MicroRNA-122 protects against interferon-α-induced hepatic inflammatory response via the Janus kinase–signal transducer and activator of transcription pathway by Fanwei Liu, Bowen Liu, Shanshan Xu, Yinhua Ni, Xiaoli Liu

“…However, the underlying mechanism of IFN-α in hepatic inflammation remains to be fully elucidated. …”
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Prevalence and Management of Septic Shock among Children Admitted at the Kenyatta National Hospital, Longitudinal Survey by Varsha Vekaria-Hirani, Rashmi Kumar, Rachel N. Musoke, Ezekiel M. Wafula, Idris N. Chipkophe

“…It was found that lack of mechanical ventilation, and presence of hypotension at admission were associated with greater mortality (p values of 0.03 and 0.01 respectively). …”
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Childhood violence exposure and its contributing factors in Indonesia: a secondary data analysis of the National Survey on Children and Adolescents’ Life Experience by Dwi Octa Amalia, Sabarinah Sabarinah, Kemal N Siregar, Ella Nurlaella Hadi

“…The independent variables included gender, education level, occupation, living arrangement, orphan status, witnessing violence, marital status and residence. …”
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Analysis of Microstructure and Performance of Cr₃C₂/Ni60A Coating on 45 Steel for Laser Cladding Piston Rod by Jiafei Pu, Viacheslav Tarelnyk, Yao Ju, Bondarev Sergii Grigorievicth, Xingrong Wang, Qi Dong, Hongfeng Wang, Weiwei Song

“…The wear resistance is optimal at a 35% Cr₃C₂ mass ratio, with a wear loss of 0.15 mg—five times lower than that of the substrate. The primary wear mechanism is abrasive wear, although localized fatigue and adhesive wear are also observed.…”
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TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway by Yan-mei Xia, Yu-qian Guan, Ji-fang Liang, Wei-dong Wu

“…Additionally, TAK-242 treatment improved the condition of CLP rats that had glomerular and tubular injuries and mitochondrial disorders (p < 0.01). Further mechanism research revealed that TAK-242 can inhibit the TLR4/NF-κB signaling pathway activated by CLP (p < 0.01). …”
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Effects of Functional Red Pine Seed Direct-Drinking Oil on Constipation and Intestinal Barrier Function in Mice by Jie Li, Haonan Zheng, Jiahui Liu, Jie Ding, Qingqi Guo, Na Zhang

“…The study investigated the effects and mechanisms of this red pine seed direct-drinking oil in alleviating constipation in mice. …”
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A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti by Bacot, Tiphaine, Haberkorn, Chloe, Guilliet, Joseph, Cattel, Julien, Kefi, Mary, Nadalin, Louis, Filee, Jonathan, Boyer, Frederic, Gaude, Thierry, Laporte, Frederic, Tutagata, Jordan, Vontas, John, Dusfour, Isabelle, Bonneville, Jean-Marc, David, Jean-Philippe

“…Target-site modification and increased insecticide detoxification are the two main mechanisms underlying insecticide resistance in mosquitoes. …”
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Russian-Japanese Relations: Long-Term Development Factors by D. V. Streltsov

“…On the other hand, Japan and Russia are both interested interest in political cooperation in creating multilateral dialog mechanisms of international security in East Asia, resolving the nuclear issue on the Korean Peninsula, and easing tensions around territorial disputes in the East China and South China seas. …”
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Regulatory factor X‐5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness by Zhi‐Zhong Zhang, Zi‐Ming Wang, Hao‐Wen Zhang, Yan‐Xin Gong, Hao‐Ran Sun, Wei Zhang

“…This study aimed to examine the regulatory mechanisms and the function of STIL in the stemness of HCC tumor cells. …”
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Seasonal Features and a Case Study of Tropopause Folds over the Tibetan Plateau by Jiali Luo, Wenjun Liang, Pingping Xu, Haiyang Xue, Min Zhang, Lin Shang, Hongying Tian

“…Tropopause fold is the primary mechanism for stratosphere-troposphere exchange (STE) at the midlatitudes. …”
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Nomogram model for predicting secondary infection in critically ill patients with heatstroke: A pilot study from China. by Guodong Lin, Hailun Peng, Bingling Yin, Chongxiao Xu, Yueli Zhao, Anwei Liu, Haiyang Guo, Zhiguo Pan

“…Infected patients required longer durations of mechanical ventilation (OR = 2.764; 95% CI, 1.735-4.405; P = 0.044) and total hospital stay than those in the non-infection group. …”
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Association between Life’s Crucial 9 and overactive bladder: the mediating role of weight-adjusted-waist index by Hongyang Gong, Hongyang Gong, Shuqin Duan, Shaoqun Huang

