Stability evaluation of karst roof of pile foundation based on variable weight fuzzy comprehensive theory by Xuewen HU, Yun’an LI, Zhigao FAN

“…Results indicate: (1) Factors obtained from Fault Tree Analysis theory can be used to evaluate stability systematically, identify potential event pathways, and mitigate incomplete evaluation factors. (2) The comprehensive evaluation method introduced variable weight fuzzy, employing a “penalty” mechanism for weight variation to determine the need for weight variation in assessment factors, achieves accurate on-site assessments through amplifying their influences. (3) The stability grade within the study area under the variable weight model was “unstable”, contrasting the evaluation of “relatively unstable” under the constant weight model, demonstrating that the variable weight fuzzy comprehensive evaluation model aligns more closely with on-site survey results. …”
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Comparative metabolic study of planktonic and sessile cells in Salmonella Enteritidis ATCC 13076: Elucidating metabolic pathways driving biofilm formation. by Yuliany Guillín, Claudia Ortiz, William Hidalgo

“…Among the metabolites that exhibited positive modulation in planktonic cells were proline, phenylalanine, which act as precursors of essential metabolites and part of the stress adaptation mechanisms. In addition, putrescine and cadaverine, play crucial roles in growth, stress response, and cell stability In contrast, the most representative metabolites in sessile cells included lysine, adenosine, purines, pyrimidines, and citrate, mainly associated with maintaining cellular homeostasis, stress response and metabolic regulation. …”
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Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via GSDMD-mediated pyroptosis by JianFeng Liu, Chenyang Han, Jian Shen, Yingcong Lin, Heping Shen, Genghuan Wang

“…AIM: We investigated the mechanism by which the environmental toxin acrylamide (AM) promotes depression. …”
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IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemar... by Arwa A. Elsheikh, Noha Ali Abd-Almotaleb, Mona Mostafa Ahmed, Eman El-Sayed Khayal

“…Therefore, the present work aimed to estimate the potential protective role of the oral extract of rosemary (RO)against the toxic effects of injected IONPs on the brain tissues of adult male rats, and to explore the potential underlying mechanisms involved in reversing such toxicity. Thirty adult male albino rats were allocated into five groups: the control, the vehicle (intravenous saline injection once/week), the RO extract group (orally gavaged100mg/kg/day), IONPs (intravenously injected 30 mg/kg once/week), and the combined RO+IONPs (orally gavaged RO extract 1 hrh before intravenous injection of IONPs). …”
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A novel graph neural network based approach for influenza-like illness nowcasting: exploring the interplay of temporal, geographical, and functional spatial features by Jiajia Luo, Xuan Wang, Xiaomao Fan, Yuxin He, Xiangjun Du, Yao-Qing Chen, Yang Zhao

“…Conclusion The incorporation of dual topology processing and the subsequent fusion mechanism allows the model to explore in-depth spatiotemporal feature interactions. …”
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Activation of Adenosine A3 Receptor Alleviates TNF-α-Induced Inflammation through Inhibition of the NF-κB Signaling Pathway in Human Colonic Epithelial Cells by Tianhua Ren, Yumei Qiu, Weiyun Wu, Xiao Feng, Shicai Ye, Zhuang Wang, Ting Tian, Yanting He, Caiyuan Yu, Yu Zhou

“…To investigate the expression of adenosine A3 receptor (A3AR) in human colonic epithelial cells and the effects of A3AR activation on tumor necrosis factor alpha (TNF-α-) induced inflammation in order to determine its mechanism of action in human colonic epithelial cells, human colonic epithelial cells (HT-29 cells) were treated with different concentrations of 2-Cl-IB-MECA prior to TNF-α stimulation, followed by analysis of NF-κB signaling pathway activation and downstream IL-8 and IL-1β production. …”
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Prevalence, outcome and conduct of in-hospital cardiopulmonary resuscitation in government hospitals of Nepal. by Pawan Kumar Hamal, Surendra Kunwar, Kapil Gautam, Ramesh Bhattarai, Rupesh Kumar Yadav, Ritesh Lamsal, Radeep Singh, Sonam Pathak, Nabin Pokhrel

“…The qualitative analysis highlighted the lack of trained staff, a dedicated system, feedback mechanism, and provision of post-arrest care.<h4>Conclusion</h4>Across various level of Nepal's healthcare system, cardiopulmonary resuscitation is prevalent with poor performance and outcome. …”
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Prediction of the Bending Strength of Boltless Steel Connections in Storage Pallet Racks: An Integrated Experimental-FEM-SVM Methodology by Zhi-Jun Lyu, PeiCai Zhao, Qi Lu, Qian Xiang, HongLiang Li

“…Despite the fact that the finite element method (FEM) and physical experiment have been used to obtain the mechanical performance of beam-to-column connections (BCCs), those methods have the disadvantages of high computational complexity and test cost. …”
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Brief Coping Scale TCS-9: Optimising the Assessment of Coping Strategies. The case of Health Care Workers. by Basant K. Puri, Anastasia Miari, Maria Theodoratou

