Tau oligomers impair memory and synaptic plasticity through the cellular prion protein by Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forloni

“…In vitro and in vivo neuronal TauO exposure leads to synaptic and cognitive dysfunction, but their mechanisms of action are unclear. Evidence suggests that the cellular prion protein (PrPC) may act as a mediator of TauO neurotoxicity, as previously proposed for β-amyloid and α-synuclein oligomers. …”
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Sex Differences in the Renal Vascular Responses of AT1 and Mas Receptors in Two-Kidney-One-Clip Hypertension by Zahra Pezeshki, Mehdi Nematbakhsh

“…However, the underlying mechanisms are not well understood. In this study, we investigated sex differences in renal vascular responses to angiotensin II (Ang II) administration with and without Ang II type 1 and Mas receptor (AT1R and MasR) antagonists (losartan and A779) in the 2K1C rat model of renovascular hypertension. …”
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Identification of new genes regulating nodule development in Medicago truncatula: an in-silico approach by Mahboobeh Azarakhsh, Sara Eslami, Maryam Moghadas, Zahra Ataei

“…Due to the importance of biological nitrogen fixation to improve soil fertility, the molecular mechanism of nodule development is studied extensively. …”
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Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

“…In the present study, the aim was to elucidate the mechanisms of DC activation by OBP-702, focusing particularly on tumor-derived exosomes. …”
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An investigative experiment in the destruction or damage to property investigation by M. H. Shcherbakovskyi

“…The second group is investigative experiments without the participation of a person, which are conducted to establish the existence of an objective fact, phenomenon, the course of a particular event as a whole or its stages, the mechanism of trace formation. Each type of investigative experiment provides suggestions for a specific location and conditions similar to the circumstances of the offence. …”
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Pathology of Red Blood Cells in Patients with SARS-CoV-2 by Sona Hakobyan, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Hranush Avagyan, Nane Bayramyan, Lyudmila Niazyan, Mher Davidyants, Knarik Sargsyan, Tehmine Ghalechyan, Anna Semerjyan, Elena Karalova, Zaven Karalyan

“…Group 2: Severe group (shortness of breath >30 breaths/min, peripheral blood oxygen saturation <92% at rest, extensive pneumonia, respiratory failure requiring mechanical ventilation, and/or organ failure necessitating intensive care). …”
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Transcriptome analysis of muscle atrophy in Leizhou black goats: identification of key genes and insights into limb-girdle muscular dystrophy by Ke Wang, Mengning Xu, Xiaotao Han, Hu Liu, Jiancheng Han, Wei Sun, Hanlin Zhou

“…These findings enhance our understanding of the mechanisms underlying muscular atrophy in LZBGs. The identification of key genes and pathways provides valuable insights for developing future breeding strategies aimed at improving meat production efficiency.…”
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β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy by Yihui Huo, Taiyu Shen, Tianyin Feng, Moli Li, Wanli Zhao, Juan J. Loor, Ben Aernouts, Androniki Psifidi, Chuang Xu

“…Therefore, this study aimed to explore the underlying mechanisms of mtDNA-induced inflammation under BHB stress and evaluate the potential therapeutic strategy of autophagy activation in mitigating this damage. …”
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Prospects for the use of ferrites with high magnetic permeability and permittivity as radio-absorbing materials by V. G. Kostishin, R. M. Vergazov, S. B. Menshova, I. M. Isaev

“…High values of the dielectric constant of ferrites are provided by a combination of the dielectric properties of grain-boundary layers and the semiconducting properties of the grains themselves, which form the barrier capacity of grain boundaries according to the Okazaki mechanism. Alloying ferrites with oxides TiO2, Bi2O3, CaO in an amount of up to 1 wt.% allows increasing the electrical resistance and dielectric constant of grain-boundary layers, providing an increase in the dielectric constant of ferrite as a whole. …”
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Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. by Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M Foster, Finlay A Martin, Kira Brüninghoff, Kathleen M Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V Forment, Matthew J Cliff, Igor Larrosa, Perdita Barran, Duncan L Smith, Henning D Mootz, Christine K Schmidt

“…Taken together, the approach opens the possibility of characterising previously undetected protein-protein interactions, with the potential of elucidating molecular mechanisms behind the most complex and poorly understood processes in the cell.…”
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Activation of endogenous tolerance to bleaching stress by high salinity in cloned endosymbiotic dinoflagellates from corals by Ching-Nen Nathan Chen, Tze Ching Yong, Jih-Terng Wang

