High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway by Deliang Xu, Jing Guo, Hongwei Xu

“…Our study was designed to investigate the underlying mechanism of Uroplakin 3A (UPK3A) in gastric cancer. …”
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Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation by Yu Tang, Ruizhi Zhang, Gan Mao, Chong Li, Yisong Gao, Xuebing Zhou, Wenxiang Nie, Tianyu Song, Suao Liu, Kaixiong Tao, Peng Zhang, Wei Li

“…Abstract Background The primary objective of this study was to examine whether ARID1A mutations confer a fitness advantage to gastric cancer from an immunological perspective, along with elucidating the underlying mechanism. Additionally, we aimed to identify the clinical potential of combining epigenetic inhibitors with immune checkpoint inhibitors to improve the efficacy of immunotherapy for gastric cancer. …”
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Temporal and Spatial Evolution Characteristics of Extreme Climate Events in Grand Shangri-La Region from 1961 to 2019 by WU Yang, JIN Hanyu, CHENG Qingping

“…The Grand Shangri-La region connects the Qinghai-Tibet Plateau,the Yunnan-Guizhou Plateau,and the Hengduan Mountains and is of great geographical significance.Five rivers flow through the region,and the climate is vulnerable.Therefore,it is necessary to explore extreme climate changes and their response mechanism,so as to assess regional climate risks and achieve disaster warnings.Based on the daily temperature and precipitation data of 56 meteorological stations from 1961 to 2019,this paper analyzes changes in extreme climate indexes and their correlation with large-scale circulation index in the region by using Mann-Kendall,Sen's slope estimation,Pettitt test,and Pearson correlation analysis.The results show that:① The extreme warm index and the extreme precipitation intensity index (RX1day,R95p,R99p,and SDII) increase significantly,while the cold index (CSDI、FD、ID、TN10p、TX10p) and the number of continuous humid days decrease greatly.In terms of different seasons,the warming amplitude of most of the extreme temperature indexes in winter is higher than that in summer,and the precipitation intensity increases gradually in summer and autumn but decreases slightly in winter.② Spatially,the diurnal temperature range in the north of the Qinghai-Tibet Plateau is higher than that in the south,and the frequency of extremely high-temperature rises,with the high temperature appearing mostly in arid valleys in the south and east of the Qinghai-Tibet Plateau.The precipitation intensity is high in the south and west of the Hengduan Mountains,and persistent precipitation is strong in the Yalong River basin and the upper reaches of the Jinsha River in the north.③ Extreme climate indexes and south China sea summer monsoon index (SCSMI) are significantly correlated in the same year.In addition,there is a one-year response lag between the extreme precipitation index and Arctic oscillation (AO),North Atlantic oscillation (NAO),and Pacific decadal oscillation (PDO).The above analysis shows that the Grand Shangri-La region generally shows warming and humid climate characteristics.The frequency of heavy precipitation in flood season and warm winter events increases and is closely related to large-scale circulation.…”
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Factors associated with multidrug-resistant organism (MDRO) mortality: an analysis from the national surveillance of multidrug-resistant organism, 2018-2022 by Sharifa Ezat WP, M Norhidayah, Muhammad Nur Amir AR

“…Improved surveillance and reporting mechanisms are necessary to better understand the burden of MDRO infections and guide research funding allocation.…”
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Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats by Mahtab Fouladi, Maryam Mahmoudabady, Zahra Gholamnezhad, Sadegh Shabab, Saeed Niazmand, Hossein Salmani

“…Given the heightened risk of diabetes-related cardiovascular events associated with inactivity, this study investigates the molecular mechanisms of vascular damage in streptozotocin (STZ)-induced diabetic rats. …”
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Hypermethylation in Calca Promoter Inhibited ASC Osteogenic Differentiation in Rats with Type 2 Diabetic Mellitus by Lei Wang, Feng Ding, Shaojie Shi, Xingxing Wang, Sijia Zhang, Yingliang Song

“…This result provides an implication for us to understand the mechanism of the decreased osteogenic ability of ASCs-T2DM and improve its osteogenic capacity.…”
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Why have tobacco control policies stalled? Using genetic moderation to examine policy impacts. by Jason M Fletcher

“…<h4>Conclusions</h4>This study provides novel evidence of "gene-policy" interaction and suggests a genetic mechanism for the large differences in response to tobacco policies. …”
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Severe Guillain-Barré syndrome with concurrent optic neuritis in a pediatric patient: a case report by Xin Xue, Yingcun Bao, Yakun Yu, Qun Li, Mei Liu, Xiaoling Li

