Immune microenvironment features underlying the superior efficacy of neoadjuvant immunochemotherapy over chemotherapy in local advanced gastric cancer by Ning Zhang, Chunyu Li, Zehua Zhao, Biying Jiang, Wentao Wang, Fujing Sun, Yong Zhang, Yanmei Zhu

“…BackgroundThe therapeutic efficacy of neoadjuvant immunotherapy combined with chemotherapy (Io+Chemo) is superior than chemotherapy alone (Chemo). However, the mechanism of Io+Chemo superiority remains to be further elucidated.MethodsThe study included 128 patients with resectable stage II-III gastric cancer, in which 63 were given neoadjuvant Io+Chemo, and 65 Chemo alone. …”
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Bisphenol A attenuates testosterone synthesis via increasing apolipoprotein A1-mediated reverse cholesterol transport in mice by Tong Zhao, Tong Zhao, Wenzhe Yang, Wenzhe Yang, Feilong Pan, Feilong Pan, Jinhao Wang, Jinhao Wang, Wenqi Shao, Wenqi Shao, Fangfang Chen, Fangfang Chen, Kexiang Liu, Kexiang Liu, Shuchen Zhao, Shuchen Zhao, Lijia Zhao, Lijia Zhao

“…However, research on the mechanisms by which BPA affects testosterone synthesis from the perspective of reverse cholesterol transport (RCT) remains limited. …”
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Falls and balance impairment; what and how has this been measured in adults with joint hypermobility? A scoping review by Yiduo Wang, Paul H. Strutton, Caroline M. Alexander

“…Although the methods used suggest a low level of evidence, it seems clear that people who are hypermobile have poor balance. The underlying mechanisms driving poor balance have not been explored in depth.…”
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Study on optimization of extraction and purification processes for total flavonoids from Lycopi herba roots and their anti-proliferative effects on fibrous synoviocytes in human rh... by Jie Chen, Chunyang Jiang, Zhenyu Liu, Panpan Wang, Qiang Ma, Nong Zhou

“…This study not only provides a scientific basis for the comprehensive utilization of L. herba root resources but also highlights the potential medicinal value of TFLHR in the treatment of rheumatoid arthritis, laying a foundation for future research into its specific mechanisms and clinical applications.…”
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CSNK1E is involved in TGF-β1 induced epithelial mesenchymal transformationas and related to melanoma immune heterogeneity by Wangbing Hong, Xin Wang, Xinyu Huang, Pengfei Chen, Yifan Liu, Ziying Zheng, Xin You, Yinghua Chen, Zengxin Xie, Gongnan Zhan, Heping Huang

“…Identifying novel biomarkers and therapeutic targets is critical for improving the prognosis and treatment of MM.MethodsIn this study, we analyzed the expression patterns of WNT signaling pathway genes in MM and explored their potential mechanisms. Using Cox regression analysis, we identified 19 prognostic-related genes. …”
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Process evaluation of the New Interventions for independence in Dementia Study (NIDUS) Family stream randomised controlled trial: protocol by Julie Barber, Laurie Butler, Claudia Cooper, Sarah Morgan-Trimmer, Danielle Laura Wyman, Peter Bright

“…The evaluation will test, refine and develop the NIDUS-Family theoretical model, associated causal assumptions and logic model to identify key mechanisms of impact, implementation and contextual factors influencing the intervention’s effectiveness. …”
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Priority areas of police bodies’ activity in ensuring the citizens’ rights in the conditions of martial law legal regime in Ukraine by O. I. Bezpalova

“…The specifics of the implementation of powers by police bodies to record and investigate war crimes, strengthening the evacuation mechanisms of the state, providing police services to all categories of the population, and paying increased attention by the police to the use of additional guarantees of protection and protection of citizens’ rights have been clarified. …”
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Differential GTP-dependent in-vitro polymerization of recombinant Physcomitrella FtsZ proteins by Stella W. L. Milferstaedt, Marie Joest, Lennard L. Bohlender, Sebastian N. W. Hoernstein, Buğra Özdemir, Eva L. Decker, Chris van der Does, Ralf Reski

“…In the moss Physcomitrella, the morphology of the FtsZ polymer networks varies between the different FtsZ isoforms. The underlying mechanism and foundation of the distinct networks is unknown. …”
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PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release by Banglun Pan, Zhu Zhang, Dongjie Ye, Xiaoxia Zhang, Yuxin Yao, Yue Luo, Haijie Hong, Xinran Cai, Yanling Chen, Nanhong Tang

“…Methods: In this study, the molecular mechanism of NET release and the potential beneficial effects of PPARα agonists on the HCC microenvironment were explored through proteomics, metabolomics, tissue microarray, immunofluorescence, flow cytometry, western blot, and dual-luciferase reporter gene assays (n = 6 per group). …”
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Problems of Small and Medium Business in Germany by B. E. Zaritskiy

