Emotional exhaustion and turnover intentions among young ICU nurses: a model based on the job demands-resources theory by Xiaona Zhang, Haitao Huang, Songtao Zhao, Dan Li, Hua Du

“…This study explore the potential mechanisms by which emotional exhaustion affects turnover intentions among young intensive care unit nurses. …”
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miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney Injury through Downregulation of NEK7 by Meng Zhang, Deyuan Zhi, Jin Lin, Pei Liu, Yajun Wang, Meili Duan

“…Sepsis-induced acute kidney injury (S-AKI) has high morbidity and mortality, of which the pathophysiological mechanisms have not been completely illuminated, leading to nonspecific therapies. …”
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Intelligent classification of computer vulnerabilities and network security management system: Combining memristor neural network and improved TCNN model. by Zhenhui Liu

“…Subsequently, structural optimization and parameter adjustments are made to the TCNN model, incorporating residual connections and attention mechanisms to improve its classification performance, making it more adaptable to the dynamically changing network security environment. …”
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Construction and validation of prognosis and treatment outcome models based on plasma membrane tension characteristics in bladder cancer by Zhipeng Wang, Sheng Li, Fuchun Zheng, Situ Xiong, Lei Zhang, Liangwei Wan, Chen Wang, Xiaoqiang Liu, Jun Deng

“…However, their specific mechanisms in bladder cancer (BLCA) remain unclear. …”
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Discoloration and Degradation of Bamboo under Ultraviolet Radiation by Haixia Yu, Shengliang He, Wenfu Zhang, Mengyao Zhan, Xiaowei Zhuang, Jin Wang, Wenji Yu

“…Effects of light sources, radiation time, and distances on discoloration and discoloration mechanism were systematically studied. For both UV 313 and high-pressure mercury light, the bamboo surface turned red-yellow, and color parameters including ΔE, Δa, Δb, and C rapidly increased first and then stabilized for long time, while ΔL showed a similar trend, except for the final decrease. …”
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Propofol Regulates ER Stress to Inhibit Tumour Growth and Sensitize Osteosarcoma to Doxorubicin by Hua Wei, Xinhui Du, Huaping Zhao, Peipei Sun, Jianjun Yang

“…In this study, we aimed to assess the role of propofol on osteosarcoma and explore the possible mechanisms. Propofol of increasing concentrations (2.5, 5, 10, and 20 μg/ml) was used to treat the MG63 and 143B cells for 72 hours, and the CCK8 assay was applied to evaluate the tumour cell proliferation. …”
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Spatiotemporal requirements of nuclear β-catenin define early sea urchin embryogenesis. by Guy Lhomond, Michael Schubert, Jenifer Croce

“…Finally, we determined that restriction of the anterior neuroectoderm territory depends on at least 2 nuclear β-catenin-dependent inputs and a nuclear β-catenin-independent mechanism. Taken together, this work is the first to comprehensively define the spatiotemporal requirements of β-catenin during the early embryogenesis of a single animal, the sea urchin Paracentrotus lividus, thereby providing new experimental evidence for a better understanding of the roles played by this evolutionary conserved protein during animal development.…”
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Core microbe Bifidobacterium in the hindgut of calves improves the growth phenotype of young hosts by regulating microbial functions and host metabolism by Yimin Zhuang, Duo Gao, Wen Jiang, Yiming Xu, Guanglei Liu, Guobin Hou, Tianyu Chen, Shangru Li, Siyuan Zhang, Shuai Liu, Jingjun Wang, Jianxin Xiao, Mengmeng Li, Wei Wang, Shengli Li, Zhijun Cao

“…However, the identification of beneficial gut bacteria and its internal mechanisms of shaping host phenotype differentiation remains unclear. …”
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Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosisResearch in context by Zeyu Liu, Qi Zheng, Zhoubin Li, Moli Huang, Cheng Zhong, Ruize Yu, Rong Jiang, Haotian Dai, Jingyuan Zhang, Xiaohua Gu, Yongle Xu, Chunwei Li, Shan Shan, Feng Xu, Yue Hong, Tao Ren

“…Single-cell RNA-sequencing was employed to elucidate the underlying mechanisms governing the BCs based therapy. Based upon these evidences, three patients with advanced IPF and small airway dysfunction received autologous-BCs transplantation. …”
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Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis by Lei Xiang, Qingzhou Li, Zhiwei Guan, Guilin Wang, Xiankuo Yu, Xianwen Zhang, Guochen Zhang, Jushan Hu, Xue Yang, Mingrui Li, Xilinqiqige Bao, Yumei Wang, Dong Wang

“…IntroductionOxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. However, its exact mechanism of action (MOA) remains unclear. This study aimed to investigate the pharmacological activity and underlying MOA.MethodsThe inhibitory effect of ORes on breast cancer cell growth was confirmed, and the effective concentrations were determined for further experiments. …”
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Development and validation of a nomogram to predict survival in septic patients with heart failure in the intensive care unit by Tong Tong, Yikun Guo, Qingqing Wang, Xiaoning Sun, Ziyi Sun, Yuhan Yang, Xiaoxiao Zhang, Kuiwu Yao

