Emerging Strategies in Cartilage Repair and Joint Preservation by Mircea Adrian Focsa, Sorin Florescu, Armand Gogulescu

“…Gene-editing tools like CRISPR/Cas9 have facilitated targeted cellular modifications, while novel biomaterials such as hydrogels, biodegradable scaffolds, and 3D-printed constructs have improved mechanical support and tissue integration. Additionally, biophysical stimuli like low-intensity pulsed ultrasound (LIPUS) and electromagnetic fields (EMFs) have enhanced chondrogenic differentiation and matrix production. …”
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Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition by Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao

“…However, the molecular mechanisms underlying renal fibrosis following AKI remain unclear. …”
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How resistant is anammox biofilm against antibiotics: A special insight into anammox response towards fluoroquinolones by Faysal-Al Mamun, Rohit Kumar, Kelvin Ugochukwu Anwuta, Sovik Das, Madis Jaagura, Koit Herodes, Tetyana Kyrpel, Agnieszka Fiszka Borzyszkowska, Anna Zielińska-Jurek, Zane Vincevica-Gaile, Juris Burlakovs, Andrey E. Krauklis, Mohamad Nor Azra, Md Salauddin, Jiexi Zhong, Taavo Tenno, Kai Bester, Ivar Zekker

“…Future research should investigate the mechanisms that underlie the anammox biofilms' resistance to various types of PhACs and investigate the long-term stability and scalability of this process with real wastewater influents.…”
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Multi-omics elucidates the kidney damage caused by aquatic Cu via the gut-kidney axis in ducks by Mingcai Duan, Jinyu Liu, Zhaoxia Cai, Li Chen, Yong Tian, Wenwu Xu, Tao Zeng, Tiantian Gu, Lizhi Lu

“…These findings shed light on the underlying mechanisms of Cu-induced kidney damage via the indirect pathway of the gut-kidney axis.…”
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Interfacial tension reduction using nitrogen graphene quantum dots with various precursors, molar ratios, and synthesis durations for enhanced oil recovery by Younes Gholamzadeh, Abdolhossein Hemmati-Sarapardeh, Mohammad Sharifi

“…In this paper, Graphene Quantum Dots (GQDs) with simple and favorable properties are developed, and their performance and mechanism for reducing IFT are evaluated. The paper also aims to explore the effects of GQD precursor type, synthesis duration, and molar percentages of precursors on reducing IFT. …”
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Functional alignment is a feasible alignment strategy in robotic assisted total knee arthroplasty for knee osteoarthritis with extra-articular deformity – A case series by Eu Wei Cheong, Yuik Ho Jade Pei, Kunalan G.

“…Intraarticular correction by TKA, which was previously performed with conventional manual jig by mechanical alignment technique, had its limits and difficulties especially extensive soft tissue release and risk of jeopardizing the collateral ligaments. …”
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Sustainable geopolymer adsorbents utilizing silica fume as a partial replacement for metakaolin in the removal of copper ion from synthesized copper solution by Pilomeena Arokiasamy, Mohd Mustafa Al Bakri Abdullah, Eva Arifi, Noorina Hidayu Jamil, Md Azree Othuman Mydin, Shayfull Zamree Abd Rahim, Andrei Victor Sandu, Shafiq Ishak

“…In addition, S1 contains exchangeable cations such as Ca2+, Mg2+ and Na+ which further promote the adsorption of Cu2+ by ion exchange. Moreover, the mechanisms such as chemical bonding and precipitation were involved in the adsorption of Cu2+. …”
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Maternal milk fat globule membrane enriched gut L. murinus and circulating SCFAs to improve placental efficiency and fetal development in intrauterine growth restricted mice model by Cuiping Feng, Yujun Wu, Xiangyu Zhang, Shuxian Wang, Junjun Wang, Huixia Yang

“…In addition, fecal microbiota transplantation (FMT) with MFGM-derived microbiota reprinted the promoted phenotypes of maternal litter characteristics, gut L. murinus enrichment, placental efficiency, and fetal gut development in MFGM-fed pregnant mice, which were also recapitulated by exogenous administration with L. murinus or SCFAs cocktail. Mechanically, MFGM, MFGM-derived microbiota, L. murinus, or SCFAs cocktail activated IUGR-induced depressive phosphorylation of PI3K-Akt signaling in the placenta. …”
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Assessing left main bifurcation anatomy and haemodynamics as a potential surrogate for disease risk in suspected coronary artery disease without stenosis by R. Gharleghi, M. Zhang, C. Shen, M. Webster, C. Ellis, S. Beier

“…Our results indicate that specific anatomical vessel characteristics may be used as a surrogate of adverse haemodynamics environment associated with clinically adverse mechanisms of disease. This is especially powerful with the latest computing resources and may unlock clinical integration via standard imaging modalities as biomarkers without further computationally expensive simulations.…”
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Advancing Pandemic Preparedness in Healthcare 5.0: A Survey of Federated Learning Applications by Saeed Hamood Alsamhi, Ammar Hawbani, Alexey V. Shvetsov, Santosh Kumar

