Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…Relevant molecules and mechanism remains to be explored in the future.…”
Get full text

Elevated troponin levels in an athlete: Myocardial infarction or a physiological reaction? by Janković Tamara, Đorđević Stefan

“…It has been recorded for years that intense physical activity is also linked to the release of troponin, even though the pathophysiological mechanism had not yet been described. This paper aims to present the case of a patient who had collapsed in a public setting during physical activity and was taken to the hospital with the suspicion of having an AMI. …”
Get full text

Short dentin etching with universal adhesives: effect on bond strength and gingival margin adaptation by Hoda Saleh Ismail, Hanan Ahmed Nabil Soliman

“…This study evaluates the microtensile bond strength (μTBS) and marginal adaptation of two universal adhesives using different etch-and-rinse strategies (15-second and 3-second etching) and self-etch strategies, both immediate and post-thermal cycling and mechanical loading. Methods Eighty-four molars underwent μTBS testing, categorized by the universal adhesive type (Tetric Uni and Prime&Bond Uni) (n = 42) and adhesive strategy (n = 14) with half tested after 24 h and the rest post aging. …”
Get full text

Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

“…One of the major consequences of schistosomiasis is its impact on brain function, and despite its severity, the underlying mechanism(s) remain inadequately understood, highlighting a knowledge gap in the disease. …”
Get full text

Analysis of significantly associated regions and candidate genes for dwarf stem trait in Brassica napus based on BSA-sequencing by ZHAO Weiguo, TA Na, WANG Hao, YANG Zelin

“…[Methods] Rapeseed dwarf stem DW1 was used to cross with tall stem lines WH14 and WH20, respectively, and the F1 and F2 generations were used to analyze the genetic mechanism behind the dwarf trait. Meanwhile, two mixed DNA pools, one from extremely tall and the other from dwarf stem lines, constructed from F2 segregated population of dwarf stem DW1 and tall stem WH20 hybrid combination, were sequenced and analyzed base on BSA-seq technology, and the significant association regions and candidate genes associated with dwarf trait were identified. …”
Get full text

Application of trichloroisocyanuric acid in controlling kiwifruit bacterial canker disease demonstrates its promising potential as an eco-friendly bactericide by Jianyou Gao, Jiewei Li, Cuixia Liu, Hongjuan Gong, Beibei Qi, Rongxiang Zhu, Liming Xia, Li Li, Shibiao Liu, Qiaosheng Jiang, Kaiyu Ye, Faming Wang

“…In this study, we evaluate the efficacy of TCCA in controlling Pseudomonas syringae pv. actinidiae (Psa), the causative agent of bacterial canker in kiwifruit, and explore its underlying mechanisms of action. Our results demonstrate that TCCA effectively inhibits Psa growth in vitro, even at low concentrations, with minimum inhibitory concentrations (MICs) of 20 mg/L (TCCA added directly to the Psa suspension) and 100 mg/L (Psa cells mixed with liquid LB medium before adding TCC). …”
Get full text

Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19. by Sarah E Holton, Mallorie Mitchem, Hamid Chalian, Sudhakar Pipavath, Eric D Morrell, Pavan K Bhatraju, Jessica A Hamerman, Cate Speake, Uma Malhotra, Mark M Wurfel, Steven E Ziegler, Carmen Mikacenic

“…Plasma was collected within 24h of ICU admission and at 7d. In mechanically ventilated patients, endotracheal aspirates (ETA) were collected. …”
Get full text

Evaluation of Insomnia Frequency, Beliefs and Attitudes Related Insomina in Primary Care by Zerrin Gamsýzkan, Selçuk Aslan

“…We aimed to determine the prevalence of insomnia disorders, understand cognitive aprasials of pateints about their insomnia symptoms, and perpeutuating factors and coping mechanism to cope with insomnia problems. METHOD: In this study; patients with sleep problems were examined in a outpatient family medicine clinic in Ankara between 2009 and 2012. …”
Get full text

Making of intrapreneurial managers: Investigating unethical behavior, risk-taking, and decision-making speed as antecedents by Rrezon Lajçi, Gentrit Berisha, Besnik Krasniqi

“…Our study also informs policymakers of the importance of formal education on entrepreneurship as a mechanism to enforce ethical awareness in future entrepreneurs and intrapreneurs. …”
Get full text

Influence of Drying Methods on the Morphological Features, Microstructural Properties, and Antioxidant Performance of <i>Floccularia luteovirens</i>: A Metabolomic Analysis by Mengjun Xiao, Tao Wang, Chuyu Tang, Min He, Xiaojian Pu, Tingjing Zhao, Yuling Li

“…This research clarifies how different drying techniques impact the metabolites or metabolic pathways of <i>F. luteovirens</i>, identifying the mechanisms that influence its quality and providing a reference for optimizing its processing and storage.…”
Get full text

Deep Transfer Learning for Classification of Late Gadolinium Enhancement Cardiac MRI Images into Myocardial Infarction, Myocarditis, and Healthy Classes: Comparison with Subjective... by Amani Ben Khalifa, Manel Mili, Mezri Maatouk, Asma Ben Abdallah, Mabrouk Abdellali, Sofiene Gaied, Azza Ben Ali, Yassir Lahouel, Mohamed Hedi Bedoui, Ahmed Zrig

“…A spatial attention mechanism was implemented as a part of the neural network architecture. …”
Get full text

The effect of different bioceramic root canal sealer removal protocols on the bond strength of composite to coronal dentin in diabetic and non-diabetic patients: an ex vivo study by Arzu Şahin Mantı, Cemile Kedici Alp

