A Fully Coupled Hydromechanical Model for CO2 Sequestration in Coal Seam: the Roles of Multiphase Flow and Gas Dynamic Diffusion on Fluid Transfer and Coal Behavior by Rui Yang, Weiqun Liu, Tianran Ma, Junhe Xie, Yang Hu, Rui Zhou, Yongjie Yang

“…Subsequently, all the mentioned mechanisms and interactions were embedded into the coupled hydromechanical model, and this new fully coupled model was well verified by a set of experimental data. …”
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Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway by Shubin Wang, Xiangjun Liu, Lu Xu, Jinyi Lang, Dengqun Liu, Dengqun Liu

“…However, the role and mechanism of iron in the phase of enteritis and the subsequent repairing phase of intestinal stem cells has not been elucidated. …”
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Orthopedic Trauma Epidemiology in Pediatric Patients at a Tertiary Care Trauma Center in North India by Syed Faisal Afaque, Vikas Verma, Farhat Fatima, Ajai Singh

“…The aim of this study is to investigate the epidemiology, etiology, mechanisms of injury, and outcomes of orthopedic trauma in pediatric patients who are admitted to a tertiary care trauma center located in North India. …”
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Understanding the dynamics driving obesity in socioeconomically deprived urban neighbourhoods: an expert-based systems map by Fleur ter Ellen, Joost Oude Groeniger, Karien Stronks, Luc L. Hagenaars, Carlijn B.M. Kamphuis, Joreintje D. Mackenbach, Mariëlle A. Beenackers, Karen Freijer, Pieter Coenen, Maartje Poelman, Karen M. Oude Hengel, Frank J. van Lenthe

“…To better understand the complex mechanisms behind this trend, we created a system map exposing the underlying system driving obesity prevalence in socioeconomically deprived urban neighbourhoods over the last three decades in the Netherlands. …”
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Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway by Azam Shiasi, Marziyeh Tavalaee, Ramesh Monajemi, Dattilo M, Mohammad Hossein Nasr-Esfahani

“…We aimed to investigate the underlying mechanisms.Therefore, the expression of the main enzyme proteins involved in the generation of endogenous antioxidant power,cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), heme oxygenase (HO-1), and also, some ofthe metabolites (methionine, homocysteine, taurine and vitamin B6) reporting on their activity was investigatedusing a surgical varicocele model in rats.Materials and Methods: In this experimental study, thirty male Wistar rats (7-8 weeks old, weighing 180-220 g)were divided into three groups: control, sham, and varicocele. …”
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Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis by Chang Liu, Yanyang Li, Yanping Chen, Shaowei Huang, Xiaojing Wang, Shuang Luo, Yulin Su, Lian Zhou, Xia Luo

“…As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the differentiation of naïve CD4+ T cells via AhR activation. …”
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Functional Tests and Surveys Used to Assess Nervous System Dysfunction in Patients with Fabry Disease – A Review by Stanislaw Jesionek, Jakub Parys, Agnieszka Mikosińska, Martyna Kaźmierczak, Partycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Justyna Jankowska

“…These results challenge the widely accepted notion that autonomic neuropathy is a major contributor to Fabry disease symptoms and emphasize the need for further research into the specific mechanisms underlying the disease's clinical manifestations. …”
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Efficacy and safety of non-pharmacological, pharmacological and surgical treatments for hand osteoarthritis in 2024: a systematic review by Féline P B Kroon, Margreet Kloppenburg, Ida K Haugen, Ingvild Kjeken, Nina Østerås, Anne Therese Tveter, Geir Smedslund, Daniel Huseby Bordvik, Kristine Aasness Fjeldstad, Ingrid Skaalvik

“…To better understand action mechanism of different treatments, future trials should include hand OA subtyping and be powered for subgroup analyses.…”
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TIBW: Task-Independent Backdoor Watermarking with Fine-Tuning Resilience for Pre-Trained Language Models by Weichuan Mo, Kongyang Chen, Yatie Xiao

“…This work provides a secure and reliable IP protection mechanism for NLP models, ensuring watermark integrity across diverse applications.…”
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Long COVID-19–related and non-COVID-19 postviral olfactory dysfunction a comparative MRI study focusing on the olfactory cleft and bulbs by Yifan Li, Yifan Li, Mengfan Liu, Mengfan Liu, Ruoqi Zhang, Ruoqi Zhang, Yibei Wang, Jianfeng Liu, Jianfeng Liu

“…ObjectiveTo compare the magnetic resonance imaging (MRI) features of the olfactory cleft (OC) and olfactory bulbs (OBs) in patients with long COVID-19-related (LCOD) and non-COVID-19 postviral olfactory dysfunction (NCPVOD) to explore mechanisms underlying persistent olfactory dysfunction.MethodsThis retrospective analysis included patients diagnosed with LCOD or NCPVOD at the China–Japan Friendship Hospital between February 2023 and July 2024. …”
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Insider threat detection based on operational attention and data augmentation by Guanyun FENG, Cai FU, Jianqiang LYU, Lansheng HAN

