Multimorbidity latent classes in relation to 11-year mortality, risk factors and health-related quality of life in Malaysia: a prospective health and demographic surveillance syste... by Michelle M. C. Tan, Charlotte Hanlon, Graciela Muniz-Terrera, Tatiana Benaglia, Roshidi Ismail, Devi Mohan, Ann Breeze Joseph Konkoth, Daniel Reidpath, Pedro José M. Rebello Pinho, Pascale Allotey, Zaid Kassim, Matthew Prina, Tin Tin Su

“…Further longitudinal studies are warranted to explore the underlying mechanisms and evolution of multimorbidity patterns.…”
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Hsa-miR-105-1 Regulates Cisplatin-Resistance in Ovarian Carcinoma Cells by Targeting ANXA9 by Xinxin Kou, Hui Ding, Lei Li, Hongtu Chao

“…Therefore, it is necessary to clearly understand the molecular mechanisms of chemoresistance. In this study, we examined how Hsa-miR-105-1 functions in cisplatin-resistant OC cells. …”
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Pembangunan Aplikasi Manajemen Penyiraman Rumput Taman Playground Berbasis Internet of Things by Komang Candra Brata, Ginanjar Wisnu Ifan A., Adam Hendra Brata

“…The garden watering management system uses a mobile application as a user interface to control the system and embedded devices for the watering mechanism. Blackbox testing of the proposed system shows that all the functional requirements are 100% valid. …”
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Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model by Uzdrowska K, Knap N, Konieczna L, Kamm A, Kuban-Jankowska A, Gierałtowska J, Belka M, Baran M, Chlanda A, Kowiorski KM, Żołnierski A, Gulczynski J, Lipińska L, Bączek T, Izycka-Swieszewska E, Górska-Ponikowska M

“…The presence of polar hydroxyl groups enables the binding of 2-ME to GO/rGO through hydrogen bonds with epoxy and hydroxyl groups located on the surface and carbonyl and carboxyl groups located at the edges of graphene flake sheets.Methods: The patented method of producing the subject of the invention and the research results regarding its anticancer effectiveness via cytotoxicity in an in vivo model (against A375 melanoma and 143B osteosarcoma cells) are described.Results: It was shown that the inhibition of PTP1B phosphotyrosine phosphatase is one of the mechanisms of action of GO functionalised with 2-ME (GO-2-ME). …”
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The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…The detected phytoconstituents in the plant extract might be involved in the tested cytotoxic activity and its molecular apoptotic mechanism. Future studies are required to isolate the active ingredient(s) and confirm the therapeutic application(s).…”
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Enterobacter-inoculation altered the C, N contents and regulated biomass allocation in Reaumuria soongorica to promote plant growth and improve salt stress tolerance by Xin-Guang Bao, Xin-Guang Bao, Pei-Fang Chong, Pei-Fang Chong, Cai He, Xue-Mei Lu, Xue-Ying Wang, Feng Zhang, Bing-Bing Tan, Jia-Li Yang, Li-Li Gao

“…PGPR assist plants in thriving under salt stress by modifying plant physiology, enhancing nutrient absorption, and synthesizing plant hormones. However, the mechanisms through which PGPR regulate the contents of carbon (C) and nitrogen (N), and biomass allocation of desert plant in response to salt stress is still unclear. …”
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Characterization and utilization of trichoderma sp. for efficient management of oil palm empty fruit bunch waste in plantations by N. Nurmiati, P. Periadnadi, K. Kartiwan, T.W. Edelwis

“…., this study examined the mechanisms associated with efficacy in bioconversion processes and waste remediation.METHODS: A survey method was used to determine sampling locations, and purposive sampling was utilized in the field. …”
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Biomechanical Basis of Interval Throwing Programs for Baseball Pitchers: A Systematic Review by Travis Dias, Benjamin G. Lerch, Jonathan S. Slowik, Kevin E. Wilk, James R. Andrews, E. Lyle Cain, Glenn S. Fleisig

“…The goal is to build back arm strength and capacity with an emphasis on proper mechanics. # Purpose To determine whether interval throwing progressively builds joint kinetics (specifically, elbow varus torque) to the level required during full-effort baseball pitching. …”
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Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway... by Dandan Liu, Peipei Tian, Yilin Hou, Tingxue Zhang, Xiaoyu Hou, Lifang Liu, Xiaolong Li, Kunjie Zheng, Chao Wang, Guangyao Song

“…Abstract Objective Free fatty acids (FFA) can increase the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in local tissues and organs. However, the mechanism underlying the effect of FFA on 11β-HSD1 expression remains unclear. …”
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The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum by Alexander A. Morano, Wei Xu, Francesca M. Navarro, Neeta Shadija, Jeffrey D. Dvorin, Hangjun Ke

“…Both organelles are common targets for antimalarials, but because many proteins involved in organellar fission are not conserved in Plasmodium, until now, the mechanisms underlying apicoplast and mitochondrial division have been unknown. …”
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Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma by Jingyuan Wang, Shuai Yan

