Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives by Ahmed A. Fadda, Rasha E. El-Mekawy, Ahmed El-Shafei, Harold S. Freeman, David Hinks, Manal El-Fedawy

“…A series of porphyrin derivatives 2a–f was synthesized, namely, 5,10,15,20-mesotetrakis[p-methoxyphenyl]-21H,23H-porphyrin (2a), 5,10,15,20-mesotetrakis[2,6-dichloro-phenyl]-21H,23H-porphyrin (2b), 5,10,15,20-mesotetrakis[4-hydroxy-3,5-dimethoxyphenyl]-21H,23H-porphyrin (2c), 5,10,15,20-mesotetrakis[3,4-dimethoxyphenyl]-21H,23H-porphyrin (2d), 5,10,15,20-mesotetrakis[2,4-dichlorophenyl]-21H,23H-porphyrin (2e), and 5,10,15,20-mesotetrakis[3,4,5-trimethoxyphenyl]-21H,23H-porphyrin (2f), in high yields using a new method via a capping mechanism. These dyes were used as a model to study the free radical-induced damage of biological membranes and the protective effects of these porphyrins. …”
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Technical Advancement in the Design of Interior Spaces for the Disabled by Yasir Kareem Hassan, Nrmeen Wameed Ahmad

“…The research aims to reveal the mechanisms and requirements of technical upgrading in the design of interior spaces for the disabled. …”
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Mild heat stress promotes the differentiation of odontoblast-like MDPC-23 cells via yes-associated protein by Peiqi Liu, Zhen Li, Hui Zhang, Yijie Wang, Yuxin Liao, Yi Guo, Chenxu Wang, Yuanwu Zou, Rui Zou, Lin Niu

“…This study examined the effects and mechanism of action of mild heat stress (MHS) on the differentiation of odontoblast-like MDPC-23 cells.Methods We used a heating device to accurately control the temperature and duration, mimicking the thermal microenvironment of odontoblast-like cells. …”
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The Influence of Reservoir Composition on the Pore Structure of Continental Shale: A Case Study from the Qingshankou Formation in the Sanzhao Sag of Northern Songliao Basin, NE Chi... by Jianguo Yang, Liu Wang, Shichao Li, Cheng Zuo, Fei Xiao, Yuchu Chen, Yulai Yao, Longhui Bai

“…Determining the pore structure characteristics and influencing factors of continental shale reservoir in the oil generation stage is of great significance for evaluating the shale oil reservoir space and analyzing shale oil enrichment mechanism. In this paper, shale from the first member of the Upper Cretaceous Qingshankou Formation (K2qn1) in the Songliao Basin was selected. …”
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QUIET WARRIOR – Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR) by Osama Dasa, Eileen Handberg, Damini Dey, Pinaki Sarder, Margaret C. Lo, Balaji K. Tamarappoo, Steven M. Smith, Leslee J. Shaw, C. Noel Bairey Merz, Carl J. Pepine

“…These data will also uncover pathophysiological mechanisms associated with angina and MACE, improving predictive tools for symptomatic women with INOCA. …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…Methods In order to characterize the impact of sugarcane ash derived (SAD) SiNPs on human kidney proximal convoluted tubule (PCT) cells and identify potential mechanisms of toxicity, HK-2 cells were exposed to treatments of either pristine, manufactured, 200 nm SiNPs or SAD SiNPs and changes to cellular energy metabolism and redox state were determined. …”
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Relationships among thriving at work, organisational commitment and job satisfaction among Chinese front-line primary public health workers during COVID-19 pandemic: a structural e... by Di Jiang, Jingjing Wang, Lei Guo, Yuanmin Jia, Mo Yi, Zeyi Zhang, Ou Chen, Baosheng Zhao

“…Objectives This study aims to explore the mediating effect and influence mechanism of organisational commitment on the association among thriving at work and job satisfaction among frontline primary public health workers (PHWs) in China during the COVID-19 pandemic.Design This study is a cross-sectional written survey.Setting We included 20 primary care units in northern provinces of China.Participants A total of 601 PHWs who worked in primary organisations and against COVID-19 on the front line were included.Methods We collected the data from the participants’ written questionnaire (Minnesota Satisfaction Questionnaire, thriving at work scale and organisational commitment scale), and programmed AMOS V.26.0 to develop a structural equation model (SEM) based on the relationships among the three variables.Results The thriving at work scores of the primary PHWs were (M=3.17, SD=0.65), and job satisfaction was (M=3.05, SD=0.69); the scores of their thriving at work, organisational commitment and job satisfaction were all significantly correlated (p<0.01); and the SEM indicated that organisational commitment had a significant partial mediating effect between thriving at work and job satisfaction. …”
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CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite by Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa

“…These soluble immunological molecules act by modulating the inflammatory response; however, the mechanisms associated with the development of AKI are still poorly understood. …”
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A method for siRNA-mediated knockdown of target genes in RA-induced neurogenesis using P19 cells by Hossein Khodadadi, Hiroaki Taniguchi

