Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient by Stéfanie Parisien-La Salle, Florence Perreault, Gilles Corbeil, Julie Morisset, Charles Poirier, Catherine Beauregard, Agnès Räkel, Marjorie Labrecque, Martine Tétreault, Martine Tétreault, Christian Cohade, Pasquale Ferraro, Isabelle Bourdeau

“…Further research is necessary to elucidate the genetic and molecular mechanisms underlying PCCs in this specific case and determine its link with hypoxemia in the context of pulmonary disease.…”
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Spatiotemporal dynamics of carbon sequestration capacity and its determinants in rubber plantation ecosystems of Hainan Island by Yinghe An, Zhixiang Wu, Runqing Zhang, Xiang Zhang, Zhenghong Tan, Zhongyi Sun

“…Net Ecosystem Productivity (NEP) is a crucial indicator of the carbon sequestration capacity of terrestrial ecosystems. However, the mechanisms underlying the spatiotemporal variations in the carbon sequestration capacity of tropical artificial forest ecosystems remain unclear. …”
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How different of the rhizospheric and endophytic microbial compositions in watermelons with different fruit shapes. by Jian Xiao, Jinyan Huang, Kezhuo Xiao, Guifen Li, Shangdong Yang, Yi He

“…To elucidate the biological mechanism of watermelon fruit shape formations, the rhizospheric and endophytic microbial community compositions between oval (OW) and circular watermelons (CW) were analyzed. …”
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Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p by Lei Xu, Gang Zhao, Hong Zhu, Shijun Wang, Aijun Sun, Yunzeng Zou, Junbo Ge

“…However, the underlying mechanism is unclear. Here we showed that Rosiglitazone treatment significantly attenuated the expressions of LOX-1, ICAM-1, VCAM-1, p47phox, and the atherosclerotic lesions in ApoE-/- mice with high-fat diet. …”
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PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression by Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai

“…However, the detailed mechanism of PRMT5 promoting colorectal cancer (CRC) malignant progression remains unclear. …”
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Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China by Shuqing Wang, Huanhuan Dong, Meiqi Wang, Wenbo Ma, Yue Cheng, Junliang Zhou, Yongming Cheng, Hui Xu, Xiaochen Yu

“…The present study aimed to explore the epidemiological characteristics of CRKP isolates in Northern China and to elucidate their drug resistance mechanisms. Methods. 45 CRKP strains were consecutively collected at a teaching hospital from March 1st, 2018 to June 30th, 2018. …”
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Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases by Caitlyn L. Holmes, Daeun Shim, John Kernien, Chad J. Johnson, Jeniel E. Nett, Miriam A. Shelef

“…These findings highlight the complexity of NET formation and the need to further define the mechanisms by which different NETs form and their implications for autoimmune disease.…”
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Dimethyl Fumarate Protects against Lipopolysaccharide- (LPS-) Induced Sepsis through Inhibition of NF-κB Pathway in Mice by He Fang, Xingtong Wang, Mahendra Damarla, Rongju Sun, Qingli He, Ruojing Li, Pengfei Luo, Jun O. Liu, Zhaofan Xia

“…In the present study, we have observed the effect of dimethyl fumarate (DMF) on lipopolysaccharide- (LPS-) induced sepsis and investigated the possible mechanism. By screening a subset of the Johns Hopkins Drug Library, we identified DMF as a novel inhibitor of nitric oxide synthesis in LPS-stimulated RAW264.7 cells, suggesting that DMF could be a potential drug to treat sepsis. …”
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Social network user geolocating method based on weighted least squares by Wenqi SHI, Xiangyang LUO, Jiashan GUO

“…When providing location-based dating and other location-based services, social networks will confuse the displayed user distance text to protect the user’s location privacy.In order to verify whether the current location confusion mechanism adopted by social networks can effectively protect user’s accurate location, a social network user geolocating method based on weighted least squares was proposed.The method constructed real-world tests to collect a large number of confused distance texts in location dating service, and identified the real distance boundary of reported distance combined with real distance data.Then, based on the discrimination of the quadrant of the coordinate system where the target user was located, the position of probes was optimally deployed, and multiple preliminary position estimations of the target user were obtained by using the trilateration model.The weights of the longest and the shortest distance of the target user were determined by the estimated position, and the related objective function was constructed.The optimal solution of the objective function was calculated based on the weighted least squares, which was the final geolocating result of the target user.The proposed method inferred the location of social network user based on the distance boundary constraint, which avoided the frequent query of location services and ensured the geolocating efficiency.The actual geolocating results based on 500 WeChat users showed that, the proposed method can accurately geolocate the “eople nearby” users of WeChat.Compared with the existing typical geolocating methods based on space partition and heuristic number theory, the proposed method have better performance in geolocating accuracy and efficiency.The average geolocating error is reduced by more than 10%, and the number of location service quarries in the geolocating process is reduced by more than 50%.…”
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Integrated transcriptomic analysis reveals evolutionary and developmental characteristics of tendon ossification in teleost by Xu-Dong Wang, Fei-Long Shi, Jia-Jia Zhou, Zheng-Yu Xiao, Tan Tu, Xue-Mei Xiong, Chun-Hong Nie, Shi-Ming Wan, Ze-Xia Gao

“…They share similarities with tendon ossification, a form of heterotopic ossification (HO). The mechanisms underlying IB formation remain incompletely understood. …”
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Preparation of phosphogypsum ecological concrete and study on its phytogenic properties by Rongxin Liu, Chunduo Liu, Jiang Du, Cheng Wang, Yonghui Yuan, Xin Zhang

