Role of the very low frequencies of the renal oxygen saturation signal in acute kidney injury in newborns with perinatal asphyxia by Daniel Botero-Rosas, Sergio Agudelo-Pérez, Sergio Agudelo-Pérez, Gloria Troncoso, Maria C. Gómez, Eduardo Tuta-Quintero

“…ObjectiveRenal autoregulation, hemodynamic response, and endothelial dysfunction play significant roles in acute kidney injury (AKI) during perinatal asphyxia. A third mechanism of autoregulation, involving very low-frequency oscillations, has been described. …”
Get full text

Comprehensive analysis of the prognostic, immunological, and diagnostic roles of SIRT1 in pan-cancer and its validation in KIRC by Qi Liu, Songxian Sun, Chunxiang Zhou, Houxi Xu, Houxi Xu

“…Quantitative reverse transcription polymerase chain reaction (qRT–PCR) and Western blot (WB) analyses confirmed that SIRT1 is differentially expressed in kidney renal clear cell carcinoma (KIRC).ConclusionsUsing an integrative approach involving bioinformatics analysis and experimental validation, we clarified the potential roles and mechanisms of SIRT1 in pan-cancer, providing a theoretical basis for the development of SIRT1-targeted therapies in clinical applications.…”
Get full text

Hippocampal dendritic spines store-operated calcium entry and endoplasmic reticulum content is dynamic microtubule dependent by Anastasiya Rakovskaya, Ekaterina Volkova, Ilya Bezprozvanny, Ekaterina Pchitskaya

“…Abstract One of the mechanisms of calcium signalling in neurons is store-operated calcium entry (SOCE), which is activated when the calcium concentration in the smooth endoplasmic reticulum (ER) decreases and its protein-calcium sensor STIM (stromal interacting molecule) relocate to the endoplasmic reticulum and plasma membrane junctions, forms clusters and induces calcium entry. …”
Get full text

College major decision making behavior of urban and rural students under cultural capital impact in China by Congbin Guo, Mengchao Guo, Chenchen Fang, Xiaowei Hao

“…These findings have implications for behavioral economics, social cognition theory, and educational policy, offering insights into the mechanisms of social mobility and the perpetuation of educational inequalities.…”
Get full text

Cellular heterogeneity and cytokine signatures in acute myeloid leukemia: A novel prognostic model by Jinxia Cao, Bin Hu, Tianqi Li, Dan Fang, ling Jiang, Jun Wang

“…Additionally, our in-depth investigation into the immune landscape revealed marked differences in immune cell infiltration and cytokine signaling between the identified risk groups, shedding light on potential immune-mediated mechanisms driving disease progression and treatment resistance. …”
Get full text

To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway by Jia-Rong Gao, Xiu-Juan Qin, Zhao-Hui Fang, Li-Shan, Li-Ping Han, Hui-Jiang, Ming-Fei Guo, Nan-Nan Jiang

“…This study was to determine the influence of high glucose and related mechanism of vascular lesion of type 2 diabetes mellitus pathogenesis. …”
Get full text

Microplastic polymers in shellfish and fish in the coastal area by S. Basri K., A. Daud, A.B. Birawida, M. Maming, H.J. Mukono, D.S. Arsyad

“…Sample preparation, including enzymatic digestion and mechanical destruction, was performed to separate the organic tissues of fish and shellfish into small particles. …”
Get full text

The skin manifestations in end-stage renal disease patients in Jordan, single-center experience by Mohammad Hassan Al-thnaibat, Heba M. Urabi, Hadeel S. Alkofahi, Ola Mohannad Alshriedeh, Raneem Alshraideh, Hanan Esmadi, Ahmed Sheyyab, Bakri Roumi Jamal, Hanan Khaled Hasan

“…Moving forward, targeted research into the underlying mechanisms and innovative therapeutic approaches is essential to enhance both dermatological outcomes and overall patient well-being.…”
Get full text

Ac2-26 Alleviates Brain Injury after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats via the eNOS Pathway by Jing Gong, Qi-Hang Tai, Guang-Xiao Xu, Xue-Ting Wang, Jing-Li Zhu, Xiao-Qing Zhao, Hai-Bin Sun, Dan Zhu, Wei Gao

“…This study is aimed at determining the mechanism by which Ac2-26 protects against inflammation during brain injury following CA and CPR. …”
Get full text

Mechanistic insights into “Three Methods and Three Acupoints” Tuina therapy for improving spinal microcirculation and motor function in sciatic nerve injury model rats by Hanyu Zhang, Yingqi Zhang, Hourong Wang, Jiayue Liu, Jiawei Sun, Jinping Chen, Zhifeng Liu, Tianyuan Yu, Jian Shu

