The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats by Steve Mabry, Jessica L. Bradshaw, Jennifer J. Gardner, E. Nicole Wilson, Janak Sunuwar, Hannah Yeung, Sharad Shrestha, J. Thomas Cunningham, Rebecca L. Cunningham

“…There is evidence that alterations in protease activity and neuronal activation are associated with cognitive dysfunction, are dependent on sex, and may be brain region-specific. However, the mechanisms mediating OSA-induced cognitive impairments are unclear. …”
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Impact of driver licensing renewal policies on older driver crash involvement and injury rates in 13 states, 2000–2019 by Cara J. Hamann, Jonathan A. Davis, Gilsu Pae, Motao Zhu, Gregory H. Shill, Brian Tefft, Joseph E. Cavanaugh

“…Additional methods to assess fitness to drive are necessary to identify the mechanisms behind the increased rates.…”
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Exploring the stigma experienced by people affected by Parkinson’s disease: a systematic review by Sophie Crooks, Gary Mitchell, Lisa Wynne, Gillian Carter

“…The fourth, responses and consequences of stigma, detailed strategies employed by individuals with PD to manage stigma, including seeking social support and adopting coping mechanisms. The fifth theme, beyond stigma, explored positive aspects of living with PD, highlighting resilience, positive interactions, and advocacy efforts. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…The exploitation of this system as a therapeutic target is impeded by a lack of understanding of the molecular mechanisms underpinning F. hepatica growth and development. …”
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Phylogeographic breaks and how to find them: An empirical attempt at separating vicariance from isolation by distance in a lizard with restricted dispersal by Rancilhac, Loïs, Miralles, Aurélien, Geniez, Philippe, Mendez-Aranda, Daniel, Beddek, Menad, Brito, José Carlos, Leblois, Raphaël, Crochet, Pierre-André

“…However, a misleading signal of phylogeographic break can arise in the absence of barrier to gene flow, under mechanisms of isolation by distance (IBD). How and under which conditions phylogeographic breaks can be reliably differentiated from populations evolving under IBD remain unclear. …”
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CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury by Zhu Zhang, Jinqi Hao, Qinghong Qiao, Junting Song, Yanqin Yu

“…In this study, the role and mechanism of circHIPK2 in MIRI were evaluated. Methods Human cardiac myocytes (HCM) were cultured under Hypoxia/Reoxygenation (H/R) condition to establish a MIRI model in vitro. …”
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Preparation of Iron Oxide and Titania-Based Composite, Core-Shell Populated, Nanoparticulates Material by Two-Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer A... by Hasan H. Bahjat, Raid A. Ismail, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Mohsen Al-Omar, Salman A. A. Mohammed, Riaz A. Khan

“…To further confirm the cytotoxic effects and the mechanism of the anticancer activity of the synthesized NPs against the A549 cell lines, several related parameters (cell viability, membrane permeability, nuclear intensity, and cytochrome-C release) were analyzed using the high-content screening (HCS) assay. …”
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Safety profiles of IDH inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database by Ximu Sun, Han Zhou, Yanming Li, Yanhui Luo, Qixiang Guo, Yixin Sun, Chenguang Jia, Bin Wang, Maoquan Qin, Peng Guo

“…In the future, it will be necessary to validate our findings in prospective large-scale studies and to investigate the underlying mechanisms.…”
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Small spheroids for head and neck cartilage tissue engineering by Sven Reutter, Johann Kern, Yvonne Jakob, Nicole Rotter, David Gvaramia

“…However, this top-down approach is associated with several limitations, including the non-uniform distribution of cells, lack of physiological cell-cell and cell-matrix interactions, and compromised mechanical properties and tissue architecture. The capacity of cells to aggregate into microtissues enables an alternative bottom-up approach to producing cartilage with or without further scaffolding support. …”
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Identification of major hemorrhage in trauma patients in the prehospital setting: diagnostic accuracy and impact on outcome by Nigel R M Tai, Evangelia Kyrimi, Jared M Wohlgemut, Zane B Perkins, William Marsh, Michael Christian, Erhan Pisirir, Rebecca S Stoner, Thomas Hurst

“…Factors associated with missed diagnosis were penetrating mechanism (OR 2.4, 95% CI 1.2 to 4.7) and major abdominal injury (OR 4.0; 95% CI 1.7 to 8.7). …”
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Effect of polishing methods on Candida albicans adhesion and contributing factors in heat-cured acrylic dentures: an in-vitro comparative study by Shahrukh Ali Khan, Zulfiqar Ali Mirani, Taimur Khalid, Engr Muhammad Wasiq Ali Khan, Ziaullah Choudhary, Syed Murtaza Raza Kazmi

“…This study explores the impact of Mechanical Polishing (MP) and Chemical Polishing (CP) methods on these surface properties and their potential to reduce Candida albicans adhesion. …”
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TNF-α Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p by Huikang Xu, Jiamin Fu, Lijun Chen, Sining Zhou, Yangxin Fang, Qi Zhang, Xin Chen, Li Yuan, Yifei Li, Zhenyu Xu, Charlie Xiang

