Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis by Xuejie Gao, Qilin Feng, Qikai Zhang, Yifei Zhang, Chaolu Hu, Li Zhang, Hui Zhang, Guanli Wang, Ke Hu, Mengmeng Ma, Zhuning Wang, Yujie Liu, Dong An, Hongfei Yi, Yu Peng, Xiaosong Wu, Gege Chen, Xinyan Jia, Haiyan Cai, Jumei Shi

“…To investigate the biological functions of ENO1 in MM and the underlying molecular mechanisms involved, we conducted the following experiment: construction of a subcutaneous graft tumor model, co-immunoprecipitation, western blot, quantitative real-time polymerase chain reaction, immunohistochemistry, flow cytometry, and cell functional assays. …”
Get full text

Physiological changes induced by green fodder expansion into grasslands and croplands enhance water-use efficiency in the Northeastern Tibetan Plateau by Xu Wang, Jilin Yang, Jie Wang, Tong Yang, Chuchen Chang, Yanbo Zhao, Xiaocui Wu, Geli Zhang, Xiangming Xiao

“…We also conducted an attribution analysis to undercover the mechanisms through which green fodder expansion influences water-use efficiency. …”
Get full text

Peculiarities of observing human rights in the conditions of emergency legal regimes caused by the pandemic by N. O. Rastorhuieva

“…The article is devoted to the study of the pandemic as a legal prerequisite for the introduction of certain mechanisms for the observance of human rights in the conditions of emergency legal regimes and to the identification of certain features of the observance and guarantee of these rights. …”
Get full text

RESEARCHON CHARACTERISTICSOFACTUAL HINGEJOINT LOAD OF HYDRAULIC EXCAVATOR WORKING DEVICE by XIANG QingYi, LV PengMin, WANG BinHua, XUE Lu

“…The first is using the three-dimensional pin-shaft force sensor to measure the positive load,lateral load and offset load at the hinge joint of stick and bucket,and using the link rod force sensor to measure the link rod force,and then the other hinge joint loads could be calculated by the mechanical equilibrium equation; The second is using the measured pressure and displacement of the boom cylinder,stick cylinder and bucket cylinder to calculate all hinge loads indirectly by a kinetic model. …”
Get full text

Dynamic reconfiguration of default and frontoparietal network supports creative incubation by Ziyi Li, Ze Zhang, Tengteng Tan, Jing Luo

“…Although creative ideas often emerge during distraction activities unrelated to the creative task, empirical research has yet to reveal the underlying neurocognitive mechanism. Using an incubation paradigm, we temporarily disengaged participants from the initial creative ideation task and required them to conduct two different distraction activities (moderately-demanding: 1-back working memory task, non-demanding: 0-back choice reaction time task), then returned them to the previous creative task. …”
Get full text

Effects of a Total Motion Release (TMR®) Protocol for the Single Leg Squat on Asymmetrical Movement Patterns by Nickolai JP Martonick, Craig P McGowan, Russell T Baker, Lindsay W Larkins, Jeff G Seegmiller, Joshua P Bailey

“… # HYPOTHESIS/PURPOSE The purpose of this study was to evaluate whether perceived asymmetries identified by a TMR® scoring protocol were related to biomechanical asymmetries and whether improving perceived asymmetries influenced movement mechanics. It was hypothesized that participants with perceived asymmetries would also present with biomechanical asymmetries. …”
Get full text

Composite microbial agent improves cotton yield and resource use efficiency under mild salt stress by optimizing plant resource allocation by Xiao Zhao, Panpan Guo, Xiong Wu, Meng Zhu, Shaozhong Kang, Taisheng Du, Jian Kang, Jinliang Chen, Ling Tong, Risheng Ding, Wanli Xu, Guangmu Tang

“…However, its broad adaptability and regulatory mechanisms require further exploration. We hypothesize that under non-saline or moderately saline conditions, STC-PGPR directs resources to shoots, especially reproductive organs, by altering the rhizosphere bacterial community, thereby enhancing seed cotton yield (SY) and resource use efficiency. …”
Get full text

Contrast Medium Use in Computed Tomography for Patients Presenting with Headache: 4-year Retrospective Two-Center Study in Central and Western Regions of Ghana by Bashiru Babatunde Jimah, Benjamin Dabo Sarkodie, Asare Kwaku Offei, Ewurama Andam Idun, Dorothea Anim, Edmund Brakohiapa, Benard Ohene Botwe

“…Further studies to improve the knowledge of agents, mechanism of action, and safety of contrast media used among practitioners in Ghana is recommended.…”
Get full text

Breast Implant Illness May Be Rooted in Mast Cell Activation: A Case-Controlled Retrospective Analysis by Èva S. Nagy, BMedSci(Hons), MBBS, PhD, FRACS, Grad Cert (Breast Surgery), Mark Westaway, MBBS, DCH, Grad Dip Allergy, Suzanne Danieletto, BSc, MBBS (Hons), FRCPA, MIAC, Lawrence B. Afrin, MD

“…To investigate the possible association between breast implant illness (BII) and mast cell activation syndrome (MCAS), which often manifests increased mast cells (MCs) in assorted tissues and may explain BII symptoms. Background:. Mechanisms by which implants cause BII symptoms remain unclear, but BII and MCAS symptom profiles heavily overlap, warranting investigation of potential linkage. …”
Get full text

Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress by Yuwei Han, Guangzhi Hao, Song Han, Tingzhun Zhu, Yushu Dong, Ligang Chen, Xinyu Yang, Xiaoming Li, Hai Jin, Guobiao Liang

“…ObjectiveThis study aims to investigate the inhibitory effect of Polydatin (PD) on endoplasmic reticulum (ER) stress following subarachnoid hemorrhage (SAH) and to elucidate the underlying mechanisms.MethodsA standard intravascular puncture model was established to mimic SAH in mice. …”
Get full text

The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke by Katherine Hernandez, Nathan Jones, Sterling B. Ortega

“…Using a murine transient middle cerebral artery occlusion (tMCAO) model, we sought to evaluate the neurotherapeutic efficacy of a positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor (α7-nAChR), PNU-120596 (PNU), specifically examining whether PNU would modulate stroke-induced neurological dysfunction and neuropathology, with modulation of neuroinflammation as a possible mechanism.MethodsYoung male C57BL/6J mice received a subcutaneous injection of 20mg/kg of vehicle (DMSO) or PNU-120596 immediately after reperfusion, and infarct area and Bederson score were analyzed 24 hours post-stroke. …”
Get full text

Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise by Yumei Zhang, Yuqing Liu, Xiao Bi, Chun Hu, Feng Ding, Wei Ding

“…CKD-induced muscle atrophy is highly prevalent, and exercise is well known to enhance muscle function in these cases, although the exact mechanism remains unclear. Here, we aim to assess whether the protective effect of aerobic exercise in 5/6 nephrectomized (CKD) mice is associated with mitochondrial dysfunction, autophagy, or inflammation. …”
Get full text

Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing by Gulam Altab, Brian J. Merry, Charles W. Beckett, Priyanka Raina, Inês Lopes, Katarzyna Goljanek-Whysall, João Pedro de Magalhães

“…Abstract Age-related muscle wasting, sarcopenia is an extensive loss of muscle mass and strength with age and a major cause of disability and accidents in the elderly. Mechanisms purported to be involved in muscle ageing and sarcopenia are numerous but poorly understood, necessitating deeper study. …”
Get full text

Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level by C. L. G. Chong, Faizah Othman, Farida Hussan

“…In conclusion, we reported the mechanism of antiatherosclerotic property of MCLE through lipids elimination and anti-inflammatory activity. …”
Get full text

Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial by Sitthiphong Suwannaphisit, Nitiphoom Sinnathakorn, Pormes Suwanno, Warangkana Fongsri, Boonsin Tangtrakulwanich

“…Previous studies have reported that topical CFAs are effective in all knee OA patients, with slightly higher evidence for those with advanced disease. The mechanism of pain in OA knee and OA hand is similar. …”
Get full text

Integrated Management of Cardiovascular–Renal–Hepatic–Metabolic Syndrome: Expanding Roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs by Nikolaos Theodorakis, Maria Nikolaou

“…Cardiovascular–Kidney–Metabolic syndrome, introduced by the American Heart Association in 2023, represents a complex and interconnected spectrum of diseases driven by shared pathophysiological mechanisms. However, this framework notably excludes the liver—an organ fundamental to metabolic regulation. …”
Get full text

Metabolic dysfunction-associated fatty liver disease and risk of nephrolithiasis: a sizeable cross-sectional study by Shengqi Zheng, Tianchi Hua, Guicao Yin, Wei Zhang, Xiaoxiang Wang, Lezhong Qi, Xiayong Jing, Qibing Fan, Xiaoping Yu, Yifan Li

“…More research is needed to elucidate the physiological and pathological mechanisms between MAFLD and nephrolithiasis.…”
Get full text

A Hysteresis Model Incorporating Varying Pinching Stiffness and Spread for Enhanced Structural Damage Simulation by Mohammad Rabiepour, Cong Zhou, James Geoffrey Chase

“…This can negatively impact the accuracy of the BWBN model in simulating structural responses and damage mechanisms in structures such as reinforced concrete (RC) and timber, which exhibit highly pinched hysteresis behavior when damaged by earthquakes. …”
Get full text

Effects of Production System With or Without Growth-Promoting Technologies on Growth and Blood Expression of (Cyto)Chemokines and Heat Shock and Tight Junction Proteins in <i>Bos t... by Mark Branine, Ashley K. Schilling-Hazlett, Pedro H. V. Carvalho, Kim R. Stackhouse-Lawson, Edilane C. Martins, Julia T. da Silva, Laura Amundson, Chris Ashworth, Mike Socha, Sami Dridi

“…However, some cattle breeds have superior physiological adaptive traits to others, yet the underlying molecular mechanisms are not fully defined. The present study aimed, therefore, to determine the expression profile of stress-related molecular signatures in the blood of thermosensitive Angus (<i>Bos taurus</i>) and thermotolerant Brahman (<i>Bos indicus</i>) cattle breeds managed without (CON) or with growth-promoting technology (TRT) during the summer (April–October, 2023) season in Colorado, US. …”
Get full text

Age as the Impact on Mortality Rate in Trauma Patients by Onchuda Wongweerakit, Osaree Akaraborworn, Burapat Sangthong, Komet Thongkhao

“…Hospital cost, intensive care unit (ICU) length of stay, gender, precomorbidity, mechanism of injury, injury severity score (ISS), and trauma and injury severity score were analyzed for any correlation with mortality, and whether or not they were associated with elderly trauma patients. …”
Get full text