Combined extracts of Syzygium aromaticum (Clove) and Xylopia aethiopica (Negro pepper) seeds inhibit testosterone propionate-induced benign prostatic hyperplasia in Wistar rats by Emmanuel Nnaemeka Uhuo, Simeon Ikechukwu Egba, Chiemeziem Adnma Obike, Paul Ndubuisi Anyiam, Prince Ogochukwu Alaebo, Pryanka Munachiso Okeke, Emmanuella Chinaza Obinali

“…TP-200 and TP-400 presented relatively normal prostatic histomorphology compared with TP. Conclusion: The mechanisms of BPH inhibition involve the regulation of sex hormone levels and the amelioration of conditions caused by oxidative damage. …”
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Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis by Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng

“…This study evaluated the efficacy and underlying mechanisms of ginsenoside Rg1 in animal models of liver injury and fibrosis, and providing a basis for future clinical investigation.MethodsA systematic review was conducted on preclinical studies published in PubMed, Web of Science, and Embase databases up to 1 August 2024, adhereing to rigorous quality standards. …”
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Azithromycin removal from water via adsorption on drinking water sludge-derived materials: Kinetics and isotherms studies. by Camilo C Castro-Jiménez, Julio C Saldarriaga-Molina, Edwin F García, Ricardo A Torres-Palma, Nancy Acelas

“…This finding aligns with FTIR analysis, which indicates that adsorption mechanisms involve π-π stacking, hydrogen bonding, and electrostatic interactions. …”
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Tamsulosin use in benign prostatic hyperplasia and risks of Parkinson's disease, Alzheimer's disease and mortality: An observational cohort study of elderly Medicare enrollees. by Kin Wah Fung, Fitsum Baye, Seo H Baik, Clement J McDonald

“…More research is needed to elucidate the underlying mechanisms of these observations. Given the availability of safer alternatives for treating benign prostatic hyperplasia, caution should be exercised when using tamsulosin in elderly patients, especially those with an increased risk of developing neurodegenerative diseases.…”
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Effect of Electroacupuncture on Shoulder Subluxation in Poststroke Patients with Hemiplegic Shoulder Pain: A Sham-Controlled Study Using Multidimensional Musculoskeletal Ultrasound... by Minghong Sui, Naifu Jiang, Luhui Yan, Jiaqing Liu, Bin Luo, Chenxi Zhang, Tiebin Yan, Yun Xiang, Guanglin Li

“…Our findings further reveal the analgesic mechanism of EA on hemiplegic shoulder pain following stroke.…”
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Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 by Roda Alhasan, Lena Rafsten, Lena Rafsten, Alexandra C. Larsson, Alexandra C. Larsson, Katharina S. Sunnerhagen, Katharina S. Sunnerhagen, Katharina S. Sunnerhagen, Hanna C. Persson, Hanna C. Persson

“…Further research is important to unravel the mechanisms of long-term symptoms following COVID-19 and to develop effective therapeutic and rehabilitative interventions.…”
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Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations by Imad Ed-Dahmani, Mohamed El Fadili, Ghizlane Nouioura, Fahd Kandsi, Yassine El Atki, Hatem A. Abuelizz, Raffaele Conte, Fatima Zahra Lafdil, Abdeslam Taleb, Abdelfattah Abdellaoui, Mustapha Taleb

“…The major compound of the studied extract, namely, p-hydroxybenzoic acid, was chosen for a molecular docking technique to discover the inhibition mechanism toward antioxidant proteins. In addition, a detailed molecular dynamics simulation was carried out to examine the thermodynamic stability of the produced intermolecular interactions. …”
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Clinical Analysis of the Patients with Isolated Low-Velocity Penetrating Neck Injury by Junepill Seok, Hyun Min Cho

“…We analyzed the patients’ age, gender, injury mechanism and causes by medical chart review. Results Among total of 36 patients, 26 (72.2%) were male and 10 (27.8%) were female. …”
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Assessing inflammatory protein factors in inflammatory bowel Disease using multivariable mendelian randomization by Qiang Su, Yun Lu, Song He, Jiang Liang, Song Huang, Yuanli He, Zhenxiang An

“…These findings provide novel insights into the biological mechanisms of IBD, and have implications for the screening, prevention, and treatment of IBD.…”
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Time effect of elastic energy release of surrounding rock and evaluation method of reasonable advancing speed by Ruifu Yuan, Qi Ma, Qunlei Zhang, Chun Feng, Chunfu Wei, Yan Gao

“…Abstract To reveal the rock burst mechanism, the stress and failure characteristics of coal-rock strata under different advancing speeds of mining working face were explored by theoretical analysis, simulation, and engineering monitoring. …”
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Enzyme-Aided Treatment of Fruit Juice: A Review by Liew Phing Pui, Lejaniya Abdul Kalam Saleena

