Development of immune-derived molecular markers for preeclampsia based on multiple machine learning algorithms by Zhichao Wang, Long Cheng, Guanghui Li, Huiyan Cheng

“…Our results indicate that these biomarkers may outperform previously reported molecular signatures in predicting PE and provide insights into the mechanisms underlying immune dysregulation in PE. Further validation in larger cohorts could lead to their clinical application in PE prediction and treatment.…”
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Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review by Joanna Pogorzelska-Dyrbuś, Jacek C. Szepietowski

“…We hypothesise that as there is a high inconsistency between the results of the studies, as far as the densities of LCs observed in the specimens are concerned, it seems that the mechanism of the influence of LCs on the antitumoural immune response is complicated. …”
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Nurse-led patient-centred intervention to increase written advance directives for outpatients in early-stage palliative care: study protocol for a randomised controlled trial with... by Katia Iglesias, Catherine Busnel, Florian Dufour, Sophie Pautex, Laurence Séchaud

“…The aims of this study are (1) to test the effectiveness of the Go Wish intervention among outpatients in early-stage palliative care and (2) to understand the role of defence mechanisms in end-of-life discussions among nurses, patients and relatives.Methods and analysis A mixed-methods study will be performed. …”
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Study of the effect of azithromycin on airway remodeling in asthma via the SAPK/JNK pathway by Dannv Ma, Huaqing Du, Yi Huang, Aiwu Pan, Lu Gan

“…Thus, this study delved into the mechanism of AZM repressing airway remodeling (AR) via the SAPK/JNK pathway in asthma. …”
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Stereospecific α-glucosidase inhibition, kinetics, and molecular docking studies on isolated diastereomeric alkaloids from Uncaria longiflora by Nurul Aina Suzlin Sulaiman, Muhammad Farhan Syakir Nor Azman, Mohd Fadhlizil Fasihi Mohd Aluwi, Zainul Amiruddin Zakaria, Mohammad Jemain Mohammad Ridhwana, Fatimah Salim

“…Kinetics analysis revealed that pteropodine and isopteropodine inhibited α-glucosidase through competitive and noncompetitive mechanisms, with IC50 values of 226.70 ± 2.82 and 98.06 ± 1.98 µg/mL, respectively. …”
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Cross-Chain Identity Authentication Method Based on Relay Chain by Qipeng Huang, Minsheng Tan, Wenlong Tian

“…The cross-chain identity authentication method based on relay chains provides a promising solution to the issues brought by the centralized notary mechanism. Nonetheless, it continues to encounter numerous challenges regarding data privacy, security, and issues of heterogeneity. …”
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The causal effect of Internet use on rural middle-aged and older adults’ depression: A propensity score matching analysis by Junqi Ma

“…Results Internet use significantly reduced depression in rural middle-aged and older adults. The mechanism was that Internet use improved mental health by improving social interaction and enhancing social support. …”
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The Sustainability of Knowledge-Sharing Behavior Based on the Theory of Planned Behavior in Q&A Social Network Community by Xin Feng, Lijie Wang, Yue Yan, Qi Zhang, Liming Sun, Jiangfei Chen, Ye Wu

“…Therefore, we propose that the platform can use incentive mechanisms to promote knowledge sharing while helping sharers realize their self-worth, improve the existing functions of the platform, or carry out activities to encourage users to participate, so as to achieve the purpose of knowledge sharing and maintain the operation of the Zhihu platform.…”
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Effect of The Rs-10 Radioprotector on Protein-Steroid Interaction in Irradiated Animals with Biphasic Adrenocortical Response to Irradiation by Nadezhda Omelchuk

“…A leading role in the mechanism of reducing affected hypercorticism under protective conditions has a lesser degree of impairment of the binding capacity of the CSG, rather than a change in the total level of 11-OKS in the blood. …”
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Effect of Xiaoxuming Decoction on Aβ and GFAP Protein Expressions in Hippocampus of APP/PS1 Mouse Model of Alzheimer's Disease and Its Behavior Analysis by Jingjie MAO, Yaping CHEN, Ruhui LIN, Zuanfang LI, Xiaoqin ZHU

“…Objective:To observe the effect of Xiaoxuming decoction (XXMD) on the expression of Aβ and GFAP protein in the hippocampus of APP/PS1 transgenic model mouse, and to explore its mechanism.Methods:APP/PS1 double transgenic mice were used to establish the Alzheimer's disease (AD) model, and the same month old littermates negative mice were chose as the control group. …”
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The influence of pedagogical reflection on design educational and professional plans of future teachers. by M. A. Golovchin

