Sustainability of regional Antarctic ice sheets under late Eocene seasonal atmospheric conditions by D. H. A. Vermeulen, M. L. J. Baatsen, A. S. von der Heydt

“…This study therefore examines whether it is plausible to develop ice sheets of sufficient scale to trigger the feedback mechanisms required to disrupt the atmospheric regime above the Antarctic continent during warm and moist late Eocene summers and establish more favourable conditions for ice expansion. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Nevertheless, in myeloma, the precise mechanisms underlying SEL-induced XPO1 degradation and its impact on drug responsiveness remain largely undefined. …”
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Clinical outcome analysis for surgical fixation versus conservative treatment on rib fractures: a systematic evaluation and meta-analysis by Penglong Zhao, Qiyue Ge, Haotian Zheng, Jing Luo, Xiaobin Song, Liwen Hu

“…The primary outcome was all-cause mortality, while the secondary outcomes included hospital length of stay (HLOS), ICU length of stay (ILOS), duration of mechanical ventilation (DMV), and the incidence of pneumonia. …”
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The Impact of Stigma of Loneliness on Psychological Distress in Older Adults: The Chain Mediating Effect by Fan Z, Shi X, Leng J, Cui D, Li D

“…Stigma of loneliness can not only directly affect the psychological distress of older adults (effect value=0.38), but also indirectly affect psychological distress through the mediating roles of distress disclosure (effect value=0.04) and loneliness (effect value=0.20), and the chain mediating effect of the two (effect value=0.05).Conclusion: The study redounds to the in-depth understanding of the effect of the stigma of loneliness on psychological distress among older people and its internal mechanism. The research results contribute to theoretical reference in explaining the formation background of psychological distress among older cohorts, which intends to provide empirical evidence for intervention studies of reducing psychological distress.Keywords: older adults, stigma of loneliness, psychological distress, distress disclosure, loneliness…”
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Development of an implementation intervention to promote adoption of the COMFORT clinical practice guideline for peripartum pain management: a qualitative study by Limi Sharif, Shelytia Cocroft, Shawna N. Smith, Christopher Benincasa, Alex F. Peahl, Lisa Kane Low, Jennifer Waljee, Carrie Miller, Carey Simpson, Michelle H. Moniz

“…Findings enabled identification of five collaborative-level implementation strategies, 27 unit-level implementation strategies, and 12 associated tools to promote COMFORT CPG adoption including the specification of each strategy’s hypothesized mechanism of action and each tool’s goal and potential uses. …”
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Clinical course, management and outcomes of COVID-19 in HIV-infected renal transplant recipients: A case series by L Bertels, K Manning, A Redd, T du Toit, Z Barday, E Muller

“…Two patients required mechanical ventilation, and 2 received acute dialysis. …”
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MMP9-Associated Tumor Stem Cells, CCL1-Silenced Dendritic Cells, and Cytokine-Induced Killer Cells Have a Remarkable Therapeutic Efficacy for Acute Myeloid Leukemia by Activating T... by Min Dong, Guozhen Zhang, Jie Meng, Biou Liu, Duanfeng Jiang, Feng Liu

“…However, the underlining mechanism and function of DC-CIK cells in acute myeloid leukemia (AML) remain largely elusive. …”
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Secondary hyperoxaluria: Cause and consequence of chronic kidney disease by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…This transporter is active at both the intestinal and renal levels, and its mechanism of action is disrupted during systemic inflammation and metabolic syndrome, which could explain the rising incidence of secondary hyperoxaluria in recent decades. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…This in vitro study demonstrates a novel odontogenic mechanism mediated by ectopic expression of the transcription factor Atoh1 in human DPSCs. …”
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Neuroprotective Role of Transchalcone in Parkinson‘s Disease through AMP-activated Protein Kinase-mediated Signaling Pathway by Yao Cheng, Shaik Althaf Hussain, Turki Mayudh Alrubie, Xiaomin Zhang

“…Inhibition of AMPK activity with compound-C suppressed the neuroprotective impacts of trans-chalcone, highlighting the contribution of AMPK signaling pathway in its mechanism of action. Neuroprotective and mitoprotective impacts of trans-chalcone were mostly mediated through the activation of AMPK-SIRT1-PGC1α pathway. …”
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The assessment of marrow adiposity in type 1 diabetic rabbits through magnetic resonance spectroscopy is linked to bone resorption by Wei Li, Wei Wang, Minlan Zhang, Qi Chen, Fengyi Li, Shaojun Li

“…BackgroundEnhanced marrow adiposity is frequently linked with a decline in bone density. The underlying mechanisms responsible for bone loss in diabetes are not well understood. …”
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DCUN1D5 is a prognostic biomarker and correlated immune infiltrates and glycolysis in lung adenocarcinoma by Song Zhao, Xiaoli Han, Jingtao Huang, Jingxiong Zheng, Baoshan Zhao, Zongying Liang