“…In recent years, there has been an increased focus on the issue of insider threats.Insider threats are a major cause security breaches in organizations and pose an ongoing challenge.By analyzing the existing insider threat data, it was identified that the biggest challenge in insider threat detection lies in data imbalance and the limited number of labeled threat samples.In the Cert R4.2 dataset, which is a classic dataset for insider threat detection, there are over 3.22 million log data, but only 7,423 are marked as malicious operation logs.Furthermore, most of the operation types in the logs are not related to malicious behavior, and only two types of operations are highly correlated with malicious behavior, such as leaking company data, creating interference in the detection process.To address this challenge, a data processing framework was designed based on operational attention and data augmentation.Anomaly evaluation was first performed on operations by the framework, and operations with low anomaly scores were then masked.This makes the model better focus on operations related to malicious behavior, which can be considered as a hard attention mechanism for operations.Next, the characteristics of the insider threat dataset were analyzed, and three rules were designed for data augmentation on malicious samples to increase the diversity of samples and alleviate the substantial imbalance between positive and negative samples.Supervised insider threat detection was regarded as a time-series classification problem.Residual connections were added to the LSTM-FCN model to achieve multi-granularity detection, and indicators such as precision rate and recall rate were used to evaluate the model.The results indicate superior performance over existing baseline models.Moreover, the data processing framework was implemented on various classic models, such as ITD-Bert and TextCNN, and the results show that the methods effectively improve the performance of insider threat detection models.…”
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Continuing exposure to disadvantageous material and perceived economic factors on self-rated health in different life stages: fixed effects analyses with data from the German Socio... by Tobias Rähse, Matthias Richter, Anja Knöchelmann

“…Future research should explore the mechanisms underlying these effects to develop well-timed measures that mitigate the negative health implications of continuing exposures to disadvantageous factors, emphasizing the importance of multiple exposures and later life health effects that may impede healthy ageing.…”
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Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men by Carla Basualto-Alarcón, Paola Llanos, Gerardo García-Rivas, Mayarling Francisca Troncoso, Daniel Lagos, Genaro Barrientos, Manuel Estrada

“…According to emerging clinical evidence, here, we will discuss the potential mechanisms with cardioprotective effects and SHBG levels to be used as an early metabolic and cardiovascular biomarker in men.…”
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Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition by Jaison Jeevanandam, Mara Gonçalves, Rita Castro, Juan Gallo, Manuel Bañobre-López, João Rodrigues

“…These findings led to a novel mechanism that has not been proposed in previous studies.…”
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Fungal Submerged Fermentation of Coffee Silverskin: A Sustainable Source of Natural Meat Additives by Stephany Carolina Terán-Rivera, Gastón Ramón Torrescano-Urrutia, Brisa del Mar Torres-Martínez, Martín Esqueda-Valle, Félix Joel Ibarra-Arias, Armida Sánchez-Escalante, Rey David Vargas-Sánchez

“…Nevertheless, further research is necessary to assess the sensory impact, biochemical mechanism, food safety, sustainability, and industrial feasibility of these extracts for broader applications.…”
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Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats by Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng

“…Recently, endothelial‒mesenchymal transition (EndMT), in which activin plays an important role, has been shown to be an important factor in RHD valvular injury. However, the mechanism of activin activity and EndMT in RHD valvular injury is not clear. …”
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Stable Isotope-Resolved Metabolomic Differences between Hormone-Responsive and Triple-Negative Breast Cancer Cell Lines by Jason H. Winnike, Delisha A. Stewart, Wimal W. Pathmasiri, Susan L. McRitchie, Susan J. Sumner

“…To conduct an exploratory study to identify mechanisms that differentiate Luminal A (BT474 and MCF-7) and triple-negative (MDA-MB-231 and MDA-MB-468) breast cancer (BCa) cell lines to potentially provide novel therapeutic targets based on differences in energy utilization. …”
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OsLAP3/OsSTRL2, encoding a rice strictosidine synthase, is required for anther cuticle formation and pollen exine patterning in rice by Dai-bo Chen, Ran Zhou, Ran Zhou, Hui-min Wang, Pei-pei Zhang, Zheng-fu Yang, Zheng-fu Yang, Dan-dan Xuan, Ying-xin Zhang, Xiao-deng Zhan, Li-yong Cao, Li-yong Cao, Shi-hua Cheng, Lian-ping Sun, Lian-ping Sun

“…Although several regulatory factors related to lipid biosynthesis during pollen wall development have been identified, the molecular mechanisms controlling these processes remain poorly understood. …”
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Immunomodulatory effects of Lactiplantibacillus plantarum CCFM8661 + stachyose on cyclophosphamide-induced immunosuppression mice by Weiwei Ma, Hang Sun, Lian Lian, Lidong Guo, Yanyan Wang, Lili Huang

“…Lactiplantibacillus plantarum and stachyose have gained attention for their immune-regulating effects, but the mechanisms of their combined application remain unclear. …”
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UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway by Lijie Yang, Penghui Si, Tuoheti Kuerban, Linfa Guo, Shanzhi Zhan, Yisha Zuhaer, Yingtong Zuo, Peixiang Lu, Xiaojie Bai, Tongzu Liu

“…However, the potential mechanisms remain to be elucidated. We aim to investigate the role of UHRF1 in EMT and renal fibrosis and to evaluate the potential benefits of Hinokitiol in preventing renal fibrosis. …”
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