“…The findings also suggest the genomes of coral symbiotic dinoflagellates have undergone evolutionary processes to develop mechanisms, regulated by gene expression, to mitigate damages caused by high temperature and high light stress. …”
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A Comprehensive Study on the Effect of Dimethyl Carbonate Oxygenate and EGR on Emission Reduction, Combustion Analysis, and Performance Enhancement of a CRDI Diesel Engine Using a... by T. Ramesh, A.P. Sathiyagnanam, Melvin Victor De Poures, P. Murugan

“…The overall clubbing of DMC additive and EGR rate indicates better performance for the selected factors than a CRDI engine with a six-hole conventional mechanical fuel injection system. The outcome of the work clearly demonstrates that both the 5 ml DMC additive and the 20% EGR rate of the B20 blend show optimum values of BTE, BSFC, and EGT of 32.93%, 0.27 kg/kw·hr, and 310.89°C, which is closer to diesel. …”
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Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet by Lingyue An, Shujue Li, Zhenglin Chang, Min Lei, Zhican He, Peng Xu, Shike Zhang, Zheng Jiang, Muhammad Sarfaraz Iqbal, Xinyuan Sun, Hongxing Liu, Xiaolu Duan, Wenqi Wu

“…However, the underlying mechanisms involving gut microbiota and metabolite disruptions in secondary hyperoxaluria remain poorly understood. …”
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WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study by Song Zhang, Sihuai Xiong, Sha Zhang, Keyu Chen, Hua Wang, Ke Li, Xudong Xu, Xianxian Zhao, Ni Zhu, Xinmiao Huang, Yongwen Qin, Zhifu Guo, Yuan Bai

“…Abstract Background Different left atrial appendage closure (LAAC) devices have been introduced into the clinical setting. A new dual-seal mechanism LACbes® occluder with isogenous barbs for LAAC has been designed to facilitate easier delivery and improve safety. …”
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Subacromial Pain Syndrome in Breast Cancer Survivors—Are Structural Shoulder Changes Verified by Ultrasound Clinically Relevant? by Ivana Klarić-Kukuz, Jure Aljinović, Blaž Barun, Marko Roki, Benjamin Benzon, Danijela Budimir Mršić, Maja Marinović Guić, Ana Poljičanin

“…While various risk factors and mechanisms for shoulder pain have been proposed, evidence is inconsistent. …”
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Characterizing Groundwater Level Response to Precipitation at Multiple Timescales in the Lubei Plain Region Using Transfer Function Analysis by Lewei Xu, Huili Gong, Beibei Chen, Chaofan Zhou, Xueting Zhong, Ziyao Ma, Dexin Meng

“…Human activities, particularly groundwater exploitation, disrupt the recharge mechanism and the regional water cycle. In this study, we propose a new research framework: On the basis of analyzing the spatiotemporal variability characteristics of precipitation and shallow GWL, we used transfer function analysis (TFA) to quantify the multi-timescale characteristics of precipitation–GWL response under the effects of climate change and human activities. …”
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Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy by Yue Wang, Kevin Chang, Aslan Mansurov, Jun Ishihara, Seounghun Kang, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Brendan T K Berg, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Melody A Swartz, Jeffrey A Hubbell

“…The combination therapy also improved the efficacy of CPI in a CPI-resistant genetically-engineered melanoma model and exhibited synergistic antitumor efficacy in a pulmonary metastasis model.Conclusion Our strategy provides a rational design for combination immunotherapy targeting both myeloid and lymphoid compartments through complementary mechanisms.…”
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FOSL1 transcriptionally dictates the Warburg effect and enhances chemoresistance in triple-negative breast cancer by Gang Zhao, Yutong Liu, Shiqi Yin, Runxiang Cao, Qian Zhao, Yifan Fu, Ye Du

“…However, the transcriptional mechanisms of aerobic glycolysis in TNBC remains poorly understood. …”
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Energy Metabolism and Lipidome Are Highly Regulated during Osteogenic Differentiation of Dental Follicle Cells by Oliver Pieles, Marcus Höring, Sadiyeh Adel, Torsten E. Reichert, Gerhard Liebisch, Christian Morsczeck

“…However, understanding of the molecular mechanisms of osteogenic differentiation, which is required for cell-based therapies, is delimited. …”
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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007) by Raj Kalkeri, Junzhong Peng, Chunsheng Huang, Zhaohui Cai, Roger G. Ptak, Mark J. Suto

“…Results indicated that SRI-32007 retained anti-HBV activity even when added 72 hours postinfection (72 h). Additional mechanism of action studies demonstrated potent inhibition of HBV core promoter activity by SRI-32007 with an EC50 of 40 nM and SI of >250. …”
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