Community services for children and youth with behavioral problems and in conflict with the law: The idea and realization of a day care center by Gajić Miona, Hrnčić Jasna, Vučinić-Jovanović Marija

“…The results of questionnaires and interviews with service providers, on the other hand, point to the need for further improvement of this service in the context of developing mechanisms for the sustainability of its quality and efficiency. …”
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A privacy-enhanced framework with deep learning for botnet detection by Guangli Wu, Xingyue Wang

“…We design a privacy confrontation algorithm based on a mutual information calculation mechanism. This algorithm simulates the game between the attacker trying to infer private information through the attack model and the data processor retaining the original content of the traffic to the maximum extent. …”
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The research progress on effective connectivity in adolescent depression based on resting-state fMRI by Xuan Deng, Jiajing Cui, Jinyuan Zhao, Jinji Bai, Junfeng Li, Kefeng Li

“…However, effective connection can reflect the upper and lower relationship of brain region interaction, and provide help for us to explore the mechanism of neurological diseases. Existing studies focus on the analysis of a single brain network, but rarely explore the interaction between multiple key networks.DiscussionTo do so, we can address these issues by integrating multiple technologies. …”
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DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway by Hui Wang, Shen Luo, Yue Yin, Yang Liu, Xiaomei Sun, Ling Qiu, Xin Wu

“…Accumulated evidence highlights the pivotal role of reprogrammed lipid metabolism in fueling OC progression, however, the intricate underlying molecular mechanisms are not fully elucidated. Methods DLAT expression was assessed in OC tissues and cell lines by immunohistochemistry, western blot and qRT-PCR analysis. …”
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Unveiling the hidden burden: Exploring the psychosocial impact of cutaneous leishmaniasis lesions and scars in southern Ethiopia. by Behailu Merdekios, Misgun Shewangizaw, Abebayehu Sappo, Eshetu Ewunetu, Johan van Griensven, Jean-Pierre van Geertruyden, Melissa Ceuterick, Hilde Bastiaens

“…The unreceptive environment affected the participant's self-esteem and coping mechanisms. The negative impact of CL scars extended to role performance, marriage prospects, and overall happiness, particularly for females facing additional societal pressure and stigma.…”
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Acupuncture Reversible Effects on Altered Default Mode Network of Chronic Migraine Accompanied with Clinical Symptom Relief by Yan Zou, Weijun Tang, Xiang Li, Manwen Xu, Ji Li

“…The DMN is useful for understanding the therapeutic mechanisms of acupuncture in CM.…”
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ADAMTS1, CRABP1, and NR3C1 Identified as Epigenetically Deregulated Genes in Colorectal Tumorigenesis by Guro E. Lind, Kristine Kleivi, Gunn I. Meling, Manuel R. Teixeira, Espen Thiis-Evensen, Torleiv O. Rognum, Ragnhild A. Lothe

“…Background: Gene silencing through CpG island hypermethylation is a major mechanism in cancer development. In the present study, we aimed to identify and validate novel target genes inactivated through promoter hypermethylation in colorectal tumor development. …”
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Magnetic resonance spectroscopy of hippocampal and striatal neurometabolites in experimental PTSD rat modeling by V. E. Tseilikman, O. B. Shevelev, N. V. Khotskin, A. S. Dotsenko, G. V. Kontsevaya, M. S. Lapshin, M. P. Moshkin, M. V. Komelkova, I. V. Feklicheva, O. B. Tseilikman, E. Dremencov, E. L. Zavjalov

“…The mate rials allow the neurobiological mechanisms of the protective action of glucocorticoids to be detailed.…”
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A risk prediction model of gestational diabetes mellitus based on traditional and genetic factors by Ying Li, Xinli Zhong, Mengjiao Yang, Lu Yuan, Dandan Wang, Ting Li, Yanying Guo

“…Among genetic factors, 11 single nucleotide polymorphisms (SNPs) (rs2779116, rs5215, rs11605924, rs7072268, rs7172432, rs10811661, rs2191349, rs10830963, rs174550, rs13266634 and rs11071657) were identified as potential predictors of the risk of postpartum DM among women with GDM history, collectively accounting for 3.6% of the genetic risk.Conclusions Both genetic and traditional factors contribute to the risk of GDM in women, operating through diverse mechanisms. Strengthening the risk prediction of SNPs for postpartum DM among women with GDM history is crucial for maternal and child health protection.…”
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Effect of High-Fat Diet on Spatial Learning and Memory and Regulatory Role of N-Methyl-D-Aspartate Receptors in the Dentate Gyrus by LIU Huaying, DONG Wei, ZHANG Zihan, LI Yingshun, JIN Qinghua