“…A nomogram model was developed to predict short-term survival probabilities, using 13 variables: age, pneumonia, endotracheal intubation, mechanical ventilation, potassium (K), anion gap (AG), lactate (Lac), activated partial thromboplastin time (APTT), white blood cell count (WBC), red cell distribution width (RDW), hemoglobin-to-red cell distribution width ratio (HRR), Sequential Organ Failure Assessment (SOFA) score, and Charlson Comorbidity Index (CCI). …”
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Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…Considering the distinct etiological agent, pathogenic mechanisms, and pathological manifestations, epigenetic research plays a pivotal role in uncovering markers and potential targets related to the cancer-promoting and morbidity-inducing liver fluke parasite prevalent in the Great Mekong Subregion (GMS). …”
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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…This research explored the relationship between the microbiomes of the upper respiratory and GI tracts in patients with COVID-19 and examined Extraesophageal reflux (EOR), a mechanism which could contribute to dysregulated communication between the GI and respiratory tract (as identified in COVID-19). 97 patients with a laboratory diagnosis of COVID-19 infection, and 50 age-matched controls were recruited and stool, saliva and sputum were obtained from each participant. …”
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The direct and urinary electrolyte-mediated effects of ambient temperature on population blood pressure: A causal mediation analysis by Ayesha Mukhopadhyay, Momenul Haque Mondol, Mahbubur Rahman, Leanne Unicomb, Rizwana Khan, Hoimonty Mazumder, Mohammad Nahian Ferdous, Emily V. Pickering, Konstantinos C. Makris, Alberto J. Caban-Martinez, Faruk Ahmed, Mohammad Shamsudduha, Fawaz Mzayek, Chunrong Jia, Hongmei Zhang, Anwar Musah, Lora E. Fleming, Matthew P. Smeltzer, Howard H. Chang, John L. Jefferies, Csaba P. Kovesdy, Xichen Mou, Abu Mohd Naser

“…Further studies are needed to uncover the underlying mechanisms of ambient heat and BP associations and to describe the clinical consequences of these associations.…”
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Sensitive windows for within- and trans-generational plasticity of anti-predator defences by Tariel-Adam, Juliette, Luquet, Émilien, Plénet, Sandrine

“…Transgenerational plasticity could be an important mechanism for adaptation to variable environments in addition to within-generational plasticity. …”
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Anti-VEGF therapy for proliferative diabetic retinopathy: translating research evidence into clinical practice by E.A. Abdulaeva, E.L. Minkhuzina, A.N. Kuskov

“…The introduction of anti-VEGF therapy has changed treatment paradigm for neovascularization as anti-VEGF agents target major pathophysiological mechanism of DR. Intensive studies on anti-VEGF therapy for PDR are now underway. …”
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Anti-inflammatory and antioxidant properties of Camellia sinensis L. extract as a potential therapeutic for atopic dermatitis through NF-κB pathway inhibition by Min Jung Kim, Ye Jin Yang, Ga-Yul Min, Ji Woong Heo, Jae Dong Son, Young Zoo You, Hun Hwan Kim, Gon Sup Kim, Hu-Jang Lee, Ju-Hye Yang, Kwang Il Park

“…Molecular docking simulations provided insights into the underlying mechanisms of CSE action, which supported its potential as a therapeutic agent for AD. …”
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Additive impact of metabolic syndrome and sarcopenia on all-cause and cause-specific mortality: an analysis of NHANES by Meng Zhang, Qing-Yue Zeng, Linli Zhuang

“…BackgroundMetabolic syndrome (MetS) and sarcopenia (SP) are increasingly significant public health issues in aging societies, sharing common pathophysiological mechanisms and being associated with severe health consequences. …”
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Palmitic Acid Methyl Ester Induces G2/M Arrest in Human Bone Marrow-Derived Mesenchymal Stem Cells via the p53/p21 Pathway by Jian-Hong Lin, Pei-Ching Ting, Wen-Sen Lee, Hung-Wen Chiu, Chun-An Chien, Chin-Hung Liu, Li-Yi Sun, Kun-Ta Yang

“…The aim of this study was to investigate the effect of PAME on human BM-MSC (hBM-MSC) proliferation and its underlying molecular mechanisms. hBM-MSCs were treated with PAME for 48 h and then subjected to various analyses. …”
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Polyploidization-driven transcriptomic dynamics in Medicago sativa neotetraploids: mRNA, smRNA and allele-specific gene expression by D. F. Santoro, G. Marconi, S. Capomaccio, M. Bocchini, A. W. Anderson, A. Finotti, M. Confalonieri, E. Albertini, D. Rosellini

“…Abstract Whole genome duplication (WGD) is a powerful evolutionary mechanism in plants. Autopolyploids have been comparatively less studied than allopolyploids, with sexual autopolyploidization receiving even less attention. …”
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