Analysis of oral cancer carcinogens in repeatedly heated cooking oils by Vidhant Krishna Nambiar, Vidya Mudliar, Inosi Salababa

“…The incidence of oral cancer in recent years has been on the rise; ninety percent of the cancers present in the oral cavity are squamous cell carcinoma with multiple major contributing lifestyle factors such well as the presence of the human papilloma virus. Not all mechanisms of carcinogenesis are fully understood and are complex. …”
Get full text

Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress by Mihai Spiridon-Bodi, Cristina Ros-Carrero, J. Carlos Igual, Mercè Gomar-Alba

“…Importantly, we identified new Whi7-specific regulatory mechanisms that do not operate in the Whi5 repressor. …”
Get full text

SARS-CoV-2 SPIKE Antibody Levels can Indicate Immuno-Resilience to Re-infection: a Real-World Study by Yue Jin, Fei Yang, Christopher M. Rank, Stanley Letovsky, Peter Ramge, Simon Jochum

“…Study outcomes included the first symptomatic SARS-CoV-2 infection (per ICD-10 diagnostic codes, occurring ≥ 7 days post-antibody titer test), and severe SARS-CoV-2 infection, characterized by adverse outcomes including hospitalization, intensive care unit admission, intubation, mechanical ventilation, or death within 30 days of infection. …”
Get full text

Subsurface investigation for pre-foundation study utilizing integrated geophysical and geotechnical methods, UNILORIN campus by Gabriel Efomeh Omolaiye, Abdulhameed Kayode Oniyangi, Taofeeq Ayinde ISSA, Sodiq Bamidele Adam

“…However, the geotechnical analysis conducted on undisturbed samples picked at different depths from eight pits dug to a depth of 2.3 m revealed the following: bulk density (1.80 g/cm3-1.99 g/cm3), dry density (1.67 g/cm3-1.86 g/cm3) liquid limits (22.3%-34.1%), plastic limits (12.6%-19.8%), plasticity index (9.7%-14.3%) and cone penetration test (89.8 kN/m2-2110.3 kN/m2 at a depth of 0.1 m to 0.3 m), in which all these geotechnical analysis results classified the soil to be competent in variations and assess soil mechanical behaviour to support structural loads within study area. …”
Get full text

Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study by Matthew A. Lee, Kate L. Burley, Emma L. Hazelwood, Sally Moore, Sarah J. Lewis, Lucy J. Goudswaard

“…Proteomics is a valuable tool in exploring mechanisms of disease. We investigated the causal relationship between circulating proteins and MM risk, using two of the largest cohorts with proteomics data to-date. …”
Get full text

Aqueous photocatalytic oxidation of lignin and humic acids with supported <mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>TiO</mml:mtext> </mml:mrow> <...

“…Proceeding most likely by a radical mechanism, the efficiency of PCO of humic acids did not benefit from an excessive presence of hydroxyl radical promoters, such as hydrogen peroxide, although the reaction rate increased. …”
Get full text

Oxygen Requirement and Associated Risk Factors in Post-COVID-19 Patients Admitted to a Tertiary Care Center: A Cross-Sectional Study by Bishnu Deep Pathak, Binit Upadhaya Regmi, Sushil Joshi, Bishal Dhakal, Suhail Sapkota, Kanchan Bishwakarma, Ashim Bhandari, Seejan Pathak, Shriya Sharma, Aakriti Adhikari, Nabin Simkhada, Dhan Shrestha

“…The mode of oxygen therapy (nasal cannula, face mask, reservoir mask, or mechanical ventilation) in the first two weeks of the study was presented appropriately in a table. …”
Get full text

Function over form: The benefits of aspen as surrogate brood‐rearing habitat for greater sage‐grouse by Michel T. Kohl, Charles P. Sandford, Paul C. Rogers, Renee Chi, Terry A. Messmer, David K. Dahlgren

“…As a result, practitioners habitually focus conservation efforts on these communities while ignoring ecological mechanisms that explain the wildlife–plant relationships. …”
Get full text

Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption by Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

“…Finally, rescue experiments were performed to confirm the molecular mechanism of NSD2 in the development of IBD. Results Deficiency of NSD2 in mouse IECs aggravated epithelial barrier disruption and inflammatory response in IBD. …”
Get full text

The relationship between interpersonal trust, family capital, and physical activity behavior among university students: a cross-lagged study by Bo Li, Ying He, Xielin Zhou

“…Abstract To explore the interaction mechanism between interpersonal trust, family capital, and physical activity behavior among college students using a cross-lagged study design, providing a theoretical basis for the healthy development of their physical and mental well-being. …”
Get full text