“…The article deals with the problems of small and medium entrepreneurship (SME) in Germany, its role in the country’s economy. It reveals the mechanism of interaction of government structures, political parties, business alliances and the expert community in formulating and carrying out policies aimed at supporting SME. …”
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Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. by Hildegard Nikki Hall, Hemant Bengani, Robert B Hufnagel, Giuseppe Damante, Morad Ansari, Joseph A Marsh, Graeme R Grimes, Alex von Kriegsheim, David Moore, Lisa McKie, Jamalia Rahmat, Catia Mio, Moira Blyth, Wee Teik Keng, Lily Islam, Meriel McEntargart, Marcel M Mannens, Veronica Van Heyningen, Joe Rainger, Brian P Brooks, David R FitzPatrick

“…Given that biallelic loss-of-function variants in MAB21L1 result in a milder eye phenotype we suggest that Arg51-altering monoallelic variants most plausibly perturb eye development via a gain-of-function mechanism.…”
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Cáncer de mama en el bazar de TikTok by Jesús Ángel Pérez Dasilva, Maria Ganzabal Learreta, Koldobika Meso Ayerdi, Urko Peña Alonso, Terese Mendiguren Galdospin

“…Los resultados muestran que 60% de las publicaciones está protagonizado por mujeres enfermas, de entre 25 y 40 años, que luchan en soledad (34%) contra esta enfermedad. Solamente en 11% de los casos aparecen mujeres que han superado esta dolencia. …”
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A sustainable breakthrough in rodent pest control: laboratory validation of novel neem-andrographolide bait with dual toxic and contraceptive effects by Meenu Verma, Harjinder Kaur, Bhupinder Kaur Babbar

“…They have a very high reproductive potential and quickly rebuild their population after management through chemical and mechanical methods. Therefore, a neem seed and andrographolide-based bait (NSA bait) with both toxic and sterilising effects was developed for their long-term management. …”
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Efficacy of Different Irrigant Activation Systems on Debris and Smear Layer Removal: A Scanning Electron Microscopy Evaluation by Ronald Wigler, Moran Herteanu, Yuval Wilchfort, Anda Kfir

“…Irrigation is an essential component of root canal treatment to enable cleaning beyond the reach of mechanical instruments. The study aimed to assess and compare the efficacy of different final irrigation protocols, including sonic- and ultrasonic-powered irrigant-activation systems, on debris and smear layer removal in the coronal, middle, and apical thirds of straight oval root canals. …”
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Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil by Lawrence Coppey, Alexander Obrosov, Hanna Shevalye, Eric Davidson, William Paradee, Mark A. Yorek

“…Wild-type and transgenic diabetic mice developed DPN as determined by slowing of nerve conduction velocity, decreased sensory nerve fibers in the skin and cornea, and impairment of thermal and mechanical sensitivity of the hindpaw compared to their respective control mice. …”
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Factor Analysis and Mental Health Prevention of Employee Turnover under the Profit-Centered Development of Modern Service Industry by Youwen Zhong, Huifang Zhang, Xiaoling Wu

“…The research innovation lies in building a relationship model between turnover intention, psychological contract, and job satisfaction; analyzing the influence mechanism and interaction of various variables in the model; and providing reference and thinking for the service industry to solve the problem of excessive turnover of employees. …”
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Electroacupuncture may protect pulmonary dysplasia in offspring with perinatal nicotine exposure by altering maternal gut microbiota and metabolites by Yana Xie, Yang Fang, Yitian Liu, Bo Ji, Reiko Sakurai, Yifei Wang, Hewen Li, Ling Zhang, Le Wu, Tingting Guo, Ye Quan, Virender K. Rehan

“…However, the beneficial effects of EA on offspring pulmonary function (FVC, PEF, PIF, and Cdyn) and lung morphology (alveolar number and MLI) were lost after maternal gut microbiota depletion.ConclusionThese findings suggest that EA may exert its therapeutic effects on PNE-induced lung phenotype by altering maternal gut microbiota. The likely mechanism involves the associated improvement in serum SCFA levels in both mother and offspring, as well as the upregulation of SCFA receptors in the lung tissue of offspring.…”
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Protein Adsorption by Basal Plane Graphite Surfaces: Molecular Images and Nano-Structured Films by A. Orasanu-Gourlay, R.H. Bradley

“…A linear fit was obtained when these data were plotted in the form of the Langmuir equation which resulted in a monolayer equivalent value of N m = 3.3 atom % protein nitrogen. The main mechanism of adsorption appeared to be dispersion- or hydrophobic-dominated, although electrostatic repulsions between polar surface oxygen groups and the negatively charged HSA may also occur.…”
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A systematic review of the effect of personal health records on patient activation by Irina Osovskaya, Ann Blandford, Henry WW Potts

“…Background Personal health records (PHRs) or patient portals have been on the healthcare policy agenda for many countries as a promising mechanism to support patient-centred healthcare by making medical records accessible to patients and those assisting patients in health self-management. …”
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The privacy protection of the internet of vehicles resource transaction details based on blockchain. by Jing Chen, Tao Li, Min Huang

“…By introducing committed value protection, zero-knowledge proof technology and constructing temporary transaction addressed mechanism. The scheme realized the comprehensive privacy protection of transaction funds, transaction details and transaction addresses, which could effectively avoid the disclosure of users' sensitive information. …”
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