“…Abstract Background Diabetes mellitus can alter the physical and mechanical properties of dentin, compromising bonding. …”
Get full text

Evaluation of the Magnet Breakaway Force Measurement Accuracy of the NT-800 Sensors for Early Detection of Defects of Their Manufacturing by A. Yu. Kutsepau, A. P. Kren, Y. V. Hnutsenka

“…Сontrol of mechanical stresses formed with the deposition of nickel coatings plays an important role in the diagnosis of coatings’ technical condition. …”
Get full text

Roles of mobile teams in tracing lost to follow–up clients: evidence from the optimization of COVID-19 vaccination uptake and routine immunization in Ekiti State by Saheed Dipo Isiaka, Dapo Awobeku, Akolade Uthman Jimoh, Mahfus Dauda, Olugbemisola Wuraola Samuel, Stephen Olabode Asaolu, Oluwafisayo Azeez Ayodeji, Sunday Atobatele, Segun Adenipekun, Chukwudinma Okoh, Zubair Adegoke, Sidney Sampson

“…Abstract Background Evidence from literature has established that tracing lost to follow-up clients is an effective strategy for complementing other mechanisms for infectious disease control like human immunodeficiency virus (HIV), tuberculosis, and other diseases such as Ebola. …”
Get full text

Effect of Electroacupuncture on Inhibition of p38 MAPK Pathway on Neuromotor Function in Rats with Spinal Cord Injury by Wei CHEN, Yaochi WU

“…Objective:To observe the effect of electroacupuncture on neuromotor function of rats with spinal cord injury, and to explore its mechanism based on p38 MAPK pathway.Methods:A total of 63 adult male SD rats were randomly divided into sham group, SCI group and SCI-EA group, with 21 cases in each group.The spinal cord was not injured in Sham group, the SCI group and SCI-EA group were established by crushing the spinal cord with external force.The sham group and SCI group did not take any intervention, At the second day after operation, SCI-EA groupwas treated by electro-acupuncture instrument (continuous wave, frequency 2 Hz, intensity 1 mA), The needling site was T₁₀Jiaji acupoint, 30 minutes per time, once a day, resting every 5 days, continuous treatment for 28 days.Spinal cord injury behavioral score (BBB) was used to evaluate the changes of motor function after spinal cord injury; apoptosis of spinal cord neurons was detected by TUNEL method; Caspase-3 positive cells in spinal cord tissue were detected by immunohistochemical SP method;and protein expression was detected by Western blot.Results:Compared with SCI group, BBB score of SCI-EA group was significantly higher after EA intervention for seven days, with statistically significant differences (<italic>P</italic>&lt;0.05); Caspase-3 positive cells in spinal cord tissue of SCI-EA group were significantly lower, and the number of apoptotic cells reduced significantly, The positive expression of p38 MAPK and iNOS decreased significantly, with statistically significant differences (<italic>P</italic>&lt;0.05).Conclusion:Electroacupuncture can inhibit the activation of p38 MAPK and iNOS pathway after spinal cord injury, reduce the apoptosis of spinal cord neurons, and improve the neuromotor function of spinal cord injury rats.…”
Get full text

Extraction, Enrichment, and Quantification of Main Antioxidant Aglycones of Flavonoids and Tannins from Melastoma Dodecandrum Lour.: Guided by UPLC-ESI-MS/MS by Yingpeng Tong, Yu Jiang, Xubo Chen, Xiaonan Li, Ping Wang, Ye Jin, Kejun Cheng

“…Because of the highest adsorption capacity and desorption ratio, HPD 500 was selected out of 14 macroporous resins for further study based on the static adsorption and desorption tests. The adsorption mechanism of the HPD 500 resin presented that pseudo-first-order kinetics model and Freundlich isotherm model could adequately explain the adsorption process. …”
Get full text

Association between sleep patterns and depression in older adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2007–2014 by Yi Niu, Yuqin Sun, Yijie Xie, Shun Yu

“…However, the study population was limited to Americans, and we recommend continued investigation of the causal relationship and mechanisms between the two in the future, and further expansion of data sources in order to assess the applicability of the findings.…”
Get full text

Transcriptomic analysis of Rhipicephalus microplus hemocytes from female ticks infected with Babesia bovis or Babesia bigemina by Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell Johnson, Lowell Kappmeyer, Perot Saelao, Naomi Taus, Chungwon Chung, Massaro Ueti

“…Upregulated genes were mainly involved in defense mechanisms, while downregulated genes were related to cell proliferation and apoptosis. …”
Get full text

Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer by Xiaoyu Kang, Lin Zhang, Shushang Liu, Fei Wang, Haiming Liu, Fenli Zhou, Fei Wu, Haohao Zhang, Daiming Fan, Yongzhan Nie, Zhangqian Chen

“…However, the impact of platinum drugs, such as cisplatin, on CXCR4 or PD‐L1 expression and the underlying mechanisms in gastric cancer (GC) remain unknown. Moreover, the correlation between their expression levels in GC remains elusive. …”
Get full text

Glucocorticoid receptor gene (NR3C1) methylation, childhood maltreatment, multilevel reward responsiveness and depressive and anxiety symptoms: A neuroimaging epigenetic study by Yajing Xu, Shan Yang, Cong Cao

“…Background: Although epigenomic and environment interactions (Epigenome × Environment; Epi × E) might constitute a novel mechanism underlying reward processing, direct evidence is still scarce. …”
Get full text