Tailoring traditional Chinese medicine in cancer therapy by Shuiquan Li, Xi Chen, Hui Shi, Ming Yi, Bing Xiong, Tianye Li

“…Recently, with the advancement of contemporary biologic and medical theory and technology, it has become both feasible and imperative to elucidate the molecular signaling mechanisms and cellular biology underlying TCM. Specifically, leveraging TCM pharmaceutic components can not only directly impact tumor biology at the molecular level, but regulate the tumor immune environment through distinct pathways. …”
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Cosmic jurisdictions: quod lege naturae, moribus et consuetudine inductum est by M. I. Myklush, V. K. Marinich

“…Moreover, the authors suggest applying different principles of international regulation to the “Ballistic space,” the “Orbital layer” and the space beyond it, based on the mechanisms of “tacit consent,” “silent disapproval”, “active consent”, and “active disapproval”. …”
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EdgeGuard: Decentralized Medical Resource Orchestration via Blockchain-Secured Federated Learning in IoMT Networks by Sakshi Patni, Joohyung Lee

“…We have made several technological advances, including a lightweight blockchain consensus mechanism designed for IoMT networks, an adaptive edge resource allocation method based on reinforcement learning, and a federated learning algorithm optimized for medical data with differential privacy. …”
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Premonitory urge in tic disorders – a scoping review by John B. Wohlgemuth, Kelly H. Watson, Kayce D. Gill, David A. Isaacs

“…The insula and supplementary motor area are the neuroanatomical structures most strongly implicated in emergence of the premonitory urge.DiscussionKnowledge of the clinical characteristics, measurement, and neural mechanisms of premonitory urge has advanced considerably in recent years, but important knowledge gaps remain in each of these domains. …”
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Evaluation of barley genotypes for the content of <i>β</i>-glucans in grain and other valuable features in Eastern Siberia by V. I. Polonskiy, N. A. Surin, S. A. Gerasimov, A. G. Lipshin, A. V. Sumina, S A. Zute

“…Early maturity and increased productivity were shown by the cultivars ‘Tarsky 3’, ‘Kolchan’ (k-31039, Altai Territory), ‘Zolotnik’ (k-30845, Altai Territory), ‘Abalak’ (Krasnoyarsk Territory, Tyumen Province), and ‘AC Albright’ (Canada). …”
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Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…Purpose: Multiple myeloma (MM) tends to develop resistance to systemic therapy through multiple mechanisms that might as well induce radioresistance, as suggested by preclinical studies. …”
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Case Report: First use of dental bisphenol A-glycidyl methacrylate composite without UV light polymerization for repair of iatrogenic CSF leak following a frontal craniotomy plus t... by Haman Nassourou Oumarou, Haman Nassourou Oumarou, Ndome Toto Orlane

“…This is due to its compactible mechanical properties, long-term stability, and good osteo-integration. …”
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A biomechanical comparison of posterior malleolar fracture fixation using screws and locking plates in Trimalleolar fractures: a finite element study by Chih-Wei Chang, Yen-Nien Chen, Guan-Heng Jhong, Kuo-Chih Su, Chun-Ting Li

“…Abstract Background The aim of the study is to compare the mechanical stability of posterior malleolar fractures fixed with different screw types and locking plates in the management of trimalleolar ankle fractures using the finite element (FE) method. …”
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Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma by David Ramada, Bente Adema, Mohamed Labib, Odyl ter Beek, Dimitrios Stamatialis

“…These membranes feature a smooth, hydrophilic outer layer, porous lumen, ultrafiltration coefficient of 13–34 mL m² h⁻¹ mmHg⁻¹, adequate mechanical properties, low albumin leakage, and toxin removal performance on par with commercial membranes in IOF and OIF. …”
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A Comparative Review of Alternative Fucoidan Extraction Techniques from Seaweed by Matthew Chadwick, Loïc G. Carvalho, Carlos Vanegas, Simone Dimartino

“…Key quality attributes for biologically active fucoidan are proposed, and areas for future research are identified, such as studies for specific bioactivities aimed at elucidating fucoidan’s mechanism of action. This review also sets out future work required to standardize the reporting of fucoidan extract data. …”
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Ghrelin Protects Lipopolysaccharide-Induced Acute Lung Injury Rats against Pulmonary Vascular Dysfunction by Inhibiting Inflammation by Guang Li, Chen-Liang Zhou, Wen-Fang Xia, Di Zhang, Hui-Qing Lin

