Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective study by Prem Chandra, Vamanjore A Naushad, Nishan K Purayil, Abazar Ahmad M Saeed, Pradeep Radhakrishnan, Irfan Varikkodan, Joe V Mathew, Jaseem Sirajudeen, Riyadh A Hammamy, Ahmad M Badi, Aasir M Suliman, Mohamed N Badawi, Saket Arya, Maryam AlMotawa, Aisha Al-Baker, Rania Alatom, Anand Kartha

“…Patients with a normal chest X-ray and those who had a negative PCR test despite a positive COVID-19 antigen test were excluded.Outcome Length of stay, need for mechanical ventilation, final disposition and mortality were the key outcomes studiedResults Influenza like symptoms (18.5% in the first wave vs 36.1% in the second wave, p 0.001), cough (79.2% vs 87%, p<0.001) and dyspnoea (27.5% vs 38% p<0.001) were more common in the second wave. …”
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Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis by Long Z, Yu X, Li S, Cheng N, Huo C, Zhang X, Wang S

“…However, whether sakuranetine has a protective effect on APAP-induced liver injury is not clear.Methods: Mouse and HepG2 cell models of APAP injury were used to investigate the effect of sakuranetin on AILI and its mechanism. Serum transaminase levels, histological changes, inflammatory mediators, oxidative stress, ferroptosis-related markers and Nrf2 signaling pathway proteins were analyzed.Results: Sakuranetin significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as inflammatory factor; increased HepG2 activity and decreased cell death; inhibited ROS production, increased glutathione (GSH) content, expression of Glutathione Peroxidase 4 (GPX4) and Solute Carrier Family 7 Member 11 (SLC7A11), and decreased malondialdehyde and Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) expression in mice and HepG2 cells after APAP treatment. …”
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CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer. by Qilu Fang, Qichuan Fang, Rui Cheng, Tingting Feng, Wenxiu Xin

“…This study aimed to investigate the effects and mechanisms of CAPE on TNBC.<h4>Methods</h4>MDA-MB-231 and MDA-MB-468 cells were treated with CAPE. …”
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El discurso xenófobo en el ámbito político y su impacto social by Hassan Arabi

“…Las sociedades, con poca tradición democrática y poco contenido cívico, fueron siempre los puntos que inquietan a los defensores de los derechos humanos y de las entidades que luchan contra el racismo y la xenofobia. En estos países las personas se sienten desamparadas y desprotegidas frente a la violencia y el odio con todos sus colores. …”
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CeRNA profiling and the role in regulating gonadal development in gold pompano by Changcan Yang, Yijun Zhao, Wendong Zhao, Hai Huang, Quanqi Zhang, Jinxiang Liu

“…To gain further insight into the function of competing endogenous RNA (ceRNA) in the gonads of T. ovatus and the regulatory mechanism of the ceRNA network, whole transcriptome libraries were constructed from the testes and ovaries. …”
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Deformation of the Juan de Fuca Plate Beneath the Central Cascadia Continental Margin (44°-45°N) in Response to an Upper Plate Load by Anne M. Tréhu, Kathy Davenport, Christopher B. Kenyon, Suzanne M. Carbotte, John L. Nabelek, Douglas R. Toomey, William S. D. Wilcock

“…Our model of a well-defined, focused and static upper plate load that locally deforms the subducted plate within the nominally seismogenic or transitional part of the Cascadia plate boundary may be unique in providing a relatively straightforward scenario for estimating the mechanical properties of the subducted Juan de Fuca plate. …”
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Acoustic Emission Characteristics and Damage Evolution Analysis of Sandstone under Three-Point Bending Test by Tao Qin, Chen Jiang, Yanwei Duan, Yiwei Wang, Chao Ju

“…It has theoretical research value for revealing the internal mechanism of rock bending and fracture and has engineering guiding significance for mine pressure and rock strata control and dynamic disaster prevention.…”
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Modelamiento del proceso de carbonatación del hormigón (UR-CORE), con datos de conversión fraccional obtenidos a través de experimentos de difracción de neutrones monitoreados in-s... by Marta Castellote, Carmen Andrade

“…<br>One of the most important depassivation mechanisms of steel reinforcement in concrete is that caused by the neutralisation of the cement matrix. …”
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Optimal Dispatch of Reactive Power Using Modified Stochastic Fractal Search Algorithm by Thang Trung Nguyen, Dieu Ngoc Vo, Hai Van Tran, Le Van Dai

“…The proposed MSFS method is newly constructed in the paper by modifying three new solution update mechanisms on standard stochastic fractal search algorithm (SSFS). …”
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The EU Sanctions Policy: A Thorny Path of Transformation by L. D. Oganisyan

“…The first section examines the key institutions responsible for the development of the EU sanctions policy, as well as the principles and mechanisms underlying the adoption and implementation of the relevant measures. …”
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Fault tolerant &amp; priority basis task offloading and scheduling model for IoT logistics by Asif Umer, Mushtaq Ali, Ali Daud, Lal Hussain, Amal Bukhari, Ali Imran Jehangiri