Mycobiome analyses of critically ill COVID-19 patients by Danielle Weaver, Sara Gago, Matteo Bassetti, Daniele Roberto Giacobbe, Juergen Prattes, Martin Hoenigl, Florian Reizine, Hélène Guegan, Jean-Pierre Gangneux, Michael John Bromley, Paul Bowyer

“…Increased fungal burden in the lungs of critically ill COVID-19 patients is linked to prolonged mechanical ventilation and increased mortality. However, specific mycobiome signatures associated with severe COVID-19 in the context of survival and antifungal drug prophylaxis have not yet been determined, and such knowledge could have an important impact on treatment. …”
Get full text

Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…MMDTR, Foxp3DTR, CD4 KO and CD8 KO mice were used to elucidate the underlying mechanisms. Gene expression levels in human MM were analyzed using Gene Expression Omnibus public datasets.Results We found that programmed cell death protein 1 (PD-1) antibody treatment had a therapeutic effect in 5TGM1 mice; it was ineffective in Vk*MYC mice. …”
Get full text

Xiaohua Funing decoction ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and bile acids by Jindong Zhao, Jindong Zhao, Yan Li

“…Previous studies have indicated that XFD protects liver function, but the underlying mechanism remains unclear.MethodsIn this study, a Wistar rat model of NAFLD (Mod) was established via a high-fat diet. …”
Get full text

Hiperoxaluria secundaria: causas y consecuencias de la enfermedad renal crónica by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…It is present at both the intestinal and renal levels. Its mechanism of action is altered in situations of systemic inflammation and metabolic syndrome, which could explain the growing increase in cases of secondary hyperoxaluria in recent decades. …”
Get full text

Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis by Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu

“…Aerobic exercise lowers PCSK9 levels, but the underlying mechanism remains unclear. Therefore, we investigated how aerobic exercise can ameliorate statin-induced increases in PCSK9 levels. …”
Get full text

RETRACTED ARTICLE: Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11 by Duanfeng Jiang, Xin Wu, Xiaoying Sun, Wei Tan, Xin Dai, Youbang Xie, Ashuai Du, Qiangqiang Zhao

“…The purpose of this study was to investigate the effects of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on the regulation of AML and the underlying mechanisms mediated by microRNA (miRNA). Methods Dysregulated miR-7-5p in AML patients was identified using qRT-PCR and its clinical significance was explored. …”
Get full text

Evaluation of gamma rays shielding properties of bismuth tungstate with different morphologies by Qiang Yan, Yong Li, Guowei Wang, Zhengxin Wu, Haitao Zhang, Chuyuan Mao, Zhiqiang Long, Guoqing Liu

“…In addition, obvious differences of mechanical properties were also observed between the composites prepared using different crystalline bismuth tungstates. …”
Get full text

Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution. by Nicolas Tessandier, Baptiste Elie, Vanina Boué, Christian Selinger, Massilva Rahmoun, Claire Bernat, Sophie Grasset, Soraya Groc, Anne-Sophie Bedin, Thomas Beneteau, Marine Bonneau, Christelle Graf, Nathalie Jacobs, Tsukushi Kamiya, Marion Kerioui, Julie Lajoie, Imène Melki, Jean-Luc Prétet, Bastien Reyné, Géraldine Schlecht-Louf, Mircea T Sofonea, Olivier Supplisson, Chris Wymant, Vincent Foulongne, Jérémie Guedj, Christophe Hirtz, Marie-Christine Picot, Jacques Reynes, Vincent Tribout, Édouard Tuaillon, Tim Waterboer, Michel Segondy, Ignacio G Bravo, Nathalie Boulle, Carmen Lía Murall, Samuel Alizon

“…Most anogenital HPV infections are cleared in less than two years, but the underlying mechanisms that favour persistence in around 10% of women remain largely unknown. …”
Get full text

Global Solar Radiation Models in Minas Gerais, Southeastern Brazil by Ana Flávia Martins Monteiro, Fabrina Bolzan Martins

“…This point is a limitation of the model for estimating global solar radiation below and above these levels, showing the influence of atmospheric systems and atmospheric attenuation mechanisms of global solar radiation.…”
Get full text

Identification of serotype O3b and high-risk clone ST37 of Klebsiella pneumoniae revealed by comparative genomic analysis by Sivaraman Gopalan Krishnan, Sudha Sajeev, Visnuvinayagam Sivam, Raja Swaminathan T., Rakshit Ojha, Bibek Ranjan Shome, Mark Holmes, Thanigaivel Sundaram, Ramesh M. D., Saranya Vinayagam, Suseela Meesala, Tabarak Malik, Tabarak Malik, Pavan Kumar Dara

“…The prevalence of ARGs linked to efflux pump resistance mechanisms is highlighted by the analysis of genome sequence data.…”
Get full text