Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…In the prospective observational study, we investigated the entire coagulation process in patients with CKD to elucidate the mechanisms of their high thromboembolic risk.Methods A total of 95 patients with CKD and 20 healthy controls who met the inclusion criteria were consecutively recruited from September 2015 to March 2016. …”
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Identification of crucial extracellular genes as potential biomarkers in newly diagnosed Type 1 diabetes via integrated bioinformatics analysis by Ming Gao, Qing Liu, Lingyu Zhang, Fatema Tabak, Yifei Hua, Wei Shao, Yangyang Li, Li Qian, Yu Liu

“…Our findings provide new insights into the molecular mechanisms and novel therapeutic targets of NT1D.…”
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Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma by Yuli Zhang, Dinggui Chen, Miaomiao Yang, Xianfeng Qian, Chunmei Long, Zhongwei Zheng

“…Two novel regulatory pathways, EGOT-miR-32-5p-XYLT2 axis and SERHL-miR-1269a/miR-193b-3p-BCL2L1/SYK/ARNT/CHST3/LPCAT1 axis, were built up and contribute to the underlying mechanism of HCC pathogenesis. The higher-expressed SERHL was associated with a higher risk of all-cause death. …”
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Worldwide Research Trends on Diabetic Foot Ulcers (2004–2020): Suggestions for Researchers by Pin Deng, Hongshuo Shi, Xuyue Pan, Huan Liang, Shulong Wang, Junde Wu, Wei Zhang, Fasen Huang, Xiaojie Sun, Hanjie Zhu, Zhaojun Chen

“…Studies on osteomyelitis, wound therapy and management, multidisciplinary integration and mechanism of DFUs, and its related diseases are the research fronts that should be closely watched in the future. …”
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AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis by Wuping Tan, Yijun Wang, Siyi Cheng, Zhihao Liu, Mengjie Xie, Lingpeng Song, Qinfang Qiu, Xiaofei Wang, Zeyan Li, Tianyuan Liu, Fuding Guo, Jun Wang, Xiaoya Zhou

“…Importantly, all these parameters get restored in the context of continued mechanical and metabolic stressors associated with HFpEF.…”
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New Development Bank as Aid Donor to School Education by Rodion Sadykov, Yevgeny Uchaev

“…At the same time, stagnating aid volumes and the increasing politicization of educational aid by traditional donors, coupled with persistent needs to improve education systems in many developing countries, underscore the challenge for BRICS states to develop more effective mechanisms for educational cooperation—both within the bloc and with the broader Global South.…”
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S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling by Liuyuan Xia, Xin Guo, Dong Lu, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin, Xin Luan, Weidong Zhang

“…Although significant progress has been made in understanding the crosstalk between cancer cells and CAFs, many underlying mechanisms remain unclear. Recent studies have highlighted the importance of calcium signaling in enhancing interactions between tumor cells and the surrounding stroma, with the S100 family of proteins serving as important regulators. …”
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Aligning strategic and participatory approaches to agri‐environment scheme design and implementation to enhance nature recovery outcomes by D. J. Baker, C. Nye, R. Wheeler, C. Masquelier, A. Binner, K. J. Gaston, M. S. Heard, M. Lobley, D. Smith, I. M. D. Maclean

“…Agri‐environment schemes (AES) have been a major mechanism for delivering environmental management across EU‐farmed landscapes, but measured benefits to nature are often negligible in large part due to a lack of strategic spatial targeting of management actions. …”
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Study on improving yield and antioxidant enzyme activities in millet by rationing molybdenum and nitrogen by Yuan Zhao, Guoliang Wang, Min Liu, HongTao Xue, PeiYue Zhao, BaiShu Han, HuiPing Fan, Rui Wang, LiXia Wang, ErHu Guo, AiYing Zhang, AiYing Zhang

“…In order to investigate the effect mechanism of nitrogen fertilizer combined with foliar molybdenum fertilizer on millet yield and antioxidant enzyme activity, two nitrogen application gradients (N0 (0 kg/hm2) and N1 (75 kg/hm2) were set with millet variety Changnong 47 as material. …”
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HSBM-Produced Zinc Oxide Nanoparticles: Physical Properties and Evaluation of Their Antimicrobial Activity against Human Pathogens by Imen Massoudi, Ridha Hamdi, Ibtisam Ababutain, Ethar Alhussain, Aya Kharma

“…In light of microorganism-ZNP interaction mechanisms, the obtained results have been discussed in depth.…”
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No easy way out: towards a framework concept of long-term governance by Dirk Scheer, Sandra Venghaus, Stefania Sardo, Sascha Stark, Sophie Kuppler, Michael W. Schmidt, Carsten Hoyer-Klick

