Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts by Yanping Lin, Yanping Lin, Rui Zhao, Rui Zhao, Jiachun Huang, Tongying Chen, Tongying Chen, Haolin Yang, Haolin Yang, Haiwei Guo, Lei Wan, Zhihai Zhang, Ying Li, Genfu Zhu, Hongxing Huang, Hongxing Huang

“…Additionally, it initially explores the functional mechanism of Beclin-1/Bcl-2-related apoptosis.MethodsOsteoblasts were isolated from the calvaria of three-day-old Sprague-Dawley female rats. …”
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Exploring the interactions and driving factors among typical ecological risks based on ecosystem services: A case study in the Sichuan-Yunnan ecological barrier area by Weijie Li, Jinwen Kang, Yong Wang

“…However, previous studies have focused more on the improvement and practical application of assessment methods, while the interactions between different ER and their driving mechanisms remain unclear. Thus, this paper examined the Sichuan-Yunnan ecological barrier area and constructed an ER characterization method based on the relative loss of ecosystem services, analyzed the dynamic changes of single risk (i.e., soil conservation risk (SC_R), grain production risk (GP_R), carbon storage risk (CS_R), water yield risk (WY_R), habitat quality risk (HQ_R)) and comprehensive risk from 2000 to 2020, and explored the interactions between ER and their driving factors by using correlation analysis, spatial autocorrelation, self-organization method and geo-detector. …”
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The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy by Ricardo Pardillo-Díaz, Patricia Pérez-García, María Ortego-Domínguez, Ricardo Gómez-Oliva, Nora Martínez-Gómez, Samuel Domínguez-García, Francisco García-Cózar, Juan Pedro Muñoz-Miranda, Rosario Hernández-Galán, Livia Carrascal, Carmen Castro, Pedro Nunez-Abades

“…Results We have found that EOF2 treatment of adult mice with mechanical cortical injuries facilitates the delivery of neuroblasts into these injuries. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…Abstract Background Diabetes treatments by the control of sodium-glucose cotransporter 2 (SGLT2) is commonly conducted while there are still uncertainties about the mechanisms for the SGLT2 overexpression in kidneys with diabetes. …”
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Implementation research logic model in the design and execution of eHealth innovations for maternal and newborn healthcare in Ethiopia by Dabere Nigatu, Muluken Azage, Eyaya Misgan, Daniel A. Enquobahrie, Tegegn Kebebaw, Enyew Abate, Esubalew Alemneh, Mirkuzie Woldie, Tsinuel Girma

“…The model depicted the mechanism of interaction between implementation determinants and implementation strategies to produce the intended implementation outcomes. …”
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Abnormal neurobehaviour and impaired memory function as a consequence of Toxocara canis- as well as Toxocara cati-induced neurotoxocarosis. by Elisabeth Janecek, Patrick Waindok, Marion Bankstahl, Christina Strube

“…Findings provide valuable hints towards differences in key regulatory mechanisms during T. canis- and T. cati-induced NT, contributing to a comprehensive picture and consequently a broader understanding of NT, which will aid in developing strategies towards prevention in addition to novel diagnostic and therapeutic approaches.…”
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Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons by Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough

“…Objective: Antagonism of the muscarinic acetylcholine type 1 receptor (M1R) promotes sensory axon repair and is protective in peripheral neuropathy, however, the mechanism remains elusive. We investigated the role of the heat-sensing transient receptor potential melastatin-3 (TRPM3) cation channel in M1R antagonism-mediated nerve regeneration and explored the potential of TRPM3 activation to facilitate axonal plasticity. …”
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Role of Toll-Like Receptor 2 in Regulation of T-Helper Immune Response in Chronic Obstructive Pulmonary Disease by Karolina A. Sidletskaya, Tatyana I. Vitkina, Yulia K. Denisenko, Elena E. Mineeva

“…The aim of our work is to determine the mechanisms of TLR2-mediated regulation of Th immune response in COPD of varying severity. …”
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Predictive value of integrated pulmonary index for the outcome of ventilator withdrawal failure in elderly patients with hypoxic respiratory failure by Nan Wu, Jin Liu, Xianrong Feng

“…ROC curves showed that the AUC was 0.820 [95% CI: 0.719-0.920, P<0.001] , the sensitivity was 70.3%, the specificity was 82.6%, the maximum Youden index was 0.529, and the optimal cut-off value for IPI score was 4.77 scores. The duration of mechanical ventilation, ICU stay, and total hospital stay in patients with IPI<4.77 scores were longer than those in patients with IPI ≥ 4.77 scores, and the tracheotomy rate in patients with IPI<4.77 scores was higher than those in patients with IPI ≥ 4.77 scores. …”
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Transcriptome-Wide Identification of miRNAs and Their Targets During Riboflavin-Promoted Dormancy Release in <i>Lilium</i> ‘Siberia’ by Xiaoping Xu, Chenglong Yang, Yiping Zheng, Wenjie Guo, Zhongxiong Lai, Shaozhong Fang

