The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

“…However, the causal mechanisms are not well understood. A distinct three-lipid signature (3LS) has previously been proposed as a prognostic biomarker for PCa. …”
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Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume by Edelweiss Touron, Robin de Flores, Laurent Coulbault, Cassandre Palix, Anne Chocat, Elizabeth Kuhn, Brigitte Landeau, Florence Mézenge, Daniel Roquet, Léa Chauveau, Sacha Haudry, Denis Vivien, Vincent de La Sayette, Natalie L. Marchant, Gaël Chételat, Géraldine Poisnel, for the Medit-Ageing Research Group

“…The neurobiological mechanisms underlying this link may involve stress system dysfunction, notably related to the hippocampus which is particularly sensitive to AD. …”
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Sex differences in the expression of lipid oxidation and glucose uptake genes in muscles of fasted mice by N. A. Feofanova, T. V. Yakovleva, E. N. Makarova, N. M. Bazhan

“…Sex differences in the mechanisms of adaptation to fasting may contribute to choosing a therapeutic strategy for correction of metabolic disorders. …”
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Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease by Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh

“…However, the exact underlying mechanism underlying this effect remains unclear. In this study, we investigated whether long-term exercise has neuroprotective effects on dopaminergic nigrostriatal neurons and whether it further alleviates impairment of the gait pattern, locomotor activity, akinesia, and anxiety-like behavior in PD rats. …”
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Development of a Small-Working-Volume Plunger Hydraulic Pump with Improved Performance Characteristics by Alexey N. Beskopylny, Denis Medvedev, Vyacheslav Grishchenko, Evgeniy Ivliev

“…It offers production costs that are several times lower compared to existing cam-type plunger or diaphragm pumps with oil sumps and precision valve mechanisms. Additionally, it has significantly better operating characteristics and a longer service life compared to vibrating plunger pumps.…”
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Clinical Characteristics of Children with Acute Post-Streptococcal Glomerulonephritis and Re-Evaluation of Patients with Artificial Intelligence by Emre LEVENTOGLU, Mustafa SORAN

“…Questions assessing the definition, epidemiologic characteristics, pathophysiologic mechanisms, diagnosis, and treatment of APSGN were answered correctly by ChatGPT 3.5. …”
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A Lightweight CNN-Transformer Implemented via Structural Re-Parameterization and Hybrid Attention for Remote Sensing Image Super-Resolution by Jie Wang, Hongwei Li, Yifan Li, Zilong Qin

“…To address these challenges, this study introduces a novel hybrid CNN-Transformer network model named RepCHAT for remote sensing single image reconstruction, which incorporates a structural re-parameterization technique and a hybrid attention mechanism. This method leverages the strengths of transformers in terms of learning long-distance dependencies (global features) and CNNs with respect to extracting local features. …”
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Extraction of Cellulosic Compound from Jackfruit Peel Waste and Characterization of PVA Cellulose Composite as Biodegradable Film by Aquib Rahman, Shah Md Ashiquzzaman Nipu, Md Shamsul Alam, S. Sharar Alam, Md. Tanvir Ahmed, Anika Afroz Shantona, Mahjabin Moon

“…The percentage of cellulose being used in PVA is 0%, 20%, 50%, and 80% compared to pure PVA film. Mechanical properties (tensile atrength, elastic modulus, tensile energy absorption, and strain) as well as thermogravimetric analysis (TGA/DTA), Fourier transform infrared (FTIR), water absorption, and soil burial test were done to define the material and functional properties of 0%, 20%, 50%, and 80% cellulose-PVA composite film. …”
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Study on the Transfer Threshold from Meteorological to Hydrological Drought in Dongjiang River Basin by MO Xiaomei, TU Xinjun, WANG Tian, XIE Yuting, ZHAO Guoyang

“…The study on transfer threshold between different drought types can effectively analyze the occurrence law and mechanism of drought transfer,especially the study on transfer threshold from meteorological drought to hydrological drought.Taking the Dongjiang River Basin as the research object,this paper calculates the standardized precipitation index (SPI) and the standardized runoff index (SRI) at month scale,identifies and extracts the drought events and their characteristics,including drought duration and drought severity based on the run theory,matches the meteorological drought events and hydrological drought events that occur at the fully or partially same time,fits the edge distribution of the matched drought characteristic attributes to verify the correlation between the duration or severity of meteorological and hydrological droughts,establishes the joint distribution models of meteorological drought and hydrological drought based on two-variable Copula function,calculates the conditional probability of different grades of hydrological drought (moderate drought,severe drought and extreme drought) under different meteorological drought conditions,and takes the drought duration or severity value corresponding to the conditional probability of 0.95 as the drought duration or severity threshold for the transfer of meteorological drought to the hydrological drought of this grade.The results show that:The optimal fit functions of meteorological drought duration and severity in the Dongjiang River Basin were gamma distribution.The optimal fit function of hydrological drought duration is gamma distribution,and the marginal distribution function of hydrological drought severity was generalized normal distribution.The drought duration and severity were better when fitting by the Gumbel-copula function.The thresholds of drought duration of middle,severe and extreme drought grades in Dongjiang River basin were 6.9 months,8.3 months,9.4 months,respectively.While the thresholds of drought severity were 4.6,5.7 and 6.6,respectively.Drought transfer threshold can provide reference for hydrological drought prediction and government decision-making of drought prevention and mitigation.…”
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3D Printing of Polymer-Derived Graphene/SiC_p/SiC Composite by Direct Ink Writing by Hongjun Liu, Yajun Li, Run Tang, Yamin Li

