Investigation of Coolant Local Hydrodynamics in the Mixed Core of the VVER Reactor by S. M. Dmitriev, A. V. Gerasimov, A. A. Dobrov, D. V. Doronkov, A. N. Pronin, A. V. Ryazanov, D. N. Solntsev, A. E. Khrobostov

“…The results of the study of the coolant cross flow between fuel assemblies interaction, i.e. between the adjacent TVSA-T and TVSA-T mod.2 fuel assemblies were adopted for practical use in the JSC of “Afrikantov OKB Mechanical Engineering” for assessing the heat engineering reliability of VVER reactor cores; also, they were included in the database for verification of computational hydrodynamics programs (CFD codes) and for detailed cell-based calculation of the reactor core.…”
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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy. …”
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Autoregulation of the glial gene reversed polarity in Drosophila by Jamie L. Wood, Saroj Nepal, Bradley W. Jones

“…Evidence supports autoregulation to be one of the mechanisms that maintains repo expression, as ectopic repo expression in embryos can activate repo-lacZ reporter constructs. …”
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N-Butyl-2-Cyanoacrylate Adhesive Versus Absorbable Tacks in Laparoscopic Groin Hernia Repair: A Multicenter Randomized Clinical Trial by Clayton C. Petro, MD, Benjamin K. Poulose, MD, Michael J. Rosen, MD, Alfredo M. Carbonell, II, DO, Adel G. El-Ghazzawy, MD, Jeremy A. Warren, MD, Emanuele Lo Menzo, MD, Ajita S. Prabhu, MD, David M. Krpata, MD, Samuel Szomstein, MD, Vimal Narula, MD, Crystal F. Totten, MD, Kelly R. Haisley, MD, Andrew C. Bernard, MD, Henrik O. Berdel, MD, Jessica K. Reynolds, MD, Zachary D. Warriner, MD, John S. Roth, MD

“…We aimed to determine whether n-butyl-2-cyanoacrylate (NB2C) adhesive is a safe and effective mechanism for nonpenetrating mesh and peritoneal fixation during laparoscopic groin hernia repair. …”
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Comparative Analysis of Financial Flows in the Healthcare Systems of Germany, Austria and Czechia: Opportunities for Savings and Assessing the Tax-Like Nature of Health Insurance C... by Mini, Patrick

“…Recommendations: Policymakers should consider measures such as integrating care services in Germany, streamlining administrative processes in Austria, and refining fund redistribution mechanisms in Czechia. Leveraging digital health technologies and fostering transparency in healthcare financing are critical for achieving systemic savings and equity. …”
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Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer by Feifei Yao, Feng Guo, Chuanzhong Sun, Erdong Wang, Hang Wang, Na Li

“…Research focuses on molecular mechanisms of ferroptosis, including endoplasmic reticulum stress, tumor microenvironment, and autophagy. …”
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Cabozantinib Resolves Bone Scans in Tumor-Naïve Mice Harboring Skeletal Injuries by Michael G. Doran, Daniel E. Spratt, John Wongvipat, David Ulmert, Brett S. Carver, Charles L. Sawyers, Michael J. Evans

“…In summary, although the mechanism by which cabozantinib suppresses radionuclide incorporation into foci undergoing bone remodeling remains unknown, that this phenomenon occurs in tumor-naïve models indicates that caution should be exercised in interpreting the clinical significance of this event.…”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Further researches on SCO may help understand its in-depth mechanisms of action and pave the way for the development of novel drugs to prevent and treat various immune-mediated inflammatory disorders as well as hepatic diseases, thereby significantly advancing its innovations and pharmaceutical applications.…”
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The problem of conservation of gene pools of domesticated animals by Yu. A. Stolpovskiy, I. A. Zakharov-Gezekhus

“…The arguments in favor of preserving local breeds are: 1) economic factors, such as moderation of quality requirements for food products, moderation of hygienic and climatic conditions (new types of diseases, vaccines, changes in the external environment), necessity to keep a reserve for successful breeding, opportunity to use local breeds in harsh environmental conditions; 2) scientific factors, in particular, possibility of studying the gene pool of local breeds in order to reconstruct the evolution of domesticated species (exploring local breeds can reveal the mechanisms of the evolutionary processes, ontogeny, behavior patterns, natural and artificial selection); 3) cultural and historical factors related to the fact that native breeds represent living monuments of traditional culture of the population. …”
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Interaction of norsecurinine-type monomeric and dimeric alkaloids with α-tubulin: a molecular docking study by Gérard Vergoten, Christian Bailly

“…The study contributes to a better understanding of the mechanism of action of Flueggea alkaloids and should help the design of anticancer analogues targeting the pironetin site of α-tubulin.…”
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Recovery Method and Parameter Optimization of a Pilot Test for Conformance Control Flooding and Thermal Recovery in the Offshore Heavy Oilfield by Yanxia Zhou, Xiangguo Lu, Bao Cao, Yigang Liu, Yunbao Zhang, Xun Zhong