“…Inflammatory bowel disease (IBD) is a chronic idiopathic intestinal inflammation, the etiology and mechanism of which are unclear. At present, the existing therapeutic methods are ineffective for many patients and have obvious side effects. …”
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Device and Methods for Measuring of Acoustic Anisotropy and the Residual Stress in the Main Gas Pipelines’ Metal by L. V. Volkova, O. V. Murav’eva, V. V. Murav’ev, I. V. Buldakova

“…As an object of research, we used fragments – the cuttings of gas pipelines with circumferential welds both after fabrication and removed from service with stress corrosion cracking, including ones with corrosion damage and without visible damage.The method of determining the plane stress-strain state of pipeline elements is based on the phenomenon of acoustoelasticity – the dependence of the propagation velocity of ultrasonic waves on mechanical stresses. The method for determining the elastic characteristics of materials and the anisotropy of their properties is based on the relationship between the velocities of ultrasonic waves and the elastic properties of the medium. …”
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Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome. by Kaitao Zhao, Jingjing Wang, Zichen Wang, Mengfei Wang, Chen Li, Zaichao Xu, Qiong Zhan, Fangteng Guo, Xiaoming Cheng, Yuchen Xia

“…However, the detailed mechanisms are not well characterized. To dissect the biogenesis of cccDNA, we took advantage of an in vitro rcDNA repair system to precipitate host factors interacting with rcDNA and identified co-precipitated proteins by mass spectrometry. …”
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MODERNIZATION AND FUNCTIONING OF PRINCIPLES OF CIVIL PROCEDURAL LAW OF UKRAINE IN THE CONTEXT OF EUROPEAN INTEGRATION PROCESSES by Olga Voloshchenko

“…The doctrinal study of the processes of novelization of the principles of civil procedural law in the light of European integration processes made it possible to formulate the following theses: expanding the list of sources of civil procedural law, as a way of revising the principle of the Rule of Law, strengthened the latter both in the aspect of expanding the tools for ensuring the competitiveness of the process and in the processes of law-making and application practice; precedent practice of the Grand Chamber of the Supreme Court is considered as an element of legal certainty of the principle of the rule of law; it legally enshrined possibility of filing a claim using the "Electronic Court" services strengthened the principle of the Rule of Law in terms of ensuring human rights, as well as expanded the mechanisms of dominance and implementation of the principle of dispositiveness (in terms of the possibility of choosing methods of filing claims on the merits of the case, etc.); it was established that the establishment of the principle of proportionality in Article 11 of the Code of Criminal Procedure of Ukraine is an additional guarantee of ensuring the proper justification of the decision made by the judge (in the context of writing the motivational part of the court decision). …”
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Emerging trends in the construction market under increasing sanctions pressure by N. Yu. Yaskova, L. I. Zaitseva

“…The article took into account approaches to accelerate the commissioning of various types of capital construction projects, which allowed the study to identify the directions of improving market mechanisms across different ССP. The unity of different directions is ensured by preventive methods of avoiding the conflict of economic interests, and the resolution of inevitably arising contradictions of development is proposed using methods of extrajudicial resolution of economic disputes, based on the use of spatial-territorial, legal, judicial, cost, construction and technical, environmental expertise.…”
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Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats by Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying

“…This study aims to confirm whether it has a therapeutic effect on bleomycin-induced IPF in rats and to elucidate its mechanism of action. Male SD rats were randomly divided into the following groups: control, model, CQ + QFTL (84 mg/kg chloroquine (CQ) + 3.64 g/kg QFTL), QFTL-L, M, H (3.64, 7.28, and 14.56 g/kg, respectively) and pirfenidone (PFD 420 mg/kg). …”
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Motor Learning Deficits in a Neonatal Mouse Model of Hypoxic-Ischemic Injury by Maria Marlicz, Weronika Matysik, Emily Zucker, Sarah Lee, Hannah Mulhern, Jennifer Burnsed

“…Rodent models of motor deficits in neonatal hypoxia–ischemia (HI) allow improved understanding of the underlying mechanisms and neuroprotective strategies. Our goal was to test motor performance and learning in a mouse model of neonatal HI. …”
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Antidiabetic agent use and clinical outcomes in patients with diabetes hospitalized for COVID-19: a systematic review and meta-analysis by Jordan N. Keels, Isabella R. McDonald, Christopher S. Lee, Andrew A. Dwyer, Andrew A. Dwyer

“…Further work is needed to uncover mechanism(s) and clarify medical management approaches.…”
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Correlation analysis of the impact of Clonorchis sinensis juvenile on gut microbiota and transcriptome in mice by Xueling Deng, Shitao Li, Yuhong Wu, Jiali Yao, Wei Hou, Jiangyao Zheng, Boying Liang, Xiaole Liang, Qiping Hu, Zhanshuai Wu, Zeli Tang

“…This study aimed to investigate their relationship and potential pathogenic mechanisms. The BALB/c mouse model of early infection with C. sinensis juvenile was constructed. …”
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