Regional Elastic Properties of the Achilles Tendon Is Heterogeneously Influenced by Individual Muscle of the Gastrocnemius by Jiping Zhou, Jiafeng Yu, Chunlong Liu, Chunzhi Tang, Zhijie Zhang

“…Anatomical studies and the mechanical property studies showed that there is a strong correlation between Achilles tendon (AT) elasticity and individual gastrocnemius muscle (the medial head of gastrocnemius (MG) and the lateral head of gastrocnemius (LG)) elasticity. …”
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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

“…From the ADC’s PK/PD property while coming into play in vivo and the PK/PD study strategy, to specific ADC optimization methods and recommendations based on PK/PD, it has been study-approved that the PK/PD properties exert a subtle role in the development of ADC, whether in preclinical trials or clinical promotion.ConclusionThe study of PK/PD unfolds the detailed mechanism of ADC action, making it easier to control related parameters in the process of designing ADC, limited efficacy and inevitable off-target toxicity remain a challenging bottleneck.…”
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A methotrexate labelled dual metal oxide nanocomposite for long-lasting anti-cancer theranostics by Joyce L.Y. Tang, Shehzahdi S. Moonshi, Yuao Wu, Gary Cowin, Karla X. Vazquez- Prada, Huong D.N. Tran, Andrew C. Bulmer, Hang Thu Ta

“…This dual metal oxide nanocomposite is conjugated with MTX which is a structural analogue of folate, serving both as a targeting mechanism for folate receptors on cancer cells and as a chemotherapeutic drug. …”
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Role of Intraoperative Left Ventricular Global Longitudinal Strain in Hemodynamic and Cognitive Outcomes in On-Pump Coronary Artery Bypass Surgery: A Prospective Observational Stud... by Eric B. Lineburger, Rajesh C. Arya, Celso G. Junior, Fernanda S. Lima, Eduardo M. Búrigo, Gabriel Simoni R. Fermo

“…Acoustic windows necessary to obtain the 2D-LVGLS were acquired with transthoracic echocardiography (TTE) before induction of anesthesia (LVGLSBI) and after with mechanical ventilation (LVGLSAI) using transesophageal echocardiography (TEE). …”
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Identification of KIFC1 as an independent prognostic marker in renal clear cell carcinoma correlates with tumor proliferation and immune infiltration by Bin Du, Jia Wang, Jinping Zheng, Jing Huo, Pu Wang

“…We analyzed the prognostic value, associated signaling pathways, and regulatory mechanisms of KIFC1 in ccRCC through bioinformatics and proteomics. …”
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Analysis of the Synergistic Effect of Endophytic Bacteria and Metabolites on Yield in Soybean Roots Under Biochar with Nitrogen Fertilization by Hui Liu, Wanyu Dou, Wenlong Zhang, Yutao Li, Guoxin Shi, Lifang Fu, Lihong Wang

“…C1N1 comparison group; they were both associated with regulatory mechanisms such as plant growth promotion and nutrient cycling. …”
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Improved Localization and Recognition of Handwritten Digits on MNIST Dataset with ConvGRU by Yalin Wen, Wei Ke, Hao Sheng

“…Secondly, we introduce an enhanced ConvGRU architecture that replaces traditional linear operations with convolutional operations in the gating mechanism, substantially reducing spatiotemporal information loss. …”
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Study on the Influence of Sand Core Compactness on Surface Entropy considering Engineering Disturbance by Ding-li Su, Hang Chen, Xuemiao Xu, Mengxiong Tang, He-song Hu

“…The two-dimensional entropy reveals the internal correlation mechanism of the influence of the engineering state on the surface structure of sand more clearly than the one-dimensional entropy and more effectively characterizes the dense degree of sand particles. (5) Using two-dimensional entropy to judge the compactness of sand image in the same borehole, the data fluctuation is small, and the algorithm is stable and reliable. …”
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A Whole Plant Analysis of Chloride and Sodium Exclusion Using a Range of Grapevine Rootstock Genotypes by R. R. Walker, D. H. Blackmore, J. D. Dunlevy, P. R. Clingeleffer, A. R. Walker

“…The study addressed the knowledge gap by examining Cl− and Na+ exclusion on a whole plant basis, highlighting a range of within-plant mechanisms that act in limiting the accumulation of both ions in the laminae.…”
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Autoinflammatory diseases. Part 1: concept, classification, immunobiology, diagnosis by O.V. Shvaratska, M.V. Kalichevska, O.V. Klymenko, O.M. Taran, O.V. Klimova, Y.V. Vilenskyi, T.M. Plekhanova, T.K. Mavropulo

