Linking multiple-channel information seeking and lifestyle among Chinese older adults: A moderation and mediation analysis by Qingrui Li, Yifang Wu, Xinshu Zhao

“…Conclusions Our findings show evidence supporting a cognitive mechanism of moderated mediation that links seeking health information to improve LSM in older Chinese adults. …”
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Quantification of Rear-End Crash Risk and Analysis of Its Influencing Factors Based on a New Surrogate Safety Measure by Qiangqiang Shangguan, Ting Fu, Junhua Wang, Rui Jiang, Shou’en Fang

“…Traditional surrogate measures of safety (SMoS) cannot fully consider the crash mechanism or fail to reflect the crash probability and crash severity at the same time. …”
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Exploring Core Genes Associated with Sepsis and Systemic Inflammatory Response Syndrome Using Single-Cell Sequencing Technology by Shen Y, Leng L, Hu Y

“…The frequency of occurrence is on the rise, but there is a lack of certain indicators for the timely detection and recognition of illnesses.Methods: By virtue of scRNA-seq, this research has analyzed single-cell transcriptome data from samples taken from groups with septic death and systemic inflammatory response syndrome so as to identify the unique markers and patterns in immune response.Results: By revealing the status of twelve cell clusters of four major cell types in blood samples through UMAP cell clustering and the differences of major cell populations between the dead and SIRS patients, the results have elucidated the components of different cells and their marker genes in two disease states, and the response mechanism beneficial to disease diagnosis in blood samples.Conclusion: By establishing a theoretical framework centered on cellular and molecular regulation, the study has introduced a novel approach for diagnosing and treating sepsis death group and SIRS patients early, as well as differentiating and preventing these conditions.Keywords: sepsis, SIRS, single cell sequencing, biomarkers, single cell transcriptome…”
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La institución matrimonial después del matrimonio homosexual by Beatriz Gimeno, Violeta Barrientos

“…That is to say rather than a conservative assertion, which modifies the naturalized character of marriage by imposing it on new subjects (homosexuals), it is a deinstitutionalization mechanism. This means that while affirming the full citizenship of the GLTB groups, in other words their social recognition, it also deconstructs marriage in two ways. …”
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Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis by Yijian Deng, Liying Zeng, Yigui Lai, Shuai Ji, Baizhao Peng, Hanqi Lu, Ming Wang, Hiu Yee Kwan, Qi Wang, Xiaoshan Zhao

“…Conclusion: The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation.…”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…Background Clofarabine (Clo) is a Food and Drug Administration (FDA)-approved drug for the treatment of acute lymphoblastic leukemia; however, its effects on solid tumors remain largely unknown.Methods In vitro and in vivo experiments have demonstrated the cytotoxic effects of Clo on melanoma and lung cancer. The molecular mechanisms of Clo-induced tumor cell death were analyzed using western blotting, ELISA, reverse transcription-PCR, immunofluorescence, co-immunoprecipitation (CO-IP), short hairpin RNA, co-culture, chromatin immunoprecipitation, and flow cytometry. …”
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Bivalirudin exerts antiviral activity against respiratory syncytial virus-induced lung infections in neonatal mice by Zhuang Shihao, Tang Qiuyu, Chen Ping, Wang Chengyi, Liu Guanghua

“…Thus, the study shows that RSV infection induces specific changes in lung tissue and the clotting related signalling mechanism. Additionally, BR treatment significantly reduces bronchiolitis and prevents the severity of the infections suggesting that BR can possibly be used to reduce the viral-mediated infections in neonates.…”
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Multi-type low-rate DDoS attack detection method based on hybrid deep learning by Lijuan LI, Man LI, Hongjun BI, Huachun ZHOU

“…Low-Rate distributed denial of service (DDoS) attack attacks the vulnerabilities in the adaptive mechanism of network protocols, posing a huge threat to the quality of network services.Low-Rate DDoS attack was characterized by high secrecy, low attack rate, and periodicity.Existing detection methods have the problems of single detection type and low identification accuracy.In order to solve them, a multi-type low-rate DDoS attack detection method based on hybrid deep learning was proposed.Different types of low-rate DDoS attacks and normal traffic in different scenarios under 5G environment were simulated.Traffic was collected at the network entrance and its traffic characteristic information was extracted to obtain multiple types of low-rate DDoS attack data sets.From the perspective of statistical threshold and feature engineering, the characteristics of different types of low-rate DDoS attacks were analyzed respectively, and the effective feature set of 40-dimension low-rate DDoS attacks was obtained.CNN-RF hybrid deep learning algorithm was used for offline training based on the effective feature set, and the performance of this algorithm was compared with LSTM-Light GBM and LSTM-RF algorithms.The CNN-RF detection model was deployed on the gateway to realize the online detection of multiple types of low-rate DDoS attacks, and the performance was evaluated by using the newly defined error interception rate and malicious traffic detection rate indexes.The results show that the proposed method can detect four types of low-rate DDoS attacks online, including Slow Headers attack, Slow Body attack, Slow Read attack and Shrew attack, and the error interception rate reaches 11.03% in 120 s time window.The detection rate of malicious traffic reaches 96.22%.It can be judged by the results that the proposed method can significantly reduce the intensity of low-rate DDoS attack traffic at the network entrance, and can be deployed and applied in the actual environment.…”
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Liposomal Formulations: A Recent Update by Surendra S. Agrawal, Vrinda Baliga, Vaishali Y. Londhe

