A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1 by Zhen Zhang, Yinghui Hu, Ningning Xu, Wenjun Zhou, Lei Yang, Rongping Chen, Rui Yang, Jia Sun, Hong Chen

“…The regulation on the GLP1 receptor and its downstream transcription factor PI3K/AKT/FOXO1 pathway, which causes increased pancreatic and duodenal homeobox 1 (Pdx1) and MafA mRNA expression but causes decreased MAFB expression, may be the mechanism involved in this process.…”
Get full text

The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach by Huibin Ma, Zhou Xie, Lina Huang, Yanyan Gao, Linlin Zhan, Su Hu, Jiaxi Zhang, Qingguo Ding

“…These results support the role of WM functional neural activity as a potential neuromarker in classifying patients with TIA and offer novel insights into the underlying mechanisms in patients with TIA from the perspective of WM function.…”
Get full text

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling by Jennifer S. Ward, Karl J. Schreiber, John Tam, Ji-Young Youn, Roman A. Melnyk

“…Further characterizing the intoxication mechanisms of these proteins is important for the development of vaccines and treatments for toxin-mediated disease. …”
Get full text

Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3 by Huiny Miriane Tienoue Fotso, Mary-Ann Mbong Angie, Françoise Raïssa Ntentie, Inelle Makamwe, Ferdinand Lanvin Edoun Ebouel, Emmerencia Kenjing Ndansack, Enyong Julius Oben

“…Then, the line where the extract was the most active was selected to evaluate the expression of certain genes involved in cancerogenesis by RT-PCR and the expression of cleaved caspase-3 involved in cell death mechanism by western blot. The AE-Ac showed the best scavenging activity with IC50s of 0.52 and 0.02 for DPPH● and NO●, respectively. …”
Get full text

Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder by Mengmeng Yang, Yuxuan Lu, Shufan Jin, Wanqiu Liu, Miaoshi Yao, Zhiwei Jiang, Yachun Shu

“…Aim of the study: This study investigated the mechanism by which the Postoperative Tongqi Formula (PTQF) treats postoperative ileus (POI) through regulation of the p38 MAPK signaling pathway, Zona occludens 1 (ZO-1) protein, and metabolism. …”
Get full text

Risk of renal complications and death in young and middle-aged Swedes with parental type 1 diabetes: a nation-wide, prospective cohort study by Torbjörn Lind, Marie Fredriksson, Emma Persson, Anna Möllsten

“…Although the exact mechanisms behind these differences are unclear, we suggest that individualized care may benefit individuals with parental type 1 diabetes.…”
Get full text

First report on comprehensive genomic analysis of a multidrug-resistant Enterobacter asburiae isolated from diabetic foot infection from Bangladesh by Md. Rafiul Islam, Spencer Mark Mondol, Md. Azad Hossen, Mst. Poli Khatun, Shahjada Selim, Amiruzzaman, Donald James Gomes, Md. Mizanur Rahaman

“…Further research and in-depth comprehensive studies are required to investigate the prevalence of E. asburiae in Bangladesh and emphasize towards unraveling the bacterium’s inherent pathogenic potential and the intricate molecular mechanisms that underlie its resistance traits and virulence properties.…”
Get full text

Cryptogenic Organizing Pneumonia with a Rare Radiographic Presentation of a Diffuse Micronodular Pattern Mimicking Miliary Lung Infiltration: A Case Report and Review of the Litera... by Jakrin Kewcharoen, Kittika Poonsombudlert, Sakda Sathirareuangchai, Wichit Sae-Ow, Hanh La, Narin Sriratanaviriyakul

“…Upon admission, the patient’s clinical condition rapidly progressed to respiratory failure requiring mechanical ventilation. Initial Chest X-ray (CXR) showed diffuse reticulonodular infiltration mimicking miliary pattern. …”
Get full text

The impact of parental phubbing on social withdrawal in preschool children: the serial mediating roles of parent–child conflict and negative emotions by Pan Zhang, Xiaoying Wang

“…Conclusions These findings in the present study contribute to understanding the mechanisms underlying the association between parental phubbing and social withdrawal and have important implications for interventions aimed at improving social withdrawal among preschool children in China. …”
Get full text

Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria by Anna Wójtowicz, Małgorzata Zembala-Szczerba, Dorota Babczyk, Monika Kołodziejczyk-Pietruszka, Olga Lewaczyńska, Hubert Huras

“…Children born to women with EOP had lower Apgar scores (p<0.001) and higher rates of intraventricular hemorrhage (p<0.0001), respiratory disorders requiring mechanical ventilation (p<0.0001), and early (p=0.0004) and late sepsis (p=0.002). …”
Get full text

