Investigating the Expression of c-Myc and BIRC5 in TRAIL and PBOX-15 treated Metastatic Prostate Cancer Cells by Corinne Kai Leng Chew, Hannah O'Toole, Daniela M Zisterer, Seema M. Nathwani, Jade K. Pollock

“…The specific tumour receptor mechanism of the death ligand TRAIL (tumour necrosis factor related apoptosis inducing ligand) has attracted remarkable therapeutic interest. …”
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Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels by Junyuan Du, Junyuan Du, Zhiyi Wu, Zhiyi Wu, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Feike Zhao, Feike Zhao, Binghu Fang, Binghu Fang

“…Through the application of metabolomics, the underlying metabolic mechanisms by which cystine exerts its effects on Salmonella have been elucidated, offering a novel perspective in the domain of metabolic reprogramming aimed at counteracting drug resistance. …”
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Development of indicators and analysis of barriers for assessment and prevention of cutaneous graft-versus-host disease after haematopoietic stem cell transplantation in children by YANG Liling, ZHAN Sha, XUE Xiaoyan, CHEN Kai, LIU Qing, WANG Li, WANG Yiyi, WU Meng, LU Qunfeng

“…The main obstacles were the lack of relevant training and the absence of a rational management mechanism. The main facilitating factors were reliable sources of evidence and a high level of cooperation from potential stakeholders. …”
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The principle of “dolus specialis” and the problem of proving the genocidal actions of the russian federation in Ukraine by Andrukhiv O.

“…The principle of «dolus specialis» remains fundamental to the legal mechanism for combating genocide, ensuring the effectiveness of prosecution and prevention of crimes against humanity. …”
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Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth by Li-Yan Zhang, Tian-Tian Li, Hong-Xin Liao, Jin-Rui Wen, Hong-Yan Nie, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong

“…Menthone affected the growth of F. proliferatum by reducing the expression of ribosome biogenesis-related genes (FPRO_06392, FPRO_01260, FPRO_10795, and FPRO_01372).ConclusionThis study elucidated the mechanism by which menthone inhibits F. proliferatum growth from a histone acetylation modification perspective, providing insights into its application as an antifungal agent to prevent root rot in Panax notoginseng.…”
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Global human exposure of atmospheric polybrominated diphenyl ethers: Variation patterns of exposure pathways and phase contributions by Pengtuan Hu, Shimin Zhong, Jin Guo, Mengyao Wang, Shiyu Shi, Donghai Liu, Hao Yu, Fujie Zhu, Yi-Fan Li, Zhiguo Cao

“…This study clarified the contribution rates of inhalation and dermal exposure of particulate and gaseous polybrominated diphenyl ethers (PBDEs) on a global scale, as well as their influencing factors and mechanisms. Data on gaseous PBDEs were collected from 125 cities across 38 countries and regions to predict size-resolved particulate exposure levels, utilizing our previous method for inhalation alongside a size-dependent prediction method for dermal exposure developed in this study. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…To examine the hypotheses on the predictive biomarkers of response to pembrolizumab, and the mechanisms of resistance. Methods Our trial is a Phase 2 randomized study of immunotherapy drug pembrolizumab given in combination with azacitidine (HMA). …”
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Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus) by Jiale Shi, Congji Yang, Yuanyuan Qin, Qingqing Liu, Shengqi Hua, Defeng Wu, Wei Dong

“…Our findings may serve as a foundation for elucidating the mechanism underlying the molecular metabolism of programmed cell death and should be useful for marker-assisted selection breeding in watermelon.…”
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Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells by Cai-Jie Zhou, Bai-Ling Xie, Hai-Yang Han, Yin Wang, Yong-Hua Wang, Jing-Yi Hong, Yi-Xia Wei, Zhi-Gang Liu, Yan Feng, Gui Yang, Ping-Chang Yang

“…The dysfunction of regulatory B cells (Breg) may result in immune inflammation such as allergic rhinitis (AR); the underlying mechanism is not fully understood yet. Short-chain fatty acids, such as propionic acid (PA), have immune regulatory functions. …”
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Assessing Mitigation Strategies to Reduce Potential Exposures to Indoor Particle Release Events by Katie Van Valkinburgh, Ali Mohammadi Nafchi, Ehsan Mousavi, Vincent Blouin, Nigel Kaye, Andrew R. Metcalf

“…As is observed in numerous other studies, the particle concentration half-life in each classroom setup decreases as the mechanical air changes per hour increases from about 1.3 to 9.3. …”
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Forms of Realizing the Right to Freedom of Peaceful Assembly by М. A. Sambor

