KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis by Yonghu Chen, Xilin Wu, Zhe Jiang, Xuezheng Li

“…This study aimed to investigate the molecular mechanisms through which KAE regulates the cGAS-STING pathway in the context of ALI.MethodsALI was induced using LPS. …”
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Repairable electronic products for the circular economy: a review of design for repair features, practices and measures to contrast obsolescence by Nataliia Roskladka, Gianmarco Bressanelli, Nicola Saccani, Giovanni Miragliotta

“…The systematic analysis revealed that, while DfR features (and the relative practices and measures) that contrast mechanical, technological and service obsolescence have been frequently investigated by the literature, lower attention has been dedicated to DfR features preventing relative obsolescence. …”
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Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma by Amir Hossein Alizadeh Bahmani, Susanne J.H. Vijverberg, Simone Hashimoto, Christine Wolff, Catarina Almqvist, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Anna M. Hedman, Michael Kabesch, Leyre López-Fernández, Aletta D. Kraneveld, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Barbara S. Dierdorp, Tamara Dekker, Nariman K.A. Metwally, Jan Willem Duitman, René Lutter, Paul Brinkman, Mahmoud I. Abdel-Aziz, Anke H. Maitland-van der Zee

“…Background Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. …”
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Iron-oxidizing microorganisms affect the iron-bound organic carbon in the subsoil of alpine grassland during the thawing of seasonal frozen soil by Yuxin Tian, Maidinuer Abulaizi, Zailei Yang, Tianle Kou, Yuanbin Jia, Yunpeng Hu, Mo Chen, Mo Chen, Mo Chen, Hongtao Jia, Hongtao Jia, Hongtao Jia

“…We characterized changes in the Fe phase, Fe-OC, Fe-oxidizing bacteria (FeOB), and Fe-reducing bacteria (FeRB) in the subsoil and analyzed the microbial mechanism underlying Fe-OC changes in alpine grassland by constructing a composite structural equation model (SEM). …”
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Categorizing and Determining of BI-RAD Breast Cancer Score by Using Deep Learning Techniques by Azhar Kassem Flayeh, Ali Douik

“…The study investigated DL algorithms (Attention mechanism and efficintNetB7 ) to determine the breast imaging-reporting and data system (BI-RADS) score by categorizing mammography images. …”
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Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction by Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu

“…Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in macrophage necroptosis and inflammasome activation, the downstream mechanism of MLKL in necroptosis remain poorly characterized in AMI. …”
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Valoriser les produits du palmier doum pour gérer durablement le système agroforestier d’une vallée sahélienne du Niger et éviter sa désertification by Régis Peltier, Claudine Serre Duhem, Aboubacar Ichaou

“…A small-sized palm-tree, the doum, has proved to have a significant economic, social and ecological value.The wood of its stem, mechanically resistant and little damaged by termites, is used as timber. …”
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Endometrial Cancer Cells Promote M2-Like Macrophage Polarization by Delivering Exosomal miRNA-21 under Hypoxia Condition by Li Xiao, Yumin He, Fan Peng, Jianlin Yang, Chengfu Yuan

“…In summary, we found that endometrial cancer KEL cells in hypoxic condition promoted monocyte THP-1 cell transformation to M2-like polarization macrophages through delivering exosomal miRNA-21, which may be a potential mechanism of the formation of the immune microenvironment in EC progression.…”
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Renal Tissue-Derived Exosomal miRNA-34a in Diabetic Nephropathy Induces Renal Tubular Cell Fibrosis by Promoting the Polarization of M1 Macrophages by Shuai Zheng, Yi Zeng, Liqing Chu, Taiyang Gong, Sihong Li, Min Yang

“…This study aimed to explore the mechanism of exosomes in macrophages and diabetes nephropathy and the role of miRNA-34a, which might provide a new path for treating DN. …”
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Causal Discovery of Flight Service Process Based on Event Sequence by Qian Luo, Lin Zhang, Zhiwei Xing, Huan Xia, Zhao-Xin Chen

“…The study did not conduct an in-depth study of the causal mechanism behind the ground support link and did not reveal the true cause of flight delays. …”
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Prior Anticoagulation and Risk of Hemorrhagic Transformation in Acute Stroke: A Post Hoc Analysis of the PRODAST Study by Gerrit M. Grosse, Anika Hüsing, Andreas Stang, Nils Kuklik, Marcus Brinkmann, Martin Grond, Jens D. Rollnik, Lars Marquardt, Andrea Kraft, Eckhard Schlemm, Carsten Eggers, Christoph C. Eschenfelder, Christian Weimar, Hans‐Christoph Diener

