New evidence on the nephrotoxicity of fine particulate matter: Potential toxic components from different emission sources by Fu-Jen Cheng, Chien-Er Huang, Pei-Shih Chen, Yu-Lun Tseng, Chung-Shin Yuan, Ching-Shu Lai

“…However, the specific mechanisms and components causing renal damage remain unclear. …”
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Reconsidering “Critical” Bone Loss in Shoulder Instability: 17-Year Follow-Up Study following Arthroscopic Bankart Repair by Lawrence Chun-Man Lau, Wai-Wang Chau, Randy Ng, Jonathan Patrick Ng, Elvis Chun-Sing Chui, Michael Tim-Yun Ong, James Francis Griffith, Patrick Shu-Hang Yung

“…Western Ontario Shoulder Instability (WOSI) score, Single Assessment Numeric Evaluation (SANE) score, redislocation after operation, mechanism of recurrence, and revision details were reviewed. …”
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Sevoflurane Exacerbates Cognitive Impairment Induced by Aβ1–40 in Rats through Initiating Neurotoxicity, Neuroinflammation, and Neuronal Apoptosis in Rat Hippocampus by Yue Tian, Ke-yan Chen, Li-dan Liu, Yun-xia Dong, Ping Zhao, Shan-bin Guo

“…This study was aimed at investigating whether sevoflurane inhalation induced cognitive impairment in rats with a possible mechanism involved in the event. Methods. Thirty-two rats were randomly divided into four groups of normal saline (NS) + O2, NS + sevoflurane (sevo), amyloid-β peptide (Aβ) + O2, and Aβ + sevo. …”
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Network Intrusion Detection and Prevention System Using Hybrid Machine Learning with Supervised Ensemble Stacking Model by Godfrey A. Mills, Daniel K. Acquah, Robert A. Sowah

“…However, the growing level and sophistication of malicious attacks launched on networks in the current technological landscape have necessitated the need for advanced and robust detection mechanisms to mitigate against security breaches of confidentiality, integrity, and denial-of-service. …”
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Association of blood manganese and selenium levels with hepatic steatosis among adolescents: a nationwide cross-sectional analysis by Bin You, Bin You, Bin You, Bin You, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen

“…These findings suggest a potential role of trace elements in the development of hepatic steatosis, highlighting the need for further research to better understand the underlying mechanisms involved in liver fat accumulation in this population.…”
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Evaluating a novel team learning approach for integrating drugs in sports education in preclinical medical training by Samuel Pelobello, Grayson Potter, Daniel K. Rogstad, Andrew J. Mock, Sean M. Wilson

“…Future iterations will focus on emphasizing drug pharmacology, mechanisms of action, and physiological effects for MS1 students, while providing opportunities for more comprehensive knowledge integration through the case studies for MS2 students. …”
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Correlations of inflammatory processes caused by cerebral stroke with the outcome of the disease by A. Vaitkus, J. Valinčiūtė, S. Gylytė

“…In this analysis, we review the positive and negative role of neuroinflammatory mechanisms in stroke. Negative influence of inflammatory cells and mediators in brain injury patients. …”
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Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…Adsorption data were modeled using Langmuir, Freundlich, and Dubinin-Radushkevich isotherms, indicating monolayer adsorption consistent with the Langmuir model. The adsorption mechanism involves a two-step process where positively charged Cd2⁺ and Pb2⁺ ions diffuse toward the negatively charged surface of the Alg-OP-Ni nanobiocomposite and subsequently fix through interactions with surface oxygen atoms. …”
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fMRI Analysis on Electroacupuncture on Tongli Acupoint in Healthy People by Lin LU, Wanzhang YANG, Yunhai QIU, Liping YE, Linling LI

“…Objective:To investigate the effect and mechanism of electroacupuncture on Tongli acupoint on the right hand of normal subjects that may activate brain language area by functional magnetic resonance imaging (fMRI).Methods:Twenty-four healthy volunteers were recruited and divided into treatment group and control group. …”
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Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells by Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Brice Magne, Brice Magne, Brice Magne, Karel Ferland, Karel Ferland, Karel Ferland, Natallia E. Uzunbajakava, Daniel Barolet, Daniel Barolet, Lucie Germain, Lucie Germain, Lucie Germain