“…This study provides a theoretical basis for rational diet and understanding the mechanism of HFD-induced impairments in learning and memory.…”
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Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics by Andong Guo, Andong Guo, Chenrui Wu, Jishuang Cao, Kejia Zhu, Kejia Zhu, Sentai Ding, Sentai Ding

“…This study highlights the need to explore HER2’s biological mechanisms further and pursue combined therapeutic strategies.…”
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The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice by Irene Santos-García, Pablo Bascuñana, Mirjam Brackhan, María Villa, Ivan Eiriz, Thomas Brüning, Jens Pahnke

“…During AD pathogenesis, neuroinflammation is one of the key mechanisms involved. Therefore, we wanted to investigate the specific role of ABCA7 in microglial activation via the NLRP3 inflammasome. …”
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Development and Application of Well-Test Model after Injection Biological Nanomaterials by Qing Feng, Ping Gao, Xianchao Chen, Jiang Li, Jingchao Zhou, Feng Qian, Shengsheng Li, Yanni Sun, Yingying Wang

“…Then, using the basic principles of fluid mechanics and the Laplace transform principle, a mathematical model of the bottom hole pressure response of water injection wells in the third zone of the bionanosolution reservoir is obtained, and the influence of the key process parameters of the bionanosolution water injection on the bottom hole pressure is analyzed. …”
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Profiling endogenous airway proteases and antiproteases and modeling proteolytic activation of Influenza HA using in vitro and ex vivo human airway surface liquid samples. by Stephanie A Brocke, Boris Reidel, Camille Ehre, Meghan E Rebuli, Carole Robinette, Kevin D Schichlein, Christian A Brooks, Ilona Jaspers

“…The airway proteolytic environment likely contains redundant antiproteases and proteases with diverse catalytic mechanisms, however a proteomic profile of these enzymes and inhibitors in airway samples has not been reported. …”
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Characteristics, Management, and Outcomes of Community-Acquired Pneumonia Due to Human Rhinovirus—A Retrospective Study by Ibrahim Bahabri, Abdulaziz Abdulaal, Thamer Alanazi, Sultan Alenazy, Yasser Alrumih, Rakan Alqahtani, Mohammad Bosaeed, Hasan M. Al-Dorzi

“…Most (69.2%) ICU patients received mechanical ventilation (median duration of 8 days). …”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…Understanding the spatial heterogeneity of glucose deficiency can reveal the molecular mechanisms regulating cancer metabolism and identify therapeutic targets to improve effective nutrient-starvation therapies. …”
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Processing, characterisation and oxidation resistance of βNiAl bond coat: Al and Zr effects by Chandio A.D., Shaikh A.A., Salman W., Ahmed H.

“…Moreover, the study focused on the development of a systematic understanding of underlying mechanisms behind the beneficial effects of REs. Initially, three sets of BCs were prepared: Zr-free βNiAl (undoped), Al and Zr co-deposited in a single-step process (1SP), and Zr and Al, which were individually deposited in two processing steps (2SP): zirconizing and aluminizing. …”
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3-Acetyldeoxynivalenol induces pyroptosis in leydig cells via METTL3-mediated N6-methyladenosine modification of NLRP3 by Yangyun Wang, Chaoliang Shi, Wei Jiao, Xiaoxiang Wan

“…Collectively, our findings reveal a novel mechanism by which 3-ADON exerts its reproductive toxicity, underscoring the pivotal role of METTL3-mediated m6A modifications in regulating Leydig cell dysfunction.…”
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Identification and Verification of Hub Mitochondrial Dysfunction Genes in Osteoarthritis Based on Bioinformatics Analysis by Hui Niu, Xingxing Deng, Qian Zhang, Yijun Zhao, Jinfeng Wen, Wenyu Li, Huan Liu, Xiong Guo, Cuiyan Wu

“…The aim of this study was to identify hub genes associated with mitochondrial dysfunction in osteoarthritis (OA) patients, helping predict the risk of OA, and revealing the mechanism of OA progression. Methods. OA expression data and mitochondrial dysfunction genes were downloaded from GEO (GSE55235, GSE82107, and GSE114007) and GeneCard databases. …”
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Heterogeneity of avian infectious bronchitis virus population by Ye. V. Ovchinnikova, L. O. Scherbakova, S. N. Kolosov, A. N. Andriyasova, N. G. Zinyakov, Z. B. Nikonova, A. A. Kozlov, P. B. Akshalova, D. A. Altunin, D. B. Andreychuk

“…Due to the lack of mechanisms to correct errors during genome replication, the virus can quickly mutate and generate new strains. …”
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