“…Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. …”
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Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…Nevertheless, research on its role and mechanisms in causing liver disease is severely limited. …”
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Spatial sorting and selection within urban agglomerations: a tripartite evolutionary game model approach by Yunsheng Zhang, Shuting Wang, Ruomeng Zhou

“…To address this, we develop a tripartite evolutionary game model to investigate the spatial sorting and selection mechanisms among high-, medium-, and low-skill firms in urban settings. …”
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A human acellular dermal matrix coated with zinc oxide nanoparticles accelerates tendon repair in patients with hand flexor tendon injuries in zone 5 of the hand by Seyedeh-Sara Hashemi, Mohsen Pirmoradi, Alireza Rafati, Mehdi Kian, Ali Akbar Mohammadi, Mohamad Ali Hoghoughi

“…Methods: Morphological, mechanical, cell viability, and antibacterial tests were performed to evaluate the physical and biological properties of the fabricated ADM/ZnO-NPs graft. …”
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Impact of Economic Agglomeration on Carbon Emission Intensity and Its Spatial Spillover Effect: A Case Study of Guangdong Province, China by Qian Xu, Junyi Li, Ziqing Lin, Shuhuang Wu, Ying Yang, Zhixin Lu, Yingjie Xu, Lisi Zha

“…However, the impact of economic development on carbon emission intensity has rarely been considered from the perspective of economic agglomeration, and the relationships and mechanisms between the two remain poorly understood. …”
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Directions for improving the organizational framework for quality control of higher education in Ukraine by V. O. Neviadovskyi

“…It has been noted that a necessary step to improve the organizational framework for exercising control over the quality of education is interaction and coordination in the system of subjects of such control, since today these aspects of the organization and functioning of the mechanism for controlling the quality of higher education are rather superficially regulated and do not provide a clear understanding of how this interaction takes place, what is the place of coordination in it, and who it is carried out by. …”
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Ferroptosis in kidney disease: a bibliometric analysis from 2012 to 2024 by Yuxin Hu, Yuxin Hu, Yuxin Hu, Jingyi Tang, Jingyi Tang, Jingyi Tang, Hanzhang Hong, Hanzhang Hong, Yexin Chen, Yexin Chen, Beibei Ye, Ziheng Gao, Ziheng Gao, Gegongming Zhu, Lin Wang, Lin Wang, Lin Wang, Weijing Liu, Weijing Liu, Weijing Liu, Yaoxian Wang, Yaoxian Wang, Yaoxian Wang

“…In recent years, however, there has been a shift towards biomarkers, inflammation and necrosis, which indicate current and future research directions in this area.ConclusionThe global landscape of the ferroptosis research in kidney disease from 2012 to 2024 was presented. Basic research and mechanism exploration for renal fibrosis and chronic kidney disease may be a hot spot in the future.…”
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Comparative study of packaging materials developed from fish and legume protein concentrates by Evmorfia Athanasopoulou, Angeliki Katsiroumpa, Chrysavgi Gardeli, Theofania Tsironi

“…The developed films were characterized for optical, mechanical and water barrier properties, hydrophobicity (via contact angle measurement), moisture content, water solubility, and biodegradability. …”
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Diabetes and Hemoglobin A1c as Risk Factors for Nosocomial Infections in Critically Ill Patients by Eirini Tsakiridou, Demosthenes Makris, Vasiliki Chatzipantazi, Odysseas Vlachos, Grigorios Xidopoulos, Olympia Charalampidou, Georgios Moraitis, Epameinondas Zakynthinos

“…Inclusion criteria: ICU hospitalization >72 hours and mechanical ventilation >48 hours. HbA1c was calculated for all participants. …”
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CircFndc3b Mediates Exercise‐Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice by Yun Zhao, Xiaofei He, Xiaofeng Yang, Zhongqiu Hong, Yin Xu, Jinghui Xu, Haiqing Zheng, Liying Zhang, Zejie Zuo, Xiquan Hu

“…This study unveils a novel mechanism underlying exercise‐induced neuroprotection in ischemic stroke and positions circFndc3b as a promising therapeutic target for stroke management, mimicking the beneficial effects of exercise.…”
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Form and functioning: contextualising the start of the Global Financing Facility policy processes in Burkina Faso by Joël Arthur Kiendrébéogo, Orokia Sory, Issa Kaboré, Yamba Kafando, Meghan Bruce Kumar, Asha S. George

“…Few empirical papers deal with how global funding mechanisms, and specifically GFF, support resource mobilisation for health nationally. …”
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Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2 by Liuzhao Zhang, Quanwang Chu, Shuyue Jiang, Bo Shao

“…Conclusion RGL4,ATP9A,MAP3K7CL, and DDX11L2 play important roles in pediatric sepsis risk and immune response regulation, offering insights into genetic and immune mechanisms that may inform future sepsis research and treatment.…”
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