The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…The aim: to study the role of cystatin C in neurodegeneration and evaluate the results in relation to the mechanism of autophagy. In our study on humans, a higher concentration of cystatin C was noted in cerebrospinal fluid than in serum; much lower concentrations were observed in other biological fluids (intraocular fluid, bile, and sweat). …”
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Understanding the limitations of substrate degradation in bioelectrochemical systems by Hannah Bird, Sharon Velasquez-Orta, Elizabeth Heidrich

“…However, MFC performance optimization remains challenging due to limited understanding of microbial metabolic mechanisms, particularly with complex substrates under realistic environmental conditions. …”
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Knee phenotypes distribution according to CPAK classification in Turkish population by Vahit Emre Özden, Göksel Dikmen, Kayahan Karaytuğ, Arda Mavi, Yılmaz Onat Köylüoğlu, İsmail Remzi Tözün

“…CPAK type 5, which is the target of the mechanical alignment strategy, is only 7.8% in the nonarthritic group and 8.4% in the osteoarthritic group in the Turkish population. …”
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Valuation method for sub-indicators of rock burst risk based on mining depth and tectonic stress by Zhen LI, Guanyang WU, Shangjin SI, Xin GAO, Xun LIU, Dongdong ZHANG, Chengxiang ZHANG, Jiachen LIU

“…The mechanical properties of deep rocks differ from those of the shallow layers due to the complex environment. …”
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High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy. by Yu Zhao, Yuteng Jiang, Fengmei Wang, Li Sun, Mengyuan Ding, Liyuan Zhang, Beibei Wu, Xiaoliang Zhang

“…Studies have indicated that autophagy plays an important role in M1/M2 activation. However, the mechanism by which autophagy regulates the macrophage M1/M2 phenotype in DKD is unknown. …”
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Relationship between meteorological factors and the incidence of severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis by Guangju Mo, Hongmei Zhu, Jing Li, Huaiping Zhu, Qiyong Liu

“…Future studies on the relationship between meteorological factors and the incidence of SFTS should fully consider human activities and environmental factors, and explore the pathogenesis and transmission mechanisms in greater depth, so as to provide targeted preventive measures. …”
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NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…However, in the HFD/STZ-induced diabetic mice model combined with myocardial infarction, Nlrp3 knockout EPC significantly restored angiogenic capacity. Mechanically, CEBPB regulated the transcriptional level of Nlrp3 as a transcription factor in EPC. …”
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Etiopathogenic theories of nervous system diseases in Vilnius in the early 19th century: “insanity and epilepsy exacerbate when the moonlight shines” by E. Sakalauskaitė-Juodeikienė

“…It was also stated that some NS diseases may be triggered by physical and mechanical causes, concomitant diseases, medications and drinks, strong emotions, or violation of sleep hygiene. …”
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Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy by Xiaojie Liang, Jia Guo, Baiwei Luo, Weixiang Lu, Qiumin Chen, Yeling Deng, Yunong Yang, Liang Wang

“…Methods Using data from multiple researches, we comprehensively evaluated the characteristics and prognostic impact of PSI features in DLBCL, and developed a novel risk stratification model (PSI score) with a consistent cutoff value to stratify the risk of 3,229 DLBCL patients from different cohorts. Mechanisms underlying adverse prognosis in the high-risk DLBCLs were investigated through transcriptomic (n = 3,229), genomic (n = 576), and scRNA-seq (n = 20) analyses. …”
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Identifying Key Biomarkers Related to Immune Response in the Progression of Diabetic Kidney Disease: Mendelian Randomization Combined With Comprehensive Transcriptomics and Single-... by Hu M, Deng Y, Bai Y, Zhang J, Shen X, Shen L, Zhou L

“…Subsequently, the specific mechanisms of key regulatory genes involved in disease progression were analyzed through transcriptome and single-cell analysis. …”
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The Mediation of Circulating Inflammatory Proteins in the Causal Pathway from Immune Cells to COPD by Yan K, Wang Y, Xin P