“…On admission, he displayed severe respiratory and autonomic instability requiring mechanical ventilation. Neurological examination revealed flaccid paralysis of all four limbs with absent reflexes, along with bilateral optic neuritis, confirmed by MRI showing inflammation of the optic nerve. …”
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Securing fog computing in healthcare with a zero-trust approach and blockchain by Navjeet Kaur, Ayush Mittal, Umesh Kumar Lilhore, Sarita Simaiya, Surjeet Dalal, Kashif Saleem, Ehab Seif Ghith

“…Additionally, tasks are dynamically allocated to fog nodes based on a multi-metric scheduling mechanism that considers fog node capacity, proximity, and compliance with predefined security protocols. …”
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Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway by Attalla Farag El-kott, Ali A. Shati, Mohammed Ali Al-kahtani, Sultan Alqahtani

“…This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF-κB survival pathways. …”
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CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis by Yuan Zhang, Zhenggong Li, Jiao Wang, Hao Chen, Rui He, Hongkun Wu

“…However, its biological role and functional mechanism in AMI remain to be researched. Methods. …”
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Identification of biomarkers associated with ferroptosis in macrophages infected with Mycobacterium abscessus using bioinformatic tools. by Jiahua Qian, Chenghua Lu, Kai Meng, Zhihong Xu, Honghao Xue, Weijie Yang

“…Our findings identified biomarkers linked to ferroptosis in M. abscessus infection, providing new insights into its pathogenic mechanisms and potential therapeutic strategies.…”
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Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles by D. V. Petrovskii, A. V. Romashchenko, S. Yu. Troitskii, M. P. Moshkin

“…Thus, tbody was signi­ficantly lower after nasal administration the PtO nano­particles than after administration of the K2[PtCl 4] solution. To study the mechanism of this decrease, we compar­ed the respective values for Δtbody following intra­nasal, intravenous and peroral administration of PtO nanoparticles in Balb/c mice. …”
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Combination of functional dyspepsia syndrome and irritable bowel syndrome by V. T. Ivashkin, Ye. A. Poluektova

“…The factor determining quite low efficacy of pharmacotherapy at combined functional disorders is the personality features of the patient, that determine relationship with society, and development of symptoms as the adaptive mechanism protecting from necessity to be socially active.…”
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Global research trends on gastrointestinal cancer and mental health (2004–2024): a bibliographic study by Wenjin Han, Tianmeng Wang, Zhiqiang He, Caihua Wang, Zhaozhao Hui, Shuangyan Lei, Nan Hao, Ning Li, Xiaoqin Wang, Xiaoqin Wang

“…More detailed clinical symptom assessment is needed to distinguish between CRF and mental health issues and to provide targeted intervention measures in the future. The mechanism of mental health effects on the occurrence and development of GI cancer will be a frontier.…”
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Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review by Claire Goodman, Tom Dening, Neil H Chadborn, Maria Zubair, Lídia Sousa, John R F Gladman, Adam, L Gordon

“…Care planning needed to accommodate visiting clinicians and there was evidence that a core MDT often used care planning as a mechanism to seek external specialist support. Goal-setting processes were not always sufficiently patient-centred and did not always accommodate the views of care home staff. …”
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Diabetes and tuberculosis: a systematic review and meta-analyis of mendelian randomization evidence by Ivaan Pitua, Raafidha Raizudheen, Mark Muyanja, Joseph Nyero, Morrish Okello Obol

“…Future MR studies should include diverse populations to enhance generalizability and explore genetic mechanisms underlying this association.…”
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Nanoconfined Water in Shales and Its Impact on Real Gas Flow by Yudan Li, Shaohua Gu, Cheng Dai

“…The presented model and its results will further advance our understanding of the mechanisms responsible for the water and gas transport in nanoporous media, and consequently, the hydrocarbon exploration of shale reservoirs.…”
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Material screening for the development of a photovoltaic module using biodegradable materials from renewable raw materials by Pander Matthias, Koepge Ringo, Jaeckel Bengt, Mordvinkin Anton

“…It is shown how these materials behave under the standard requirements of the PV industry, which materials are generally suitable and which mechanisms could prove to be showstoppers. The selected wood-based material as substitute for aluminum showed resistance in aging tests, but the dependence of the properties on the moisture content must be considered. …”
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ROS-Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells by Lingjun Zhang, Zhengde Du, Lu He, Wenqi Liang, Ke Liu, Shusheng Gong

“…Previous evidence suggests that reactive oxygen species (ROS) may play an important role in the occurrence and development of SNHL, while its mechanism remains unclear. We cultured dissected organs of Corti in medium containing different concentrations (0, 0.25, 0.5, 0.75, 1, and 1.25 mM) of hydrogen peroxide (H2O2) and established a four-concentration model of 0, 0.5, 0.75, and 1 mM to study different degrees of damage. …”
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