Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile aci... by Jian Chen, Kanwar K. Malhi, Xiaowei Li, Xiangwen Xu, Jianxun Kang, Bichen Zhao, Yaru Xu, Xuenan Li, Jinlong Li

“…Metasilicate-based alkaline mineral water (AMW) has shown potential therapeutic effects on gastrointestinal disorders; however, the mechanisms involved and their overall effects on the gut-liver axis have not been explored. …”
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Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment by Li G, He F, Feng J, Xu G, Wu C, Qiao Y, Liu Y, Chen H, Du P, Wang J

“…Guangjie Li,1,2,* Fei He,2,* Jianbao Feng,3 Ge Xu,1 Chengye Wu,1 Yufei Qiao,1 Yang Liu,3 Hanlin Chen,1 Pengcheng Du,4 Jizeng Wang2 1The First Hospital of Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 2College of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 3Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 4College of Chemistry and Chemical Engineering, Lanzhou University, Gansu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jizeng Wang, Email jzwang@lzu.edu.cnBackground: Osteoarthritis (OA), a prevalent joint disease, causes immense suffering to thousands of patients, impairing their mobility and diminishing their quality of life. …”
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Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review by Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli

“…Hypermethylation of H3K4 and hypomethylation of H3K27 at the TGFBIp locus are putative pathogenic mechanisms involved in corneal dystrophies. Determining how, where, and when specific epigenetic changes trigger ocular diseases may provide useful clinical biomarkers for their prevention, diagnosis, and management, as well as innovative drug targets. …”
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Effect of amisulpride on the expression of serotonin receptors, neurotrophic factor BDNF and its receptors in mice with overexpression of the aggregation-prone [R406W] mutant tau p... by E. M. Kondaurova, A. A. Komarova, T. V. Ilchibaeva, A. Ya. Rodnyy, E. A. Zalivina, V. S. Naumenko

“…Serotonin 5-HT7 receptors (5-HT7R) are attracting increasing attention as important participants in the mechanisms of Alzheimer’s disease and as a possible target for the treatment of various tau pathologies. …”
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Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…These findings highlight the critical role of heat shock proteins in the low-temperature response of L. vannamei and provide valuable insights into understanding the mechanisms of shrimp cold tolerance and the development of cold-tolerant varieties.…”
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IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers by Sunita Mathur, John Muscedere, David M Maslove, Miranda Hunt, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Michelle Tryon, Natasha Arianne Jawa, Michaela Hanley, Robin Westphal, Afolasade Fakolade

“…We define high risk as ICU stay ≥4 days or involving 1+ of mechanical ventilation, tracheostomy, delirium or lack of access to a primary care physician (PCP). 20 ICU survivor-primary caregiver dyads will be enrolled (n=10 dyads per group) and randomised 1:1 to the intervention versus control group. …”
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Effective BCDNet-based breast cancer classification model using hybrid deep learning with VGG16-based optimal feature extraction by Meenakshi Devi P., Muna A., Yasser Ali, Sumanth V.

“…Methods The BCDNet model utilizes transfer learning from a pre-trained VGG16 network for feature extraction and employs an AHDNAM classification approach, which includes ASPP, DTCN, 1DCNN, and an attention mechanism. The RPAOSM-ESO algorithm is used to fine-tune the weights and parameters. …”
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Scientific support of small fruit growing in Russia and prospects for its development by I. M. Kulikov, S. M. Evdokimenko, T. A. Tumaeva, A. V. Kelina, F. F. Sazonov, N. V. Andronova, M. A. Podgaetsky

“…In the near future, the most relevant areas for the breeding of small fruit crops will be: breeding for resistance to the most harmful viruses, winter hardiness, increased transportability and long-term post-harvest storage of fruits, suitability for mechanized cultivation, high content of biologically active substances.…”
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Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Mi-Rae Shin, Sung Ho Shin, Seong-Soo Roh

“…In the present study, we investigate the ameliorative effects of PCM, a combination of Diospyros kaki fruit and Citrus unshiu peel mixture, on high-fat diet- (HFD-) induced NAFLD and clarify the potential mechanisms. PCM in HFD-fed mice was orally administered at a dose of 50 or 100 mg/kg subsequently for 2 months. …”
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miR-199a-5p Exacerbated Intestinal Barrier Dysfunction through Inhibiting Surfactant Protein D and Activating NF-κB Pathway in Sepsis by Xianjin Du, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu, Wenbin Yang, Zhanyong Zhu

“…Herein, we evaluated the mechanism of miR-199a-5p on the intestinal barrier dysfunction in sepsis. …”
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STUDY OF THE EFFECT OF METHIONINE HYPERHOMOCYSTEINEMIA AND ITS CORRECTION WITH CHOLINE AND VITAMIN D ON THE CONDITION OF THE PERIODONTIUM, SMALL INTESTINE, AND LIVER OF RATS by Oleh Kutelmakh, Yulia Chumakova, Lina Kovalchuk, Yulia Odnorih, Olexandra Kutelmakh, Anastasiya Spodaruk

