Evaluation of Preptin and other Biomarkers in Coronary Artery Disease Patients with and without Diabetes Mellitus by Saja T. Yassen, Layla O. Farhan

“…Preprint’s primary metabolic effect is to raise insulin synthesis, which is achieved through both an amplifying mechanism and a triggering route that is dependent on calcium signalling. …”
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If Music is Ongoing Experience, What Might Music Theory Be? . A Suggestion from the Drastic by Christopher F. Hasty

“…If we take experience as essentially predetermined by the musical work or, in cognitivist information processing terms, by rule-governed mechanisms for manipulating internal representations (be these rules syntactic or semantic) we shall not be able to account for the creativity of music and the production of novel meaning. …”
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Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpace by Han Q, Kim SM

“…Current research is centered on the design and mechanisms of exercise intervention programs. Future studies will prioritize integrated intervention strategies, systematic evidence synthesis, and personalized interventions for specific populations.Keywords: exercise intervention, exercise therapy, mild cognitive impairment, cognitive dysfunction, bibliometric, visualization analysis, CiteSpace…”
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UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…Conclusions Overall, this study elucidated the role of plasma cells and revealed UBE2J1 as a novel oncogene in HGSOC, uncovering new mechanisms related to HGSOC tumorigenesis and promising therapeutic targets for HGSOC patients.…”
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Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy by Han-han He, Xiao-ge Zhang, Fen-fang Chen

“…However, the precise mechanisms by which autophagy deficiencies involved in epileptogenesis are still not fully understood.MethodsTwo datasets of epilepsy (GSE143272 and GSE256068) were downloaded from the Gene Expression Omnibus (GEO) database. …”
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The association between physician sex and patient outcomes: a systematic review and meta-analysis by Kiyan Heybati, Ashton Chang, Hodan Mohamud, Raj Satkunasivam, Natalie Coburn, Arghavan Salles, Yusuke Tsugawa, Ryo Ikesu, Natsumi Saka, Allan S. Detsky, Dennis T. Ko, Heather Ross, Mamas A. Mamas, Angela Jerath, Christopher J. D. Wallis

“…Further work is necessary to examine these effects in other care contexts across different countries and understand underlying mechanisms and long-term outcomes to optimize health outcomes for all patients. …”
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Perceived stress and academic procrastination among higher vocational nursing students: the mediating roles of positive and negative emotions by Congjie Cao, Dandan Chen, Yi Zhou

“…While perceived stress and emotions are known significant predictors, the mechanisms through which they influence academic procrastination remain unclear. …”
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Self-compassion and work engagement among clinical nurses: the mediating role of moral resilience by Xingxing Liu, Fang He, Tian Tian, Jun Zhang, Yuanjiao Ji, Yuexia Zhong

“…Although it is well-established that self-compassion significantly contributes to improved work engagement, there remains a notable lack of research investigating the specific mechanisms through which self-compassion influences work engagement, particularly from the perspective of moral resilience. …”
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Supervised and Unsupervised Screen Time and Its Association With Physical, Mental, and Social Health of School-Going Children in Dhaka, Bangladesh: Cross-Sectional Study by Shahria Hafiz Kakon, Tanjir Rashid Soron, Mohammad Sharif Hossain, Rashidul Haque, Fahmida Tofail

“…Further research is needed to demonstrate causal mechanisms; identify the best interventions; and determine the role of mediators and moderators in households, surroundings, and schools.…”
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The potential synergistic effect of combining doxorubicin with vorinostat in urothelial carcinoma therapy by Cheng-Huang Shen, Shou-Chieh Wang, Kah-Min Lee, Hsin-Ting Liu, Szu-Wei Huang, Jin-Yi Wu, Yi-Wen Liu

“…We aim to investigate the combined effects and mechanisms of doxorubicin and vorinostat in human bladder cancer cells. …”
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Norepinephrine use in cardiogenic shock patients is associated with increased 30 day mortality by Xin Lu, Xue Wang, Yanxia Gao, Joseph Harold Walline, Shiyuan Yu, Zengzheng Ge, Mubing Qin, Huadong Zhu, Yi Li

“…Patients in the norepinephrine group required more mechanical ventilation (84% vs. 67%, OR 2.67, 95% CI 1.70–4.25, P < 0.001) and experienced longer ICU stays (median 7 vs. 4 days, OR 7.92, 95% CI 1.40–44.83, P = 0.020) than non‐norepinephrine group. …”
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Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy by Chengji Wang, Yuan Qu, Xiaoqin Shen, Xiaoxiao Tang, Xiaoxiao Tang, Gaiyu Tong, Meier Wati, Manzeremu Naibi, Manzeremu Naibi, Cheng Zhang, Shaohong Zou

