Risk Estimation of Severe Primary Graft Dysfunction in Heart Transplant Recipients Using a Smartphone by Souhila Ait-Tigrine, Roger Hullin, Elsa Hoti, Matthias Kirsch, Piergiorgio Tozzi

“…Methods: Severe PGD was defined as the need for mechanical circulatory support and/or death from an unknown etiology within the first 24 hours following HTx. …”
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Creating pragmatic, rapid‐cycle, evidence‐based innovation: The Kaiser Permanente Northern California Delivery Science and Applied Research (DARE) program by Douglas A. Corley, Julie A. Schmittdiel, Smita Rouillard, Yi‐Fen Chen, Tracy A. Lieu

“…Key factors in the DARE program's success include explicitly defining high‐impact ideas; engaging researchers with analysts experienced with large clinical data systems; developing several research funding mechanisms scaled to project size; prioritizing rapid and efficient project completion; supporting clinician‐investigators embedded within their specialties; and structured organization‐wide dissemination of findings for informing potential implementation. …”
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Accelerating phase field simulations through a hybrid adaptive Fourier neural operator with U-net backbone by Christophe Bonneville, Nathan Bieberdorf, Arun Hegde, Mark Asta, Habib N. Najm, Laurent Capolungo, Cosmin Safta

“…For one such process as liquid-metal dealloying (LMD), phase field models have been developed to understand the mechanisms leading to complex morphologies. However, the LMD governing equations in these models often involve coupled non-linear partial differential equations (PDE), which are challenging to solve numerically. …”
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Impact of Dietary Intake and Cardiorespiratory Fitness on Glycemic Variability in Adolescents: An Observational Study by Mingliang Ge, Stephanie R Lebby, Shivani Chowkwale, Caleb Harrison, Grace M Palmer, Keith J Loud, Diane Gilbert-Diamond, Mary Ellen Vajravelu, Jennifer L Meijer

“…Glycemic patterns may provide a mechanism between CRF and health. Objectives: This study assessed the feasibility of measuring glycemic patterns using continuous glucose monitoring (CGM) in adolescents, aged 14–22 y, to estimate the relationship between VO2 max and glucose patterns. …”
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Effect of Joint Geometrical Parameters on Hydraulic Fracture Network Propagation in Naturally Jointed Shale Reservoirs by Zhaohui Chong, Qiangling Yao, Xuehua Li

“…The geometrical parameters of these joints exert effects on the propagation of a hydraulic fracture network in the hydraulic fracturing process. Therefore, mechanisms of fluid injection-induced fracture initiation and propagation in jointed reservoirs should be well understood to unleash the full potential of hydraulic fracturing. …”
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Microplastics: A threat to Fetoplacental unit and Reproductive systems by Abass Toba Anifowoshe, Md Noor Akhtar, Abisola Majeed, Asem Sanjit Singh, Toyyibah Funmilayo Ismail, Upendra Nongthomba

“…This growing concern underscores the urgent need for comprehensive research into the mechanisms through which plastic particles impact the fetoplacental unit. …”
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Augmented Feedback Response Prediction by Peak Vertical Ground Reaction Force in Adolescent Female Athletes by Hannah Jaime, Drew Rutherford, Becky Heinert, C. Nate Vannatta, Sherwin Toribio, Thomas W Kernozek

“…# Background and Purpose Anterior cruciate ligament (ACL) tears often occur due to non-contact mechanisms in landing within females. Impact loading and aberrant landings may be addressed with augmented feedback training. …”
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Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology. Among them, Lysosome-Targeting Chimeras (LYTACs) acting through mannose 6-phosphate receptor (M6PR) have been shown to facilitate degradation of several soluble and membrane-associated proteins in lysosomes with high efficiency. …”
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Comprehensive analysis of a-and b-thalassemia genotypes and hematologic phenotypes by Heng Wang, Hai Huang, Yaping Chen, Xie Dan, Bangquan An, Shengwen Huang

“…Conclusions: The clinical phenotype of thalassemia is influenced by molecular mechanism, and the two kinds of thalassemia can interact with each other. …”
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[MG49-LiClO4]:[TiO2-SiO2] Polymer Electrolytes: In Situ Preparation and Characterization by Oon Lee Kang, Azizan Ahmad, Nur Hasyareeda Hassan, Usman Ali Rana

“…[MG49-LiClO4]:[HNO3-THF/TiO2-SiO2] and [MG49-LiClO4]:[ClHNO2-THF/TiO2-SiO2] polymer electrolytes had exhibited distinct conduction mechanisms in similar experimental configuration. [MG49-LiClO4]:[HNO3-THF/TiO2-SiO2] and [MG49-LiClO4]:[ClHNO2-THF/TiO2-SiO2] polymer electrolytes had exhibited different stability characteristics over certain operational condition.…”
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Biomechanical Analysis and Solution Suggestions of Screw Replacement Scenarios in Femoral Neck Fracture Surgeries: Finite Element Method by Yılmaz Güvercin, Murat Yaylacı, Ayberk Dizdar, Mehmet Emin Özdemir, Sevil Ay, Ecren Uzun Yaylacı, Umitcan Karahasanoğlu, Hüseyin Uygun, Gökhan Peker

“…When the results are evaluated, it is seen that the MBP has a decreasing effect on the results. Mechanical evaluation of six different options used in femoral neck fractures was performed. 85 mm CCS applied to our standard model gave the best results, while the use of 80 mm CCS in the same model showed promising results compared to other models. …”
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DIABETES MELLITUS IN PATIENTS WITH LIVER CIRRHOSIS: NEW TREATMENT OPTIONS by L. Yu. Morgunov