“…Furthermore, this study provides a robust and reliable protocol for gene knockdown in neuronal-like cells derived from P19 cells, thereby facilitating further investigations into the intricate molecular mechanisms that govern neurogenesis, neuronal maturation, and overall brain development. • Developed a novel protocol for targeted gene knockdown in P19 cells during neuronal differentiation. • Successful silencing of the Nfe2l1 gene during neuronal differentiation, validated by western blot. • This study provides a reliable protocol for gene knockdown in neuronal differentiation, aiding functional studies of genes in neurogenesis.…”
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Experiences of healthcare professionals returning to work post breast cancer diagnosis in China: A descriptive qualitative study by Bijun Mao, Ya Shen, Yan Chen, Peihong Zhou, Yuping Pan

“…Additionally, interviewees expressed guilt during sick leave, it was suggested that hospitals implement comprehensive support mechanisms related to leave, acknowledging the imperative need for adequate rest during the treatment period.…”
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Development of a new solar system integrating photovoltaic and thermoelectric modules with paraffin-based nanomaterials by A. M. Alinia, M. Sheikholeslami

“…Abstract This study investigates a comprehensive enhancement strategy for photovoltaic (PV) panel efficiency, focusing on increasing electrical output through the integration of parabolic reflectors, advanced cooling mechanisms, and thermoelectric generation. Parabolic reflectors are implemented in the system to maximize solar irradiance on the PV panel’s surface, while a specialized cooling system is introduced to regulate temperature distribution across the silicon layer. …”
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Digital things as objects of civil rights by Babetska I.

“…The purpose of the article is to define the concept of “digital things”, “objects of civil rights”, “digital relations” and to clarify the issue of the mechanism of circulation of digital things in civil circulation. …”
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Amplified impact of contact uniformity on the performance of low-catalyst-loading fuel cells by Yuanzhe Ma, Xuanyu Wang, Ziliang Deng, Yongzhen Wang, Nanfeng Zheng, Kai Han, Zipeng Zhao

“…Our findings suggest that the requirement of mechanical design and manufacturing accuracy of the components should be higher for PEMFC with lower catalyst loading.…”
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Àfìhàn Àwo̩ n O̩ lo̩ ́pàá Oríle̩ ̀-èdè Nàijíríà Nínú Às̩ àyàn Lítírés̩ o̩ ̀ Àpile̩ ̀ko̩ by Justina O̩lábo̩wálé Adams

“…Ìwé ìtàn àròso̩ marun-un, eré- onítàn me̩ ́ fà àti ewì meji la s̩ àtúpalè ̩ . …”
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Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity by Jessica M. V. Pino, Vitória F. Silva, Marcos Mônico-Neto, Danielle C. Seva, Melissa Y. Kato, July N. Alves, Gabriela C. Pereira, Hanna Karen M. Antunes, Thales D. Galvao, Lia R. A. Bitterncourt, Sergio Tufik, Lysien I. Zambrano, Ana R. Dâmaso, Lila M. Oyama, David Thivel, Raquel M. S. Campos, Kil S. Lee

“…Insulin resistance, the abundance of advanced glycated end-products, and inflammation are some of the mechanisms associated with the lower cognitive performance observed in obesity. …”
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Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review by Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin YQ Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard PL Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri

“…Conclusion: Although the systemic manifestations of SARS-CoV-2 infection are variegated, they are deeply interwoven by shared mechanisms. Two phases of extrapulmonary disease were identified: (a) an early phase with possible gastrointestinal, ocular and cutaneous involvement; and (b) a late phase characterised by multiorgan dysfunction and clinical deterioration. …”
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First note of QTL mapping of low vigor traits using the updated F2 ‘Koroneiki’ linkage map of olive by Irene Granata, Aparna S. Balan, Aparna S. Balan, Claudio Di Vaio, Antonino Ioppolo, Tiziano Caruso, Silvia Fretto, Jubina Benny, Antonio Giovino, Daniel James Sargent, Francesco Paolo Marra, Annalisa Marchese

“….), which characterizes the agriculture of the Mediterranean basin, faces challenges adapting to high-density orchards and mechanized cultivation. This study addresses a key issue: controlling tree size to enhance efficiency and manageability in olive cultivation. …”
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Study on Impact Tendency of Coal and Rock Mass Based on Different Stress Paths by Chengliang Zhang, Danyong Ye, Ping Yang, Shunchuan Wu, Chao Wang

“…The results are shown as follows: (1) The rock roof was determined to have a weak impact tendency through the mechanical test. (2) With the increased size, the microcracks in the rock samples increased correspondingly, and the increased meso-defect leading to the increased heterogeneity was an essential reason for the size effect. …”
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Predictive factors for extubation success in very low and extremely low birth weight preterm infants by Nilson Willamy Bastos de Souza Júnior, Tathiane Ribeiro Rosa, Jane Cecília Kreling Cerântola, Ligia Silvana Lopes Ferrari, Vanessa Suziane Probst, Josiane Marques Felcar

“…# Background Although invasive mechanical ventilation (IMV) has contributed to the survival of preterm infants with extremely low birth weight (ELBW), it is also associated with unsatisfactory clinical outcomes when used for prolonged periods. …”
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Commonality of Virulence-Promoting Function in Rhodococcus equi Virulence Associated Proteins (Vaps) by Timothy R. Ganderton, Daniel Ghete, Karen Hogg, Graeme J. Park, Christoph G. Baumann, Anthony J. Wilkinson, Paul R. Pryor

“…These data imply that the molecular mechanism(s) that VapA uses to neutralise lysosomal acidity should also be seen in VapN and K which will help guide researchers in identifying their precise mode of action and aid the future development of targeted therapeutics.…”
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