Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Although antioxidant treatments may improve the mdx phenotype, the precise molecular mechanisms remain unclear. This study investigates the effects of aminoguanidine hemisulfate (AGH), an inhibitor of reactive oxygen species (ROS), on mitochondrial autophagy, oxidative stress, and muscle force in mdx mice. …”
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INVESTIGASI DESAIN ARSITEKTUR YANG TIDAK TERKONDISI BERBASIS METODE PARTISIPATIF by Rian Faisal Asqhor, Yandi Andri Yatmo, Kristanti Dewi Paramita

“…The analysis of these case studies demonstrates how community participation changes function and emphasize material localities that are unconditioned that generate new urban identity. Understanding the mechanism of unconditioned architecture aims to expand architectural knowledge that values architecture beyond its orderliness, and highlights possibilities of the community as the main actor in the production of everyday urban space.  …”
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Enhancing Older Adults’ Lives Through Positive Aging Perception, Quality-of-Life Enhancement, and Social Support to Drive Acceptance and Readiness Toward Indoor Assistive Technolog... by Ka Po Wong, Pei-Lee Teh, Weng Marc Lim, Shaun Wen Huey Lee

“…Future research should investigate the underlying mechanisms and create targeted interventions to support successful technology adoption in this population.…”
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The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction by Nestor Ruiz, Jiawei Xing, Igor B. Zhulin, Chad A. Brautigam, David R. Hendrixson

“…We provide an understanding of the mechanics of an unusual mode of signal transduction executed by BumSR and other bacterial sensor phosphatase-driven TCSs.…”
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Study of factors associated with obesity in patients using antipsychotics in schizophrenia by Vishalakshi Patnam, P Ramya Keerthi, P Ravi Kiran, Dinesh Panati

“…It may also encourage research on the causal pathways and mechanisms mediating the relationship. Aims and Objectives: To study the factors associated with obesity in patients with schizophrenia using antipsychotics. …”
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Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate by Francesca Lazzara, Federica Conti, Grazia Maugeri, Velia D’Agata, Velia D’Agata, Ludovica Sotera, Claudio Bucolo, Claudio Bucolo

“…Moreover, the strictly correlated oxidative damage and inflammatory processes impair the corneal reparative wound healing mechanism. Corneal protection after damage remains an unmet medical need that requires urgent management. …”
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Impact of Amarogentin on Gastric Carcinoma Cell Multiplication, Apoptosis and Migration via circKIF4A/miR-152-3p by Zhi Tan, Weining Wang, Jin Peng, Zhen Zhou, Jia Pan, Aiming Peng, Hui Cao, Wenling Fan

“…To investigate the impact of Amarogentin (AG) on GC cell multiplication, apoptosis and migration and the possible mechanisms. Methods. qRT-PCR quantification of circKIF4A and miR-152-3p in GC tissues and normal counterparts as well as HGC-27 (human GC cell strain) and GES-1 (human gastric mucosal epithelial cell strain) was performed. …”
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Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…Herein, our work was set out to study the potential role and possible mechanism of SGD in PICI through network pharmacology, Mendelian analysis and animal experiments. …”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…Protein mass spectrometry, western blotting, and bioinformatic analyses were performed to identify critical components of mammalian RS1 to model its structure and explore the pathological mechanism of IQUB deficiency. Intracytoplasmic sperm injection (ICSI) was applied for the patient and Iqub −/− mice. …”
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Molecular Dynamics Simulation of CO₂-ECBM Under Different Moisture Contents by Xiaoyu Cheng, Xuanping Gong, Cheng Cheng, Quangui Li, Ziqiang Li

“…In this study, Monte Carlo and molecular dynamics methods were used to investigate the microscopic mechanism of CH₄/CO₂ competitive adsorption and diffusion during CO₂-enhanced coal bed methane mining (ECBM) under different moisture contents, and the geological storage potential of CO₂ was predicted. …”
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High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

“…Comparative analyses of metabolomic profiles in purebred pigs can provide insights into the basic biological mechanisms that may explain differences in production performances. …”
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Antimicrobial and antioxidant study of combined essential oils of Anethum Sowa Kurz. and Trachyspermum ammi (L.) along with quality determination, comparative histo-anatomical feat... by S.A. Wasim Akram, Mary Shamya Arokiarajan, J. John Christopher, Mohammad Jameel, Mohd Saquib, Tirumala Santosh Kumar Saripally, Noman Anwar, Mohd Asif, Kabiruddin Ahmed K