“…However, the neuropathophysiological mechanisms behind NSSI in ABD remain unclear. Therefore, this study employed proton magnetic resonance spectroscopy (1H-MRS) technology to investigate the potential relationship between NSSI and neurometabolism in the ventromedial prefrontal cortex (vmPFC) of patients with ABD.MethodsThis study compared brain biochemical metabolism between ABD with and without NSSI. …”
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Identification of a pancreatic stellate cell gene signature and lncRNA interactions associated with type 2 diabetes progression by Jinjun Qiu, Peng Zhu, Peng Zhu, Xing Shi, Jinquan Xia, Shaowei Dong, Liqun Chen

“…BackgroundType 2 diabetes (T2D) has become a significant global health threat, yet its precise causes and mechanisms remain unclear. This study aims to identify gene expression patterns specific to T2D pancreatic islet cells and to explore the potential role of pancreatic stellate cells (PSCs) in T2D progression through regulatory networks involving lncRNA-mRNA interactions.MethodsIn this study, we screened for upregulated genes in T2D pancreatic islet samples using bulk sequencing (bulkseq) datasets and mapped these gene expression profiles onto three T2D single-cell RNA sequencing (scRNAseq) datasets. …”
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Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma by Qianru Li, Qianru Li, Heli Li

“…However, the specific downstream targets and mechanisms by which AhR influences melanoma remain insufficiently understood.MethodsMelanoma samples from The Cancer Genome Atlas (TCGA) and normal skin tissues from the Genotype-Tissue Expression (GTEx) database were analyzed to identify differentially expressed genes, which were intersected with a curated list of AhR-related pathway genes. …”
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Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study by Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz

“…Intervention consisted of steps 1 (oral hygiene instructions and professional mechanical plaque removal) and 2 (subgingival instrumentation) of periodontal therapy, including an antiseptic mouth rinse for 7 days. …”
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A Review of the Therapeutic Potential of Ginseng and Its Bioactive Components in Nonalcoholic Fatty Liver Disease by Hao L, Li S, Li C, Zhang Z, Hu X, Yan H

“…This review summarizes the existing evidence on the mechanisms of action of ginseng and its active components in human NAFLD, assesses their potential as therapeutic options, and proposes future research directions to provide stronger scientific support for clinical application. …”
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Ginseng-derived Nanoparticles Inhibit Lung Cancer Cell Growth by Promoting Macrophage M1 Polarization by Liangliang FAN, Limei REN, Song YANG, Wenjing LI, Yueming ZHAO, Ronghua ZHAO, Daqing ZHAO, Jiawen WANG

“…Objective: To explore the molecular mechanism by which ginseng-derived nanoparticles (GDNPs) inhibit the growth of human non-small cell lung cancer cells (A549) by altering the polarization state of macrophages. …”
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Performance of RIS-Secured Short-Packet NOMA Systems With Discrete Phase-Shifter to Protect Digital Content and Copyright Against Untrusted User by Nguyen Quang Sang, Hye-Young Kim, Tan N. Nguyen, Minh Bui Vu, Phuong T. Tran, Tran Trung Duy, Byung-Seo Kim, Miroslav Voznak

“…On this foundation, we derive closed-form expressions for the average block-error rate (BLER) to analyze the performance of trustworthy users as well as the average secure BLER to quantify the secure performance when untrustworthy users wiretap trustworthy users&#x2019; information using successive interference mechanisms. Moreover, we further develop asymptotic expressions for both cases to measure the diversity gain and induce key parameters. …”
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Determination of streptococcus mutans retention in acidic and neutral pH artificial saliva environment of all-ceramic materials with different surface treatment by Yeliz Hayran, Süha Kuşcu, Ali Aydın

“…Abstract Background Although surface finishing processes are effective against Streptococcus mutans biofilm, the mechanism of action of saliva with different acidity values ​​has not been studied in detail. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…The application of commensal probiotic bacteria is one of the preferable green feed additives for antibiotic substitution in aquaculture, while the application methods and detailed action mechanisms of commensal bacteria isolated from aquatic animals are not consistent with normal mammalian-derived probiotics. …”
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