“…We further conducted comprehensive analyses of molecular mechanisms, immune microenvironment, and drug sensitivity associated with the risk stratification.ResultsWe identified distinct histone modification patterns across five major cell populations in LGG and developed a robust 20-gene HMRS from 129 candidate genes that effectively stratified patients into high- and low-risk groups with significantly different survival outcomes (training set: AUC = 0.77, 0.73, and 0.71 for 1-, 3-, and 5-year survival; P < 0.001). …”
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Effects of Baicalin on Gout Based on Network Pharmacology, Molecular Docking, and in vitro Experiments by Liu C, Liu W, Lu H, Fan Y, Wang A

“…A network pharmacology approach, molecular docking and experimental validation were applied to investigate the pharmacological mechanisms of baicalin in treating gout.Methods: The potential targets of baicalin were retrieved from the TCMSP, PharmMapper, STITCH, and Swiss Target Prediction databases. …”
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Significance of Tool Coating Properties and Compacted Graphite Iron Microstructure for Tool Selection in Extreme Machining by Anna Maria Esposito, Qianxi He, Jose M. DePaiva, Stephen C. Veldhuis

“…The machinability of CGI and wear mechanisms were analyzed using pre-cutting characterization, in-process optical microscopy, and post-test SEM analysis. …”
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Midgut immune profiling and functional characterization of Aedes aegypti ABC transporter gene(s) using systemic and local bacterial challenges by Vikas Kumar, Shilpi Garg, Diksha Sisodia, Lalita Gupta, Sanjeev Kumar, Vishal Saxena

“…Interestingly, Toll and IMD immune pathways actively participated in the late hours of local bacterial challenges, suggesting that the route of infection influences these immune responses; however, the molecular mechanism behind these phenomena still needs to be explored. …”
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Injection Rate-Dependent Deflecting Propagation Rule of Hydraulic Fracture: Insights from the Rate-Dependent Fracture Process Zone of Mixed-Mode (I-II) Fracturing by Yuekun Xing, Bingxiang Huang

“…Mixed-mode (I-II) fracturing is a prominent mechanical characteristic of hydraulic fracture (HF) deflecting propagation. …”
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The additional impact of metabolic syndrome on left ventricular deformation and myocardial energetic efficiency impairment in ischemia with nonobstructive coronary arteries patient... by Chen-Yan Min, Yue Gao, Yuan Li, Yi-Ning Jiang, Ying-Kun Guo, Hua-Yan Xu, Rong Xu, Xi Liu, Li-Ting Shen, Zhi-Gang Yang

“…MetS was found to be an independent factor of impaired MEEI and LV GLPS, the further decrease of MEEI and LV GLPS in INOCA patients caused by MetS might involve the synergistic injury mechanism. Early diagnosis and treatment of MetS in patients with INOCA are important.…”
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Effectiveness after Designation of a Trauma Center: Experience with Operating a Trauma Team at a Private Hospital by Kyoung Hwan Kim, Sung Ho Han, Soon-Ho Chon, Joongsuck Kim, Oh Sang Kwon, Min Koo Lee, Hohyoung Lee

“…Results No significant differences were found in the annual patients’ average age (54.1±20.0 vs. 52.8±18.2, p=0.201), transportation pathways (p=0.462), injury mechanism (p=0.486), injury severity score (22.93 vs. 23.96, p=0.877), emergency room (ER) stay in minutes (199.17 vs. 194.29, p=0.935), time to operation or procedure in minutes (154.07 vs. 142.1, p=0.767), time interval to intensive care unit (ICU) in minutes (219.54 vs. 237.13, p=0.662). …”
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Eksplorasi ABAC dan XACML untuk Design Access Control pada Resource Digital by Fauzan Natsir, Imam Riadi, Yudi Prayudi

“…Hasil analisis dengan pendekatan ABAC dengan model XACML ini menyajikan suatu keamanan sistem dengan model akses kontrol berbasis atribut dari policy statement untuk menjadi solusi model akses kontrol yang dibuat sebelumnya dan mendukung model akses kontrol yang relevan untuk resource digital Abstract Digital resources require a mechanism to regulate policy against controls to get access rights to a system. …”
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Optimal Information Hiding: Advanced Bitstream-Based Watermarking for Secure and Efficient Integration of Image Data in Digital Videos by null Ramyashree, Venugopala P. S., Raghavendra S., null Sarojadevi

“…These strategies encompassed the intricate infusion of watermark fragments into the frame area through chaotic mechanisms, the integration of error-correcting codes to ensure data fidelity, and the selective omission of dynamic video segments during information extraction processes. …”
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Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad

“…COX inhibition was suggested as the molecular mechanism of the anti-inflammatory activity of the new compounds while no clear relationship could be observed between COX inhibition and anticancer activity. …”
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