MicroRNA-150-3p enhances the antitumour effects of CGP57380 and is associated with a favourable prognosis in non-small cell lung cancer by Hongmei Zheng, Songqing Fan, Jiadi Luo, Qiuyuan Wen, Hongjing Zang

“…Additionally, this study provides valuable insights into the molecular mechanisms underlying the effects of this treatment.…”
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Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo by Sura Akram, Ahmed Majeed Al-Shammari, Hayder B. Sahib, Majid Sakhi Jabir

“…Furthermore, combination therapy is favorable, as it attacks cancer cells with multiple mechanisms and enhances virus entrance into the tumor mass, overcoming cancer cells’ resistance to therapy. …”
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Scraping Therapy and Muscle Resistance Training in Patients with Neck Dysfunction by Yucheng DUAN, Guangping SHEN, Xinjian LI, Enming ZHANG, Zhenmin BAI, Anli WANG

“…Objective:To investigate the effect of muscle resistance training and scraping therapy on patients with neck dysfunction and evaluate the treatment effect and follow-up effect so as to research on the mechanism of neck dysfunction.Methods:Gave one time isometric muscle resistance training to subjects suffering from neck dysfunction in the resistance training group (<italic>n</italic>=15), one time scraping therapy to subjects in scraping group (<italic>n</italic>=15), and evaluated the neck function through the visual analogue scale (VAS), neck disability index (NDI) and range of motion (ROM) before the intervention, immediately after the intervention, on the 3rd day after the intervention.Results:Compared with the VAS before the intervention, there was a very significant decrease in VAS immediately after the intervention in scraping group (<italic>P</italic>&lt;0.01) and resistance training group (<italic>P</italic>&lt;0.05). …”
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siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study by Muhammad Hossein Ashoub, Ali Afgar, Alireza Farsinejad, Razieh Razavi, Samira Anvari, Ahmad Fatemi

“…Given that hTERT overexpression characterizes various cancer phenotypes and elevated telomerase activity is observed in early-stage and relapsed ALL, we investigated the molecular mechanisms linking hTERT regulation and ferroptosis in leukemia cells. …”
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Morphological Changes of Renal Corpuscles in Male Mongolian Gerbils at Different Ages by LI Meng, CHEN Bai'an, LU Jing

“…Objective By observing and comparing the changes in renal corpuscles at the largest longitudinal section in male Mongolian gerbils of different ages, this study preliminarily explored potential patterns of renal corpuscle changes, providing foundational data for the selection of male Mongolian gerbils for research on the pathogenic mechanisms and drug screening of nephropathy. Methods Kidney samples were collected from male Mongolian gerbils aged 12, 48, and 72 weeks. …”
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Effect of Reforestation Tree Species on the Distribution and Stability of Purple Soil Aggregates by ZHONG Yujian, HE Feng, HAN Guangzhong, ZHAO Xia, YANG Fan

“…[Objective] Afforestation following the Grain for Green initiative is a crucial measure to improve soil structure and reduce soil erosion. Understanding the mechanisms of the effects of afforestation tree species on the formation of soil aggregates can provide valuable insights for soil conservation. …”
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Electrooxidation and Development of a Highly Sensitive Electrochemical Probe for Trace Determination of the Steroid 11-Desoxycorticosterone Drug Residues in Water by Wejdan T. Alsaggaf, Mohammad S. El-Shahawi

“…The dependency of the anodic peak current of the CV at 0.4 V at various concentrations and scan rate of the DCS drug was characteristic of an electrode-coupled electron transfer of EE type mechanism. At the optimized parameters, the proposed strategy allowed quantification of DCS in the concentration range 2.5 -13.19 nM (0.83-4.36 ng mL−1) with satisfactory limits of detection (LOD) and quantization (LOQ) of 9.3 × 10−1 nM (3.1 × 10−1 ng mL−1) and 3.1 nM (1.02 ng mL−1), respectively. …”
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Single-cell transcriptome analysis reveals cellular reprogramming and changes of immune cell subsets following tetramethylpyrazine treatment in LPS-induced acute lung injury by Mingyan Wu, Shanmei Wang, Xiaolan Chen, Li Shen, Jurong Ding, Hongbin Jiang

“…Tetramethylpyrazine (TMP) has shown potential in ALI treatment, and understanding its effects on the pulmonary microenvironment and its underlying mechanisms is imperative. Methods We established a mouse model of lipopolysaccharide (LPS)-induced ALI and performed single cell RNA sequencing (scRNA-seq). …”
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Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province by Bingsi Gao, Xingping Zhao, Xinyi Liu, Xuan Yang, Aiqian Zhang, Huan Huang, Yu-ligh Liou, Dabao Xu

“…This study provided insights into the potential change of gut microbiota of MAs and the potential underlying mechanisms through certain impaired lipid metabolism and aroused inflammation pathways. …”
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Practitioner, patient and public views on the acceptability of mobile stroke units in England and Wales: A mixed methods study. by Lisa Moseley, Peter McMeekin, Christopher Price, Lisa Shaw, Anna Laws, Michael Allen, Gary A Ford, Martin James, Stephen McCarthy, Graham McClelland, Laura J Park, Kerry Pearn, Daniel Phillips, Phil White, David Wilson, Jason Scott