“…By optimizing the mix ratio and curing process, we were able to achieve a concrete material that not only performs well mechanically but also supports plant growth.…”
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Investigation and Identification of let-7a Related Functional Proteins in Gastric Carcinoma by Proteomics by Yimin Zhu, Xingyuan Xiao, Lairong Dong, Zhiming Liu

“…The data suggest that these differential proteins are involved in a novel let-7a signal pathway and these findings provide the basis to investigate the functional mechanisms of let-7a in gastric carcinoma.…”
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Characterization of Acid Hydrolyzed Taro Boloso-I (Colocasia esculenta Cultivar) Starch as a Diluent in Direct Compression of Tablets by Solomon Gashaw, Afewerk Getachew, Fantahun Mola

“…Furthermore, paracetamol tablets made with the modified starch exhibited higher mechanical strength and lower friability in all paracetamol concentrations. …”
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A novel iron/zinc phosphate layered composite coating on Zn-0.5Li alloy for guided bone regeneration membrane applications by Chang Chen, Zhengqin Shi, Yanfang Deng, Xin Chu, Jun Cheng, Yixuan He, Yilong Dai

“…Furthermore, the Fe/ZnP composite coating sample demonstrates superior wear resistance and corrosion resistance (1.72 μm/year) when compared to the Zn–Li alloy substrate; additionally, it induces a shift in corrosion mechanism from local corrosion to uniform corrosion. …”
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Strategies for Gait Retraining in a Collegiate Runner with Transfemoral Amputation: A Case Report by Jillian Santer, Stephanie MacDonald, Katherine Rizzone, Shawn Biehler, Tanya Beiswenger

“…Significant improvements were noted in PLP, running gait mechanics, and the patient’s psychological and functional status as measured with a standardized outcome tool, the Patient-Reported Outcomes Measurement Information System^®^ (PROMIS^®^)…”
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Preparation of Composite Films Based on Methyl Cellulose/Polyvinyl Alcohol-loaded Nanosilver (AgNPs@PVA/MC) and Its Effect on Storage Quality of Ougan by Shuaishuai DAI, Weijie WU, Xiangjun FANG, Hangjun CHEN, Jun HUANG, Ruiling LIU, Huizhi CHEN, Ben NIU, Haiyan GAO

“…The effects of different mass fractions (0%, 0.05%, 0.1%, 0.2%, 0.3%) of AgNPs on the properties of the composite films were investigated, and its appearance, mechanical properties, microstructure and antibacterial properties were characterized, in order to provide theoretical support for the development of preservation materials for storing Ougan. …”
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Evaluation of the efficiency of smear layer removal during endodontic treatment using scanning electron microscopy: an in vitro study by Svetlana Razumova, Anzhela Brago, Anzhelika Kryuchkova, Vasiliy Troitskiy, Ruzanna Bragunova, Haydar Barakat

“…Conclusion The smear layer formed during mechanical treatment of the root canal was better removed during irrigation with etidronate solution.…”
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EMPIRICAL VERIFICATION OF THE STRUCTURAL MODEL RELATING EQUILIBRIUM VALUES OF COSTS, QUALITY, AND COMFORT OF MEDICAL SERVICES WITH INDIVIDUALIZED ELASTICITIES OF DEMAND by Oleg Klymenyuk, Oleksandr Ocheredko, Volodymyr Klymenyuk, Anastasiia Rudenko

“…The healthcare system in Ukraine is moving to flexible mechanisms to support the quality and comfort of medical services, in particular through the introduction of co-payments. …”
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The Life Adjustment Process in Chronic Pain: Psychosocial Assessment and Clinical Implications by Ann-Christine Gullacksen, Jan Lidbeck

“…The following clinical implications are reviewed in the present study: distrust from health professionals may obstruct the adjustment process, prolong sick leave and hinder rehabilitation; providing the patient with a diagnosis (eg, an explanation of pain mechanisms) will facilitate life adjustment; acknowledging the individual experience of suffering from chronic pain will make concepts related to pain behaviour, secondary gain and sick role liable to question; and vocational rehabilitation measures should be harmonized with the actual stage of life adjustment.…”
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Reversible data hiding scheme based on enhanced image smoothness by Jinghan WANG, Hui ZHU, Helin LI, Hui LI, Xiaopeng YANG

“…With the prosperity of Internet technology and the popularity of social networks, reversible data hiding technology has been widely adopted in concealed information transmission of medical and military fields with its advantages on secret information recovery.Traditional reversible data hiding schemes mainly focus on the enhancement of embedding capacity and the reduction of the distortion rate of stego image, but pay less attention to the understanding of image details with the human eyes.Thus, it is difficult to resist hidden information detection methods.To solve the above challenge, a reversible data hiding algorithm was proposed, which ensured the visual quality of the stego image in the process of data hiding through the image visual smoothness enhancement.Specifically, the original image was divided into reference area and non-reference area.The secret data was embedded through the translation of the difference, which was calculated according to the predicted pixel value and the original pixel value of the non-reference area.To guarantee the visual quality of the image, smoothing mechanism was constructed, in which a Gaussian filter was utilized as a template to filter the predicted value and to add the filter difference into the cover image without loss.The pixel value of the reference region was used as edge information for lossless restoration of the original image.The filtering coefficient in Gaussian function was exploited as the embedded key to ensure the security of secret information.Simulation results regarding a large number of classical image data sets illustrated that the visual smoothness of stego image processed by this scheme was effectively enhanced with lower distortion rate, higher embedding rate, and higher embedding and extraction efficiency.In a typical circumstance, the similarity between the generated stego image and the Gaussian filter image can reach 0.9963.The PSNR and the embedded capacity can be up to 37.346 and 0.3289 BPP, respectively.…”
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