“…The incidence, frequency of hospitalizations and mortality from this combined pathology are very high. There are common mechanisms that provoke metabolic and autoimmune disorders in the development of chronic hepatitis and cirrhosis, leading to steatosis, insulin resistance, impaired glucose tolerance and the development of diabetes mellitus. …”
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lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis by Shan-zheng Wang, Jun Jia, Chang-hong Chen

“…This study was aimed at investigating the role of ADSCs-Exos and a novel long noncoding RNA KCNQ1OT1 played in osteoporosis as well as the underlying mechanism. Methods. Primary osteoblasts were treated with different doses of tumor necrosis factor-α (TNF-α) (0, 1, 2.5, 5, and 10 ng/ml) and then cocultured with ADSCs-Exos or exosome-derived from lnc-KCNQ1OT1-modified ADSCs (KCNQ1OT1-Exos). …”
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Functional Characterization of the <i>PoWHY1</i> Gene from <i>Platycladus orientalis</i> and Its Role in Abiotic Stress Tolerance in Transgenic <i>Arabidopsis thaliana</i> by Chun Ou, Zhiyu Dong, Xudong Zheng, Wenhui Cheng, Ermei Chang, Xiamei Yao

“…The important role of the <i>PoWHY1</i> gene in regulating plant growth and adaptation to environmental stress has become a hot research topic. However, the mechanism of the <i>PoWHY1</i> gene in <i>Platycladus orientalis</i> under abiotic stress is still unclear. …”
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Activation of ClO₂ by Nanoscale Zero-Valent Iron for Efficient Soil Polycyclic Aromatic Hydrocarbon Degradation: New Insight into the Relative Contribution of Fe(IV) and... by Xiaojun Hu, Xiaorong Xing, Fan Zhang, Bingzhi Li, Senlin Chen, Bo Wang, Jiaolong Qin, Jie Miao

“…However, the related activation mechanisms are still not clear. Herein, the variation of iron species and ClO₂, the generated reactive oxygen species, and the toxicity of the degradation intermediates were explored and evaluated with nanoscale zero-valent iron (nFe⁰) being employed to activate ClO₂ for soil polycyclic aromatic hydrocarbon (PAH) removal. …”
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SYSTEM ANALYSIS AND DESIGN OF THE GAME «SHOOTING SIMULATION IN A SHOOTING RANGE» by D. Yanchev, O. Sakaliuk, D. Popkov

“…The shooting simulation can be beneficial for training in shooting disciplines and engaging users with top-tier gaming mechanics. The work underscores the importance of integrating innovative technologies into the process of creating gaming products that meet modern standards of quality and convenience. …”
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N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1 by Toru Miwa, Toru Miwa, Akihito Tarui, Akihito Tarui, Teppei Kouga, Yasunori Asai, Yasunori Asai, Hideaki Ogita, Hideaki Ogita, Taro Fujikawa, Nobuhiro Hakuba, Nobuhiro Hakuba

“…Future research should explore mechanisms underlying SIRT1-induced cochlear damage and strategies to maintain balanced SIRT1 expression. …”
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CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials by Dimitrios Zouraris, Angelos Mavrogiorgis, Andreas Tsoumanis, Laura Aliisa Saarimäki, Giusy del Giudice, Antonio Federico, Angela Serra, Dario Greco, Ian Rouse, Julia Subbotina, Vladimir Lobaskin, Karolina Jagiello, Krzesimir Ciura, Beata Judzinska, Alicja Mikolajczyk, Anita Sosnowska, Tomasz Puzyn, Mary Gulumian, Victor Wepener, Diego S.T. Martinez, Romana Petry, Naouale El Yamani, Elise Rundén-Pran, Sivakumar Murugadoss, Sergey Shaposhnikov, Vasileios Minadakis, Periklis Tsiros, Harry Sarimveis, Eleonora Marta Longhin, Tanima SenGupta, Ann-Karin Hardie Olsen, Viera Skakalova, Peter Hutar, Maria Dusinska, Anastasios G. Papadiamantis, L. Cristiana Gheorghe, Katie Reilly, Emilie Brun, Sami Ullah, Sebastien Cambier, Tommaso Serchi, Kaido Tämm, Candida Lorusso, Francesco Dondero, Evangelos Melagrakis, Muhammad Moazam Fraz, Georgia Melagraki, Iseult Lynch, Antreas Afantitis

“…Significant progress has been made in generating atomistic and quantum-mechanical descriptors for various NMs, evaluating their interactions with biological systems (from small molecules or metabolites, to proteins, cells, organisms, animals, humans and ecosystems), and in developing predictive models for NMs risk assessment. …”
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Gasdermin D regulates the activation of EGFR in colorectal cancer by Ying Li, Jiayao Chen, Huijun Liang, Qindan Du, Jingjie Shen, Xiaoying Wang

“…In this study, we observed that GSDMD modulates CRC progression through other mechanisms in addition to activating GSDMD-NT. Methods Clinical CRC samples and human-derived CRC cell lines were used in this study. …”
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Cinnamic acid alleviates endothelial dysfunction and oxidative stress by targeting PPARδ in obesity and diabetes by Yizhen Bai, Dechao Tan, Qiaowen Deng, Lingchao Miao, Yuehan Wang, Yan Zhou, Yifan Yang, Shengpeng Wang, Chi Teng Vong, Wai San Cheang

“…This study was aimed to study the potential protective effects of CA against diabetes-associated endothelial dysfunction and its underlying mechanisms. Methods High-fat diet (HFD) with 60 kcal% fat was used to induce obesity/diabetes in C57BL/6 mice for 12 weeks. …”
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