“…However, the regulatory mechanisms of microRNAs (miRNAs) and their target genes during the dormancy release of lily remain elusive. …”
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Evaluation of a Low-threshold Exercise And Protein supplementation intervention for Women (LEAP-W) experiencing homelessness and addiction: Protocol for a single-arm mixed methods... by Fiona Kennedy, Deirdre Murray, Clíona Ní Cheallaigh, Roman Romero-Ortuno, Julie Broderick

“…Addiction, as a coping mechanism for prior trauma, is common among people who are homeless and can have a gendered dimension. …”
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The Different Insulin-Sensitising and Anti-Inflammatory Effects of Palmitoleic Acid and Oleic Acid in a Prediabetes Model by Denisa Miklankova, Irena Markova, Martina Hüttl, Barbora Stankova, Hana Malinska

“…POA-treated rats showed elevated circulating NEFA associated with increased lipolysis, lipoprotein lipase gene expression, and fatty acid reesterification in visceral adipose tissue (VAT). The mechanism of improved insulin sensitivity of peripheral tissues (measured as insulin-stimulated lipogenesis and glycogenesis) in POA-treated HHTg rats could contribute increased circulating adiponectin and omentin levels together with elevated FADS1 gene expression in VAT. …”
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Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease by David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson

“…We showcased the practical applicability of this approach by identifying candidate mechanisms underlying the altered pace of aging observed in pediatric Crohn’s disease.DiscussionIn this study, we present a deep neural network epigenetic clock, named NCAE-CombClock, that improves age prediction accuracy in large datasets, and a suite of explainable neural network clocks for robust age classification across youth. …”
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Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway by Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo

“…This study investigates the anti-inflammatory effects of gedunin on <i>C. acnes</i>-induced skin inflammation and elucidates the underlying mechanisms. <b>Methods</b>: The anti-inflammatory activity of gedunin was assessed using RAW 264.7 mouse macrophage cells and mouse bone-marrow-derived macrophages (BMDMs). …”
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Optimizing VGG16 deep learning model with enhanced hunger games search for logo classification by Mohammed Hussain, Thaer Thaher, Mohamed Basel Almourad, Majdi Mafarja

“…The proposed enhancement to HGS involves modified search strategies, incorporating the concepts of ”local best” and a ”local escaping mechanism” to improve its exploration capability. To validate our approach, the evaluation is conducted in three folds. …”
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Comprehensive metabolite profiling and evaluation of anti-nociceptive and anti-inflammatory potencies of Nypa fruticans (Wurmb.) leaves: Experimental and in-silico approaches by Farhana Islam, Md. Aktaruzzaman, Md. Tarikul Islam, Fariya Islam Rodru, Saquiba Yesmine

“…Further research, including pure compound isolation and biomolecular studies, is needed to understand the underlying mechanisms of these activities.…”
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Enhanced Performance of the Composite of FeMgAl-Layered Double Hydroxide and Rice Husk Biochar to Adsorb Heavy Metal Ions of Lead and Cadmium in Aqueous Solutions by M. T. Amin, A. A. Alazba, M. Shafiq, A. A. Khan

“…A perfect fitting of the adsorption data was seen using the pseudo-second-order kinetic model, suggesting the chemical sorption to be the control mechanism of adsorption. The fitting of the Langmuir and Temkin isotherm models proposed a monolayer as well as heterogeneous adsorption system. …”
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Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…Oxford Nanopore Technologies long-read RNA sequencing (ONT long-read RNA-seq) revealed the occurrence of ferroptosis in HSF and ferroptosis executioner-cathepsin B (CTSB). The mechanisms underlying FRA-induced HSF ferroptosis were examined through fluorescence staining, qRT‒PCR, WB and molecular docking study. …”
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SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients with Immune Thrombocytopenia by Zhe Chen, Shufen Zhou, Jianyun Li, Hui Li, Can Huang, Qin Guo, Tiantian Zhang, Bingya Yang, Chuanqing Tu, Chengshan Guo

“…Mesenchymal stem cells (MSCs) have been demonstrated in the ability to induce immunosuppression, and stromal cell-derived factor-1α (SDF-1α) plays an important role in the migration and survival of MSCs. To investigate the mechanism of SDF-1α in controlling umbilical cord-derived MSCs (UC-MSCs) in inducing regulatory B cell differentiation of patients with ITP, we reconfirmed that SDF-1α promotes the proliferation of MSCs at the low doses of 0.05 μg/mL and 0.1 μg/mL but inhibits the proliferation and promotes the apoptosis of UC-MSCs at the high doses 0.5 μg/mL and 1 μg/mL; when UC-MSCs are cocultured with SDF-1α at 0.1 μg/mL, the decreased proportion of CD19+/CD24hi/CD38hi cells and IL-10-producing B cells (B 10 cell), considered as the Breg subset from ITP significantly enhanced, and the content of IL-10 in the supernatant is also obviously increased. …”
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Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in... by Stephanie N. Fox, Cody H. Savage, Narcy R. Amireddy, Laura J. McMeekin, David K. Crossman, Peter J. Detloff, Michelle Gray, Rita M. Cowell

“…Ongoing studies are investigating mechanisms underlying ERRγ's roles in transcriptional activation and repression in SPNs to inform strategies to promote neuroprotective actions of ERRγ in SPNs in HD.…”
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