Structure and identification of the native PLP synthase complex from Methanosarcina acetivorans lysate by Angela Agnew, Ethan Humm, Kang Zhou, Robert P. Gunsalus, Z. Hong Zhou

“…As a result, there is a gap in knowledge concerning the mechanisms governing archaeal protein behavior and their impacts on both the environment and human health; case in point, the synthesis of the widely utilized cofactor pyridoxal 5′-phosphate (PLP; a vitamer of vitamin B6, which humans cannot produce). …”
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Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury by Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang

“…Emerging evidence suggests a novel role for ferroptosis in the pathophysiology of ALI, though the precise mechanisms remain unclear. Mild hypothermia (32–34 °C) has been shown to inhibit inflammatory responses, reduce oxidative stress, and regulate metabolic processes. …”
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Category-terminological apparatus of modern social upbringing by Z. A. Aksyutina

“…Categories of the second order are allocated on the basis of the use of mechanisms for the formation of categories, contain in their composition: a key category, synthesised, integrated and additional categories. …”
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Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells by Jing Xiong, Meifang Nie, Chun Fu, Xiaoshan Chai, Yongjing Zhang, Ling He, Shujuan Sun

“…This study explored the mechanism of hypoxia in CC cell ferroptosis resistance by regulating HIF1α/KDM4A/H3K9me3. …”
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Progress in Treatment of Temporomandibular Joint Disorder by Wei YANG, Minghua XIE, Yu CAI, Zhuoming CHEN

“…Medical-biological-psychological model, perfects the three-level prevention mechanism of etiology, disease and disability, and suppresses the occurrence of TMD from the source, which is provided for prevention with the help of healthy lifestyle. …”
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Flowering Characteristics and Expression Patterns of Key Genes in Response to Photoperiod in Different <i>Chrysanthemum</i> Varieties by Qiuling Zhang, Xueru Li, Shuyu Cai, Junzhuo Li, Jiaying Wang, Yanfei Li, Silan Dai

“…This result provides guidance for the artificial regulation of <i>chrysanthemum</i> flowering and improvement of ornamental quality, as well as clues for analyzing the flowering mechanism of <i>chrysanthemums</i> under different photoperiod conditions.…”
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Comprehensive assessment of a nationwide simulation-based course for artificial life support. by Mateusz Puslecki, Marek Dabrowski, Marcin Ligowski, Bishoy Zakhary, Ahmed S Said, Kollengode Ramanathan, Elaine Cooley, Lukasz Puslecki, Sebastian Stefaniak, Piotr Ziemak, Ilona Kiel-Puslecka, Agata Dabrowska, Tomasz Klosiewicz, Maciej Sip, Radoslaw Zalewski, Malgorzata Ladzinska, Wojciech Mrowczynski, Piotr Ladzinski, Lidia Szlanga, Konrad Baumgart, Piotr Kupidlowski, Lukasz Szarpak, Marek Jemielity, Bartlomiej Perek

“…Moreover, the results of training in mechanical chest compression were also evaluated.<h4>Results</h4>There were 115 participants (60% men) predominantly in the age of 30-40 years. …”
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Molecular characterization and genome sequencing of selected highly resistant clinical isolates of Pseudomonas aeruginosa and its association with the clustered regularly interspac... by Hekmat A. Owaid, Mushtak T.S. Al-Ouqaili

“…Furthermore, the WGS approach can lead to a better understanding of the genomic mechanism of pseudomonal resistance to antibiotics.…”
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Financing of Preschool Education in Ukraine in 1919–1933: Historical and Legal, Historical and Economic Aspects by S. O. Tkachenko, О. V. Golovko

“…There is a destruction of the old pre-revolutionary pedagogy, which considered preschool education only as a forced measure for working parents and orphans, by giving preference to family upbringing of children at an early stage of life. …”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…., 2022); however, studies focused on understanding mechanisms contributing to NDD-relevant behaviors are lacking, especially studies understanding the contributions of GATOR1's critical GAP catalytic subunit, nitrogen permease regulator like-2 (Nprl2). …”
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Adaptation for Staphylococcus aureus to hosts via insertion mutation in the accessory gene regulator agrC gene: decreased virulence and enhanced persistence capacity by Jiawei Chen, Yun Wu, Ying Zhu, Li Zhang, Yingchun Xu, Yali Liu