“…Recently, some molecular mechanisms typical for autoinflammation have also been recognized in the pathogenesis of several autoimmune and immunodeficiency states. …”
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Impact of Personal Protection Habits on the Spread of Pandemics: Insights from an Agent-Based Model by Lindsay Álvarez-Pomar, Sergio Rojas-Galeano

“…We extended an agent-based COVID-19 epidemic model in a simulated community to incorporate the mechanisms of these aforementioned personal care habits and measure their incidence in person-to-person transmission. …”
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Migration of primordial germline cells is negatively regulated by surrounding somatic cells during early embryogenesis in Drosophila melanogaster by N. V. Dorogova, A. S. Khruscheva, Iu. A. Galimova, D. Yu. Oshchepkov, D. E. Maslov, E. D. Shvedkina, K. A. Akhmetova, S. A. Fedorova

“…At present, there is no exact understanding of the genetic mechanisms of this regulation. To determine the role of the cell environment in the regulation of individual cell migration, we studied the migration of primordial germline cells (PGC) during early embryogenesis in Drosophila melanogaster. …”
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Specific features of succession of a share in the right to joint tenancy by O. Ye. Kukhariev

“…An exception to the general rule on the succession of a share in the right to joint tenancy is the construction of the last will and testament of the spouses, which provides for a special mechanism for acquiring the right of ownership to the property by the second spouse, in respect of which such last will and testament is drawn up.…”
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Alendronate partially rescues the periodontal defects in OIM mouse model of osteogenesis imperfecta by Po-Jung Chen, Ke Wang, Meng-Hsuan Lin, Radhika Sharma, Zana Kalajzic, Mara O’Brien, Sumit Yadav

“…PDL fibers in oim mice were disrupted and discontinuous, while Sharpey’s fibers at the PDL-bone entheses were reduced. Mechanism-based studies showed that catabolism of the PDL was elevated in oim mice, as revealed by an increase in MMP13 and CTSK expression. …”
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Human Development from Concept "Soft Skills" Communication by Emilawati Binti Othman, Masfizaizan Binti Manaf

“…This is because IPS students have developed effective and productive communication skills for orphans and their environment.…”
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Incidence, Outcomes, and Factors Associated with Intra-Abdominal Hypertension and Primary Abdominal Compartment Syndrome in Abdominopelvic Injury Patients by Amonpon Kanlerd, Krissada Nakornchai, Karikarn Auksornchart, Warapan Watkwaw

“…Data of age, gender, weight, height, body mass index, injury mechanisms, initial vital signs, imaging, laboratory data, blood component requirements, abdominal organs involved, treatments including surgery and intervention radiology, abbreviated injury scale (AIS) and injury severity score (ISS), length of ICU stays, and results of treatment were all analyzed. …”
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Pooled PPIseq: Screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platform. by Darach Miller, Adam Dziulko, Sasha Levy

“…In particular, viral-host PPI networks can be used to further our understanding of the molecular mechanisms of tissue specificity, host range, and virulence. …”
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Human development III: Bridging Brain-Mind and Body-Mind. Introduction to “Deep” (Fractal, Poly-Ray) Cosmology by Søren Ventegodt, Tyge Dahl Hermansen, Erik Rald, Trine Flensborg-Madsen, Maj Lyck Nielsen, Birgitte Clausen, Joav Merrick

“…The traditional way of thinking in science today is the first: an often simple and mechanical interpretation of reality that empowers us to handle the outer physical world with great, often brutal efficiency. …”
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Maximum value of the spin-independent cross section in the 2HDM+a by Tomohiro Abe, Motoko Fujiwara, Junji Hisano, Yutaro Shoji

“…This model can explain the measured value of the DM energy density by the freeze-out mechanism. Also, σSI is suppressed by the momentum transfer at the tree level, and loop diagrams give the leading contribution to it. …”
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ANALYSIS OF THERMAL PROPERTIES OF THE LED-LINES BY METHOD OF ELECTRICАL TRANSIENT PROCESSES by S. A. Manеgo, Yu. A. Bumai, I. A. Khorunzhii, Yu. V. Trofimov

“…The optoelectronic apparatuses reliability assessment is based on investigation of the development principles and deterioration mechanisms leading to failures of one kind or another. …”
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