Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…This study investigates the role and potential mechanisms of metallothionein 1B (MT1B) in MASH through bioinformatics analysis and experimental validation. quantitative reverse transcription PCR and Western blot analyses confirm that MT1B expression is significantly downregulated in liver tissues of MASH patients, in high-fat diet–induced mouse models, and in hepatocytes induced by FFAs. …”
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The Impact of Climate Change on India-Russia Relations by Uma Purushothaman, Reinhart Philip

“…Collaboration in these areas can enhance preparedness and response mechanisms, strengthening overall resilience.The study also considers the Northern Sea Route (NSR) as a potential collaboration opportunity. …”
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Predictors of 7-day symptomatic hemorrhagic transformation in patients with acute ischemic stroke and proposal of a novel screening tool: A retrospective cohort study by Mehmet Muzaffer Islam, Cemrenur Uygun, Melike Delipoyraz, Merve Osoydan Satici, Servan Kurt, Enis Ademoglu, Serkan Emre Eroglu

“…Symptomatic HT was present in 31 (7.3%) patients. Mechanical thrombectomy, atrial fibrillation, and diabetes mellitus were the independent predictors (P < 0.001, P = 0.003, P = 0.006, respectively). …”
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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…This protective effect is primarily attributed to USP25’s ability to inhibit the differentiation of naïve CD4+ T cells into Th17 cells. The underlying mechanism may involve the downregulation of RORγt. …”
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Predictive Modeling and Experimental Analysis of Cyclic Shear Behavior in Sand–Fly Ash Mixtures by Özgür Yıldız, Ali Fırat Çabalar

“…The findings highlight the trade-offs in mechanical behavior associated with varying fly ash proportions. …”
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Targeting the EZH2-PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic Cancer by Jilong Hu, Zhinan Zheng, Jia Lei, Yuxin Cao, Qiyun Li, Zhi Zheng, Chuanjun Chen

“…These results suggest that the combination of bezafibrate and GSK126 has synergistic effects on PC, and the molecular mechanism may be related to the enhanced inhibition of the Wnt/β-catenin signaling pathway. …”
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Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice by Elena Niccolai, Leandro Di Gloria, Maria Chiara Trolese, Paola Fabbrizio, Simone Baldi, Giulia Nannini, Cassandra Margotta, Claudia Nastasi, Matteo Ramazzotti, Gianluca Bartolucci, Caterina Bendotti, Giovanni Nardo, Amedeo Amedei

“…Further elucidating the mechanisms underlying these interactions could offer novel insights into ALS pathogenesis and potential therapeutic targets.…”
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RETRACTED ARTICLE: Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis by Fan-dong Meng, Ping Ma, Cheng-guang Sui, Xin Tian, You-hong Jiang

“…More well-designed studies with larger samples are warranted to show the underlying mechanisms of CYP1A1 in the development of RCC.…”
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Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors by Yifan Yang, Jing Xu, Qingxin Su, Yiran Wu, Qizheng Li, Zongren Ma, Tao Ding

“…Taken together, the possible mechanism by which LPA secretion in LSS patients aggravates patient injury was further elucidated using an LPA-induced spinal cord neuronal injury cell model in vitro.…”
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Properties characterization and microstructural analysis of alkali-activated solid waste-based materials with sawdust and wastewater integration. by Liang Li, Xianhui Zhao, Haoyu Wang, Jianran Cao, Xian-En Zhao

“…The substitution of 12.28% SDW to NaOH solution improves the resistance to drying shrinkage and long-term mechanical strength development of the AACs. Interestingly, the addition of SDW does not affect the product compositions due to the generation and decomposition of organic acid salts from organic impurities in the acidic SDW during long-term curing at room temperature. …”
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Schistosome feeding and regurgitation. by Patrick J Skelly, Akram A Da'dara, Xiao-Hong Li, William Castro-Borges, R Alan Wilson

“…Furthermore, definition of the molecular mechanisms for the uptake of selected metabolites (glucose, certain amino acids, and water) establishes it as a vital site of nutrient acquisition. …”
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Comparison of Spatiotemporal Gait Variables Between Healthy Individuals and Patients with Heel Spur During Walking by Mohamad amin Shahbazi, Ali Jalalvand

“…Plantar fasciitis is a common foot condition that affects gait mechanics due to pain and inflammation in the plantar fascia. …”
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A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes by Elizabeth Rendina-Ruedy, Kelsey D. Hembree, Angela Sasaki, McKale R. Davis, Stan A. Lightfoot, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith

“…The C57BL/6 mouse model of diet-induced obesity has been used to study the mechanisms by which altered glucose homeostasis affects bone mass and quality, but genetic variations in substrains of C57BL/6 may have confounded data interpretation. …”
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Starożytne źródła antropocentryzmu by Anita Ganowicz-Bączyk

“…It appeared that man falls outside the mechanical laws of nature because he is able to understand them and use this knowledge for his own goals (Democritus), man’s soul makes him transcend nature and dominate it (Socrates), man’s existence is purposeful, he is superior to other material beings as a crown of nature and the most complex and perfect being (Aristotle). …”
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Construction of a 5G Wireless Semantic Web-Assisted English Digital Learning Resource Query System by Lili Liu

“…We propose a quality algorithm for 5G wireless networks, which not only captures the characteristics of 5G wireless networks such as local broadcast and node movement but also combines quality predicates as guards with broadcast reception actions, which are used to portray that a node can continue to execute subsequent processes only when the node reception actions satisfy certain conditions, which works together with the node default value mechanism to reduce the impact caused by unreliable links. …”
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Autobodies: Detectives, Disorders, and Getting out of the Neighborhood by James Peacock

“…Essrog’s tics and outbursts mirror the chaos of his Brooklyn, but his obsessive, smoothing-over tendencies reflect his guilt over his orphan status, his desire to reach back into and repair the past. …”
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Temporal trends of community and climate changes in the anthropocene: 21-year dynamics of four major functional groups in a rocky intertidal habitat along the Pacific coast of Japa... by Hiroki Sato, Ken Ishida, Takashi Noda

“…We aimed to examine the 21-year trends in regional abundance at both functional-group and species levels, plus their driving mechanisms and their dependence on species properties (thermal niche, calcification status, and vertical niche). …”
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La reescritura prismática del orfismo y sus dimensiones en la poesía de Carles Riba, Agustí Bartra y Josep Sebastià Pons by Marta López Vilar

“…Carles Riba recreates and makes use of the mechanisms of religion and the Orphic mysteries to give form to his particular initiation after a metaphysical death that appears, for example, in elegy 10 of Elegies de Bierville (second edition, Santiago de Chile, 1949). …”
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The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism by Yu Hu, Hongyan Zai, Wei Jiang, Zhenglin Ou, Yuanbing Yao, Qin Zhu

“…This study is aimed at exploring the effect of FoxO1 and SREBP-1c on HB and their mechanism. Methods. FoxO1, SREBP-1c, FASN, ACLY, ACC, and MAGL expressions in tissue samples were detected by RT-qPCR and WB. …”
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Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance by Kimberly N. Kremer, Hadeel A. Khammash, Anjelica M. Miranda, Lauren N. Rutt, Shannon M. Twardy, Paige E. Anton, Margaret L. Campbell, Christian Garza-Ortiz, David J. Orlicky, Roberta Pelanda, Rebecca L. McCullough, Raul M. Torres

“…This self-preservation mechanism can however decrease the efficiency of immunosurveillance of malignant cells by CD8 T cells. …”
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