APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology by Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

“…This suggests that the Christchurch variant's protective effects likely involve multiple mechanisms, including changes in receptor binding and microglial programming. …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…However, the specific biological link between anoikis and COAD, as well as its mechanisms in tumor progression, remains unclear, making it a potential new direction for therapeutic strategy research.MethodsWe employed transcriptomic data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) to pinpoint differentially expressed anoikis-related genes (ARGs) in COAD. …”
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Calculation of Correction Factors for Vickers’ Hardness Measurements on a Non-Planar Surface by S. G. Sandomirski, A. L. Val’ko, S. P. Rudenko

“…The exact determination of Vickers HV hardness is important for determining of the product material mechanical properties. An important aspect of measuring HV is to obtain its values on a non-planar surface. …”
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Miramistin effect on BHK-21 and PSGK-30 cell line proliferation and FMD virus reproduction in these cells by M. I. Doronin, D. A. Lozovoy, V. V. Pronin, D. V. Mikhalishin, V. A. Starikov, A. V. Borisov, A. A. Shishkova

“…Use of cell structures as test systems for assessing the toxicity of pharmacological substances instead of conventional tests on experimental animals allows us to better clarify the possible mechanism of the effect of the investigated substance. …”
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Effect of Thrombolysis on Circulating Microparticles in Patients with ST-Segment Elevation Myocardial Infarction by Zhe Li, Wei Zhang, Qun-Rang Wang, Yu-juan Yang, Xin-Hong Liu, Gong Cheng, Feng-Jun Chang

“…Changes in MP function after thrombolysis may be one of the mechanisms leading to ischemia–reperfusion after thrombolysis.…”
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The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023 by Miaomiao Zhao, Miaomiao Zhao, Haoxiang Chang, Haoxiang Chang, Yuxu Yue, Yuxu Yue, Xinyue Zeng, Xinyue Zeng, Shaobang Wu, Shaobang Wu, Xiuyun Ren, Xiuyun Ren

“…A visual analysis of keywords identifies “oral microbiota,” “oral health,” “adverse pregnancy outcomes,” and “global burden” as emerging research hotspots in exploring the correlation between periodontal disease and adverse pregnancy outcomes.ConclusionsThis first bibliometric and visual analysis of periodontal disease and adverse pregnancy outcomes offers a concise overview of the field and suggests future research should focus on risk factors, high-risk populations, oral microbiota, mechanisms, interventions, and international collaboration.…”
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Bending Moment Characteristics of Hard Roof before First Breaking of Roof Beam Considering Coal Seam Hardening by Shitan Gu, Bangyou Jiang, Yue Pan, Zheng Liu

“…The mechanical properties of a coal seam affect the distribution of support pressure. …”
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Advanced Glycation End Products Enhance Murine Monocyte Proliferation in Bone Marrow and Prime Them into an Inflammatory Phenotype through MAPK Signaling by Xian Jin, Liang Liu, Yaping Zhang, Yin Xiang, Guizhi Yin, Yi Lu, Ludong Shi, Jian Dong, Chengxing Shen

“…Increased monocytes, particularly the inflammatory subset, are associated with accelerated atherosclerosis in diabetes through thus far incompletely defined mechanisms. The present study tested the hypothesis that advanced glycation end products (AGEs) promote bone marrow monocytes to proliferate and drive them into an inflammatory phenotype. …”
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Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α by Xiaomin Luo, Fang Liu, Lijun Zhu, Caizhi Liu, Ruhui Shen, Xiaoyin Ding, Yufan Wang, Xiaofang Tang, Yongde Peng, Zhijian Zhang

“…Following, we used CUT&Tag and chip qPCR to identify the LPXN-mediated mechanisms underlying the observed abnormal gluconeogenesis. …”
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Pathological effects of pregabalin toxicity in rats by Roaa Salih Mahdi, Nawras Najah, Sura Salman Ejam

“…Abstract Background: Pregabalin (PGB) is one kind of gabapentinoid. The main mechanism of action is binding at the alpha-2-delta site, which inhibits calcium influx in response to depolarization at nerve terminals and, in turn, suppresses the release of glutamate, noradrenaline, and substance P. …”
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Identification and functional characterization of AsWRKY9, a WRKY transcription factor modulating alliin biosynthesis in garlic (Allium sativum L.) by Jiaying Wu, Min Li, Wanni Wang, Yiren Su, Jie Li, Jiaxin Gong, Xianfeng Meng, Chenyuan Lin, Qiantong Zhang, Yanyan Yang, Chunyan Xu, Limei Zeng, Jihong Jiang, Xuqin Yang

“…However, the molecular mechanisms regulating alliin biosynthesis remain unexplored. …”
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Programming Regulation and Strategic Planning in the Health Care Sector by G. V. Muliar

