Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided ca... by Ying Zhou, Chen Cheng, Qi Wang, Min Zheng, Pan Li, Yang Zhou, Yuting Cao, Li Wan, Xun Guo, Xiaohong Lin, Rui Tang, Hongye He, Nianhong Wu, Qiaoqi Chen, Yaqin Hu, Xialin Xiong, Faqi Li

“…Flow cytometry and immunofluorescence were used to clarify the potential mechanism of HIFU+M@P-SOP and their role in anti-programmed death ligand-1 (PD-L1) therapy.Results Guided by photoacoustic/MR/ultrasound (US) multimodal imaging, M@P-SOP was abundantly enriched in tumor, which greatly enhanced HIFU’s killing of tumor tissue in situ, induced stronger tumor immunogenic cell death, stimulated dendritic cell maturation and activated CD8+ T cells. …”
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Improvement of engineering properties and environmental impact of fired clay bricks utilizing industry sludge waste by Amir Detho, Aeslina Abdul Kadir, Ahmad Shayuti, Bin Abdul Rahim, Nejib Ghazouani, Abdelkader Mabrouk, Ahmed Babeker Elhag, Hesham Hussein Rassem

“…Incorporating up to 30% of body mill sludge (BS) and polishing sludge (PS) into the brick mix significantly enhances physical and mechanical properties, resulting in reduced shrinkage, increased porosity, and improved compressive strength, reaching up to 25 N/mm². …”
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Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells by Yujing Tao, Yujing Tao, Qun Niu, Qun Niu, Yuanqian Yao, Yuanqian Yao, Kaixin Wang, Kaixin Wang, Haijian Dong, Haijian Dong, Xin Zhao, Xin Zhao, Zijian Zeng, Zijian Zeng, Hui Li

“…In this study, we explored the effects and potential mechanisms of Qizhu-Ruogan-Granules (QZRG), a formulation from the Affiliated Hospital of the Chengdu University of TCM, on carbon tetrachloride (CCl4)-induced liver fibrosis in mice.MethodsA total of 40 male C57BL/6J mice were randomly divided into five groups (n = 8 per group), with liver fibrosis induced by injecting 10% CCl4 for 15 weeks. …”
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Total Glucosides of Paeony Alleviate Cell Apoptosis and Inflammation by Targeting the Long Noncoding RNA XIST/MicroRNA-124-3p/ITGB1 Axis in Renal Ischemia/Reperfusion Injury by Fang Chen, Yi Hu, Yuetao Xie, Zonghui Zhao, Lin Ma, Zhili Li, Wanlong Tan

“…This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods. Rat RI/RI models were constructed by surgical operation. …”
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Application of synthesized Fe3O4@Gelatin nanoparticles on interfacial properties and enhanced oil recovery by Hossein Ghalenavi, Abdolhossein Hemmati-Sarapardeh, Mahin Schaffie, Saeid Norouzi-Apourvari

“…They enhance oil recovery by improving EOR mechanisms including decreasing interfacial tension (IFT), wettability alteration to water-wet, and preventing asphaltene precipitation. …”
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Evaluating the reinforcements efficiency of sawdust and corncob wastes in structural concrete: A comprehensive review by Abiodun Kilani, Ademilade Olubambi, Bolanle Ikotun, Oladipupo Oladejo, Babatunde Famodu

“… Sawdust (SD) and Corncob (CC) wastes possess up to 89.4% and 83.03% pozzolanic properties with a high impact on the mechanical properties required for high concrete strength reinforcement respectively. …”
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Type II Diabetes Patients under Sildenafil Citrate: Case Series Showing Benefits and a Side Effect by Livia M. Zimmermann, Mauricio S. Baptista, João Paulo Tardivo, Maria A. Pinhal

“…Since off-label use of SC in patients suffering from microcirculatory alterations has increased recently, our results showed that more studies are needed to verify the prevalence of hypoglycemia episodes as well as it's possible physiologic mechanism.…”
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Depression in adolescence and young adulthood: the difficulty to integrate motivational/emotional systems by Teodosio Giacolini, Antonio Alcaro, David Conversi, Lorenzo Tarsitani

“…Depression is an evolutionarily conserved mechanism in mammals to terminate both separation anxiety, so as to protect the vulnerable social brain from the consequences of prolonged separation anxiety, and the stress of social competition when social defeat is predictable. …”
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Surgical antimicrobial prophylaxis among surgical patients: results from a retrospective observational study at a public hospital in Liberia by Michelle Niescierenko, John Shakpeh, Kayla Enriquez, Saned Raouf, Finda Mayah-Toto

“…More studies need to be done to explore the contributing factors to this. Implementing mechanisms to achieve proper use of SAP is needed.…”
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Assessing clenbuterol’s modulation of metabolic and inflammatory pathways in Nile tilapia (Oreochromas niloticous) fed high fat diet by Aya G. Rashwan, Doaa H. Assar, Abdallah S. Salah, Muyassar H. Abualreesh, Shimaa M. R. Salem, Norah Althobaiti, Zizy I. Elbialy

