Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…There is uncertainty around the individual or combined effect of these concepts compared with computer-assisted surgery (CAS) and mechanical alignment (MA), respectively. This study aims to assess the effectiveness of RAS, KA or both to improve clinical outcomes, functional measures, radiographic precision and prosthetic survivorship when compared with current gold standards of surgical care.Methods and analysis A national registry-nested, multicentre, double-blinded, 2×2 factorial, randomised trial will be undertaken with 300 patients undergoing primary unilateral TKA performed by 15 surgeons. …”
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Combination of Compound Kushen injection with first-line treatment versus first-line treatment alone for advanced colorectal cancer: a study protocol for a multicenter, openlabel,... by Jingyuan Wu, Yuansha Ge, Guanghui Zhu, Ruike Gao, Xiaoyu Zhu, Ying Zhang, Jie Li

“…Metabolomics and gut microbiota analysis will be conducted on biological samples to explore the metabolic and gut microbiota differences associated with the efficacy of CKI, guiding further research into its mechanism of action. Trial registration ClinicalTrials.govNCT05894694. …”
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Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study by Xiyu Wei, Chao Li, Dongyu Liu, Jieyi Chen, Yumeng Ju, Jin Liu, Bangshan Liu, Yan Zhang

“…Future studies can delve deeper into the mechanisms underlying this full-dimensional relationship between physical and cognitive domains.…”
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Short Pulse Epiretinal Stimulation Allows Focal Activation of Retinal Ganglion Cells by Laurin X. Koppenwallner, Gunther Zeck, Paul Werginz

“…Computational modeling points to somatic polarization as the underlying mechanism for lower somatic thresholds. Our results demonstrate focal activation with pulses in the range of <inline-formula> <tex-math notation="LaTeX">$10\mu $ </tex-math></inline-formula>s as a potential strategy to avoid the long-standing problem of axonal co-activation in epiretinal implants.…”
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Multi-decadal stability of water ages and tracer transport in a temperate-humid river basin by Siyuan Wang, Markus Hrachowitz, Gerrit Schoups, Anna Störiko

“…The temporal dynamics of water ages provide crucial insights into hydrological processes and transport mechanisms, yet there remains a significant gap in quantifying water age variability across different temporal scales. …”
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Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing by Anwen Huang, Jinxiu Wu, Jiakuan Wang, Chengwen Jiao, Yunfei Yang, Huaiwen Xiao, Li Yao

“…Conclusions Our study develops an immune-related prognostic model and Nomogram that reliably predicts survival outcomes in CRC patients and enhances understanding of the tumor immunity and molecular mechanisms of CRC.…”
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Skin Metabolic Signatures of Psoriasis and Psoriasis Concurrent with Metabolic Syndrome by Yan L, Wang W, Dong M, Wang R, Li C

“…There were some metabolites with consistent alterations in both the PVNMS/HC and PVMS/PVNMS comparisons.Conclusion: This study may provide new insights into the link between skin metabolism and psoriatic inflammation and the mechanism underlying the interaction between psoriasis and MetS.Keywords: psoriasis, metabolic syndrome, metabolomics, nucleotide metabolism, glycerophospholipid metabolism…”
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A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research by Max L. A. Ebert, Vanessa F. Schmidt, Osman Öcal, Anne von Thaden, Olaf Dietrich, Bastian Popper, Sandra Elges, Max Seidensticker, Jens Ricke, Melanie A. Kimm, Astrid Jeibmann, Moritz Wildgruber

“…Along with a high-fat diet, the rabbits developed lumen-narrowing atherosclerosis and neointimal hyperplasia of the iliac arteries within a 6-week period after mechanical injury. The stent-retriever method was compared with a conventional rabbit model (n = 10) using balloon denudation via surgical access, and both models were analyzed with a particular focus on animal welfare. …”
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Genomic signatures of selection in Brangus cattle revealing the genetic foundations of adaptability and production traits using a breed of origin approach by Gabriel A. Zayas, Raluca G. Mateescu

“…These findings provide deeper insights into the genetic mechanisms driving adaptation and production performance in cattle and offer valuable information for strategic breeding practices aimed at optimizing the strengths of both parental breeds.…”
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Biochemical and Histopathological Studies of Key Tissues in Healthy Male Wistar Rats Fed on African Yam Bean Seed and Tuber Meals by Omena Bernard Ojuederie, John Adebayo Ajiboye, Olubukola Oluranti Babalola