“…To determine the effect and mechanism of the anti-inflammatory agent ghrelin on pulmonary vascular dysfunction (PVD) in lipopolysaccharide- (LPS-) induced acute lung injury (ALI) rat models. …”
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Identification and functional analysis of hub genes involved in deoxynivalenol-induced enterotoxicity in porcine (Sus scrofa) by Jinhua He, Geng Zhao, Mingxia Chen, Ximing Ren, Peizhi Zhu, Zhizhong Liu, Jiayi Zhou, Hanwei Chen, Chuqiao Xiao, Xiang-Guang Li

“…This study provides new insights into the mechanisms underlying DON-induced enterotoxicity and could guide interventions for this condition.…”
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SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia by Zhonghua Xu, Manhui Zhu, Hua Xie, Jiacheng Zhu, Hongming Zheng, Xiaojuan Liu, Yuting Zhang, Jinbo Liu

“…This study aimed to evaluate the role and underlying mechanisms of SIX1 in microglia polarization in vitro (LPS-treated mouse microglia; BV2 cells) and in vivo (a mouse model of SCI). …”
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Heat Transfer Management of Thermal and Electronics Systems using Convective-Radiative Porous Fins with Thermal Contact Resistance and Diabatic Tip by Joy Nneka Ojuro, Gbeminiyi Musibau Sobamowo, Antonio Marcos de Oliveira Siqueira

“… The miniaturization of electronics, electrical, thermal, mechanical and optical devices and systems calls for increasing demand for efficient cooling systems with higher thermal efficiency. …”
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Advances in Molecular Genetics of Reproductive Isolation in Rice by Shunmei LI, Zihan ZHENG, Ruiying LIU, Hongze GUO, Lin ZHENG, Yongyao XIE

“…Based on the rice model, this review summarizes the advances of RI in rice, including RI types, molecular genetic basis and overcoming strategies, and provides a forward-looking perspective on the development trend and challenges in the field of rice RI, with an aim to provide ideas and references for further study of molecular genetic mechanism of plant RI and distant crop hybrid breeding.…”
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Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation by Hui He, Tianyu Jiang, Meng Ding, Yuan Zhu, Xiaoting Xu, Yashuang Huang, Wenfeng Yu, Hailong Ou

“…In this study, we aim to determine the role of Nox1 in the progression of AAA and explore the underling mechanism. ApoE−/−Nox1SMCko mice in which the Nox1 gene was smooth muscle cell (SMC)-specifically deleted in ApoE−/− background, were infused with angiotensin II (Ang II) for 28 days. …”
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Multi-scenario analysis of green water resource efficiency under carbon emission constraints in the Chengdu-Chongqing urban agglomeration, China: A system dynamics approach by Keyao Yu, Zhigang Li

“…This model is used to explore complex mechanisms and feedback loops influencing GWRE. Five scenarios are then set up: baseline development, economic priority, green innovation, water-saving and emission reduction, and comprehensive development. …”
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Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src by Xieyi Guo, Liu Yang, Xiaoning An, Maofang Hu, Yilan Shen, Niansong Wang, Youhua Xu, Dingkun Gui

“…This study aimed to assess the therapeutic potential of NR2 in DN and explore its underlying mechanisms. Methods In vivo models were developed using db/db mice, while in vitro models utilized HK-2 cells exposed to high glucose and palmitic acid (HGPA). …”
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Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids by Akimi Yonezawa, Kana Shimomura, Koji Okamoto, Haruna Takeda

“…These data suggested that the inhibition of Brd4 could increase cell viability in the cancer microenvironment where IFNγ is abundant, revealing a new aspect of the molecular mechanism of CRC development. Our results may help in evaluating the application of Bet inhibitors in treating CRC. …”
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Features of Measuring the Hardness of a Metal Surface Modified with Ultrafine Particles of Minerals by A. V. Skazochkin, G. G. Bondarenko, P. Żukowski

“…A possible way out of the situation lies in the transition from the use of hardness measures when calibrating instruments to standard samples of properties for which the constancy of mechanical properties in the measured range of indentation depths will be ensured, but which are not yet available in research practice. …”
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