“…For some raw materials, enzymatic procedures are more efficient than mechanical comminution or thermal processing. The fruit juice industry uses enzymes for streamlining. …”
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The BASIDIN effector of the fungus Moniliophthora perniciosa promotes positive effects on the seed germination and seedlings development of Lactuca sativa by Keilane Silva Farias, Monaliza Macêdo Ferreira, Ivina Barbosa De Oliveira, Ronaldo José Durigan Dalio, Carlos Priminho Pirovani

“…Plant resistance inducers that activate plant defense mechanisms may be useful in reducing agrotoxic use. …”
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Insulin Resistance Markers to Detect Nonalcoholic Fatty Liver Disease in a Male Hispanic Population by Maritza Pérez-Mayorga, Jose P. Lopez-Lopez, Maria A. Chacon-Manosalva, Maria G Castillo, Johanna Otero, Daniel Martinez-Bello, Diego Gomez-Arbelaez, Daniel D. Cohen, Patricio Lopez-Jaramillo

“…Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease and is closely associated with cardiometabolic disorders, being insulin resistance (IR) the common pathogenic mechanism. The triglycerides/glucose (TyG) index and triglycerides/HDL-c (TG/HDL) ratio are markers correlated with IR. …”
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Effect of extracted phycocyanin by-products as a synbiotic supplement on the production performance and intestinal morphology of broilers by Kannikar Hamprakorn, Buaream Maneewan, Wantamas Jantasin, Mohd Nizam Lani, Tossapol Moonmanee, Julakorn Panatuk

“…Further research is recommended to explore the mechanisms underlying these effects and their implications for long-term poultry health and productivity.…”
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Transcriptomic responses of sponge holobionts to in situ, seasonal anoxia and hypoxia by Strehlow, Brian W., Schuster, Astrid, Francis, Warren R., Eckford-Soper, Lisa, Kraft, Beate, McAllen, Rob, Nielsen, Ronni, Mandrup, Susanne, Canfield, Donald E.

“…The tolerance of some sponges to prolonged anoxia warrants further investigation and could give them an advantage in future oceans following climate change as well as in ancient oceans when oxygen concentrations were lower than at present.…”
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Distribution and frequency of genetic mutations in three insecticide targets in field populations of Culex tritaeniorhynchus in Mianyang City, Sichuan Province, China by Hongwei Xie, Meilin Tang, Hongying Sun, Zhengzheng Huang, Mengmeng Dong, Xianying Wen

“…Unfortunately, there is little information on the status and underlying mechanisms of insecticide resistance in field populations of Cx. tritaeniorhynchus, the main JE vector in this region. …”
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Effect of Artemisia annua on anticoccidial action, intestinal microbiota and metabolites of Hu lambs by Shuaiqi Liu, Shiheng Li, Shuqi Cheng, Manyu Liu, Jing Li, Senyang Li, Xiaoying Li, Longxian Zhang, Fuchun Jian

“…These differences in gut microbiota and metabolites provide valuable insights for subsequent research on the mechanisms underlying anticoccidial action.…”
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FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle by Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Fan Wang, Fan Wang, Fan Wang, Fan Wang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Yongping Zhang, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…Furthermore, we used db/db mice and FGF21 direct therapy for 8 weeks to investigate changes in fasting glucose and creatinine expression as well as pathological changes in glomeruli glycogen deposition, fibrosis, and nephrin expression. To investigate the mechanism of action of FGF21 in the treatment of glycolytic kidney, transcriptome sequencing of renal tissues and KEGG pathway enrichment analysis of differential genes were performed.ResultsThe study’s findings demonstrated that FGF21 intervention increased clotting time, decreased oxidative stress and inflammation, and avoided thrombosis in addition to considerably improving glomerular filtration damage. …”
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Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of <i>Ganoderma lucidum</i> by Xiaolan Xu, Chunxia Li, Fangjing Wu, Shuangshuang Zhao, Tiqiang Chen, Haihong You, Yijie Lin, Xiaoxing Zou

“…However, the manner in which they accumulate, and their biosynthesis mechanisms remain unclear. To screen for the genes that are involved in the biosynthetic pathway of GTs, this study analyzed the differential metabolites and differentially expressed genes (DEGs) among different growth stages of <i>G. lucidum</i>, including the primordia (P), the matured fruiting body (FM), and the post-spore fruiting bodies (FP) using targeted metabolomics and transcriptomics analysis, respectively. …”
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The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways by Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song

“…Western blot analysis showed that hAAT reduced the expression of the active form (cleaved) of TLR9 in DCs, indicating a novel mechanism of hAAT function in the immune system. We next tested the effect of hAAT on TLR7/8 signaling. …”
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