“…We start by laying out the concepts of FL and Healthcare 5.0, followed by an analysis of current pandemic preparedness and response mechanisms. We delve into FL’s applications and case studies in healthcare, highlighting its potential benefits, including privacy protection, decentralized decision-making, and implementation challenges. …”
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Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…Introduction Yeast beta-glucan (YBG) are recognised for enhancing the immune system by activating macrophages, a key defence mechanism. Given the global prevalence and impact of upper respiratory tract infections (URTIs) on productivity and healthcare costs, YBG has shown promise as a potential therapeutic and preventive strategy for recurrent respiratory tract infections. …”
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Differential expression of circulating microRNAs in lactating Holstein and Jersey cows exposed to heat stress by Jihwan Lee, Doosan Kim, Byeonghwi Lim, Gyeonglim Ryu, Hyeonguk Baek, Joohwan Kim, Seungmin Ha, Sangbum Kim, Seunghwan Lee, Taejeong Choi, Inchul Choi

“…To explore molecular mechanisms, we analyzed circulating microRNA profiles from whole blood samples collected under heat stress and normal conditions using microRNA-sequencing. …”
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TRANSFORMATION AND SCATTERING OF SURFACE WAVES ON THE ACOUSTIC LOAD TO ULTRASONIC EVALUATION AND MEASUREMENTS. Part 2. The object to study – solid with ledge by A. R. Baev, A. L. Mayorov, M. V. Asadchaya, G. E. Konovalov, O. S. Sergeeva

“…The aim of this work was to study of mechanism of acoustical mode's transformation and determination the laws of the fields forming of scatted volume edge wave's in solids with ledge of different geometry and to suggest direction of the study application in area of acoustical testing and measurements.The features of transformation of surface waves into edge transverse and longitudinal wave modes scatted and their fields forming in the volume of the object with ledge vs. its angle of the slope front surface side (0–135°) and a dimensionless transition radius (0–10,2) varied were studied. …”
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Transformer-Based Ionospheric Prediction and Explainability Analysis for Enhanced GNSS Positioning by He-Sheng Wang, Dah-Jing Jwo, Yu-Hsuan Lee

“…To gain a deeper understanding of the model’s prediction mechanism, we employ integrated gradients for explainability analysis. …”
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THE EFFECT OF PROPANOLOL ON C-REACTIVE PROTEIN IN PATIENTS WITH SEVERE BURNS AT DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA by Muhammad Aulia U H, Iswinarno Doso Saputro, Magda Rosalina Hutagalung

“…Highlights: • The biochemical marker of inflammation and suggests a potential mechanism through which propranolol affects hypermetabolism in burn patients…”
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Effect of Jiangu Granule on miR-141 and Osteogenic Gene Dlx5/Msx2/Runx2 in Ovariectomized Mice by Zhiheng ZHANG, Wenming ZHANG, Zhenpu WEI, Chutian ZHANG, Juan YANG, Yanping LIN

“…Objective:To observe the effect of Jiangu granule on the expression of miR-141, Dlx5, Msx2 and Runx2 in bone tissue of ovariectomized mice, and to explore the mechanism of Jiangu granule in preventing and treating postmenopausal osteoporosis.Methods:A total of 30 C57 mice were randomly divided into sham operation group, saline group and Jiangu granule group, with 10 cases in each group. …”
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Lactiplantibacillus plantarum (CECT7484 and CECT7485) and Pedioccoccus acidilactici (CECT7483) enhance actin cytoskeleton and CYP1A1 expression restoring epithelial permeability al... by Maria Raffaella Barbaro, Francesca Bianco, Cesare Cremon, Giovanni Marasco, Francesca Bonomini, Marta Palombo, Cecilia Delprete, Marta Perez, Jordi Espadaler-Mazo, Vincenzo Stanghellini, Simone Guglielmetti, Giovanni Barbara

“…The aim of the present study was to assess the ability of a probiotic blend (PB) consisting of two Lactiplantibacillus plantarum strains (CECT7484 and CECT7485) and one strain of Pediococcus acidilactici (CECT7483) to recover the permeability increase induced by mediators from IBS mucosal biopsies and to highlight the underlying molecular mechanisms. Twenty-one IBS patients diagnosed according to ROME IV criteria (11 IBS-D and 10 IBS-M) and 7 healthy controls were enrolled. …”
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Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status by Leon Marković, Anja Bukovac, Ana Maria Varošanec, Antonia Jakovčević, Davor Tomas, Zdenko Sonicki, Borna Puljko, Fran Dumančić, Reno Hrašćan, Nives Pećina-Šlaus

“…While TNM classification helps in prognosis, understanding molecular mechanisms is vital for the clinical behavior of retinoblastoma prediction. …”
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Prenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort by Hui Wang, Dezheng Fu, Xiaoning Liu, Xiaochen Chang, Siyu Guo, Xiaomeng Cheng, Ying Tian, Jinjun Ran, Jun Zhang, Shengju Yin

“…Additional research is required to validate our findings and elucidate the underlying mechanisms.…”
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A two‐stage reactive power optimization method for distribution networks based on a hybrid model and data‐driven approach by Ghulam Abbas, Wu Zhi, Aamir Ali

“…For the second stage, a transformer network framework with a self‐attention mechanism and multi‐head attention for deep learning training is applied to uncover the intrinsic and physical spatial relationships among high‐dimensional features. …”
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