“…Abstract This study was performed to reveal the metabolic effects and molecular mechanisms that govern the dietary incorporation of clenbuterol on growth performance, haemato-biochemical changes, histological alteration, and gene expression regulating glucose and lipid metabolism in normal and high-fat diets fed in Nile tilapia (Oreochromis niloticus). …”
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Analysis of the 2016 – 2025 fiscal budget of U.S. Centers for Disease Control and Prevention by Nana LIU, Lieyu HUANG, Yuan DANG, Zekai YU, Qianqiu LIU, Yan GUO

“…It actively seeks financial support and establishes a needs-matched, project-driven financial support and response mechanism. It strengthens interdepartmental and international cooperation to effectively improve the capacity to respond to health challenges. …”
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Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Conclusion: Astrocyte NLRP3 knockout demonstrated a protective mechanism in mice subjected to mild TBI, possibly attributed to the inhibition of pyroptosis through the NLRP3 signaling pathway in astrocytes.…”
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SCHOOL TEXTBOOKS OF NATIONAL HISTORY AS AN INSTRUMENT OF THE MEMORY POLICY OF THE SOVIET STATE by Isabella S. Ogonovskaya

“…This allowed us to draw conclusions that at each stage of development of Soviet society, school history textbooks were used as conductors of state policy, as an instrument of memory policy and a mechanism for interaction between the authorities and the education system, as a factor influencing the minds of the younger generation and a means of controlling the mentality of historians - authors of textbooks, as a mass book that subjectively assessed the past and provided guidelines for the future.…”
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Effect of Central Pattern Generators Depended Different Walking Strategies on Gait Ability of Patients after Stroke by Hua WU, Zaihua RU, Congying XU, Xudong GU, Jianming FU

“…This indicated that fMRI is valuable in exploring the mechanisms of CPG neural network, and possessing positive effects on the improvement of walking ability and the reshaping of neural networks.…”
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Targeted Polymer–Peptide Conjugates for E-Selectin Blockade in Renal Injury by Nenad Milošević, Marie Rütter, Yvonne Ventura, Valeria Feinshtein, Ayelet David

“…Conclusion: Our findings provide valuable insights into the interconnection between CAMs and compensatory mechanisms in controlling leukocyte migration in AKI and CKD. …”
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Chromosome Numbers and Reproductive Life Cycles in Green Plants: A Phylotranscriptomic Perspective by Rijan R. Dhakal, Alex Harkess, Paul G. Wolf

“…These findings could provide novel avenues to investigate and probe the underlying mechanism that may underpin the association between heterospory and genomic changes. …”
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Clinical Epidemiological Characteristics and Risk Factors for Severe Bronchiolitis Caused by Respiratory Syncytial Virus in Vietnamese Children by Sang Ngoc Nguyen, Thuy Ngoc Thi Nguyen, Lam Tung Vu, Thap Duc Nguyen

“…This study confirms that age, preterm birth, breastfeeding under 6 months, history of exposure to cigarette smoking, low birth weight, having sibling(s) under five years old going to kindergarten, history of undergoing cesarean section, history of mechanical ventilation, poor living condition, and maternal education are 10 risk factors of severe bronchiolitis caused by RSV.…”
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A study on the impact of sports participation support on the level of sports participation of urban junior high school girls in China by Mingyuan Dong, Mingtian Niu, Zhengxin Jiang, Yongchul Choi, Ning Li

“…However, the relationship between middle school girls’ physical activity levels and the actual social support they receive remains unclear.AimThis study aims to explore the support mechanisms that promote increased physical activity participation among middle school girls.MethodsA survey was conducted with 1,371 middle school girls from 16 regions and cities in China. …”
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Intraoperative transcutaneous electrical acupoint stimulation combined with anesthesia to prevent postoperative cognitive dysfunction: A systematic review and meta-analysis. by Lin Gan, Kecheng Qian, Jinding Yang, Qian Cai, Qinyu Ye, Mengyuan Dai, Zhaoxing Jia, Tianxiang Jiang, Congcong Ma, Xianming Lin

“…Additionally, intraoperative TEAS demonstrated efficacy in reducing the contents of perioperative serum S100β protein (S100β), neuron-specific enolase (NSE), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in patients, and the improvement of these indexes may be the potential mechanism of TEAS in preventing POCD.<h4>Conclusion</h4>Our results suggest that intraoperative TEAS combined with anesthesia prevents cognitive dysfunction in the immediate postoperative period, however we need additional evidence of its utility in preventing long-term cognitive dysfunction. …”
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Immunoprotection of mice against Schistosomiasis mansoni using solubilized membrane antigens. by Guidenn Sulbarán, Oscar Noya, Beatríz Brito, Diana E Ballén, Italo M Cesari

“…<h4>Conclusions</h4>Immunization with AWBE induced the production of specific antibodies to various adult worm membrane molecules (including AP) and a partial (43%) protection against a challenging S. mansoni infection by mechanism(s) that still has to be elucidated.…”
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