“…In recent years, there have been reports of a clinical relationship between periodontitis, intestinal and liver diseases of the human body, the so-called "oral-intestinal-hepatic axis", although the causal mechanism of such an "association" is still unclear. …”
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MSCPNet: A Multi-Scale Convolutional Pooling Network for Maize Disease Classification by Mehdhar S. A. M. Al-Gaashani, Reem Alkanhel, Muthana Ali Salem Ali, Mohammed Saleh Ali Muthanna, Ahmed Aziz, Ammar Muthanna

“…The Multi-Scale Convolutional PoolFormer block captures both local and global dependencies through parallel convolutional branches of varying kernel sizes, while the PoolFormer module efficiently handles feature aggregation without the heavy computational cost associated with traditional attention mechanisms. This design allows the model to balance computational efficiency and high accuracy, making it highly suitable for real-time maize disease detection. …”
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Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response by Shamma Almuraikhy, Maha Alser, Khaled Naja, Aisha Al-Malki, Nayef A. Mazloum, Mohamed A. Elrayess

“…While GATA-3 knockout primarily affects adipogenesis, Pyrrothiogatain modulates inflammatory responses and potentially cellular stress mechanisms without directly impacting adipocyte differentiation. …”
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Multisectoral actions in primary health care: A realist synthesis of scoping review. by Resham B Khatri, Daniel Erku, Aklilu Endalamaw, Eskinder Wolka, Frehiwot Nigatu, Anteneh Zewdie, Yibeltal Assefa

“…Proper functional institutional mechanisms are warranted at all levels of health systems to implement MSAs on health.…”
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Successful Management of Peri-Implantitis around Short and Ultrashort Single-Crown Implants: A Case Series with a 3-Year Follow-Up by Giorgio Lombardo, Mauro Marincola, Andrea Cicconetti, Miguel Angel Simancas-Pallares, Jacopo Pighi, Jeffrey Lehrberg, Annarita Signoriello, Giovanni Corrocher, Xiomara Serpa-Romero, Luis Armando Vila Sierra, Luisa Arevalo-Tovar, Pier Francesco Nocini

“…The study is a retrospective evaluation of patients suffering from peri-implantitis and those who underwent access flap surgery, concomitant chemical and mechanical decontamination of implant surface, and bone grafting using a self-hardening mixture of bone substitutes and biphasic calcium sulfate. …”
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Evolution of CFD as an engineering science. A personal perspective with emphasis on the finite volume method by Runchal, Akshai Kumar

“…These include both traditional disciplines such as aerospace, automotive, mechanical and thermal sciences, and newer disciplines and emerging fields of human and social relevance such as biomedical, sports, entertainment, food processing, fire safety, HVAC and energy efficiency. …”
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Determination of Carbapenemase-Producing OXA- 48 and KPC Genes in Antibiotic-Resistant Gram-Negative Bacilli Isolated from Infectious Samples of Cardiovascular Patients Hospitalize... by Mina Owrang, Ebrahim Taheri Hossein Abad, Shakiba Shafaie

“…Carbapenem antibiotics are frequently used as the last line of treatment for infections caused by Gram-negative bacteria. The primary mechanism of resistance to carbapenems is the production of carbapenemase enzymes. …”
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Network relationship between cognitive function and quality of life in community-dwelling older adults: an observational study from Beijing by Yitian Ye, Yichun Zhang, Jiaju Ren, Yanbo Zhu, Yanbo Zhu

“…ObjectiveThis observational study aims to comprehensively explore the network relationship and mechanism of action between cognitive function and quality of life among community-dwelling older adults aged 60 and above in Beijing.MethodsThe research encompassed a cohort of 323 older adults individuals residing in the community in Beijing. …”
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Structure and metabolic function of spatiotemporal pit mud microbiome by Zhihua Li, Chi Zhao, Zhenyu Mao, Fengju Zhang, Ling Dong, Chuan Song, Yao Chen, Xin Fu, Zonghua Ao, Yanfei Xiong, Qin Hui, Weizhi Song, Petri Penttinen, Suyi Zhang

“…The Wood-Ljungdahl pathway and reverse TCA cycle were identified as the main carbon fixation mechanisms, with both hydrogenotrophic and aceticlastic methanogens playing a major role in methane production, and methylotrophic pathway observed in older PM. …”
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Candidate genes for domestication and resistance to cold climate according to whole genome sequencing data of Russian cattle and sheep breeds by N. S. Yudin, D. M. Larkin

“…The study of the convergent evolution of several species under the influence of the same environmental factor makes it possible to identify common mechanisms of genetic adaptation. Local cattle and sheep breeds have been formed over thousands of years under the influence of domestication, as well as selection aimed at adaptation to the local environment and meeting human needs. …”
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