“…In  the  course  of  further generalization,  a  procedural  model  of  the  influence  of  pedagogical  reflection  on  the  professional development of a university graduate was developed.The scientific novelty of the study lies in the new perspective of posing the question of pedagogical reflection as a factor in educational and professional choice; the author’s methodology for summarizing the  level  of  formation of  professional  reflection  within  the framework  of  factor analysis; a conceptual model that describes the influence of reflection on the professional development of a graduate, focusing on “soft” mechanisms that can be used to solve personnel problems in the education system. …”
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Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing by Mangle Chen, Donghai Wang, Jiali Yang, Yuhao Cao, Xuemei Song, Yuwen Lu, Hongying Zheng, Jiejun Peng, Guanwei Wu, Jian Wu, Junmin Li, Jianping Chen, Fei Yan, Shaofei Rao

“…RNA silencing is an evolutionarily conserved antiviral mechanism. In virus-infected plants, virus-derived small interfering RNAs (vsiRNAs) are one of the key components involved in the RNA silencing-based antiviral activity in plants. …”
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A New Method of Central Axis Extracting for Pore Network Modeling in Rock Engineering by Xiao Guo, Kairui Yang, Haowei Jia, Zhengwu Tao, Mo Xu, Baozhu Dong, Lei Liu

“…Compared to traditional rock mechanics and geophysical experiments, digital core and pore network modeling is attracting more interests as it can provide more details on rock microstructure with much less time needed. …”
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FOSL2 activates TGF‐β1‐mediated GLUT1/mTOR signaling to promote diabetic kidney disease by Xuelin He, Min Xia, Guanghui Ying, Qien He, Zhaogui Chen, Li Liu, Qiao Zhang, Jianxin Cai

“…This study aimed to characterize the role of FOSL2 in DKD and its mechanism. Method The kidney tissues of DKD mice induced by STZ and a high‐fat diet were subjected to PAS and Masson's staining. …”
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Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis by Fang-Chen Gong, Ran Ji, Yu-Ming Wang, Zhi-Tao Yang, Ying Chen, En-Qiang Mao, Er-Zhen Chen

“…In this study, we aimed to identify key genes involved in the molecular mechanisms of sepsis and search for potential new biomarkers and treatment targets for sepsis using bioinformatics analyses. …”
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ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-κB signaling pathway by Shuo Zhou, Yuhang Yang, Feiyu Qi, Wanliang Sun, Dengyong Zhang, Zheng Lu, Yongliang Chen

“…However, its regulatory mechanism in CCA remains unclear. Public databases and clinical tissue samples were used to evaluate whether ADAMDEC1 expression was correlated with the prognosis of CCA. …”
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Genome-wide identification and comparative analysis of the AP2/ERF gene family in Prunus dulcis and Prunus tenella: expression of PdAP2/ERF genes under freezing stress during dorma... by Dongdong Zhang, Bin Zeng, Yawen He, Jiangui Li, Zhenfan Yu

“…The findings provide a theoretical foundation for future research on almond improvement and breeding, as well as the molecular mechanisms underlying resistance to freezing stress.…”
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Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice by Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Harder-Rauschenberger, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip

“…The disease is caused by mutations in the THAP1 gene, although the precise mechanisms by which these mutations contribute to the pathophysiology of dystonia remain unclear. …”
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E-Selectin/AAV Gene Therapy Promotes Myogenesis and Skeletal Muscle Recovery in a Mouse Hindlimb Ischemia Model by Antoine J. Ribieras, Yulexi Y. Ortiz, Yan Li, Nga T. Le, Carlos T. Huerta, Francesca A. Voza, Hongwei Shao, Roberto I. Vazquez-Padron, Zhao-Jun Liu, Omaida C. Velazquez

“…The response to ischemia in peripheral artery disease (PAD) depends on compensatory neovascularization and coordination of tissue regeneration. Identifying novel mechanisms regulating these processes is critical to the development of nonsurgical treatments for PAD. …”
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Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration by Tesfa Dejenie Habtewold, Prabhavi Wijesiriwardhana, Richard J. Biedrzycki, Cuilin Zhang, Katherine L. Grantz, Jagteshwar Grewal, Fasil Tekola-Ayele

“…Abstract Background Dysregulation of maternal glucose homeostasis has been related to an increased risk of morbidity and mortality in mothers and fetuses, yet the mechanism remains unclear. This study investigated the association between maternal glycemic levels and placental epigenetic age acceleration (PAA) in a multiethnic cohort. …”
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