Explore Alteration of Lung and Gut Microbiota in a Murine Model of OVA-Induced Asthma Treated by CpG Oligodeoxynucleotides by Wang Q, Ji J, Xiao S, Wang J, Yan X, Fang L

“…Qingqing Wang, Jingjing Ji, Shuaijun Xiao, Jiong Wang, Xuebo Yan, Lei Fang Department of Geriatric Respiratory and Critical Care, The First Affiliated Hospital of Anhui Medical University, Anhui Geriatric Institute, Hefei, Anhui, People’s Republic of ChinaCorrespondence: Jiong Wang, Email wangjiong7286@163.comAim: We sought to investigate the impact of CpG oligodeoxynucleotides (CpG-ODN) administration on the lung and gut microbiota in asthmatic mice, specifically focusing on changes in composition, diversity, and abundance, and to elucidate the microbial mechanisms underlying the therapeutic effects of CpG-ODN and identify potential beneficial bacteria indicative of its efficacy.Methods: HE staining were used to analyze inflammation in lung, colon and small intestine tissues. …”
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Viable Ileosigmoid Knotting, A Very Phenomenon Finding and Rare Cause of Intestinal Obstruction: A Case Report and Literature Review by Beyene SA, Bogale NT, Abdinasir MM, Desalegne AZ, Wossen MA

“…It is an unusual cause of intestinal obstruction, accounting for 1– 2% of cases of all mechanical obstruction in the majority published literatures. …”
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The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions by Xuegang Li, Haijian Jiang, Xu Wang, Shuping Zhong

“…Cellular elements and their secreted bone turnover markers might be one of the underlying mechanisms that drive the new bone formation. Our study aimed to investigate the role of bone turnover markers in r-axSpA patients with fatty lesions. …”
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Assessing factors influencing green hydrogen conversion at Vietnam's gas turbine power plants using combined SWOT-AHP analysis method by Duong Doan Ngoc, Kien Duong Trung, Phap Vu Minh, Thao Nguyen Van

“…At the level of element factors in the groups, the lack of infrastructure and insufficient legal framework/specific incentive mechanisms are the biggest weaknesses, with weights of 0.362 and 0.326, respectively, while the consistent policies of the state and abundant potential of renewable energy resources, weighing 0.446 and 0.235, respectively, are Vietnam's prominent strengths. …”
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Incidence and Risk Factors of Ventilator-Associated Pneumonia among Patients with Delirium in the Intensive Care Unit: A Prospective Observational Study by Morteza Shamsizadeh, Ali Fathi Jouzdani, Farshid Rahimi-Bashar

“…Of 108 delirium patients, 86 patients (79.6%) underwent mechanical ventilation (MV) and 16 patients (18.6%) experienced VAP during ICU stay. …”
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Exploring the perceptual experiences of nurses regarding the care of patients with COVID-19: A mixed methodological approach by Vaishali S. Jadhav, Arunima Sreeletha, Natasha Mahajan

“…Social resistance included pressure to resign, lack of familial support, and societal stigma. Coping mechanisms involved communicating with loved ones, receiving support from colleagues, and engaging in activities such as listening to music, meditation, prayer, exercise, and yoga. …”
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High-resolution 4D electrical resistivity tomography and below-ground point sensor monitoring of High Arctic deglaciated sediments capture zero-curtain effects, freeze–thaw transit... by M. O. Cimpoiasu, O. Kuras, H. Harrison, P. B. Wilkinson, P. Meldrum, J. E. Chambers, D. Liljestrand, C. Oroza, S. K. Schmidt, P. Sommers, L. Vimercati, T. P. Irons, Z. Lyu, A. Solon, J. A. Bradley, J. A. Bradley

“…Understanding the physical mechanisms and processes that determine soil liquid moisture availability contributes to the way we conceptualize and understand the development and functioning of terrestrial Arctic ecosystems. …”
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Peptide Design for Enhanced Anti-Melanogenesis: Optimizing Molecular Weight, Polarity, and Cyclization by Putri SA, Maharani R, Maksum IP, Siahaan TJ

“…The balance between hydrophilic and hydrophobic properties in peptides is crucial for effective TYR inhibition, as higher hydrophilicity enhances affinity for the TYR active site and stronger catalytic inhibition, while hydrophobicity can contribute through alternative mechanisms. Cyclization of peptides enhances their structural stability, serum resistance, and binding affinity while reducing toxicity. …”
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Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…In 40% of cases, a key mechanism of endocrine resistance to the standard first line is a mutation of the ligand-binding domain (LBD) of Estrogen Receptor 1 (ESR1) encoding estrogen receptor α (ER). …”
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A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…Understanding the underlying mechanism associated with sepsis is essential for discovering biomarkers for better management and treatment. …”
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Skipping Breakfast Is Associated with an Atherogenic Lipid Profile in Overweight and Obese Prepubertal Children by A. Blasetti, S. Franchini, V. Castorani, L. Comegna, E. Fornari, F. Daniele, G. Prezioso, C. Piona, V. Federico, D. Zona, I. Bresadola, F. Chiarelli, C. Maffeis