“…Their existence in dishes portrayed key roles in improving shelf life by regulating spoilage of cuisine with different synergistic mechanism. Histo-anatomically (A) sowa exhibited distinguished cellular attributes which created remarkable differences with T. ammi. …”
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Association between composite dietary antioxidant index and Epstein–Barr virus infection in children aged 6–19 years in the United States: from the national health and nutrition ex... by Wei Cheng, Yunfei Wang, Nan Ding, Rutao Xie

“…Future prospective and experimental studies are needed to confirm causality and clarify the exact mechanism concerning antioxidant diets with EBV infection.…”
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The effects of magnitude of calcium decline at the onset of lactation on serotonin dynamics and the serotonin-calcium axis by M.K. Connelly, R.M. Rodney, J. Kuehnl, J.P.N. Andrade, F. Sonnewend Andrade, S. Henschel, E. Block, I.J. Lean, L.L. Hernandez

“…Our data suggest that serotonin is an important factor in the regulation of Ca homeostasis during the prepartal period and that the mechanism may be integrated with blood pH.…”
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Influence of hip morphology on gluteal muscle biomechanics: a computational modeling study by Shangcheng Wang, Ryan Serbin, Kirby Bonvillain, Josef Jolissaint, Nahir Habet, Durham Weeks

“…Conclusions Our biomechanical modeling suggests patients with narrow iliac width may be predisposed to gluteal tendinopathy through increased tendon loading. The protective mechanical effect of decreased neck shaft angle suggests its clinical association with tendinopathy likely involves other factors, such as IT band compression which was not accounted for in this study. …”
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A mixed-methods observational study of strategies for success in implementation science: overcoming emergency departments hurdles by Deonni P. Stolldorf, Alan B. Storrow, Dandan Liu, Cathy A. Jenkins, Rachel A. Hilton, Karen F. Miller, Joy Kim, Deepika Boopathy, Satheesh Gunaga, Bory Kea, Joseph Miller, Sean P. Collins

“…., education needs, feedback mechanisms, champions). Conclusions Specific determinants of implementation exist in ED settings and require the refining of implementation strategies to overcome site-specific barriers and enhance facilitators. …”
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Defining and measuring long COVID fatigue: a scoping review by Deborah Edwards, Jennifer Davies, Christine Bundy, Rachael Pattinson, Bethan Thomas, Carys Dale, Benjamin Jenkins, Helena Lande

“…There is an urgent need to better understand long COVID fatigue and to identify the different mechanisms involved. In order to do this, we need consistency with the language around fatigue and its measurement within research and across disciplines.Review registration The protocol has been registered on Open Science Framework (https://doi.org/10.17605/OSF.IO/HNF8Z).…”
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A comparative study on the efficacy of kirschner wire tension band combined with anchor cross-suture internal fixation versus partial patellectomy in the treatment of comminuted in... by Siyu Duan, Rongda Xu, Hanfei Liu, Ming Sun, Hairui Liang, Zhencun Cai

“…This technique provides reliable fixation, restores the original extensor mechanism, promotes early postoperative rehabilitation, and reduces the incidence of complications, making it suitable for clinical application and widespread use. …”
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A novel minimally invasive neurosurgical cranial fixation device for improved accuracy of intraventricular catheter placement: an experimental animal study by Atai Daniel, Matan Coronel, Segev Peer, Ben Grinshpan, Soner Duru, Jose L. Peiro, James L. Leach, Elena Abellán, Carolyn M. Doerning, David Zarrouk, Francesco T. Mangano

“…These experiments included functionality bench testing and pullout force measurements for the ball mechanism and catheter fixation. For the in-vivo experiments the fixation device was initially tested at the Cincinnati Children’s Hospital Medical Center (CCHMC) in Cincinnati, Ohio on one day of life 1 (DOL 1) male control lamb. …”
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Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway by Teerapap Panklai, Prapapan Temkitthawon, Nungruthai Suphrom, Corine Girard, Perle Totoson, Kowit Hengphasatporn, Yasuteru Shigeta, Krongkarn Chootip, Kornkanok Ingkaninan

“…Conclusions: Both WLE and its flavonoids (1–3) vasodilated PA. The mechanism of WLE vascular action involved the endothelial nitric oxide (NO) pathway and stimulation of sGC, while showing no VSMC cytotoxicity.…”
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