“…However, it still presents challenges in improving the mechanical properties of composites and endowing them with multifunctionality. …”
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Longitudinal Metabolomics Data Analysis Informed by Mechanistic Models by Lu Li, Huub Hoefsloot, Barbara M. Bakker, David Horner, Morten A. Rasmussen, Age K. Smilde, Evrim Acar

“…., revealing biomarkers of various phenotypes, metabolomics data analysis can significantly benefit from incorporating prior information about metabolic mechanisms. This paper introduces a novel data analysis approach to incorporate mechanistic models in metabolomics data analysis. …”
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“An Ancient System of Caste”: How the British Law against Caste Depends on Orientalism by Prakash Shah

“…Further no case was made that a mechanism like the Equality Act is appropriate for caste discrimination. …”
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A new perspective on cardiovascular function and dysfunction during endurance exercise: identifying the primary cause of cardiovascular risk by Amine Souissi, Ismail Dergaa, Samia Ernez Hajri, Karim Chamari, Helmi Ben Saad

“…Exercise mechanical efficiency typically falls within the range of approximately 20 to 25%. …”
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A Semianalytical Production Prediction Model and Dynamics Performance Analysis for Shale Gas Wells by Yingying Xu, Xiangui Liu, Zhiming Hu, Xianggang Duan, Jin Chang

“…The shale gas productivity model based on shale gas nonlinear seepage mechanism is an effective way to reasonably predict productivity. …”
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Efficient and accurate tobacco leaf maturity detection: an improved YOLOv10 model with DCNv3 and efficient local attention integration by Yi Shi, Hong Wang, Fei Wang, Yingkuan Wang, Jianjun Liu, Long Zhao, Hui Wang, Feng Zhang, Qiongmin Cheng, Shunhao Qing

“…Furthermore, the incorporation of the Efficient Local Attention (ELA) mechanism at multiple stages of the model has substantially enhanced the efficiency and fidelity of feature extraction. …”
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Insights into the toxic impact of long-term exposure to diethyl phthalate on commercially important species Catla (Labeo catla) by Satabdi Ganguly, Basanta Kumar Das, Anupam Adhikari, Subir Kumar Nag

“…It is a potential endocrine disruptor, but the underlying mechanism in fish needs to be investigated. The present study evaluated the toxic impacts of DEP exposure for 30 days on commercially important fish Labeo catla (Catla). …”
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Experimental and Simulation Study on Reducing the Liquid Film and Improving the Performance of a Carbon-Neutral Methanol Engine by Yongzhi Li, Zhi Zhang, Haifeng Liu, Weide Chang, Zanqiao Shu, Hu Wang, Zunqing Zheng, Hua Zhao, Xinyan Wang, Mingfa Yao

“…However, further advancing the EOI results in the BTE remaining basically unchanged. Optimized injection timing can enhance the BTE by 1.4% to 2.4% under various load conditions. …”
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GGCT participates in the malignant process of hepatocellular cancer cells by regulating the PTEN/PI3K/AKT pathway through binding to EZH2 by Junbo He, Liangzhi Wang, Mengjia Lv, Yiming Yuan

“…Nevertheless, the roles and relevant mechanisms of GGCT in hepatocellular carcinoma (HCC) remain vague. …”
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Rhein Inhibits NF-κB Signaling Pathway to Alleviate Inflammatory Response and Oxidative Stress of Rats with Chronic Glomerulonephritis by Qian Chen, Hai Guo, JuanJuan Hu, Xiaofeng Zhao

“…To explore the effect and mechanism of rhein on chronic glomerulonephritis (CGN). …”
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The Isolation of Lead-Tolerant PGPR from Red Clover Soil and Its Role in Promoting the Growth of Alfalfa by Wanting Nie, Yuchen Wu, Jingwen Jiang, Zicheng Wang, Meiqi Mu, Siwen Zhao, Minghao Yang, Xi Long, Xiujie Yin, Xiaohua Teng

“…The results imply that PGPR can be employed to facilitate plant growth and microbial-assisted remediation of lead and other heavy metal-contaminated soil and establish a basis for further research on the growth-promoting mechanism of PGPR in plants.…”
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