“…It has been summarized that the forms of realizing the right to freedom of peaceful assembly make it possible to understand the purpose pursued by the subject of realizing this right, and the place of holding a peaceful assembly significantly influences the further mechanism of ensuring its realization, since the combination of the form and content of the right to freedom of peaceful assembly makes it possible to understand the true essence of this right, as well as to adjust measures to ensure its realization in order to create optimal conditions not only for the realization of this right, but also to prevent its abuse. …”
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Integrated Analysis of Metatranscriptome and Amplicon Sequencing to Reveal Distinctive Rhizospheric Microorganisms of Salt-Tolerant Rice by Wenna Meng, Zhenling Zhou, Mingpu Tan, Anqi Liu, Shuai Liu, Jiaxue Wang, Zhiguang Sun, Yiluo Tan, Yan Liu, Baoxiang Wang, Yanming Deng

“…Salt stress poses a significant constraint on rice production, so further exploration is imperative to elucidate the intricate molecular mechanisms governing salt tolerance in rice. By manipulating the rhizosphere microbial communities or targeting specific microbial functions, it is possible to enhance salt tolerance in crops, improving crop yields and food security in saline environments. …”
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Uniaxial Experimental Study of the Deformation Behavior and Energy Evolution of Conjugate Jointed Rock Based on AE and DIC Methods by Jiliang Pan, Xu Wu, Qifeng Guo, Xun Xi, Meifeng Cai

“…These findings can be regarded as a reference for future studies on the failure mechanism of granite with conjugate joints.…”
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Design of an iterative method for enhanced early prediction of acute coronary syndrome using XAI analysis by Shital Hajare, Rajendra Rewatkar, K.T.V. Reddy

“…The escalating prevalence and acute manifestations of Acute Coronary Syndrome (ACS) necessitate advanced early detection mechanisms. Traditional methodologies exhibit limitations in predictive accuracy, sensitivity, and timeliness, thus hindering effective intervention and patient care management. …”
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Possibilities and scope of environmental protection through criminal law: The new environmental crime directive by Stojanović Zoran, Bodrožić Ivana

“…The changes in the area that defines new environmental crimes at the European Union level, minimum common standards in prescribing criminal sanctions, and enhancing the existing ones, as well as setting brand new tools and mechanisms in strengthening and enhancing the effectiveness of the law enforcement cooperation in the field of environmental crimes have been brought about by the new Environmental Crime Directive aimed to crack down on environmental crime, and they can be seen and marked as an important contribution to criminal law protection of the environment, but only seen as the ultimate instrument of the state reaction to environmental crimes. …”
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Significance of Broken μ−τ Symmetry in Correlating δCP, θ13, Lightest Neutrino Mass, and Neutrinoless Double Beta Decay 0νββ by Gayatri Ghosh

“…The estimated three-dimensional density parameter space of the lightest neutrino mass m1, δCP, and reactor mixing angle θ13 is constrained here for the requirement of producing the observed value of baryon asymmetry of the Universe through the mechanism of leptogenesis. Carrying out numerical analysis, the allowed parameter space of m1, δCP, and θ13 is found out which can produce the observed baryon to photon density ratio of the Universe.…”
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A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes by Zhen Xiong, Liwen Zhang, Wei Fan

“…Gene Set Enrichment Analysis (GSEA) was performed to further understand the underlying molecular mechanisms. In this study, we identified 47 differentially expressed peroxisome-related genes (PRGs), including 25 increased and 22 decreased PRGs. …”
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Kidney and gallbladder stones and the risk of prostate cancer: Results from the EPICAP study. by Melissa Sawaya, Emilie Cordina-Duverger, Pierre-Jean Lamy, Brigitte Trétarre, Florence Menegaux

“…Findings from this study underscore the need for a more comprehensive investigation to understand the role of chronic inflammation or metabolism and delineate the mechanisms underlying these potential associations in order to guide the development of targeted preventive strategies for aggressive prostate cancer.…”
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Evaluating Audience Engagement as a Measure of Digital Diplomacy Effectiveness by M. M. Bazlutckaia, A. N. Sytnik, N. A. Tsvetkova

“…The analysis of selected metrics reveals two key trends in US digital diplomacy in Russia: since 2022 there has been a notable shift in focus toward Telegram as the primary platform, and while the content partially reaches the existing Russian-speaking audience, it struggles to expand its overall reach.The authors provide six recommendations for diplomatic agencies and consulting firms to enhance the tools for analyzing digital diplomacy engagement: (1) adopt automated engagement metrics that account for the interface differences among social media platforms; (2) incorporate built-in topic modeling of posts; (3) integrate sentiment analysis of comments; (4) develop mechanisms to detect traffic manipulation; (5) track multi-level reposts, the timing and spread of hashtag diplomacy, and audience growth considering these processes; and (6) evaluate digital diplomacy activity concerning responses to comments. …”
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Study on the Impact of Climate Warming on Mariculture in China by GAO Jia, YANG Huaiyu

“…Based on the above research results, this paper puts forward a series of targeted policy suggestions, including strengthening the construction of climate change research and early warning system, optimize the spatial layout of mariculture industry, strengthen disease prevention and control and health management measures, establish and improve the risk management mechanism, in order to cope with the impact of climate warming, promote the sustained, stable and development of mariculture in China provide important reference.…”
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