“…Dynamic re-clustering fault tolerance mechanisms are utilized to manage task failures after offloading. …”
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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

“…Intensive study of the T6SS structure has led to an understanding of certain issues related to its functional activity, but the exact regulatory mechanisms of E-I protein pair activity remain unclear. …”
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Occurrence of Florfenicol and Linezolid Resistance and Emergence of optrA Gene in Campylobacter coli Isolates from Tunisian Avian Farms by Manel Gharbi, Rihab Tiss, Chadlia Hamdi, Safa Hamrouni, Abderrazak Maaroufi

“…Recently, acquired linezolid-resistance mechanisms have been reported in Campylobacter spp. isolates, which is a cause of concern to human health. …”
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Activity of oxidative processes and the state of the redox regulating system in tumor tissue in skin cancer by I. A. Goroshinskaya, E. M. Frantsiyants, N. I. Larina, Yu. V. Przhedetskiy, I. V. Kaplieva, L. A. Nemashkalova, V. A. Bandovkina, V. V. Pozdnyakova, V. Yu. Przhedetskaya

“…Activation of SOD in tumor tissue, to a greater extent in men (2.4 times with superficial growth and 1.7 times with solid growth, p &lt; 0.05 relative to conditionally healthy tissue), can be considered as a mechanism of antiradical protection of the tumor.Conclusions. …”
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Identification of macrophage polarisation and mitochondria-related biomarkers in diabetic retinopathy by Weifeng Liu, Bin Tong, Jian Xiong, Yanfang Zhu, Hongwei Lu, Haonan Xu, Xi Yang, Feifei Wang, Peng Yu, Yunwei Hu

“…Therefore, the common mechanism of mitochondrial related genes (MRGs) and macrophage polarisation related genes (MPRGs) in DR is explored in our study to illustrate the pathophysiology of DR. …”
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Chinese economic presence in East Africa: the case of Kenya by K. A. Gemueva

“…Based on the analysis of current trends, the author concludes that the further development of bilateral cooperation will depend to a great extent on the commitment from both sides to gradually change the priority areas of cooperation and to use new tools and mechanisms of interaction.…”
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A Standardized Classification Scheme for Gastroduodenal Disorder Evaluation Using the Gastric Alimetry System: Prospective Cohort Study by Chris Varghese, Gabriel Schamberg, Emma Uren, Stefan Calder, Mikaela Law, Daphne Foong, Vincent Ho, Billy Wu, I-Hsuan Huang, Peng Du, Thomas Abell, Charlotte Daker, Christopher N. Andrews, Armen A. Gharibans, Gregory O’Grady

“…We used Gastric Alimetry spectral and symptom profiles to develop a mechanism-based test classification scheme, then assessed correlations with symptom severity, psychometrics, and quality of life. …”
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Prediction of drought-flood prone zones in inland mountainous regions under climate change with assessment and enhancement strategies for disaster resilience in high-standard farml... by Yongheng Shen, Qingxia Guo, Zhenghao Liu, Yanli Shen, Yikun Jia, Yuehan Wei

“…The overall findings indicate that: (1) Precipitation (Pr) and the Standardized Precipitation-Evapotranspiration Index (SPEI) have increased in recent years, with Pr expected to continue rising until 2035. (2) The integration of historical data with the predictions from the PSO-LSTM-GAT model reveals significant spatial overlap between historical and future disaster-prone areas and intensive cropland, especially in the central region. (3) Compared to single models, the PSO-LSTM-GAT model demonstrates significantly improved performance and precision in predicting drought- and flood-prone areas. (4) Through the FDRA integrated adjustment mechanism, 6.6668 km² of unsuitable land was identified, and 6.7349 km² of high-quality land was selected as the proposed site for the next round of HSF projects. …”
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A Native LH1–RC–HiPIP Supercomplex from an Extremophilic Phototroph by Kazutoshi Tani, Ryo Kanno, Kenji V. P. Nagashima, Mai Kawakami, Naho Hiwatashi, Kazuna Nakata, Sakiko Nagashima, Kazuhito Inoue, Shinichi Takaichi, Endang R. Purba, Malgorzata Hall, Long-Jiang Yu, Michael T. Madigan, Akira Mizoguchi, Bruno M. Humbel, Yukihiro Kimura, Zheng-Yu Wang-Otomo

“…The structure of the Hlr. halophila LH1–RC–HiPIP complex provides insights into the mechanism of light energy acquisition coupled with a long-distance electron donating process toward the charge separation site in a multi-extremophilic phototroph.…”
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Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation by Lais Morandini Rodrigues, Elis Andrade Lima Zutin, Elisa Mattias Sartori, Daniela Baccelli Silveira Mendonça, Gustavo Mendonça, Yasmin Rodarte Carvalho, Luana Marotta Reis de Vasconcellos

“…Studies have been directed towards the production of new titanium alloys, aiming for the replacement of Ti-6 Aluminium-4 Vanadium (TiAlV) alloy in the future. Many mechanisms related to biocompatibility and chemical characteristics have been studied in the field of implantology, but enzymatic defenses against oxidative stress remain underexplored. …”
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