“…IntroductionRecent findings show that visible light, particularly blue light, stimulates melanogenesis in human skin, though the underlying mechanisms remain debated. This study aimed to determine the cell damage threshold of non-ionizing blue light on keratinocytes while preserving their ability to stimulate melanogenesis.MethodsHuman keratinocytes (N = 3) and melanocytes (N = 3) were isolated from skin samples of varying Fitzpatrick skin phototypes and irradiated with blue light (λpeak = 457 nm) and UVA light (λpeak = 385 nm). …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…The rats were divided into Control, Model, Sig-1R agonist PRE-084 (0.3, 0.6, 1 mg/kg), and metformin (Met, 20 mg/kg) groups, with seven rats per group, and their body weight, fasting blood glucose, mechanical withdrawal threshold and thermal withdrawal latency were tested weekly for two weeks. …”
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Numerical Simulation of Gas–Liquid–Solid Three-Phase Erosion in a Gas Storage Tank Tee by Zongxiao Ren, Chenyu Zhang, Zhaoyang Fan, Yanfei Ren

“…The findings of this study offer valuable insights into the mechanisms governing tee erosion under elevated temperatures and pressures within storage reservoirs.…”
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Innate Immune Responses Associated with Resistance against Haemonchus contortus in Morada Nova Sheep by João Henrique Barbosa Toscano, Cintia Hiromi Okino, Isabella Barbosa dos Santos, Luciana Aparecida Giraldelo, Marei Borsch von Haehling, Sérgio Novita Esteves, Ana Carolina de Souza Chagas

“…However, the exact mechanisms associated with increased sheep resistance against this parasite remains poorly elucidated. …”
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Unidirectional freeze–thaw redistributes water and amplifies soil microbial heterogeneity in a mecrocosm experiment by Huimin Liu, Yaxian Hu, Yuan Song, Xianwen Li, Xiaorong Wei

“…Such unidirectional freeze–thaw induced soil water redistribution tended to alleviate the dryness in the L1 of the low moisture columns initially with 30% of water holding capacity (WHC), but rendered the L1 of the high moisture columns (initially with 80% WHC) more susceptible to intensive mechanical destruction during ice crystallization. On the contrary, the water depletion in the inner layer L6 appeared to introduce secondary dry stress to the low moisture columns, but helped to temper the destructive ice expansion in the L6 of the high moisture columns. …”
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Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants by null Turyadi, Billy Witanto, Korri E. El-Khobar, M. Luthfi Parewangi, M. Rezki Rasyak, Dhita P. Wibowo, Meta D. Thedja, Irawan Yusuf, Muh. Nasrum Massi, Ilhamjaya Patellongi, Din Syafruddin, David H. Muljono

“…It would be beneficial to study not only the effect of host determinants but also the viral factor to understand the mechanisms of CHB phase progression.…”
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Establishing a GRU-GCN coordination-based prediction model for miRNA-disease associations by Kai-Cheng Chuang, Ping-Sung Cheng, Yu-Hung Tsai, Meng-Hsiun Tsai

“…This model offers a valuable tool for complementing traditional experimental methods and enhancing our understanding of miRNA-related disease mechanisms.…”
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Using a clinical decision support system to reduce excess driving pressure: the ALARM trial by Ursula Burger-Klepp, Mathias Maleczek, Robin Ristl, Bettina Kroyer, Marcus Raudner, Claus G. Krenn, Roman Ullrich

“…However, there was no significant difference between groups in mechanical power, the number of ventilator-free days, or the percentage of patients showing progression to ARDS. …”
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Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes by Islam Alfreahat MS, Hamdi Nsairat PhD, Ibrahim Deeb Aldeeb PhD, Ali Al-Samydai PhD, Walhan Alshaer PhD

“…Background Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness is often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. …”
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Modern view on the treatment of diabetic macular edema by A.V. Shelankova, M.V. Budzinskaya, I.V. Andreeva

“…The pathophysiological process of DME development includes several mechanisms associated with chronic hyperglycemia. It has been proven that the level of vascular endothelial growth factor (VEGF) in the eye is not only elevated in DME, but is also proportional to the severity of edema. …”
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Local democracy and forms of direct citizen participation in governance: Case study Serbia by Radojević Mijodrag

“…In the Republic of Serbia, institutional mechanisms for direct citizen participation in local self-government have been created, such as referendums, citizens' initiatives, and assembly of citizens (zbor). …”
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