Copper and iron as unique trace elements linked to fibromyalgia risk by Wenxing Zeng, Minhua Hu, Luyao Ma, Feng Huang, Ziwei Jiang

“…Future research should further validate these findings and explore the specific biological mechanisms through which Cu and Fe influence FM risk.…”
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An Approach for Detecting Parkinson’s Disease by Integrating Optimal Feature Selection Strategies with Dense Multiscale Sample Entropy by Minh Tai Pham Nguyen, Minh Khue Phan Tran, Tadashi Nakano, Thi Hong Tran, Quoc Duy Nam Nguyen

“…DM-SamEn employs a weighting mechanism that considers the dynamic properties of the signal, thereby reducing redundancy and improving the distinctiveness of features extracted from vertical ground reaction force (VGRF) signals in patients with Parkinson’s disease. …”
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Improvement of the Power System's Transient Stability Using the Unified Power Flow Controller with Fuzzy Logic Technique by Raghad Hameed Ahmed, Ahmed Said Nouri

“…This article discusses the power flow mechanism in a transmission line, which is necessary for understanding the functioning of UPFC in a transmission line and using a standard PI controller with voltage references in the control circuit of both converters. …”
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A Polymer-Binder-Free Approach to Creating Functional LiFePO₄ Cathodes by Organic Ionic Plastic Crystal-Derived Ion-Conductive Binders by Daniela M. Josepetti, Maria Forsyth, Patrick C. Howlett, Hiroyuki Ueda

“…In this context, binary composites of organic ionic plastic crystals (OIPCs) and lithium salts show promise due to their impressive mechanical properties and ionic conductivity. Taking advantage of this, the present paper substitutes the commercial non-electrochemically active binder with an OIPC component, <i>N</i>-ethyl-<i>N</i>-methylpyrrolidinium bis(fluorosulfonyl)imide ([C₂mpyr][FSI]), in combination with LiFSI. …”
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Vegetation greening and climate change respectively regulates the long-term trend and interannual variability in evapotranspiration over the Loess Plateau since the 21st century by Qiaoyin Tan, Ting Hua, Ting Hua, Haichen Zhao, Peiye Zhou, Peiye Zhou

“…Despite these findings, the underlying mechanisms driving ET variations remain contentious due to the complex interplay of multiple factors. …”
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Comparative transcriptome analysis reveals the key role of photosynthetic traits in the formation of differences in photothermal sensitivity in tobacco by Yanfeng Zheng, Qiwei Yu, Anbin Lu, Xiue Chen, Kai Yang, Jingyao Zhang, Ying Huang, Renxiang Liu

“…However, the precise mechanisms underlying the development of photothermal sensitivity in tobacco remain unclear. …”
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Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity by Darya V. Bazovkina, Elena M. Kondaurova, Vladimir S. Naumenko, Evgeni Ponimaskin

“…Taken together, our data indicate the implication of 5-HT2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT2C and 5-HT2A receptors.…”
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CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53 by Hongqiang Gao, Ran Xie, Rong Huang, Chonglin Wang, Yue Wang, Dongdong Wang, Kaimin Liu, Conghui Yang, Qingxiong Yang, Long Chen

“…Pancreatic cancer is one of the most malignant gastrointestinal tumors, and it is of great significance to explore the molecular mechanism of its progression and find new biological therapeutic targets. …”
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Antimicrobial activity of Monascus purpureus-derived red pigments against Salmonella typhimurium, Escherichia coli, and Enterococcus faecalis by Islam I. Teiba, Islam Mamdouh, Mokhtar I. Yousef, Ahmed Hussein, Emad H. El-Bilawy

“…Scanning electron microscopy was employed to explore the mechanism of action of the red dye extract, highlighting its impact on bacterial plasma membrane permeability and its interference with cellular energy production. …”
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Capivasertib enhances chimeric antigen receptor T cell activity in preclinical models of B cell lymphoma by Hui-Ju Hsieh, Ryan Urak, Mary C. Clark, Larry W. Kwak, Stephen J. Forman, Xiuli Wang

“…Since PTEN deficiency is common in cancer and is the main mechanism for capivasertib function, combination therapy may provide an alternative solution for the challenges of CAR T cell therapy.…”
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How and why a multifaceted intervention to improve adherence post-MI worked for some (and could work better for others): an outcome-driven qualitative process evaluation by Holly O Witteman, Laura Desveaux, Justin Presseau, Noah Michael Ivers, Marianne Saragosa, Kirstie Russell, Nicola McCleary, J-D Schwalm

“…Objectives To explore (1) the extent to which a multicomponent intervention addressed determinants of the desired behaviours (ie, adherence to cardiac rehabilitation (CR) and cardiovascular medications), (2) the associated mechanism(s) of action and (3) how future interventions might be better designed to meet the needs of this patient population.Design A qualitative evaluation embedded within a multicentre randomised trial, involving purposive semistructured interviews.Setting Nine cardiac centres in Ontario, Canada.Participants Potential participants were stratified according to the trial’s primary outcomes of engagement and adherence, resulting in three groups: (1) engaged, adherence outcome positive, (2) engaged, adherence outcome negative and (3) did not engage, adherence outcome negative. …”
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Ecological Water Level Determination and Safeguard Measures for Rivers in Northern Jiangsu Plain by WANG Zhenqi, FANG Hongyuan, XU Guangdong, ZHU Ye, WANG Chengjie

