Effect of celecoxib and paracetamol on the functional state of the central nervous system, pain sensitivity, and physical endurance of rats with acute heat injury by P.O. Chuikova, S.Yu. Shtrygol’

“…Since the effectiveness of drugs for the treatment of thermal injuries has not been proven, the search for new thermoprotective agents with different mechanisms of action, in particular inhibitors of the arachidonic acid cascade, is urgent. …”
Get full text

Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade by Yo-Ting Tsai, Jeffrey Schlom, Renee N. Donahue

“…Further research aimed at longitudinal monitoring of circulating biomarkers is also crucial to comprehend immune dynamics and resistance mechanisms and should be used alongside tissue-based methods that interrogate the tumor microenvironment to guide treatment decisions and may inform on the development of novel therapeutic strategies. …”
Get full text

Acute kidney injury, the present on admission (POA) indicator and sex disparities: observational study of inpatient real-world data in a Swiss tertiary healthcare system. Explorati... by Michael Simon, Sarah N Musy, Karen Triep, Olga Endrich

“…Routinely collected health data, 2019 and 2020 (121 757 cases) on the patient history and intensive care treatment duration, comorbidity levels, coded diagnoses, age and sex.Software and statistic: program R, V.4.1.1, SD; median, IQR; prop.test; standardised mean difference.Results The reporting of postadmission diagnoses showed more interhospital transfers, more intensive care stays, higher scores of severity and treatment intensity, more often mechanical ventilation, a higher age, a higher number of diagnoses, a higher complexity level of the related cases and mortality. …”
Get full text

Experimental and Simulation Study on Breaking Rock under Coupled Static Loading and Ultrasonic Vibration by Yan Zhao, Congshan Zhang, Zengzeng Zhang, Ke Gao, Dajun Zhao, Zihang Sun, Xiaoshu Lv, Yu Zhou, Guobing Zhai

“…We designed the ultrasonic rotary drilling device to verify the drilling effect. The process and mechanism of rock fragmentation under static load and ultrasonic vibration load were analyzed from the perspective of energy. …”
Get full text

CHATGPT IN FOREIGN LANGUAGE TEACHING AND ASSESSMENT: EXPLORING EFL INSTRUCTORS’ EXPERIENCE by Inna Zaiarna, Olena Zhyhadlo, Olha Dunaievska

“…The article aims to investigate the perceptions of English language teachers regarding the utilization of ChatGPT in their teaching and assessment practices obtained through a survey in order to establish the degree of their familiarity with the possibilities of ChatGPT for teaching a foreign language and the mechanics of AI-generated test tasks design. The participants are mostly experienced English language instructors, affiliated with higher education institutions in Ukraine, the EU and the USA. …”
Get full text

Groundwater Aquifer Vulnerability Assessment using a Dar-Zarrouk Parameter in a Proposed Aboru Residential Estate, Lagos State, Nigeria by M.A. Ayuk

“… The need to build an automobile mechanic settlement, abattoir and a proposed meat processing factory at Aboru residential estate necessitated a geophysical assessment (using a Dar-Zarrouk parameter – longitudinal unit conductance, S) of the vulnerability of the subsurface aquifers in the study area against the expected long-term anthropogenic impacts of these facilities on the groundwater system. …”
Get full text

Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway by Lechu Yu, Yuanyuan Liu, Yichun Jin, Tinghao Liu, Wenhan Wang, Xuemian Lu, Chi Zhang

“…This possible protective mechanism was investigated in the present study. A high-fat diet, along with a one-time dose of streptozotocin, was applied to metallothionein (MT) knockout mice, nuclear factor-erythroid 2-related factor (Nrf) 2 knockout mice, and age-matched wild-type (WT) control mice, in order to induce type 2 diabetes. …”
Get full text

A novel open-source cultivation system helps establish the first full cycle chemosynthetic symbiosis model system involving the giant ciliate Zoothamnium niveum by P. E. Contarini, E. Emboule, P. Jean-Louis, T. Woyke, S. V. Date, O. Gros, J-M. Volland, J-M. Volland, J-M. Volland

“…Highlighting the benefit of this new system, we here describe a new step in the first hours of development where the host pauses growth, expels a coat, before resuming growth, hinting at a putative symbiont selection mechanism early in the colony life cycle. With this simple, open-source, cultivation setup, Z. niveum holds promises for comparative studies, standardization of research and wide adoption by the symbiosis research community.…”
Get full text

Investigating the role of cathepsins in breast cancer progression: a Mendelian randomization study by Shengyi Zhou, Shengyi Zhou, Shengyi Zhou, Yizhou Sun, Yizhou Sun, Wenzhang Zha, Wenzhang Zha, Guangjun Zhou, Guangjun Zhou

“…BackgroundBreast cancer, a major threat to women’s health worldwide, has mechanisms of onset that remain unclear. Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors, suggesting that they may play key roles in cancer progression.MethodsThis study employed the two-sample Mendelian randomization (MR) approach to investigate the potential causal relationship between cathepsin levels and the risk of developing breast cancer. …”
Get full text

Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver DiseasesSummary by Lan Zhou, Min Yan, Qin Luo, Wen Qiu, Yu-Ru Guo, Xiao-Qing Guo, Hong-Bin Yu, Jing-Ru Huo, Yan-Lin Feng, De-Ping Wang, Teng Sun, Kai-Fang Wang, Jian-Yun Shi, Xuan Shang, Mei-Na Wu, Lin Wang, Ji-Min Cao

“…This study explores the mechanisms underlying CRSDs in CLDs and novel therapies. …”
Get full text

Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis by Yu. O. Zharikov, M. S. Zharkova, A. N. Gadjiakhmedova, A. M. Aliyeva, V. N. Nikolenko, V. T. Ivashkin

“…Further research in this area will help to better understand the mechanisms of ascites development and develop effective methods of prevention and treatment of this complication in patients with liver cirrhosis.…”
Get full text

MUC5B regulates alterations in the immune microenvironment in nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway by Hongming Wang

“…Abstract Objective To screen potential differentially expressed genes related to immune function in nasopharyngeal carcinoma through an online database, and to verify their mechanism of action, so as to provide a reference for the diagnosis and treatment of nasopharyngeal carcinoma in the future. …”
Get full text

Prediction Score for Cervical Spine Fracture in Patients with Traumatic Neck Injury by Natsinee Athinartrattanapong, Chaiyaporn Yuksen, Sittichok Leela-amornsin, Chetsadakon Jenpanitpong, Sirote Wongwaisayawan, Pittavat Leelapattana

“…Five independent factors (i.e., high-risk mechanism of injury, paraparesis, paresthesia, limited range of motion of the neck, and associated chest or facial injury) were considered good predictors of C-spine fracture. …”
Get full text

Temporal Study of Environmental DNA and Acoustic Data Reveals Coexistence of Sympatric Bat Species in a North American Ecosystem by Vrinda M. Suresh, Trevor Hébert, Kirsten Isabel Verster, Elizabeth A. Hadly

“…We hypothesized that the insectivorous bats at this site would rely on one or more niche partitioning mechanisms to promote interspecific coexistence and limit competition. …”
Get full text

Compound weather and climate extremes in the Asian region: science-informed recommendations for policy by R. Krishnan, Chirag Dhara, Takeshi Horinouchi, C. Kendra Gotangco Gonzales, C. Kendra Gotangco Gonzales, A. P. Dimri, A. P. Dimri, M. Singh Shrestha, P. Swapna, M. K. Roxy, Seok-Woo Son, Seok-Woo Son, D. C. Ayantika, Faye Abigail T. Cruz, Fangli Qiao

“…Anthropogenic climate change has led to rapid and widespread changes in the atmosphere, land, ocean, cryosphere, and biosphere, leading to more pronounced weather and climate extremes globally. …”
Get full text

Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Changes in the renin–angiotensin system and in the mineralocorticoid axis activity could be involved as potential mechanisms in their pathogenesis, in addition to cortisol excess. …”
Get full text

Dynamic and efficient vehicular cloud management scheme with privacy protection by Min XIAO, Tao YAO, Yuanni LIU, Yonghong HUANG

“…The vehicular cloud (VC) formed by vehicles is used for localization processing and consumption of traffic sensing data to achieve timely intelligent traffic management.The vehicle cloud is highly dynamic, self-organizing and timely, in which the identity and location privacy of vehicle users need to be protected as this poses challenges to the vehicular cloud management.A dynamic and self-organizing vehicle cloud management scheme based on the asymmetric group key agreement protocol was designed, where the vehicle cloud is automatically formed through the self-organized group key agreement of vehicles.The group key was used to control the provision and access of vehicle cloud services, and the dynamic management of the vehicle cloud was implemented through group key update.The scheme used traceable one-time pseudonym technology to achieve anonymous authentication and conditional privacy protection of vehicle users, and the group key agreement stage only included one bilinear pair operation to achieve high efficiency.In addition, the key negotiation and update process used lightweight signatures, supporting batch verification, to achieve efficient message source authentication and integrity authentication.Then the security and efficiency of vehicle cloud communications in the self-organizing environment can be ensured.The dynamic key update mechanism of the key agreement protocol realized the dynamic joining or exiting of vehicles in the vehicle cloud, adapting to the dynamic characteristics of the vehicle cloud.Under the random oracle model and the difficult assumption of the inverse computational Diffie Hellman (ICDH) problem, it was proved that the asymmetric group key agreement scheme satisfied the selective-plaintext security.The security analysis shows that the scheme can protect the identity and location privacy of vehicle users, realize the legal tracking of malicious vehicles, and ensure the confidentiality, integrity and anti-counterfeiting of communications, as well as the forward security of vehicle cloud dynamic management.The performance comparison analysis shows that this scheme has certain advantages in communication and computing efficiency under the condition of the same function and security level.…”
Get full text

Nitrate–Nitrite–Nitric Oxide Pathway, Oxidative Stress, and Fertility Outcomes in Morbidly Obese Women Following Bariatric Surgery: A Systematic Review by Charalampos Voros, Despoina Mavrogianni, Aspasia Minaoglou, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitrios Loutradis, Georgios Daskalakis

“…This review investigates the molecular mechanisms by which bariatric surgery affects eNOS activity, the NO₃-NO₂-NO pathway, and oxidative stress reduction, with an emphasis on intracellular activities including mitochondrial biogenesis and NO production. …”
Get full text

DMPNet: dual-path and multi-scale pansharpening network by Gurpreet Kaur, Manisha Malhotra, Dilbag Singh, Dilbag Singh, Sunita Singhal

“…The MSAAF module adaptively combines spatial and spectral data across different scales, employing a self-calibrated attention (SCA) mechanism for dynamic weighting of local and global contexts and a spectral alignment network (SAN) to ensure spectral consistency. …”
Get full text

Construction of a potentially functional long noncoding RNA-microRNA-mRNA network in diabetic cardiomyopathy by Qiwen Cao, Zhihui Dong, Yangbo Xi, Jiana Zhong, Jianzhong Huang, Qunfeng Yang

“…Despite various implicated mechanisms, effective DCM treatments remain elusive. …”
Get full text