“…Main text We elaborate an analytical framework for long-term governance (LTG), based on five building blocks: the ‘environment’, which details the policy-making arena; the ‘policy issues’, which elaborates on the problems to be dealt with by LTG; the ‘key challenges and driving force’, revealing LTG mechanisms; the ‘key strategies’, in which promising approaches for LTG are identified; and the ‘policy cycle’, where governance impacts on different policy phases are discussed. …”
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NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled... by Deborah D Stocken, Maureen Twiddy, Hisham Mehanna, Jonathan Wadsley, Neil Corrigan, Katie Gordon, Julie Croft, Neil Sharma, Anna Perry, Mark Strachan, Gemma Ainsworth, Elizabeth Glenister, Sabapathy Prakash P Balasubramanian

“…Phase III secondary outcomes include protracted hypoparathyroidism, hypercalcaemia, complications, length of stay, readmissions and patient reported quality of life using the Short Form 36 Health Survey Questionnaire and Hypoparathyroid Patient Questionnaire instruments.Ethics and dissemination NIFTy is funded by National Institute for Health and Care Research Efficacy and Mechanism Evaluation Programme (Grant Ref: 17/11/27) and approved by a Research Ethics Committee (reference: 21/WA/0375) and Health Research Authority (HRA). …”
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Chlorpromazine and Promethazine (C+P) Reduce Brain Injury after Ischemic Stroke through the PKC-δ/NOX/MnSOD Pathway by Sichao Guo, Fengwu Li, Melissa Wills, James Yip, Alexandra Wehbe, Changya Peng, Xiaokun Geng, Yuchuan Ding

“…Cerebral ischemia-reperfusion (I/R) incites neurologic damage through a myriad of complex pathophysiological mechanisms, most notably, inflammation and oxidative stress. …”
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"Cross Paths": Once Again About the Relevance of a Combined Medical and Psychological Approach to a Person as a Client and a Patient at the Same Time by Alexander Kocharian, Nataliia Barinova

“…Instead, during the retraining of medical workers and doctors, it is necessary to strengthen the psychological nuances of understanding the experience of anxiety, emotional trauma, acute emotional reactions, the specifics of the action of protective mechanisms, etc. Only a comprehensive medical and psychological approach can optimally provide effective assistance to a person who has suffered in a traumatic situation. …”
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An Investigation of the Capabilities of Resin Tire Carbon Black “N-330” as a Waste Binder in Asphalt Concrete Mixtures by Amr. A. Nada, Walid Fouad Edris, Hebah Mohammad Al-Jabali, Ahmed D. Almutairi, Abd Al-Kader A. Al Sayed, Shady Khairy

“…A comprehensive experimental program has been designed to evaluate the mechanical and performance properties of asphalt mixtures containing varying proportions of RTCB N-330, ranging from 2% to 10% by weight of the binder. …”
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Problems in the formation and implementation of the methodology for investigating homicides related to domestic violence by R. L. Stepaniuk, V. O. Husieva, V. V. Kikinchuk

“…A systematic analysis of the elements of the mechanism of domestic homicide and domestic violence, the activities of law enforcement agencies to prevent, detect and investigate this type of homicide, as well as scientific recommendations concerning the methodological and forensic support of pre-trial investigation in criminal proceedings on homicide has been carried out. …”
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Exploring diazotrophic diversity: unveiling Nif core distribution and evolutionary patterns in nitrogen-fixing organisms by Bruno Thiago de Lima Nichio, Roxana Beatriz Ribeiro Chaves, Fábio de Oliveira Pedrosa, Roberto Tadeu Raittz

“…The analysis revealed the phylogenetic and functional organization of different groups, identifying synteny patterns and new nif gene arrangements across various bacterial and archaeal species.The identified groups serve as a valuable framework for further exploration of the molecular mechanisms underlying biological nitrogen fixation and its evolutionary significance across different bacterial lineages.…”
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Management and Outcome of Patients with Acetabular Fractures: Associated Injuries and Prognostic Factors by Do-Hyun Yeo, Jong-Keon Oh, Jae-Woo Cho, Beom-Soo Kim

“…Falling was the most common injury mechanism (32.4%). Chest injury was the most common associated injury (16.2%), followed by head injury (13.5%). …”
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Frontal Plane Knee Kinematics and Kinetics During Gait in Children and Youth with Achondroplasia—Correspondence with Static X-Ray Images and Relevance to Symptoms by Matthias Hösl, Antonia Thamm, Faik Kamel Afifi, Sean Nader

“…X-rays were analyzed for mechanical tibiofemoral angle (mTFA). Relationships between X-rays and 3DGA were determined. …”
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Bioactive Properties of <i>Pentacalia vaccinioides</i> (Kunth) Cuatrec. (Asteraceae) Essential Oils: Evaluation of Antimicrobial and Antioxidant Activities by Luis G. Sequeda-Castañeda, María A. Castellanos-Gómez, Carlos L. A. Céspedes-Acuña

“…Future research should investigate how microclimatic conditions and plant development affect the chemical composition and elucidate the molecular mechanisms behind the observed bioactivities to better understand their cellular actions. …”
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