“…Effective methods of calculating the threshold of river ecological flow (water level) need to be employed to obtain measures of controlling the ecological state of rivers in a plain river network and to build a robust long-term mechanism of ecological flow control.The Zongliutang River in the river network area of Northern Jiangsu Plain is divided into upper,middle,and lower reaches according to its objective environment and its actual operation and management situation.Then,the controlling condition of the ecological water level of each reach is analyzed respectively.Considering the hydrological characteristics,hydrodynamic characteristics,and observed hydrological data conditions of rivers in this river network area,several methods are utilized to calculate the ecological water level threshold of the middle reach of the river respectively.Those methods include the annual minimum water level method with a 90% guarantee rate,the wetted perimeter method,the minimum monthly average water level method,and the lowest survival water depth method.Through the comparative analysis of actual river operation and management schemes,the ecological water level targets of the upper,middle,and lower reaches of the river are comprehensively determined as 17.40 m,8.96 m,and 7.50 m respectively.After the control value of the ecological water level of the river is obtained by comprehensive analysis,the actual operation and management situation of the river is taken into account to propose specific safeguard measures for maintaining the ecological water level (flow) target of the river from multiple perspectives.Some of the measures are constructing a robust and feasible ecological flow control system,accelerating the construction of an information monitoring system of ecological flow and water intake and an early warning system safeguarding the ecological water level target,and strengthening the supervision and assessment of the implementation of river and lake ecological flows (water levels).…”
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Roles of core nosZ denitrifiers in enhancing denitrification activity under long-term rice straw retention by Shijie Zhang, Shijie Zhang, Mengyao Hou, Mengyao Hou, Bing Li, Bing Li, Panfeng Guan, Panfeng Guan, Qing Chi, Qing Chi, Hao Sun, Hao Sun, Hangbo Xu, Hangbo Xu, Dongjie Cui, Dongjie Cui, Yupan Zhu, Yupan Zhu

“…The denitrification process is known to contribute to soil nitrogen (N) loss, which is strongly affected by fertilization strategies; however, the effects of distinct straw retention modes on soil denitrification activity have rarely been discriminated and the underlying mechanisms remain unclear. This study coupled field and incubation experiments to explore the characteristics of soil denitrification activity, soil and standing water physicochemical properties, and the abundance, community diversity, and co-occurrence network of nosZ denitrifiers, based on a paddy field implementing 10-year straw retention under a rice–wheat rotation system. …”
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Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies by Feng Zhang, Feng Zhang, Tao Li, Junli Wan, Junli Wan, Lu Wang, Lu Wang, Wenmei Guo, Wenmei Guo, Yue Hu, Yue Hu, Hao Wang, Hao Wang, Wei Bian, Wei Bian

“…The primary outcome measures included the survival of retinal ganglion cells and retinal thickness.ResultsThe comprehensive analysis of the 30 included studies revealed that resveratrol can enhance the expression of Sirtuin 1(SIRT1) protein in retinal tissue (SMD: 3.00, 95% CI: 2.46, 3.53, P = 0.095), boost the survival rate of retinal ganglion cells (SMD: 4.33, 95% CI: 3.28, 5.38, P &lt; 0.05), decelerate the thinning of retinal thickness (SMD: 4.26, 95% CI: 2.77, 5.75, P &lt; 0.05), and enhance visual function. Its potential mechanism of action may involve the suppression of pro-inflammatory cytokine levels and cell apoptosis.DiscussionResveratrol emerges as a promising agent for mitigating glaucoma-related retinal damage. …”
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Polymorphism of angiogenesis regulation factor genes (<i>VEGF/VEGFR</i>), and extracellular matrix remodeling genes (<i>MMP/TIMP</i>), and the levels of their products in extracell... by V. I. Konenkov, V. V. Nimaev, A. V. Shevchenko, V. F. Prokofiev

“…Violations of the normal drainage of tissue fluids accompany lymphedema. An important mechanism of angiogenesis and vasculogenesis regulation in tissue fluids is the production and reception of vascular endothelial growth factors in combination with the regulation of matrix metalloproteinases. …”
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Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…However, the effective targets and mechanisms for specific toxicity and biological activity are still unclear. …”
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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

“…In this study, we assessed the function-immunogenicity relationship of the multi-component vaccine candidate (referred to as VC-13) to elucidate a mechanism of action. We identified a potential universal delivery platform, not only capable of adjuvanting different peptide epitopes (e.g., NS1 and 88/30 from group A Streptococcus, gonadotropin hormone releasing hormone [GnRH]), but also protein antigens (e.g., bovine serum albumin [BSA], receptor binding domain (RBD) of the SARS-CoV-2 protein responsible for COVID-19 infection [SARS-CoV-2 RBD]) and small molecular haptens (e.g., cocaine). …”
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Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden by Ann Bremander, Maria L E Andersson, S Bergman, Katarina Aili, Emma Haglund

“…We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain.Future plans By studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. …”
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Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure by Marcelo Rodrigues Dos Santos, Guilherme Wesley Peixoto daFonseca, Letícia Pironato Sherveninas, Francis Ribeiro deSouza, Antônio Carlos Battaglia Filho, Caio Eduardo Novaes, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Antônio Carlos Pereira Barretto, Maria‐Janieire de Nazaré Nunes Alves

“…Future studies are needed to address possible mechanisms involved in this relationship.…”
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Development of an algorithm impacting COPD care through personalized nutrition and IoT-based monitoring by Prachi Sharma, Mihir Gharia, Devina Aswal, Vishva Trivedi, Bhavnita Soni, Prerna Soni, Devesh Joshi, Dhvni Lalan, Vrushali Athavale, Irfan Shaikh, Koshy Jacob

“…Conclusion The comprehensive features and functionalities of the MyTatva app, combined with the personalized care plan and real-time feedback mechanisms, have led to substantial clinical improvements in COPD management. …”
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