Severe reversible cardiomyopathy associated with adrenal crisis caused by isolated adrenocorticotropin deficiency: a case report by Li Wang, Fangfang Bu, Lanjie He, Guihua Yao, Guihua Yao

“…The patients was initially diagnosed with “septic shock” because of elevated inflammatory indicators and treated with mechanical circulatory support, antibiotics, fluid resuscitation, and intravenous administration of 50 mg hydrocortisone every 6 h for 2 days (400 mg in total). …”
Get full text

Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Since platelets play an important role in regulating endothelial cell barrier function and over 95 % of the circulating soluble CD40 ligand (sCD40L) is derived from activated platelets, we speculated that the release of CD40L from activated platelets induced by diabetes was the key mechanism that aggravated BBB injury and leaded to DACD. …”
Get full text

Melatonin attenuates MPP+-induced autophagy via heat shock protein in the Parkinson’s disease mouse model by Yinli Guo, Chengbo Liu

“…Background This study investigates the protective properties of melatonin in an in vivo Parkinson’s disease (PD) model, focusing on the underlying mechanisms involving heat shock proteins (HSPs). Methods Twelve adult male C57BL/6 mice were randomly divided into four groups (normal control, melatonin control, Parkinson’s model, and melatonin treatment; n = 3 per group) and housed in a single cage. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was injected intraperitoneally in the Parkinson’s model and treatment groups to establish a subacute PD model, while controls received saline. …”
Get full text

Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure. by Mohammed Aufy, Mahmoud Abd-Elkareem, Medina Mustafic, Mostafa A Abdel-Maksoud, Ali Hakamy, Veronika Baresova, Akram A Alfuraydi, Mahmoud Ashry, Jana Lubec, Ayman S Amer, Christian R Studenik, Ahmed M Hussein, Mohamed H Kotob

“…These alterations highlight potential mechanisms underlying age-associated changes in lung tissue integrity and provide insights into protease-mediated ECM remodeling in the context of aging lungs.…”
Get full text

Fast perceptual learning induces location-specific facilitation and suppression at early stages of visual cortical processing by Yajie Wang, Zhe Qu, You Wang, Mingze Sun, Mengting Mao, Yulong Ding

“…Here we developed a novel experimental design to investigate the cognitive neural mechanism of location specificity of fast PL. Specifically, we manipulated attentional settings and recorded event-related potentials (ERPs) in both the training and tests. …”
Get full text

Developing an indicator system and assessing China's progress on climate change adaptation in 2010–2022 from dual-dimension by Yang Song, Xiu Yang, Huimin Li, Mingyu Liu

“…Future research should address issues such as incorporating adaptation costs into the indicator system, establishing long-term monitoring mechanisms for dynamic adjustments, developing local-level indicators, and analyzing the sensitivity and correlation of adaptation actions to enhance the scientific support for climate change adaptation work.…”
Get full text

Ultrasonic and Microwave-assisted Solid-Liquid Extraction of Ginkgo biloba Phenolics: Study about Mass Transfer and PID Control by Chi XU, Hebin XU, Rui ZHU, Jing LI, Dandan LI, Yongbin HAN, Yi ZHENG, Yang TAO

“…A diffusion-based mathematical model was developed to explore the mass transfer mechanism about the studied extraction processes, and PID control algorithms were implemented to accurately control the extraction process. …”
Get full text

Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition by Yasmin F Melzer, Nadine L Fergen, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Ysabel A Schwietzer, Julian Kött, Klaus Pantel, Stefan W Schneider, Jochen Utikal, Ewa Wladykowski, Sabine Vidal-y-Sy, Alexander T Bauer, Christoffer Gebhardt

“…This research bridges gaps in understanding melanoma response mechanisms and highlights avenues for further investigation into immune-related markers, fostering advancements in precision medicine for melanoma patients.…”
Get full text

The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department by Birsen Ertekin, Mehmet Yortanlı, Ozan Özelbaykal, Ali Doğru, A. Sadık Girişgin, Tarık Acar

“…There was a significant difference between the two groups in terms of age, gender, length of hospital stay, need for mechanical ventilation, white blood cell, neutrophil, lymphocyte, monocyte, eosinophil, platelet counts, CRP, ferritin, procalcitonin values, NLR, MLR, and PLR (p<0.001 for all). …”
Get full text

Cognitive, linguistic, and methodological considerations in teaching professional vocabulary to information technology (IT) students. by V. Borshchovetska, T. Harbuza, A. Durdas, V. Semidotska

“…The authors emphasize the effectiveness of the cognitive approach to vocabulary acquisition, which implies consideration of the role of memory and the identification of mechanisms and models of vocabulary processing. Among these are the concept mediation model, which demonstrates that words in both languages are not related to each other but are associated only via a conceptual system, and the word-association model. …”
Get full text