“…BackgroundResearch suggests a potential connection between cardiovascular health, obesity, and overactive bladder (OAB). However, the mechanisms by which obesity influences the relationship between cardiovascular health and OAB remain unclear. …”
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Resistance-breaking strains of tomato spotted wilt virus hamper photosynthesis and protein synthesis pathways in a virus accumulation-dependent manner in Sw5-carrying tomatoes by Maria Isabella Prigigallo, Ugo Picciotti, Giovanni Bubici

“…We investigated the interaction between Sw-5b-carrying tomatoes and Sw5-Resistance-Breaking (SRB) TSWV to elucidate the molecular mechanisms underlying resistance breakage. Transcriptome sequencing (RNA-Seq) was used to analyze 18 tomato leaf samples collected from a field crop naturally infected by SRB TSWV in Italy. …”
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Hybridize Machine Learning Methods and Optimization Techniques to Analyze and Repair Welding Defects via Digital Twin of Jidoka Simulator by Ahmed M. Abed, Tamer S. Gaafar

“…Hybridising the Random-Forest algorithm with Dingo optimisation and called Regulated Random Forest (RRF) to precisely identify defect clusters and then predict the welding defect growth rate (<inline-formula> <tex-math notation="LaTeX">$\boldsymbol {{R}_{s}}$ </tex-math></inline-formula>) using the Cat-boost optimiser, which is enhanced by a beetle search mechanism called CatBAS. The RRF is superior to Apriori, ECLAT, and FP Growth by 23.98%, 7.44%, and 8.38%, respectively, while CatBAS is superior to XG-boost by 94.62% in response time with a 1.04175% error that activates the treating stage-V quickly. …”
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Prediction of Ultimate Load of Rectangular CFST Columns Using Interpretable Machine Learning Method by Tien-Thinh Le, Hieu Chi Phan

“…To this end, compression test data on CFST members were extracted from the available literature, including: (i) the mechanical properties of the constituent materials (i.e., steel’s yield strength and concrete’s compressive strength) and (ii) the geometric parameters (i.e., column length, width and height of cross section, and steel tube thickness). …”
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Yorkshire Enhanced Stop Smoking (YESS) study: a protocol for a randomised controlled trial to evaluate the effect of adding a personalised smoking cessation intervention to a lung... by Richard D Neal, David Baldwin, Sarah Lewis, John Britton, Rachael L Murray, Qi Wu, Kate Brain, Samantha L Quaife, Matthew EJ Callister, Philip A J Crosbie, Harriet D Quinn-Scoggins, Grace M McCutchan, Alex Ashurst, Suzanne Rogerson, Rebecca Thorley

“…A process evaluation will explore under which circumstances and on which groups the intervention works best, test intervention fidelity and theory test the mechanisms of intervention impact.Ethics and dissemination This study has been approved by the East Midlands-Derby Research Ethics Committee (18/EM/0199) and the Health Research Authority/Health and Care Research Wales. …”
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ILN-YOLOv8: A Lightweight Image Recognition Model for Crimped Wire Connectors by Xiaojian Zhou, Jicheng Kan, Nur Fatin Liyana Mohd Rosely, Xu Duan, Jiajing Cai, Zihan Zhou

“…Additionally, the Efficient Local Attention(ELA) attention mechanism is introduced into the Cryptographic Service Provider(CSP) bottleneck with 2 convolutions(C2F) module in the Backbone, improving feature localization accuracy without increasing network complexity. …”
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Immediate-Early Genes and Delayed Primary Response Genes Regulated by NmU in SKBR3 HER-2 Positive Breast Cancer Cell Line by Jessica Murphy, Sweta Rani

“…Rani et al. (2014), have associated the acquirement of resistance to HER2-treatment with Neuromedin U, but the mechanisms by which it works remain elusive. AimThe aim of this study was to investigate the effects of NmU on the regulation of immediate early and delayed primary response genes in HER2-positive SKBR3 breast cancer cells using RT-qPCR gene expression analysis. …”
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Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease by Yajuan Gao, Shengnan Chen, Jiani Fu, Cui Wang, Yali Tang, Yongbai Luo, Xiaozhen Zhuo, Xueying Chen, Yan Shen

“…The main pattern of HF in CKD patients is preserved ejection fraction (HFpEF), and left ventricular diastolic dysfunction (LVDD) is a frequent pathophysiological mechanism and specific preclinical manifestation of HFpEF. …”
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Engineered testbeds for investigating syringe injection performance in human factors studies by Andrew Pack, Sabrina Su, Frank A. Drews, Amrish Chourasia, Kevin Cluff, Joy Guerrieri, Jungkyu Kim

“…Précis: Two novel testing systems mimicking variable viscosity injections through fluidic or mechanical property variation enable the quantification of user strength in Human Factors studies and inform syringe design and viscosity limits.…”
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