Integrative analysis of metabolite and transcriptome reveals the biosynthetic pathway and candidate genes for iridoid glycoside biosynthesis in Neopicrorhiza scrophulariiflora (Pen... by Ke Rao, Ke Rao, Siyu Liu, Siyu Liu, Xiaohui Tang, Guofu Jia, Shaohua Yang, Chaoxiang Ren, Chaoxiang Ren, Jin Pei, Jin Pei

“…These findings provide important genetic and metabolomic information for an in-depth understanding of the biosynthetic mechanisms of iridoids and lay the foundation for the protection and sustainable utilization of N. scrophulariiflora.…”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

“…Dysbiosis causes activation of proinflammatory mechanisms, metabolic toxicity, and insulin resistance. …”
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An attention based residual U-Net with swin transformer for brain MRI segmentation by Tazkia Mim Angona, M. Rubaiyat Hossain Mondal

“…In our paper, we present a hybrid model, 3-Dimension (3D) ResAttU-Net-Swin, which combines residual U-Net, attention mechanism and swin transformer. Residual blocks are introduced in the U-Net structure as encoder and decoder to avoid vanishing gradient problems and improve feature recovery. …”
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How and when supervisors’ information sharing reduces new employees’ errors by Tesfaye A. Bafa, Mingyu Zhang, Chong Chen

“…Secondly, the study fosters the Conservation of Resources [COR] theory, initially resource gain may not always reveal resource gain in the future as well by looking at the mediating mechanisms between the outcomes of new employees’ error reduction and the supervisor information sharing.…”
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From musk to body odor: Decoding olfaction through genetic variation. by Bingjie Li, Marissa L Kamarck, Qianqian Peng, Fei-Ling Lim, Andreas Keller, Monique A M Smeets, Joel D Mainland, Sijia Wang

“…This study provides information about coding for human body odor, and gives us insight into broader mechanisms of olfactory coding, such as how differential OR activation can converge on a similar percept.…”
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Uncovering potential causal genes for undiagnosed congenital anomalies using an in-house pipeline for trio-based whole-genome sequencing by Jeong-Min Kim, Hye-Won Cho, Dong Mun Shin, Oc-Hee Kim, Jihyun Kim, Hyeji Lee, Gang-Hee Lee, Joon-Yong An, Misun Yang, Heui Seung Jo, Ja-Hyun Jang, Yun Sil Chang, Hyun-Young Park, Mi-Hyun Park

“…Further research into the molecular mechanisms related to the development of CAs could shed light on the functional aspects of these genetic variations and contribute to the development of therapeutic drugs.…”
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Bridging brain and blood: a prospective view on neuroimaging-exosome correlations in HIV-associated neurocognitive disorders by Haixia Luo, Junzhuo Chen, Jiaojiao Liu, Wei Wang, Chuanke Hou, Xingyuan Jiang, Juming Ma, Fan Xu, Xire Aili, Zhongkai Zhou, Hongjun Li, Hongjun Li, Hongjun Li

“…Although combination antiretroviral therapy (cART) has greatly improved the prognosis for HIV patients, the incidence of HAND remains high, underscoring the urgent need to better understand its pathological mechanisms and develop early diagnostic methods. This review highlights the latest advancements in neuroimaging and exosome biomarkers in HAND research. …”
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Abundance, occurrence, and degradation of airborne antibiotic resistance genes in coastal and marine atmospheres by Shijie Jia, Shijie Jia, Xiaohong Yao, Jianhua Qi, Jianhua Qi, Xiaohuan Liu, Xiaohuan Liu, Huiwang Gao, Huiwang Gao

“…Our findings highlight the complex role of marine aerosols as both potential sources and reservoirs of airborne ARGs and highlight the critical importance of investigating the transport dynamics and variation mechanism during the long-range transport of ARGs.…”
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Structural Optimisation of a Suspension Control Arm Using a Bi-Evolutionary Bone Remodelling Inspired Algorithm and the Radial Point Interpolation Method by Carlos Oliveira, Ana Pais, Jorge Belinha

“…Today, topological structural optimisation is a valuable computational technique for designing mechanical components with optimal mass-to-stiffness ratios. …”
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Study on transportation and stress distribution of the overburden rock of gob side entry with cutting top and unloading pressure by Yunlin Shuai, Zhenqian Ma, Xiaolei Feng