“…These findings were confirmed using sensitivity analyses accounting for thrombolysis and mechanical thrombectomy, as well as timing of brain imaging. …”
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Effect of Traditional Chinese Medicine on Inflammatory Mediators in Pediatric Asthma by Hui Du, Yonghong Wang, Yumin Shi, Jian Yu, Wen Sun, Yiqun Zhang

“…To observe the effects of empirical prescriptions of traditional Chinese medicine (TCM) on inflammatory mediators in pediatric asthma and to explore the underlying molecular mechanism in the treatment of asthma. Methods. A total of 182 children with asthma were randomly placed into either the TCM group (n=97) or the salbutamol and montelukast (SM) group (n=85). …”
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Enhancing Digital Identity and Access Control in Event Management Systems Using Sui Blockchain by Suthir Sriram, P. R. Tharaniesh, Priyanka Saraf, Nivethitha Vijayaraj, Thangavel Murugan

“…It also ensures the validity of tickets and at the same time ensures that the ticket is transferable back and forth while the ownership of the ticket is wholly and clearly disclosed. zkLogin for Seamless User Authentication: zkLogin is then implemented in the platform to ensure users can be authenticated in a Privacy-Preserving manner while at the same time having High Security. This mechanism can be highly beneficial for the users because they can log in as quickly and discreetly as possible without any threat to their accounts’ safety. …”
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Integrating Individual-Based Indices of Contaminant Effects by Christopher L. Rowe, William A. Hopkins, Justin D. Congdon

“…We suggest that investigators adopt a more integrated perspective on contaminant-induced biological changes so that studies of individual-based effects can be better integrated into analyses of mechanisms of population change.…”
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Acute kidney injury in critically ill COVID-19 patients in a tertiary hospital: short and long-term kidney and patient outcomes by Juliana Alves Manhães de Andrade, Gisele Meinerz, Raphael Palma, Eduardo Rech, Marco Antônio Vinciprova Dall’Agnese, Cristiane Bundchen, Fernanda Bordignon Nunes, Gisele Branchini, Elizete Keitel

“…Female gender (p = 0.047), older age (p = 0.047), AKI stage 3 (p = 0.005), requirement of KRT (p < 0.0001), mechanical ventilation (p < 0.0001), and superimposed bacterial infection (p < 0.0001) were significantly associated death within 90 days. …”
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Referring psychiatric patients to occupational health services for earlier return to work – a qualitative implementation study of barriers and facilitators by Mikko Henriksson, Christina Tikka, Pirjo Juvonen-Posti, Marianna Virtanen, Tuula Oksanen

“…Data analysis consisted of analysing the sessions, systematically coding the transcribed texts according to the main domains of CFIR, thematic analysis, and identifying the overarching themes and context-related mechanisms. Results We identified three overarching themes crucially related to the implementation of the model: uncertainty about the scope and boundaries of the cooperation in the model, ambiguity about the size of the target group, and the existing sociocultural and self-stigma related to mental illness. …”
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A Study on Lower Limb Movement Intention Recognition Based on Multi-Source Information Fusion by Siyu Zong, Wei Li, Dawen Sun, Xiaojie Wei, Junjie Chen, Zhengwei Yue, Daxue Sun

“…The MLS algorithm controls the data flow through a flow limiting and sliding time window mechanism to ensure the efficiency and stability of the system in handling large data volumes. …”
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Relationship Between the Salivary Microbiome and Oral Malodor Metabolites in Older Thai Individuals with Periodontitis and the Cytotoxic Effects of Malodor Compounds on Human Oral... by Witsanu Srila, Kritsana Sripilai, Thunwa Binlateh, Peungchaleoy Thammanichanon, Watcharaphol Tiskratok, Parinya Noisa, Paiboon Jitprasertwong

“…<b>Conclusions</b>: This study provides insights into the mechanisms of halitosis by exploring the correlations between microbiota and metabolite profiles. …”
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Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial. by Yu-Hao Lin, Zhi-Jun Zhang, Jin-Qing Zhong, Zhi-Yi Wang, Yi-Ting Peng, Yan-Mei Lin, Huo-Ping Zhang, Jian-Qing Tian

“…The results can provide important insights into mechanisms of GLP-1 receptor agonists and/or SGLT-2 inhibitors in patients with NAFLD and T2DM.…”
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Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae by Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing

“…Our AlphaFold-assisted structure-function relationship studies underline that tetramerization is essential for bacterial UGP function and is facilitated by a common mechanism utilizing conserved key residues. Targeting the respective molecular interfaces, which are absent in human UGP, could provide a means of selectively inhibiting the bacterial virulence factor UGP and potentially rendering pathogenic species avirulent.IMPORTANCEThe enzyme uridine diphosphate-glucose pyrophosphorylase (UGP) is important for the virulence of bacterial pathogens and, therefore, a potential drug target. …”
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