“… # Contribution By enabling quicker and more efficient evaluations, the TCS-9 enhances the practicality of assessing coping mechanisms in healthcare settings, thereby contributing to the sustenance of health systems and the promotion of health equity.…”
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The role of integrated management in the realization of intelligent transportation (Case study: Zahedan city) by Amir Kaveh, Maryam Karimian Bostani, Gholam reza Miri

“…Also, the significance of the test shows that the 5 variables of intelligent transportation, namely intelligent monitoring, intelligent payment, intelligent violation registration, intelligent information, and mechanized fleet management are significant at the level of less than 0.05. …”
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Neuronauka poznawcza z punktu widzenia Mocnego Programu Socjologii Wiedzy Naukowej by Marek Więcław

“…The second is that any potential neurocognitive attempts to establish the neuronal mechanism behind meaning determinism are inevitably conducted in the mode of meaning finitism. …”
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Combined Effects of 2-Methoxyestradiol (Hypoxia-Inducible Factor 1α Inhibitor) and Dasatinib (A Second-Generation Tyrosine Kinase Inhibitor) on Chronic Myelocytic Leukemia Cells by Yuexian Zhang, Heng Chen, Yunfeng Shen, Xin Zhou

“…To clarify the therapeutic effect of inhibiting this gene on CML, the present study is aimed at exploring the treatment effects of 2-methoxyestradiol (2-ME2), dasatinib alone, and combined both on K-562 cells and the possible mechanism of 2-ME2 in treating the disorder. The levels of HIF-1α, vascular endothelial growth factor (VEGF), and glutamate synthase 1 (GLU1) genes in K-562 cells were affected dose-dependently after 2-ME2 administration. 2-ME2 induced cell apoptosis by downregulating antiapoptotic protein expressions of Bcl-xl and Bcl-2. …”
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A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles by Ziqi Zhao, Kun Xu, Boqian Hu, Yizhuo Jiang, Xisheng Xu, Yuliang Liu

“…Further research is imperative to exploit the potential of the gut microbiota in cancer therapy, advocating for personalized approaches and a more profound comprehension of the underlying mechanisms.…”
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Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy by Baijin Xia, Huolun Feng, Xinmiao Jiang, Jialing Guo, Keming Lin, Wenxing Zhang, Fan Xing, Lixue Cao, Yong Li, Hui Zhang, Xu Zhang, Wenyu Li, Fei Yu

“…On the other hand, although direct Granzyme B (GrB) administration can effectively induce tumor cell apoptosis, it lacks universal tumor targeting and efficient cellular entry mechanisms. To address these limitations, we developed a novel nanoparticle-based therapy for the precise targeting of TCL tumor cells and the delivery of GrB. …”
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The historical nature of the legal tradition by Ilyn L.

“…It reveals its importance as a mechanism for preserving the socio-cultural identity of law and proves its vital role in adapting modern law to global challenges. …”
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Diagnosis of Coronary Heart Disease Through Deep Learning-Based Segmentation and Localization in Computed Tomography Angiography by Bo Zhao, Jianjun Peng, Ce Chen, Yongyan Fan, Kai Zhang, Yang Zhang

“…Vision transformers, with their self-attention mechanisms, offer a global perspective, yet demand extensive data and computational resources, making them less adaptable for the often limited medical imaging datasets. …”
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Assessing the Prevalence of Viral and Virus-Like Diseases in Citrus Orchards of Northeast Morocco: A Contribution to Orchard Health by Abdelhak Khallou, Zineb Belabess, Yassine Boualam, Safae Mohsini, Rachid Lahlali

“…However, this agricultural heritage faces significant threats from various pathogens, transmitted either naturally or mechanically, among which viruses and virus-like organisms are predominant. …”
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Identification of hypertension gene expression biomarkers based on the DeepGCFS algorithm. by Zongjin Li, Liqin Tian, Libing Bai, Zeyu Jia, Xiaoming Wu, Changxin Song

“…Therefore, understanding its mechanisms is essential for treating and preventing hypertension. …”
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Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species by Montserrat Torres-Oliva, Elisa Buchberger, Alexandra D. Buffry, Maike Kittelmann, Genoveva Guerrero, Lauren Sumner-Rooney, Pedro Gaspar, Georg C. Bullinger, Javier Figueras Jimenez, Fernando Casares, Saad Arif, Nico Posnien, Maria D. S. Nunes, Alistair P. McGregor, Isabel Almudi

“…Conclusions Taken together, our results suggest that differential timing of otd expression may contribute to natural variation in ommatidia size between D. mauritiana and D. simulans, which provides new insights into the mechanisms underlying the regulation and evolution of compound eye size in insects.…”
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Balancing Progress and Preservation: The Complex Interplay of Economic Growth and Forest Conservation in Nepal’s Carbon Dioxide Emissions by Omkar Poudel, Pradeep Acharya, Sarad Chandra Kafle, Basanta Prasad Adhikari

“…Therefore, the implementation of effective strategies and economic measures, such as afforestation and reforestation, forest protection, sustainable forest management, and mechanisms like REDD+ (reducing emissions from deforestation and forest degradation plus), can play a vital role in mitigating carbon emissions while simultaneously addressing deforestation and ensuring long-term economic progress in Nepal.…”
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