“…<h4>Background</h4>Evidence for Mobile Stroke Units (MSUs) demonstrates that onset to treatment times for intravenous thrombolysis can be reduced and access to mechanical thrombectomy might be improved. Despite growing use of MSUs internationally, to date there have been no studies in NHS England and NHS Wales exploring the acceptability of MSUs to clinicians, patient and public representatives and other key stakeholders, which are important when considering potential feasibility and implementation.…”
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Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity by Yue Fang, Lingjie Meng, Jun Xia, Yasuhiro Gotoh, Tetsuya Hayashi, Keizo Nagasaki, Hisashi Endo, Yusuke Okazaki, Hiroyuki Ogata

“…However, the underlying genetic mechanisms driving such dynamics of these viruses remain largely unknown. …”
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Synthesis and Characterization of Modified Kaolin-Bentonite Composites for Enhanced Fluoride Removal from Drinking Water by Ebenezer Annan, Emmanuel Nyankson, Benjamin Agyei-Tuffour, Stephen Kofi Armah, George Nkrumah-Buandoh, Joanna Aba Modupeh Hodasi, Michael Oteng-Peprah

“…The adsorbents were characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) formulation, and Brunauer–Emmett–Teller (BET), whereas the adsorption mechanism and the kinetics were explained using the Langmuir isotherm, Freundlich models, and pseudo-first-order and pseudo-second-order models. …”
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Survey situation of mental health of pregnant women with breast cancer: A systematic review study by Nasim Khademi, Farzaneh Rahimi, Shadi Goli

“…To improve the level of mental health of women with cancer in Iran, the following solutions are suggested: 1. strengthening mental health services in primary health care, 2. appointing the trustee of the unit to improve the level of interdepartmental leadership and intradepartmental governance, 3. determining sustainable and targeted financial resources to provide mental health services needed by pregnant women with cancer, 4. moving the financial resources allocated to insurance mechanisms for greater financial protection, 5. expanding the umbrella of social support, and 6. a behavioral educational program that can be used to improve mental health, especially the symptoms of depression and anxiety in pregnant women with cancer.…”
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Partially Isolated Dual Work Function Gate IGZO TFT With Obviously Reduced Leakage Current for 3D DRAMs by Yunjiao Bao, Gangping Yan, Lei Cao, Chuqiao Niu, Qingkun Li, Guanqiao Sang, Lianlian Li, Yanzhao Wei, Xuexiang Zhang, Jie Luo, Yanyu Yang, Gaobo Xu, Huaxiang Yin

“…The relevant operation mechanism is carefully demonstrated and verified by the simulation of the electric field and potential barrier results by technical computer-aided design (TCAD). …”
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Associations between dietary fatty acids and kidney stones by Ning Tan, Ya Zhang

“…Future research is needed to further elucidate the underlying mechanisms and to refine dietary recommendations.…”
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A Vitamin Pattern Diet Is Associated with Decreased Risk of Gestational Diabetes Mellitus in Chinese Women: Results from a Case Control Study in Taiyuan, China by Qiong Chen, Yongliang Feng, Hailan Yang, Weiwei Wu, Ping Zhang, Keke Wang, Ying Wang, Jamie Ko, Jiaxin Shen, Lingling Guo, Feng Zhao, Wenqiong Du, Shouhang Ru, Suping Wang, Yawei Zhang

“…Additional studies are necessary to explore the underlying mechanism of this relationship.…”
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Enhancing individual task performance and productivity: an ethnographic observational study of supported employment among social services clients in Finland by Pirjo Juvonen-Posti, Mirkka Vuorento

“…From the perspectives of both enabling prolonged working careers for employees and providing a clear understanding of task-performance-based productivity to employers, there is a need for more microlevel data on what happens in work and workplaces, particularly the social mechanisms through which results are achieved.…”
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Moisture Sorption by Low‐Cost Pyridinium‐Based Protic Ionic Liquids: Kinetics and Physico‐Electrochemical Properties by Sayyar Muhammad, Najia, Zarshad Ali, Samina Aziz, Muhammad Hammad Khan, Maroosh Iqbal, Umair Hassan, Jalal Khan, Asad Ali

“…The electrochemical window (EW) data, the mechanism of moisture oxidation within the EWs of each PIL at Pt and Au electrodes, and the electrocatalytic role played by the Pt and Au surface oxides during ethanol oxidation are evaluated and discussed in light of their future sustainable energy applications.…”
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Thermally Induced Phenomena in Amorphous Nifedipine: The Correlation Between the Structural Relaxation and Crystal Growth Kinetics by Roman Svoboda

“…Overall, nifedipine was found to be prone to the rapid glass-crystal growth that occurs below the glass transition temperature; a tendency of low-temperature degradation of the amorphous phase markedly increased with decreasing particle size (the main reason being the increased number of surface and bulk micro-cracks and mechanically induced defects). The activation energies of the DSC-monitored crystallization processes varied in the 100–125 kJ·mol⁻¹ range, which is in agreement with the microscopically measured activation energies of crystal growth. …”
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Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus by Zhirong Miao, Honghua Wu, Liu Ren, Nan Bu, Lili Jiang, Huixia Yang, Junqing Zhang, Xiaohui Guo

“…The objective of the present study was to explore the long-term postpartum glucose metabolism in women with previous GDM, and study the mechanism of hyperglycemia from gestation to postpartum by investigating the postpartum insulin resistance and insulin secretion. …”
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