“…Abstract DCUN1D5 is up-regulated and promotes tumor progression in many cancers such as laryngeal squamous cell carcinoma and breast cancer, but the expression of DCUN1D5 in lung adenocarcinoma and its molecular mechanism are not clear. The differences of DCUN1D5 expression between lung adenocarcinoma and normal tissues were compared by TCGA, GEO and UALCAN databases, and the relationship between DCUN1D5 expression and clinicopathological features of patients was analyzed. …”
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Jack Surgery: Reconstructing Collapsed Femoral Head in Association Research Circulation Osseous Stage III Osteonecrosis: A Series of 13 Cases by Ying Zhong, Yichen Gong, Shuaijie Lv, Wenxi Du, Xun Liu, Jianhua Zhang, Peijian Tong

“…Conclusion For young patients with ONFH of ACRO III, this surgical technique can effectively restore the original shape of the femoral head and achieve satisfactory hip function in the short term. The mechanism is similar to jacking the roof of a house; thus, we named it “Jack surgery”.…”
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Correlation between Cortical Excitability and Hand Function in Patients with Subacute Cerebral Infarction by Ling CHEN, Junling WANG, Dongfeng HUANG

“…Objective:To observe the cortical activation characteristics of cerebral motor prediction in patients with subacute cerebral infarction in the palm grasping task, and to explore the correlation between cortical excitability and hand function in patients with cerebral infarction.Methods:A total of twenty-five patients with subacute cerebral infarction who were hospitalized in the first affiliated hospital of Sun Yat-sen University from January 2017 to March 2018 were selected as the experimental group, and twenty-five healthy individuals matched with the gender and age of the experimental group were selected as the control group.Event related potentials were used to collect the electroencephalogram signals of the two groups in the palm grasping task, and then analyzed the latencies and amplitudes of the contingent negative variation(CNV)in the cerebral cortex before motor activation.Action Research Arm Test(ARAT)was used to assess the function of hand, and the correlation between CNV amplitude and ARAT score was analyzed.Results:Compared with the control group, the CNV latencies in the midline region of the experimental group were significantly shorter during the left hand grasp and right hand grasp, and the CNV amplitude were statistically significantly increased in the midline, bilateral frontal lobe and primary motor area(M1)(<italic>P</italic>&lt;0.05).There was no significant difference in CNV latency between left hand grasp and right hand grasp in the experimental group(<italic>P</italic>&gt;0.05), with the CNV amplitude of Cz electrode in midline statistically significantly greater than that of C4 electrode in contralateral M1(<italic>P</italic>&lt;0.05).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during right hand grasp in the experimental group(F4: <italic>r</italic>=0.510; C4: <italic>r</italic>=0.442; Fz: <italic>r</italic>=0.428).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during left hand grasp in the experimental group(F4: <italic>r</italic>=0.422; C4: <italic>r</italic>=0.496; Fz: <italic>r</italic>=0.446).Conclusion:The neural mechanism of motor anticipation in patients with subacute cerebral infarction is abnormal, the time of brain motor preparation is prolonged, and the non-lesioned frontal lobe and M1 are hyperactivity compensatory during motor anticipation.There was moderate correlation between the cortical excitability and hand dysfunction.Therefore, CNV may be a neural indicator of the severity of hand dysfunction in patients with cerebral infarction.…”
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Transcription factor-dependent regulatory networks of sexual reproduction in Fusarium graminearum by Wonyong Kim, Da-Woon Kim, Zheng Wang, Meng Liu, Jeffrey P. Townsend, Frances Trail

“…These findings highlight the central roles of PNA1 and SUB1 in regulating other gene activity related to sexual reproduction, contributing to a deeper understanding of the mechanisms of the multiple TFs that regulate sexual development.…”
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WEB-BASED LEARNING AND STUDENTS' SCHOLASTIC ACCOMPLISHMENT AT NATIONAL OPEN UNIVERSITY OF NIGERIA by Taofeek Gbolahan Muibi

“…The government and all relevant stakeholders ought to address the problem of incessant power outages. Mechanical gadgets ought to likewise be made accessible to students at sponsored rates to empower everybody partake in remote learning. …”
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The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…This study aims to detect if MBD2 can reduce NETs formation and the potential mechanism in severe asthma.Methods A severe asthma model was established in C57BL/6 wild-type mice exposure to house dust mite (HDM), ovalbumin (OVA), and lipopolysaccharide (LPS). …”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…Despite similar radiographic findings, mechanical performance and histological structure displayed in both grafted groups, AOPT exhibit superior interface integration, which is critical for effective tissue restoration. …”
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Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway by Wang J, Jiang Y, Yuan Y, Ma X, Li T, Lv Y, Zhang J, Chen L, Zhou J, Meng Y, Zhang B, Dong X, Ma L

“…The objective of this study is to elucidate the mechanism underlying the impact of miR-122-5p on sepsis-associated liver and kidney injury using inhibitors for miR-122-5p as well as GW4869, an inhibitor targeting exosome release.Materials and Methods: Exosomes were isolated from serum samples of septic rats, sepsis patients, and control groups, while liver and kidney tissues were collected for subsequent analysis. …”
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Generalization of artificial neural network for predicting methane production in laboratory-scale anaerobic bioreactor landfills by M.J. Zoqi

“…However, it showed a significant sensitivity to variation of waste mechanical properties.…”
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