“…However, it is not known if skipping breakfast is also correlated with CV risk factors independently from obesity. The mechanisms explaining the role of skipping breakfast on promoting fat accumulation as well as CV risk are not known. …”
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The effects of mobile phone addiction on learning engagement of Chinese college students - the mediating role of physical activity and academic self-efficacy by Shuqiao Meng, Kai Qi, Panyi Shen, Meng Zhang, Yu Zhang, Nzubechi Onyebuchi, Ge Zhan, Fanqi Wei, Wenxia Tong, Yahui Han, Xiaoyu Ge

“…This study employs self-determination theory as a framework to examine the mechanisms through which mobile phone addiction affects students’ learning engagement. …”
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MiR- 146b-5p inhibits Candida albicans-induced inflammatory response through targeting HMGB1 in mouse primary peritoneal macrophages by Jing Cheng, Xiaoxing Tian, Chuanxin Wu, Jiaojiao Wang, Huiling Liu, Sha Cheng, Hang Sun

“…Although high mobility group box 1 (HMGB1) plays a key role in C. albicans infection, its mechanism is unclear. We aimed to explore the regulation of small-molecule non-coding RNA (miRNA) for HMGB1 in C. albicans infection. …”
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Association of physical and sexual assault with mortality in two British birth cohorts by Jayati Das-Munshi, Ioannis Bakolis, William Lee, Vishal Bhavsar, James H MacCabe

“…Greater need for medical treatment for assault was associated with a fully adjusted mortality HR of 1.56 (95% CI 1.19 to 2.05) in the combined cohorts, 1.43 (95% CI 1.00 to 2.05) in the 1958 birth cohort and 1.79 (95% CI 1.18 to 2.74) in the 1970 birth cohort.Conclusions There was statistical evidence on combining the two birth cohorts, and on analysing the 1970 birth cohort, that assault in adulthood is associated with mortality. Understanding mechanisms underlying this relationship could benefit violence reduction strategies for public health.…”
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Analysis of argument structure constructions in the large language model BERT by Pegah Ramezani, Pegah Ramezani, Achim Schilling, Achim Schilling, Patrick Krauss, Patrick Krauss

“…This research demonstrates the potential of both recurrent and transformer-based neural language models to mirror linguistic processing in the human brain, offering valuable insights into the computational and neural mechanisms underlying language understanding.…”
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Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Conclusion: The lower capability of LIT in changing the population of NKT cells compared to prednisolone therapy may be due to its mechanism of action, which is related to the production of blocking antibodies. …”
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Rethinking village malaria workers in Cambodia: Perspectives from the communities, programme managers, and international stakeholders. by Long Heng Orng, Monnaphat Jongdeepaisal, Panarasri Khonputsa, Lek Dysoley, Siv Sovannaroth, Thomas J Peto, James J Callery, Christopher Pell, Richard J Maude, Marco Liverani

“…There was emphasis on the needs for more sustainable financing mechanisms and integration with the existing community health infrastructure. …”
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Antistaphylococcal Triazole-Based Molecular Hybrids: Design, Synthesis and Activity by Kostiantyn Shabelnyk, Alina Fominichenko, Oleksii Antypenko, Olexandr Gaponov, Svitlana Koptieva, Svitlana Shyshkina, Oleksii Voskoboinik, Sergiy Okovytyy, Serhii Kovalenko, Valentyn Oksenych, Oleksandr Kamyshnyi

“…The possible molecular mechanism of the synthesized compounds (DNA gyrase inhibitors) was investigated and discussed using molecular docking, and their further study for antistaphylococcal activity was substantiated. …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…RT-qPCR measurement quantified the expression of inflammatory genes, and zymography and Western blotting were used to examine changes in invasive protein levels, epithelial-to-mesenchymal transition (EMT) markers, and underlying molecular mechanisms. Our findings demonstrated the significant ability of morin to decrease the production of IL-1β, IL-18, and IL-6 in a dose-dependent manner (<i>p</i> < 0.05), as well as suppress NSCLC cell migration and invasion. …”
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A Personalized Muscle–Tendon Assessment and Exercise Prescription Concept Reduces Muscle–Tendon Imbalances in Female Adolescent Athletes by Theresa Domroes, Kolja Weidlich, Sebastian Bohm, Falk Mersmann, Adamantios Arampatzis

“…Abstract Background Imbalances between muscle strength and tendon stiffness influence the mechanical demand on the tendon (i.e., tendon strain) and may increase tendon injury risk. …”
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