“…At last, it is thought that the synergistic effect between conformance control and thermal recovery made more oil recovered, which was intuitively clarified in the mechanism analysis.…”
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Discovery and characterization of complete genomes of 38 head-tailed proviruses in four predominant phyla of archaea by Tianqi Xu, Yimin Ni, Hailing Li, Shuang Wu, Shuling Yan, Lanming Chen, Yongxin Yu, Yongjie Wang

“…Eleven proviruses contain genes linked to antiviral defense mechanisms, including those involved in restriction modification (RM), clustered regularly interspaced short palindromic repeat (CRISPR)-associated (CRISPR–Cas) nucleases, defense island system associated with restriction-modification (DISARM), and DNA degradation (Dnd). …”
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Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway by Li-juan Du, Bing Pang, Yu-meng Tan, Ya-nan Yang, Mei-zhen Zhang, Qing Pang, Min Sun, Qing Ni

“…This study is aimed at investigating the protective effect of BXXD on tert-butyl hydroperoxide- (t-BHP-) induced apoptosis in MIN6 cells and the underlying mechanisms. Methods. MIN6 cells were preincubated with BXXD or liraglutide (Li) with or without PI3K inhibitor LY294002 (LY) for 12 h, following which t-BHP was added to induce MIN6 cell apoptosis. …”
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To stay or to go: resource diversity alters the dispersal behavior of sympatric cryptic marine nematodes by Rodgee Mae Guden, Sofie Derycke, Tom Moens

“…This indicates that resource diversity can alter the dispersal behavior of cryptic species and may be an important mechanism to achieve species coexistence in the field.…”
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Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway by Lu Cao, Wenchao Ding, Yashuo Feng, Chong Guan, Li Liu, Hongyu Xie, Kewei Yu, Dongyan Xu, Lijuan Zhao, Xuan Sha, Xiaoman Deng, Santian Wu, Yangrui Wang, Yi Wu, Tingting Zhang, Nianhong Wang

“…Objective: This study aimed to explore the cumulative effects and expression patterns of electroacupuncture (EA) on irisin secretion, observe the effects of EA on the recovery of neurobehavioral function and vascular remodeling after cerebral ischemia, and elucidate the mechanism by which EA promotes vascular remodeling by regulating irisin expression. …”
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Exogenous Janus Kinase 617 Codon Influences Small Noncoding RNAs and Gene Expression in Ba/F3 Cells by Yi-Yang Chen, Ying-Hsuan Wang, Chih-Cheng Chen, Cih-En Huang, Chia-Chen Hsu, Shu-Huei Hsiao, Yu-Wei Leu

“…Consequently, it is still unknown what molecular mechanism underlies the MPN transformation produced by JAK2V617F. …”
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Current developments in robotic assistance technology for total knee arthroplasty: a comprehensive overview by Hongli Zhang, Xing-an Jiang, Bing-chen Jin, Hong-hao Zhang, Jun-bo Liang

“…The idea is to plan the surgical plan based on the anatomical structure of the affected limb before the operation, and then to use a mechanical arm and a visual system to assist in the implantation of the prosthesis while the operation is being performed. …”
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In Vivo Structural and Functional Abnormalities of the Striatums Is Related to Decreased Astrocytic BDNF in Itpr2-/- Mice Exhibiting Depressive-Like Behavior by Shanmei Zeng, Kai Liu, Jingyu Zhang, Chunhui Chen, Yihua Xu, Yulan Wu, Yanjia Deng, Xuegang Sun, Ge Wen, Linlin Jing

“…By combining biochemistry and MR analyses, this study provides evidences to support that the Itpr2-related neuropathological effect is possibly mediated by the striatal abnormality associated with dysfunctional astrocytes in Itpr2-/- mice in vivo, thus may help us better understand underlying mechanisms of Itpr2 deficiency as well as its relation to depressive-like behavior.…”
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Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma by Soo Yeon Kim, Miaolu Tang, Stephen Y. Chih, Jessica Sallavanti, Yan Gao, Zhiqiang Qiu, Hong-Gang Wang, Wei Li

“…Abstract The association of necrosis in tumors with poor prognosis implies a potential tumor-promoting role. However, the mechanisms underlying cell death in this context and how damaged tissue contributes to tumor progression remain unclear. …”
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Investigation of the optimum calcination temperature for water treatment plant sludge to develop a sustainable alkali activated concrete by Jasmin Osama Abdelhalim, Ismail Amer, Ibrahim Abdel Latif, Ihab Fawzy, Sayed Ismail, Mohamed A. Khalaf

“…XRD and Chapelle tests were employed to chemically investigate the efficiency of the obtained calcined WTPS specimens, while strength activity index and compressive strength tests were used to mechanically verify the findings of the chemical tests. …”
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