“…Kunrong Yan, Yingjian Wang, Peng Xin Department of Anaesthesia, Chaoyang Second Hospital, Chaoyang, Liaoning, People’s Republic of ChinaCorrespondence: Peng Xin, Email cy08xp@163.comObjective: Observational studies have indicated that immune cells and circulating inflammatory proteins may play a dual role in the progression of COPD; however, the precise mechanisms remain uncertain. The objective of this study was to ascertain the causal relationship between immune cells and COPD and to quantify the potential role of circulating inflammatory proteins as mediators.Methods: A two-sample Mendelian randomisation analysis was conducted involving 731 immune cells, 91 inflammatory proteins and COPD, utilising summary-level data from genome-wide association studies. …”
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Effect of Water Content on the Impact Propensity of White Sandstone by Jiankui Bai, Chuanming Li, Ruimin Feng, Nan Liu, Xiang Gao, Zhengrong Zhang, Bochao Nie

“…In this paper, uniaxial compression test, cyclic loading and unloading test, and acoustic emission test were conducted on white sandstone using RMT-150B rock mechanics test system and DS5 acoustic emission test system. …”
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Unlocking the full potential of resistance training: a comparative analysis of low- and high-intensity effects on neurotrophic growth factors and homocysteine by Chongwen Zuo, Yi Yin, Zhiyang Zheng, Ren Mu, Yuxin Liang, Shan Wang, Chaoqun Ye

“…Abstract Objective Resistance training has been demonstrated an effective approach for preventing the cognitive function decline through physiological mechanisms; however, the effect of acute resistance training at different intensities on growth factor and homocysteine levels remains unclear. …”
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Traditions of the revived Lithuanian press in Vilnius in 1904-1914 by Violeta Černiauskaitė

“…When social democrats and peasant populists gained power, the state of war was canceled and censorship was eliminated with it. The censorship mechanism of the analyzed period was operating on two levels: state and local. …”
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Exendin-4 Exacerbates Burn-Induced Morbidity in Mice by Activation of the Sympathetic Nervous System by Xiao-Jing Ji, Ji-Wei Hao, Guang-Lei Li, Ning Dong, Xin-Qi Wang, Min Zhou, Qing-Hong Zhang, Yong-Ming Yao

“…To further elucidate the sympathetic mechanism, propranolol (30 mg/kg) or vehicle was applied 30 min prior to injury. …”
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Factors enhancing implementation of occupational safety and health management systems in manufacturing industry of Mutare, Zimbabwe by Johanes Mandowa, Mark Matsa, Steven Jerie

“…Strong senior management commitment, involvement and support was identified as a catalyst of all other factors enhancing implementation of OSHMSs, hence a recommendation is made for employers to invest in programmes aimed at bolstering management commitment, involvement and support to OSH management.DiscussionConsidering that lack of adequate resources emerged as a significant impediment to OSHMS implementation, the study challenges the Government to take a leading role in establishing policies that unlocks various funding mechanisms to support workplaces in overcoming financial barriers in the implementation of OSHMSs. …”
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Fire return intervals and recruitment affect population growth rate of canopy trees in tall open forest in humid savanna by Patricia A. Werner, Stephanie J. Peacock

“…Uniquely, under certain conditions, there was also a maximum fire return interval above which λ <1, creating a “window” of fire return intervals that allowed canopy tree populations to persist. Mechanisms underpinning results as well as implications for savanna structure, alternate states, cyclical dynamics, future research, and management by fire are discussed.…”
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Exploring the role of different coping styles in mediating the relationship between dyadic adjustment status and postpartum depression among postnatal women: a single-centre, cross... by Jing Chen, Jing Deng, Fan Liu, Xiujing Guo, Yifei Tan

“…Although the risk factors for PPD among postpartum women have been studied, the mechanisms underlying these factors remain inadequately understood. …”
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Ensuring organisational and legal conditions for financing the social sector of Ukraine by S. M. Bortnyk, I. O. Sievidova

“…The shortcomings of legal regulation of mechanisms for financing the provision of social protection services have been identified, and the main factors for improving the efficiency of budget financing and the inclusiveness of social protection have been described. …”
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Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury by Dandan Mao, Qi Chen, Shuolan Tong, Zixia Xu, Guofeng Yu, Chuan Chang, Yao Lv

“…Abstract Spinal cord injury (SCI) is a profound ailment lacking a well-defined molecular mechanism and effective treatments. Cuproptosis, identified as a recently discovered cell death pathway, exhibits diverse roles in various cancers. …”
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