian Wu, Minghong Wei, Ting Zhou, Keren Long, Mingzhou Li, Long Jin, Li Chen

“…In conclusion, our study elucidates transcriptional differences in skeletal muscle between two growth stages of pigs and provides insights into mechanisms relevant to pork meat quality and skeletal muscle diseases.…”
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Simultaneous Debridement and Titanium Mesh Reconstruction in Patients with Compound Depressed Skull Fracture: A Retrospective Descriptive Study by Srikant Das, Acharya Suryakant Pattajoshi, Mahesh Kumar Kusta, Dibakar Sarkar

“…Results: The mean age of the subjects was 28.48±13.79 years. The predominant mechanism of injury was Road Traffic Accident (RTA), affecting 59 (60.2%) patients. …”
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Angesinenolide B, A Phthalide Dimeric Peroxide, Exerts Anti-Inflammatory Properties by Suppressing MAPK/STATs Signaling Pathways and ROS Production by Zhang L, Liu Y, Wang H, Guo S, Lv J

“…The objective of the current study was to evaluate the anti-inflammatory function of ASB and the potential mechanism in lipopolysaccharide (LPS)-stimulated macrophages and CuSO4-induced zebrafish models.Methods: The level of nitric oxide (NO), a proinflammatory mediator, in LPS-stimulated RAW264.7 cells was quantified using Griess method. …”
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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

“…The already existing monitoring infrastructures have provided an enormous amount of hydrometeorological data, facilitating detailed insights into the causal mechanisms of hydrological processes, the testing of scientific theories and hypotheses, and the revelation of the physical laws governing catchment behavior. …”
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Within- and between-day test–retest reliability of responses to rapid bilateral anterolateral magnetic phrenic nerve stimulation in healthy humans (ReStim) by Kyle G. P. J. M. Boyle, Andrea A. Beglinger, Heinrich Häusler, Anna Stahel, Esther I. Schwarz, Esther I. Schwarz, Christina M. Spengler, Christina M. Spengler

“…BackgroundMechanical ventilation can lead to lung injury and diaphragmatic dysfunction. …”
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Bank Credit and Loan Repayment During Covid-19 In Kabale District: A Case of Lyamujungu SACCO. by Byamukama, Dicky

“…The study recommends SACCOs to seriously consider having in place effective credit standards, credit policy, credit terms and collection policies or procedures as mechanisms to guide their business, since the effectiveness of credit management is important to the successful management of banking institutions.…”
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Effect of Construction Waste as a Fine Aggregate on Properties of Concrete. by Sempala, Ronald

“…Construction debris, such as brick, block, and leftover mortar, was converted into aggregates by being manually or mechanically crushed in a jaw or impact crusher. A significant amount of waste (size smaller than 4.75 mm) was produced as by-product during this process. …”
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Assessment of the Impact of Floods to the Local Community in Nyarusiza Sub-County Kisoro District. by Murengezi, Innocent

“…The researcher concludes that the different coping mechanisms to seasonal floods adopted by people include among other considerations: the construction of flood protection embankments, the creation of water drainage canals, and maintaining hygiene.…”
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Investigating a Suitable Ratio of Iron Ore Tailings and Quarry Dust in Concrete Production. by Kasozi, Mark

“…The main objective of this study is to investigate a suitable ratio of iron ore tailings and quarry dust in concrete production by determining the physical properties of fine aggregate, designing a concrete mix conducting mechanical tests, and conducting a comparative study between the effect of Buhara IOT and Ntungoma quarry dust. …”
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Impact of Weed Infestation on Growth and Yield of Carrot Plants. by Mutabazi, Cosma

“…The study also recommended Implementing integrated weed management practices that combine cultural, mechanical, and chemical methods. For instance, using cover crops or mulching can suppress weed growth while promoting carrot health.…”
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Assessing the Suitability of Snail-Shell Powder as a Partial Replacement of Cement in Concrete Production. by Mukundane, Ivan

“…Concrete is considered the backbone of any construction work both economically and mechanically. It is a composite material resulting from a mixture of cement, water, and aggregates (both fine and coarse). …”
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Examining the Role Played by Remand Homes Towards Curbing the Rate of Juvenile Delinquency in Kabale Municipality. by Ampurire, Evarine

“…The causes of juvenile delinquency in Southern Division Kabale Municipality included lack of parental guidance 13%, family breakages 06%, insecurity in families 10%, peer pressure 06%, drug abuse 09%, bad relationship with parents 10%, being orphaned 14%, poverty 12%, social media influence 07% and adolescence phase influence 13%. …”
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Effects of Temperature and Light Intensity on the Growth and Physiological and Biochemical Characteristics of Young Sporophyte of a Novel Saccharina japonica "Huangguan No.2" by Guiyang SONG, Zhourui LIANG, Xiaoping LU, Yanmin YUAN, Wenjun WANG

“…The study aimed to investigate the optimal light and temperature conditions, and physiological and biochemical mechanisms for the growth of young sporophytes (3–4 cm) of "Huangguan No.2". …”
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