Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control studyResearch in context by Amazigh Mokhtari, El Chérif Ibrahim, Arnaud Gloaguen, Claire-Cécile Barrot, David Cohen, Margot Derouin, Hortense Vachon, Guillaume Charbonnier, Béatrice Loriod, Charles Decraene, Ipek Yalcin, Cynthia Marie-Claire, Bruno Etain, Raoul Belzeaux, Andrée Delahaye-Duriez, Pierre-Eric Lutz

“…Methods: We characterised gene expression and two mechanisms of epigenomic regulation, DNA methylation (DNAm) and microRNAs (miRNAs), in blood samples from a cohort of individuals with MDD and healthy controls (n = 169). …”
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evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

“…Semaglutide may have a disease-modifying, neuroprotective effect in AD through multimodal mechanisms including neuroinflammatory, vascular, and other AD-related processes. …”
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Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study by Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng

“…The study’s exposures encompassed genetic variants within drug target genes (HMGCR, PCSK9, NPC1L1), each representing distinct lipid-lowering mechanisms. Causal effects were estimated using the inverse variance weighting (IVW) method, while the Summary Data-based Mendelian Randomization (SMR) method, leveraging pooled data, was applied to compute effect estimates. …”
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Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study by Hongwei Wang, Fangying Tian, Caizheng Yang, Xinyu Cui, Yongxia Ding, Ming Zhao, Xueyu Wang, Shanshan Ge

“…Conclusions Our study suggests that there is a causal effect between Hp infection and Mets diagnosis and its composition, and further studies are needed to understand the mechanism of its influence.…”
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Changes in Soil Organic Carbon and Enzyme Activity After Land Use Change in Northeast China by Yang Wang, Te Shan, Peng Zhang, Ming Li

“…In conclusion, the conversion from upland fields to paddy fields changes the occurrence mechanism of SOC in the aggregate, which is an important way of sustainable C sequestration in cropland ecosystems.…”
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Insights from Dysregulated mRNA Expression Profile of β-Cells in Response to Proinflammatory Cytokines by Zhen Wang, Kunlin Huang, Jing Xu, Jia Liu, Ying Zheng

“…The current study provided a systematic perspective on the potential functions and possible regulatory mechanisms of mRNAs in proinflammatory cytokine-induced β-cell destruction.…”
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Effects on the Functionality and Structure of Rice-Pea Composite Protein by Industry-scale Microfluidizer Combined with pH Cycling Treatment by Yunfeng LU, Taotao DAI, Zhaoying LI, Jialong HAN, Ti LI, Chengmei LIU, Jun CHEN

“…To investigate the solubilization of composite plant protein after co-processing with an industry-scale microfluidizer and pH cycling and to clarify its solubilization mechanism, this paper used rice protein and pea protein as raw materials, a mixed protein solution with a protein ratio of 1:1 and a total protein concentration of 4% were configured. …”
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Effects of Smoking on Intima-Media Thickness of the Common Carotid Artery Using Ultrasonography by Asmaa Mustafa Alsiddig, Ibrahim Abdelrhim Ali

“…Abstract Background Cigarette smoking is a causative factor in premature atherosclerosis, but the exact mechanism of smoking-induced damage to the arterial wall and its relationship to the atherosclerotic process are still largely unknown. …”
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Blood Lead Levels among Blood Donors and High-Risk Occupational Groups in a Mining Area in Ghana: Implications for Blood Transfusion among Vulnerable Populations by Veronica Agyemang, Joseph K. Acquaye, Samuel B. E. Harrison, Felix B. Oppong, Stephany Gyaase, Kwaku P. Asante, Edeghonghon Olayemi

“…We enrolled 40 participants each from the following high-risk occupational groups: small scale miners, painters/sprayers, drivers/fuel station attendants, and auto-mechanics as well as 40 healthy blood donors (made up of teachers, traders, and office workers). …”
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Analysis of Factors Related to Pulmonary Nodules in Patients With Fatty Liver: A Large-Scale Cohort Study Based on a Physical Examination Population by Qin Y, Huang X, Lin J, Pan L, Liang Q, Li W

“…Yan Qin,1,* Xiaozhi Huang,1,* Jiali Lin,2,* Liuxian Pan,1,* Qiuyu Liang,2 Wei Li1 1Health Management Center, People’s Hospital of Guangxi Zhuang Autonomous Region and Guangxi Academy of Medical Sciences, Nanning, People’s Republic of China; 2Health Management Research Institute, People’s Hospital of Guangxi Zhuang Autonomous Region and Guangxi Academy of Medical Sciences, Nanning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Li, Health Management Center, People’s Hospital of Guangxi Zhuang Autonomous Region and Guangxi Academy of Medical Sciences, Nanning, Guangxi, 530021, People’s Republic of China, Email lw6666gx@aliyun.com Qiuyu Liang, Health Management Research Institute, People’s Hospital of Guangxi Zhuang Autonomous Region and Guangxi Academy of Medical Sciences, Nanning, Guangxi, 530021, People’s Republic of China, Email liang_qiu_yu@foxmail.comPurpose: People with fatty liver are at high risk for pulmonary nodules, but the underlying mechanism is unclear. This study aimed to investigate the occurrence of lung nodules in fatty liver patients and explore influencing factors.Patients and Methods: We retrospectively analyzed 57,119 individuals who underwent health checkups at the People’s Hospital of Guangxi from May 2020 to May 2024. …”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…In contrast, the constant presence of Psy throughout the catchment in absence of regular and widespread disease outbreaks due to this group of bacteria suggests that surveillance should focus on future changes in land use, river water conditions and agronomic practices that could destabilize the mechanisms currently holding Psy outbreaks in check. …”
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Multivariate Statistical Analysis Reveals the Heterogeneity of Lacustrine Tight Oil Accumulation in the Middle Permian Jimusar Sag, Junggar Basin, NW China by Yuce Wang, Jian Cao, Keyu Tao, Xiuwei Gao, Erting Li, Chunhua Shi