“…The results show that: ① the establishment of lateral suspension mechanical model analysis found that, with the increase of coal seam dip angle, the reduction of the coal pillar bearing capacity before and after cutting the top gradually decreases, the dip angle of coal seam is 30°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2164 KN; with the increase of the overburden rock caving angle, the reduction of the coal pillar bearing capacity before and after cutting the top increases continuously, the caving angle of overburden rock is 63°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2218 KN. ② After the implementation of roof cutting and cutting off the overhanging roof structure, the stress of the surrounding rock of the coal pillar gang in the roadway has significantly decreased by 18.87%, and the stress of surrounding rock of roadway solid coal gang, roof and floor is reduced by 8.48%,5.79% and 4.81% respectively, which relieved the concentration in the surrounding rock stress of the roadway and improves the stress condition of the roadway. …”
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Application of BPNN Optimized by Fireworks Algorithm on Structural Bearing Capacity Analysis of Transmission Tower under Icing Conditions by Jian Guo, Wu Guo

“…In order to accurately predict the structural bearing capacity, reduce the adverse effects of line icing, and ensure the structural stability of the transmission tower, the FWA is introduced into the neural network model. The self-adjusting mechanism of the local search ability and global search ability of the FWA is used to optimize the optimization process of weights and thresholds in the neural network, and a structural bearing capacity prediction model based on the FWA improved backpropagation neural network (BPNN) is proposed. …”
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Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study by Malte Beckmann, Julian Schlüter, Michael Erdmann, Rafaela Kramer, Sarah Cunningham, Holger Hackstein, Robert Zimmermann, Lucie Heinzerling

“…With cancer patients having a higher risk of thrombotic events per se, it is crucial to dissect and characterize the mechanisms that cause pro-coagulative effects induced by systemic tumor therapies and their potential interplay with anti-tumor response. …”
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Colibactin-induced damage in bacteria is cell contact independent by Emily Lowry, Amir Mitchell

“…Colibactin crosslinks DNA and induces genotoxic damage in both mammalian and bacterial cells. While the mechanisms facilitating colibactin delivery remain unclear, results from multiple studies supported a delivery model that necessitates cell-cell contact. …”
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A Complementary Low Schottky Barrier Nonvolatile Bidirectional Reconfigurable Field Effect Transistor Based on Dual Metal Silicide S/D Contacts by Liu Xi, Ya Wang, Meile Wu, Lin Qi, Mengmeng Li, Shouqiang Zhang, Xiaoshi Jin

“…The scale of CLSB-NBRFET can be reduced to nanoscale while maintain high performance. The physical mechanism of the proposed CLSB-NBRFET has been analyzed in detail. …”
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Peripherally inserted central catheters versus implanted port catheters in patients with breast cancer: a post hoc analysis of the PICCPORT randomised controlled trial by Anton Utas, Stefanie Seifert, Knut Taxbro

“…The primary endpoint was a composite variable encompassing thrombotic, occlusive, infectious, or mechanical complications, while patient satisfaction served as a secondary endpoint. …”
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Multi-omics analysis of hexaploid triticale that show molecular responses to salt stress during seed germination by Dongxia Wang, Jiedong Li, Shiming Li, Jiongjie Fu, Baolong Liu, Baolong Liu, Baolong Liu, Dong Cao, Dong Cao, Dong Cao

“…This study improved understanding about the potential molecular mechanisms associated with hexaploid triticale salt tolerance and contributed to the breeding of salt-tolerant germplasms and the utilization of saline soils.…”
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Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis by Zijian Kang, Yu Du, Ran Cui, Qian Wang, Miao Chen, Yu-Hsun Wang, James Cheng‐Chung Wei, Sheng-Ming Dai

“…The overlapping immunological mechanisms may underlie the co-occurrence of psoriasis and SS.…”
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Digital society: theoretical outlines of the emerging paradigm by Yu. A. Chernavin

“…Digital institutions and the digital sphere, acting as mechanisms for the emergence of society, rely on their own type of activity, have a new type of personality as a subject – “information person”.The analysis, undertaken within the framework of the neo-institutional approach, the features of the socialization of e-Homo Sapiens are revealed, based on the need for presence and activity in the information space, taking into account the impact of modern information technologies, which ultimately contribute to the inconsistency of the emerging typological properties. …”
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A Current Overview of Next-Generation Probiotics and Their Prospects in Health and Disease Management by Ke-Yan Loo, Joanne Yuen Heng Thong, Loh Teng-Hern Tan, Vengadesh Letchumanan, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law

“…Nevertheless, future research is essential to better elucidate the exact mechanisms, safety profiles, and therapeutic applications of these NGPs.  …”
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Improved Therapeutic Effect of Puerarin-Encapsulated PEG-PLGA Nanoparticle on an In Vitro Cerebral Infarction Model by Lei Li, Yan Li, Cheng Miao, Rui Liu

“…This study was to explore the therapeutic effect and mechanism of puerarin (PUE) combined with PEGylated nanoparticles on a rat cerebral infarction cell model. …”
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