Pharmacogenomics predictors of aromatic antiepileptic drugs-induced SCARs in the Iraqi patients by Ali Fadhel Ahmed, Dzul Azri Mohamed Noor, Majeed Arsheed Sabbah, Nur Fadhlina Musa, Nur Aizati Athirah Daud

“…Common types of SCARs include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). Immune-mediated mechanisms involving human leukocyte antigen (HLA) alleles have been implicated in the pathogenesis of this reaction. …”
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Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants by Christian C. Ndu, Wonder K. M. Abotsi, Priscilla K. Mante

“…With interaction indices less than one, synergism of antidepressant effect was observed in the Xylopia aethiopica extract/fluoxetine (γXAE/FL = 0.502), Xylopia aethiopica extract/imipramine (γXAE/IP = 0.322), Xylopia aethiopica extract/venlafaxine (γXAE/VL = 0.601), xylopic acid/imipramine (γXA/IP = 0.556), xylopic acid/venlafaxine (γXA/VL = 0.451), and xylopic acid/fluoxetine (γXA/FL = 0.298) combinations, which may be potentially due to elevation of serotonergic neurotransmission via varying mechanisms. The AUC of imipramine (AUCIP = 1966 ± 58.98 µg/ml.h) was significantly (P<0.0001) reduced by Xylopia aethiopica extract (AUCIP = 1228 ± 67.40 µg/ml.h) and xylopic acid (AUCIP = 1250 ± 55.95 µg/ml.h), while the AUC of xylopic acid (AUCXA = 968.10 ± 61.22 µg/ml.h) was significantly (P<0.0001) reduced by venlafaxine (AUCXA = 285.90 ± 51.92 µg/ml.h) and fluoxetine (AUCXA = 510.60 ± 44.74 µg/ml.h), possibly due to the effect of interfering agents on gastric emptying hence reducing oral absorption. …”
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Impact of new coalbed methane wells on old well productivity and its controlling factors: a case study of Shizhuangnan block in Qinshui Basin by Xueting HAN, Shangzhi MENG, Guangjing LIU, Zhenyu REN, Shu TAO, Xinyang MEN, Ziyang WEI

“…There are two propagation mechanisms depending on well spacing: hydraulic fracture communication and fracturing fluid front propagation. …”
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Psychosocial determinants of the willingness to pay for social health insurance among workers at a commercial bank in Dessie, Ethiopia: a multi-setting study by Alemayehu Mebratu Abate, Asnakew Molla Mekonen, Abebe Kibret Assfaw, Husien Nurahmed Toleha, Ewunetie Mekashaw Bayked

“…BackgroundA lack of health insurance is a major barrier to the “health for all” agenda, where out-of-pocket (OOP) spending is the primary healthcare funding mechanism, a characteristic of Ethiopia’s healthcare sector, leading it to plan to fully implement social health insurance (SHI) by 2014, but not yet, owing to significant opposition from public employees. …”
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Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models by Luisa Maria Nieto Ramirez, Carolina Mehaffy, Karen Marie Dobos

“…Immunomodulatory drugs targeting autophagy and other mechanisms were studied, exhibiting their potential as therapeutic alternatives.ConclusionSimpler, physiologically relevant, and ethically sound models, such as G. mellonella, are needed for studying innate responses in MTBC infection. …”
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Chemotherapy-induced cellular senescence promotes stemness of aggressive B-cell non-Hodgkin’s lymphoma via CCR7/ARHGAP18/IKBα signaling activation by Yangyang Wang, Fan Wu, Yang Wan, Huiping Wang, Linhui Hu, Qianshan Tao, Zhimin Zhai, Jiyu Wang, Keke Huang, Anwen Ren, Jinlan Li, Liuying Yi, Yanjie Ruan, Zhixiang Wanyan, Chaohong Liu

“…Therapy-induced senescence (TIS) is one of the most important mechanisms of drug resistance.Methods This study used single-cell RNA sequencing to analyze doxorubicin-induced senescent B-NHL cells. …”
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Effects of Chemical Fertilizer Reduction Combined with Straw and Organic Fertilizer Application on Soil Acidification Mitigation and Erosion Control by SHEN Mengxue, HAO Rui, LIU Xinwei, WEI Wanhao, CAO Yunfei, SHU Hujia, HAO Zongyu, WANG Huyu, WANG Ling, SHI Zhihua

“…Additionally, the total exchangeable base increased by 7.63%~34.68%, and the total nitrogen and organic matter contents in the soil also significantly increased (by 19.22%~62.86% and 18.43%~61.50%, respectively). Analysis of soil mechanics properties indicated that with the increase of organic fertilizer application, soil shear strength was significantly enhanced, while the cohesion and internal friction angle exhibited a trend of first increasing and then decreasing. …”
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Hippocampal Anti-inflammatory Effect of Electroacupuncture at Baihui and Shenting on Cognitive Dysfunction Induced by Systemic Inflammation by CHEN Xiaomei, PANG Lina, WANG Zhifu