“…From base to top, the accumulation mechanisms in the Lucaogou Formation were NA, VLMA (vertical and lateral migration and accumulation), NA and VLMA, thereby showing strong heterogeneities. …”
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Foliar application of 24-epibrassinolide enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco by regulating cold stress tol... by Haiyang Chen, Shuaitao Zhang, Jianbo Chang, Hongru Wei, Hongchen Li, Chaoyang Li, Junjie Yang, Zhengxiong Song, Zhaojun Wang, Jin Lun, Xuelin Zhang, Lihua Li, Xiaoquan Zhang

“…And further research is needed to elucidate the molecular mechanisms of EBR on enhancing leaf nicotine content. …”
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Phylogeography and genetic diversity of Ulmus elongata (Ulmaceae), a Tertiary relict tree with extremely small populations (PSESP) by Yakun Wang, Xiankun Wang, Junyuan Wu, Jun Yang, Yanpei Liu, Peng Guo, Fude Shang, Nan Lin

“…Abstract Background Assessing the current status and identifying the mechanisms threatening endangered plants are significant challenges and fundamental to biodiversity conservation, particularly for protecting Tertiary relict trees and plant species with extremely small populations (PSESP). …”
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The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation by Mark Bitsch Vestergaard, Aftab Bakhtiari, Merete Osler, Erik Lykke Mortensen, Ulrich Lindberg, Ian Law, Martin Lauritzen, Krisztina Benedek, Henrik Bo Wiberg Larsson

“…However, the exact mechanisms are not known. A possible pathway could be that Aβ affects the cerebral vessels, causing inadequate cerebrovascular function. …”
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Informing climate-health adaptation options through mapping the needs and potential for integrated climate-driven early warning forecasting systems in South Asia-A scoping review. by Festus A Asaaga, Emmanuel S Tomude, Nathan J Rickards, Richard Hassall, Sunita Sarkar, Bethan V Purse

“…However, the scale and mechanisms of the impacts are uncertain and it is unclear whether existing forecasting capacities will foster successful local-level adaptation planning, particularly in climate vulnerable regions in developing countries. …”
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A1, an innovative fluorinated CXCR4 inhibitor, redefines the therapeutic landscape in colorectal cancer by Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Ali Darehkordi, Alireza Najafi, Milad Karimi, Majid Khoshmirsafa, Gholamhossein Hassanshahi, Elaheh Safari, Reza Falak

“…Results Molecular dynamic simulation studies with molecular mechanics Poisson-Boltsman surface area (MM-PBSA) analysis revealed that A1 exhibits significantly lower binding energy for the CXCR4 receptor than AMD3100. …”
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Theoretical Study of CO, NO, NO₂, Cl₂, and H₂S Adsorption Interactions with PdO–Graphene Composites for Gas Sensor Applications by Piumantha Samaranayake, Azeez Ahamed, Visal de Silva, Nadeesha Manohari Wickramage, Muhammad Raziq Rahimi Kooh, Roshan Thotagamuge

“…This study used density functional theory methods to explore the mechanism and sensitivity of a PdO–graphene composite sensor towards various gases (CO, NO, NO₂, H₂S, and Cl₂). …”
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Ruptured Noncoronary Sinus of Valsalva Aneurysm by Amaury Dagoberto Martínez Hernández, Dayana Pino Jiménez

“…--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <!…”
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المکتبات الخضراء ودورها فى مواجهة تحدیات الاستدامة البیئیة : دراسة تحلیلیة مقارنة by د. مها لؤى حاتم

“…Achievingenvironmental sustainability is not limited to the library building, but also tomanagement, equipment, collections, and technical processes, services providedand marketing.The study draws its importance from the rules and standards that must beavailable to achieve the elements of environmental sustainability in libraries as afacade of civilization, heritage portfolio, and a model of social development.Libraries can continuously check the environmental sustainability rules andprovide their components of: structure, building, facades, atmosphere, interior  environment of ventilation, cooling, heating, lighting and other interior fittings,along with green ICT and other characteristics that refer to green marketing in theend to represent a real interface to innovation Civilization.The study aims at identifying the nature of green libraries, the reasonsand justifications for their transformation, the mechanisms of such transformation,in addition to surveying of their standards specifications, and comparing thedifferent models of green libraries in the world.One of the most prominent results of the study is the presentation oflibrary institutions as a living voice for the environment, and their role inrepresenting a model of green and sustainable development. …”
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