“…Conclusion: TMTP Tuina therapy may restore motor function in rats, enhance ventral horn motor neuron morphology, and promote angiogenesis and vascular smooth muscle proliferation. The mechanism may involve the activation of the PI3K/Akt signaling pathway.…”
Get full text

Compression Performance of Newly Designed Replaceable Tubular Steel Piers by Haifeng Li, Xuehang Zhao, Wei Sun, Zhe Xiong

“…For type IV-A specimens with LYP steel tubular plates and constrained steel plates on both sides, the mechanical behaviour of the new tubular steel piers is significantly improved, and increasing the height of the constrained LYP steel tubular plate can improve the compressive behaviour of the new tubular steel pier. …”
Get full text

Relevance of anxiety in clinical practice of Guillain-Barré syndrome: a cohort study by Raphaël Porcher, Djillali Annane, Andrea Polito, Tarek Sharshar, Takoua Merhbene, Morgane Blanc, Marion Antona, Marie-Christine Durand, Diane Friedman, David Orlikowski, Marie-Hélène Marcadet

“…Either language barrier or cognitive decline that precluded understanding was considered as exclusion criteria.Primary outcome Acute respiratory failure.Interventions At admission, anxiety and clinical factors (including known predictors of respiratory failure: delay between GBS onset and admission, inability to lift head, vital capacity (VC)) were assessed and related to subsequent need for mechanical ventilation (MV). Anxiety was assessed using a Visual Analogical Scale (VAS), the State Anxiety Inventory form Y1 (STAI-Y1) score and a novel-specific questionnaire, evaluating fears potentially triggered by GBS. …”
Get full text

Factors influencing participation in physical activity for persons living with dementia in rural and northern communities in Canada: a qualitative study by Chelsea Pelletier, Laura Elizabeth Middleton, Shannon Freeman, Kirsten Ward, Lauren Bechard, Kayla Regan, Salima Somani

“…Limited capacity in the health system to support physical activity due to a lack of referrals, poor communication mechanisms and limited resources for programming created challenges for physical activity participation. …”
Get full text

Zinc oxide seed priming enhances drought tolerance in wheat seedlings by improving antioxidant activity and osmoprotection by Rasha M. El-Shazoly, A. A. Othman, Muhammad Saqlain Zaheer, Ahmed F. Al-Hossainy, Dalia A. Abdel-Wahab

“…In conclusion, the application of ZnO NPs or bulk ZnO was found to create effective mechanical and physiological barriers, as confirmed by the analysis of antioxidant enzyme activities, nonenzymatic components, free radical scavenging, and osmoprotectant constituents.…”
Get full text

Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells by Yongsheng Zeng, Chengcheng Du, Pengcheng Xiao, Yiting Lei, Piao Zhao, Zhenglin Zhu, Shengqiang Gao, Bowen Chen, Shengwen Cheng, Wei Huang, Chen Zhao

“…Therefore, the underlying mechanism is not clear. Currently, an increasing number of studies have shown that microRNAs play a pivotal role in chondrogenic and pathophysiological processes of cartilage. …”
Get full text

High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population by Hongyang Wang, Dan Bing, Jin Li, Linyi Xie, Fen Xiong, Lan Lan, Dayong Wang, Jing Guan, Qiuju Wang

“…To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and identified by Sanger sequencing or next-generation sequencing; the participants included 30 patients from 16 reported families and 20 new cases. …”
Get full text

Simple hypertrophic tonsils have more active innate immune and inflammatory responses than hypertrophic tonsils with recurrent inflammation in children by Qun Huang, Hu Hua, Wei Li, Xi Chen, Lei Cheng

“…These differences, together with the patient’s clinical manifestations, suggest that tonsillar hypertrophy might be regulated by diverse immune and/or inflammatory mechanism through which novel therapeutic strategies might be created.…”
Get full text

Mekong cooperation frameworks and geopolitical dynamics: a Cambodian perspective by Kin Phea

“…The author also emphasizes leveraging existing ASEAN mechanisms for collective action and advocating for a unified approach to the Mekong. …”
Get full text

Impact of Alzheimer’s Disease on Caregivers in the United States by Megan Vu, Rohan Mangal, Thor Stead, Carlos Lopez-Ortiz, Latha Ganti

“…Caregivers rely on numerous support systems and coping mechanisms, with physical activity (54.5%) and increased alcohol and marijuana usage (35.5%) the most frequent…”
Get full text

The BET inhibitor JQ1 targets fat metabolism and counteracts obesity by Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna

“…Conclusion: In conclusion, the current data highlight a potential benefit of JQ1 administration to counteract obesity, suggesting epigenetic modulation as a prospective target in the treatment of obesity and sarcopenic obesity, despite the underlying multiorgan molecular mechanism is still not completely elucidated.…”
Get full text