“…ObjectiveTo investigate the hippocampal anti-inflammatory mechanism of electroacupuncture at Baihui and Shenting on cognitive dysfunction induced by Lipopolysaccharide (LPS) intraperitoneal injection.MethodsA total of 45 clean grade adult C57BL/6 male mice (bodyweight 18-22 g) were randomly divided into control group, endotoxic brain injury group (model group) and endotoxic brain injury + electroacupuncture group (EA group). …”
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Association between C-reactive protein and chronic pain in US adults: A nationwide cross-sectional study. by Chunsheng Huang, Qizhen Tong, Qiaoling Tong

“…Additional investigation is necessary to explore the presence of a causal association between the two variables, as well as the potential underlying mechanisms.…”
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Measuring the Average Peak Timing of Kinematic Variables in Youth and Adolescent Baseball Pitchers by Mark Boland, Daniel Zambanini, Ivan Mulligan, Sean Donegan

“…The findings suggest differences in pitching mechanics exist between younger and more experienced populations…”
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Growth of microbes in competitive lifestyles promotes increased ARGs in soil microbiota: insights based on genetic traits by Zishu Liu, Xiangwu Yao, Chengyi Chen, Yuxiang Zhao, Chifei Dong, Lingtao Sun, Junxian Zhao, Baofeng Zhang, Zhendi Yu, Dongqing Cheng, Lizhong Zhu, Baolan Hu

“…Abstract Background The widespread selective pressure of antibiotics in the environment has led to the propagation of antibiotic resistance genes (ARGs). However, the mechanisms by which microbes balance population growth with the enrichment of ARGs remain poorly understood. …”
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Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice by Kazuki Harada, Eiji Wada, Yuri Osuga, Kie Shimizu, Reiko Uenoyama, Masami Yokota Hirai, Fumihiko Maekawa, Masao Miyazaki, Yukiko K. Hayashi, Kazuaki Nakamura, Takashi Tsuboi

“…Although AVP receptor-deficient mice exhibit various abnormalities in glucose and lipid metabolism, the mechanism underlying these symptoms remains unclear. …”
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Serum Apelin Levels and Correlation with illness Severity in Nonobese Patients with Bronchial Asthma by Rohan Pattanaik, Pratima Kumari Sahu, Monalisa Mohapatro, Jeetendra Kumar Patra, Nirjharini Dhal

“…Apelin, a bioactive peptide belonging to the adipokines group, is identified as an endogenous ligand of an orphan G-protein coupled receptor named Apelin receptor (AR or APJ). …”
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A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA by Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li, Robert Chunhua Zhao

“…RNA pull-down, mRNA stability tests, etc. were employed to explore mechanisms of lncRNA. Results Human-specific lncRNA, we named it MEK6-AS1, was the most up-regulated transcript during adipogenic differentiation of MSCs. …”
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Klebsiella pneumoniae induces dose-dependent shock, organ dysfunction, and coagulopathy in a nonhuman primate critical care model by Jeffrey R. Strich, Marcos J. Ramos-Benitez, Seth Warner, Heather Kendall, Sydney Stein, Andrew P. Platt, Sabrina C. Ramelli, Shelly J. Curran, Izabella Lach, Kiana Allen, Ashley Babyak, Luis J. Perez-Valencia, Mahnaz Minai, Junfeng Sun, Kevin M. Vannella, Derron Alves, Richard Herbert, Daniel S. Chertow

“…In this study, we developed a model of septic shock with a clinically relevant bacteria (Klebsiella pneumoniae) that provides standard supportive care including mechanical ventilation, invasive hemodynamic monitoring, volume resuscitation, vasopressors, antibiotics, and steroids. …”
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Association Between Urinary Metal Levels and Chronic Kidney Dysfunction in Rural China: A Study on Sex-Specific Differences by Kaisheng Teng, Qinyi Guan, Qiumei Liu, Xiaoting Mo, Lei Luo, Jiahui Rong, Tiantian Zhang, Wenjia Jin, Linhai Zhao, Songju Wu, Zhiyong Zhang, Jian Qin

“…Further research is needed to validate these observations and elucidate underlying mechanisms.…”
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Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of ne... by Martyn G. Jones, Martyn G. Jones, Liam A. Matthews, Liam A. Matthews, Scott Lempka, Scott Lempka, Scott Lempka, Nishant Verma, James P. Harris, Stephen B. McMahon

“…These findings help advance understanding of possible mechanisms for the analgesic effects of ULF neuromodulation.…”
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Effects of Source on the Nitrogen Uptake, Allocation Patterns, and Performance of Strawberry (<i>Fragaria × ananassa</i> Duch.): A ¹⁵N-Tracer Study by Sirajo Salisu Jibia, Kanokwan Panjama, Chaiartid Inkham, Takashi Sato, Norikuni Ohtake, Soraya Ruamrungsri

“…Future research should focus on refining mixed N application ratios and timings, exploring molecular mechanisms of N metabolism, and evaluating long-term impacts on strawberry production sustainability.…”
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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…The data support the cellular and molecular mechanisms of the synthetic CB1 cannabinoids, orchestrating intercellular conduits to enhance metabolic drivers to stage migratory intercellular communication in pancreatic cancer cells.…”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Immunoprecipitation, western blotting and immunofluorescence analysis were performed to elucidate the molecular mechanisms involved. Results We determined that PINK1 and Prdx2 were downregulated in the HFpEF mouse model. …”
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