“…To mitigate this effect, focus is being given to orphan or underutilized crops with immense potentials to boost food and nutrition security in Africa, such as the African yam bean (AYB) Sphenostylis stenocarpa. …”
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Evaluation of the Bonding Shear Strength between Enamel and Dentin Feldspathic Porcelain and Two Different Monolithic Zirconia with Low and High Translucency by Amirhossein Fathi, Yeganeh Natanzian, Mahsa Ghorbani, Ramin Mosharraf

“…Zirconia, distinguished by its exceptional mechanical strength, plays a pivotal role in the fabrication of posterior crowns and bridges. …”
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Optimizing Cucumber (<i>Cucumis sativus</i> L.) Fruit Metabolomics Under Elevated CO₂ and High-Temperature Stress in the Greenhouse by Xian Du, Yang Song, Lu Pan, Shimao Cui

“…This study aims to elucidate the response mechanisms of cucumber fruit metabolomics under elevated CO₂ and high-temperature stress while also exploring the potential benefits of elevated CO₂ in mitigating the adverse effects of high temperatures. …”
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Bayesian network for predicting mandibular third molar extraction difficulty by Tian Meng, Zhiyong Zhang, Xiao Zhang, Chao Zhang

“…First, the qualitative mechanism knowledge, including the effect of risk factors on the extraction difficulty and the causal relationships between risk factors, was analysed to establish the framework of the Bayesian network. …”
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Effects of physical activity participation on subjective well-being of Chinese residents: mediating effects of physical health status and perceived social development by Pingqiang Wei, Ting Qin, Chengyi Zhu

“…This study aims to explore the influence mechanism of physical exercise participation on the subjective well-being of Chinese residents and the mediating role of physical health status and social development cognition in this relationship.MethodsBased on the data from China’s comprehensive social survey in 2021, 7,923 valid samples were selected. …”
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Metatranscriptomes-based sequence similarity networks uncover genetic signatures within parasitic freshwater microbial eukaryotes by Arthur Monjot, Jérémy Rousseau, Lucie Bittner, Cécile Lepère

“…., involved in hijacking host resources, or associated with immune evasion mechanisms). All these protein families could offer valuable insights for developing antiparasitic treatments in health and economic contexts. …”
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Biodiversité et viabilité de l'agriculture paysanne dans la Réserve de Biosphère Sierra de Manantlán, Mexique by Enrique J. Jardel Peláez, Sergio H. Graf Montero, Eduardo Santana C., Ricardo Ávila Palafox

“…Therefore the design and implementation of conservation programs should provide instruments to offset the exceptional conditions created by protected areas, and to implement actions to strengthen the communal institutions, to promote the creation of effective participatory mechanisms for reserve management, and to contribute to capacity building, recovery of traditional knowledge and sustainable resource management techniques and the design of new forms of land management that allow conservation of ecosystems and agro-biodiversity, food self-sufficiency and improvement of the living conditions of the rural population. …”
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Achievements and prospects of applying high-throughput sequencing techniques to potato genetics and breeding by I. V. Bykova, N. A. Shmakov, D. A. Afonnikov, A. V. Kochetov, E. K. Khlestkina

“…Sequencing of the genome as well as transcriptomes and microRNomes of cultivated potato and its wild relatives, on one hand, is of fundamental interest, assisting in detecting features of genome evolution, ontogenetic development and mechanisms of various environmental stresses responses. …”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…Objectives: This study aimed to construct PI3Kα inhibitors by hybridization and investigate their antitumor activity and mechanism. Methods: 26 quinazoline-2-indolinone derivatives were obtained by molecular hybridization, and their structure–activity relationship was analyzed by MTT, in vitro kinase activity and molecular docking. …”
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Coexistence of multiple leaf nutrient resorption strategies in urban forests by Pin Li, Zejin Wang, Kun Ran

“…Leaf nutrient resorption is an essential strategy employed by plants to conserve available resources, and three different mechanisms have been shown to be used for the control of such resorption, including nutrient concentration, nutrient limitation, and stoichiometric control. …”
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Critical analysis of doctrinal approaches to the definition of “biological terrorism” by О. V. Shamsutdinov

“…It has been argued that terrorism is not only criminal behaviour, but also a certain ideology which justifies the purpose of terrorist activity and the mechanisms for achieving it. On this basis, two doctrinal approaches to understanding terrorism, such as comprehensive and applied, have been identified. …”
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