“…ABSTRACT Staphylococcus aureus is an important human pathogen due to its vast array of virulence factors regulated by multiple regulatory mechanisms, including the accessory gene regulator. …”
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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…However, further research is needed to explore their therapeutic potential and the mechanisms underlying their effects. Clinical trial number Not applicable.…”
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A BERT-Based Classification Model: The Case of Russian Fairy Tales by Валерий Дмитриевич Соловьев, Марина Ивановна Солнышкина, Andrey Ten, Николай Аркадиевич Прокопьев

“…Method: We pre-train BERT using a collection of three classes of documents and fine-tune it for implementation of a specific application task. Focused on the mechanism of tokenization and embeddings design as the key components in BERT’s text processing, the research also evaluates the standard benchmarks used to train classification models and analyze complex cases, possible errors and improvement algorithms thus raising the classification models accuracy. …”
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Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…This study aimed to evaluate the protective effects of UDCA against sepsis-induced acute kidney injury (AKI) and to elucidate the underlying mechanisms. Methods Sixty male C57BL/6 N mice were utilized to establish a sepsis-induced AKI model through intravenous injection of lipopolysaccharides (LPS, 10 mg/kg). …”
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Enhancing Semi-Supervised Learning With Concept Drift Detection and Self-Training: A Study on Classifier Diversity and Performance by Jose L. M. Perez, Roberto S. M. Barros, Silas G. T. C. Santos

“…Semi-supervised classifiers often consume a lot of memory and run-time, and the addition of a detection mechanism increases the computational cost. Furthermore, classification in semi-supervised environments can lead to problems related to labeling data to training: an error in this process can negatively impact model performance. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…Background Obesity is a risk factor for developing cancer but is also associated with improved outcomes after treatment with immune checkpoint inhibitors (ICIs), a phenomenon called the obesity paradox. To interrogate mechanisms of divergent immune responses in obese and non-obese patients, we examined the relationship among obesity status, clinical responses, and immune profiles from a diverse, pan-tumor cohort of patients treated with ICI-based therapy.Methods From June 2021 to March 2023, we prospectively collected serial peripheral blood samples from patients with advanced or metastatic solid tumors who received ICI as standard of care at Johns Hopkins. …”
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A bacterial membrane-disrupting protein stimulates animal metamorphosis by Kyle E. Malter, Tiffany L. Dunbar, Carl Westin, Emily Darin, Josefa Rivera Alfaro, Nicholas J. Shikuma

“…Our findings demonstrate that membrane disruption by MACs and Mif1 is necessary for Hydroides metamorphosis, connecting the activity of a bacterial protein effector to the developmental transition of a marine animal.IMPORTANCEThis research describes a mechanism wherein a bacterium prompts the metamorphic development of an animal from larva to juvenile form by injecting a protein that disrupts membranes in the larval cilia. …”
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"Effect of modified aramid nanofiber on compatibilization of natural rubber/epoxidized natural rubber composites" by ZHANG Ke-yu1,2, ZHENG Xiao-tong1, XU Ming-han1?鄢

“…"The combination of natural rubber (NR) with epoxidized natural rubber (ENR) could improve the wet slid resistance, mechanical properties, abrasion resistance and thermo-oxidative aging resistance of NR, which showed important research significance. …”
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Protein Level and Infantile Diarrhea in a Postweaning Piglet Model by Jing Gao, Jie Yin, Kang Xu, Hui Han, ZeMin Liu, ChenYu Wang, TieJun Li, YuLong Yin

“…Meanwhile, AQP, tight junction protein, and intestinal immune were compromised. Thus, the mechanism of how a highly digestible protein diet induces diarrhea might be associated with the AMPK signaling pathway and intestinal microbiome.…”
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Free-space optical spiking neural network. by Reyhane Ahmadi, Amirreza Ahmadnejad, Somayyeh Koohi

“…To ensure nanometer-scale precision in component alignment, we propose advanced micro-positioning systems and active feedback control mechanisms. To enhance signal integrity, we employ high-quality optical components, error correction algorithms, adaptive optics, and noise-resistant coding schemes. …”
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