“…These are disadvantages of both the general system of organization and effectiveness of the programs, as well as of certain mechanisms of the implementation, in particular financing of programs on a residual principle (underfunding, and sometimes even its absence); unclear formulation of the purpose and objectives of the programs, which indicate the process rather than the final result; the absence of clearly identified performers and obligated entities; insufficient analytical activity; lack of responsibility for non-compliance with mandatory measures and action plan; insufficient control over funds spending; declarative nature, etc.…”
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Mild drought conditions at the tillering stage promote dry matter accumulation and increase grain weight in drip-irrigated spring wheat (Triticum aestivum L.) by Yilin Ma, Jingyi Cai, Shuting Bie, Ziqiang Che, Guiying Jiang, Jianguo Liu

“…IntroductionIn order to elucidate the physiological mechanism of post-flowering assimilate transport regulating the formation of yields in arid regions and to provide technological support for further water-saving and high yields in the wheat region in Xinjiang, we conducted a study on the effects of different fertility periods and different degrees of drought and re-watering on the post-flowering dry matter accumulation and transport of spring wheat and the characteristics of grain filling.MethodsIn two spring wheat growing seasons in 2023 and 2024, a split-zone design was used, with the drought-sensitive variety Xinchun 22 (XC22) and drought-tolerant variety Xinchun 6 (XC6) as the main zones and a fully irrigated control during the reproductive period [CK, 75%~80% field capacity (FC)], with mild drought at the tillering stage (T1, 60%~65% FC), moderate drought at the tillering stage (T2, 45%~50% FC), mild drought at the jointing stage (J1, 60%~65% FC), and mild drought at the jointing stage (J2, 45%~50% FC) as the sub-zones. …”
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Cytotoxicity and Exposure Assessment of PM2.5 in a Residential Home during COVID-19 Lockdown by Ummi Sabariah Mahamud, Armania Nurdin, Eliani Ezani

“…Due to the limited yield of indoor and outdoor PM2.5, further optimization on the extraction of PM2.5 should be carried out to evaluate further the mechanism of cytotoxicity of indoor PM2.5 on the lung cells.…”
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Anaemia Associated with Trypanosomes Infections in Cattle of West Gojjam Zone, Northwest Ethiopia by Kumela Lelisa, Behablom Meharenet

“…Anaemia is a cardinal sign of trypanosome infections. The mechanism of anaemia due to trypanosomosis is complex and multifactorial in origin. …”
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Airway microbiota dysbiosis and metabolic disorder in ozone and PM2.5 co-exposure induced lung inflammatory injury in mice by Lin Yang, Fei Xu, Shuaiqi Zhao, Yuling Zeng, Qiong Wu, Ling Zhang, Saige Shi, Fengquan Zhang, Juan Li, Zhen An, Huijun Li, Hui Wu, Jie Song, Weidong Wu

“…However, the underlying mechanisms for respiratory toxicity induced by this co-exposure have not been adequately elucidated. …”
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<i>Lin28b-let-7</i> Modulates mRNA Expression of <i>GnRH1</i> Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells by Yujing Xie, Xin Li, Meng Wang, Mingxing Chu, Guiling Cao

“…These results indicate that <i>Lin28b-let-7</i> regulates <i>GnRH1</i> expression through several pathways, including the Kiss1/Gpr54, MAPK, and mTOR signaling pathways, which are all related to glucose metabolism and provide new insights into the molecular mechanism of the regulatory role of <i>Lin28b</i> on GnRH production.…”
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Mathematical modeling of quorum sensing dynamics in batch culture of luminescent bacterium <i>Photobacterium phosphoreum</i> 1889 by S. I. Bartsev, A. B. Sarangova

“…The discrepancies noted between the expectations and the results of experimental data processing, together with the assumptions about the causes of these discrepancies, set the direction for further experimental and theoretical studies of quorum sensing mechanisms in a culture of luminescent bacteria.…”
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Aesthetic evaluation underpinning brand love relationship development: an activation likelihood estimation meta-analysis and multivariate analysis by Shinya Watanuki

“…Moreover, we performed a correspondence analysis to identify relationships of mental processes between aesthetic experiences and brand love in each developmental stage of brand love.FindingsOur results suggest that the same neural mechanism and mental processes may be underlaid between brand love and aesthetic experiences across all stages. …”
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LIPUS promotes osteogenic differentiation of rat BMSCs and osseointegration of dental implants by regulating ITGA11 and focal adhesion pathway by Chao Liang, Yuqing Zhang, Yuwei Yan, Wei Geng, Jun Li, Xiu Liu

“…This study aimed to clarify the effect and mechanism of LIPUS on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and implant osseointegration, and to provide an experimental basis for future clinical applications. …”
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